Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-06

AUTHORS

Ikuroh Ohsawa, Masahiro Ishikawa, Kumiko Takahashi, Megumi Watanabe, Kiyomi Nishimaki, Kumi Yamagata, Ken-Ichiro Katsura, Yasuo Katayama, Sadamitsu Asoh, Shigeo Ohta

ABSTRACT

Acute oxidative stress induced by ischemia-reperfusion or inflammation causes serious damage to tissues, and persistent oxidative stress is accepted as one of the causes of many common diseases including cancer. We show here that hydrogen (H(2)) has potential as an antioxidant in preventive and therapeutic applications. We induced acute oxidative stress in cultured cells by three independent methods. H(2) selectively reduced the hydroxyl radical, the most cytotoxic of reactive oxygen species (ROS), and effectively protected cells; however, H(2) did not react with other ROS, which possess physiological roles. We used an acute rat model in which oxidative stress damage was induced in the brain by focal ischemia and reperfusion. The inhalation of H(2) gas markedly suppressed brain injury by buffering the effects of oxidative stress. Thus H(2) can be used as an effective antioxidant therapy; owing to its ability to rapidly diffuse across membranes, it can reach and react with cytotoxic ROS and thus protect against oxidative damage. More... »

PAGES

688-694

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nm1577

DOI

http://dx.doi.org/10.1038/nm1577

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031138180

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17486089


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Administration, Inhalation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antioxidants", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cerebral Infarction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hydrogen", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hydroxyl Radical", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Potential, Mitochondrial", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oxidation-Reduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "PC12 Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Sprague-Dawley", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reperfusion Injury", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Nippon Medical School", 
          "id": "https://www.grid.ac/institutes/grid.410821.e", 
          "name": [
            "Department of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Graduate School of Medicine, Nippon Medical School, 1-396 Kosugi-cho, Nakahara-ku, Kawasaki City 211-8533, Japan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ohsawa", 
        "givenName": "Ikuroh", 
        "id": "sg:person.01250650327.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01250650327.09"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Ishikawa", 
        "givenName": "Masahiro", 
        "id": "sg:person.01115222151.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115222151.03"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Takahashi", 
        "givenName": "Kumiko", 
        "id": "sg:person.01173037501.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173037501.13"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Watanabe", 
        "givenName": "Megumi", 
        "id": "sg:person.01307266101.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307266101.51"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Nishimaki", 
        "givenName": "Kiyomi", 
        "id": "sg:person.01000773551.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000773551.67"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Yamagata", 
        "givenName": "Kumi", 
        "id": "sg:person.01170315142.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170315142.67"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Katsura", 
        "givenName": "Ken-Ichiro", 
        "id": "sg:person.0721711403.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721711403.34"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Katayama", 
        "givenName": "Yasuo", 
        "id": "sg:person.01141355146.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01141355146.64"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Asoh", 
        "givenName": "Sadamitsu", 
        "id": "sg:person.0602077541.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602077541.76"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Ohta", 
        "givenName": "Shigeo", 
        "id": "sg:person.012113643732.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012113643732.70"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1161/01.res.0000188210.72062.10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008614623"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.0000188210.72062.10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008614623"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.brainres.2004.02.031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008864749"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1742-4658.2005.05103.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009805946"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1742-4658.2005.05103.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009805946"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s004210050050", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011189293", 
          "https://doi.org/10.1007/s004210050050"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-4159.2005.03530.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014748469"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-4159.2005.03530.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014748469"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000047804", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016874296"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.freeradbiomed.2004.06.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017819454"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1113/jphysiol.2003.049478", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018334362"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bst0340232", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022933989"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bst0340232", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022933989"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neures.2005.08.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029091749"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neures.2005.08.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029091749"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1248/bpb.27.475", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030026087"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.0000182241.07096.06", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030214659"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.0000182241.07096.06", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030214659"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbadis.2005.10.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030374552"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbadis.2005.10.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030374552"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10540-005-2741-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038299351", 
          "https://doi.org/10.1007/s10540-005-2741-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10540-005-2741-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038299351", 
          "https://doi.org/10.1007/s10540-005-2741-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1368-5031.2006.00825.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039658064"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1368-5031.2006.00825.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039658064"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0169-328x(98)00040-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049039009"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m209264200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049337439"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1471-4159.2003.01619.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049957920"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0531-5565(02)00241-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050111928"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0531-5565(02)00241-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050111928"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1602/neurorx.1.1.46", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050398314", 
          "https://doi.org/10.1602/neurorx.1.1.46"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mad.2005.03.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050968469"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mad.2005.03.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050968469"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.262460299", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051056202"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.genet.39.110304.095751", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053197411"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.genet.39.110304.095751", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053197411"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0300-483x(02)00286-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053421354"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.297.8.842", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054167645"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bst20060232", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056717499"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1063/1.1696199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057767415"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1063/1.555805", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058109677"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/0929867033456440", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069160041"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/1381612043384718", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069165254"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/physrev.1999.79.4.1431", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074529426"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.18-01-00205.1998", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083190460"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2007-06", 
    "datePublishedReg": "2007-06-01", 
    "description": "Acute oxidative stress induced by ischemia-reperfusion or inflammation causes serious damage to tissues, and persistent oxidative stress is accepted as one of the causes of many common diseases including cancer. We show here that hydrogen (H(2)) has potential as an antioxidant in preventive and therapeutic applications. We induced acute oxidative stress in cultured cells by three independent methods. H(2) selectively reduced the hydroxyl radical, the most cytotoxic of reactive oxygen species (ROS), and effectively protected cells; however, H(2) did not react with other ROS, which possess physiological roles. We used an acute rat model in which oxidative stress damage was induced in the brain by focal ischemia and reperfusion. The inhalation of H(2) gas markedly suppressed brain injury by buffering the effects of oxidative stress. Thus H(2) can be used as an effective antioxidant therapy; owing to its ability to rapidly diffuse across membranes, it can reach and react with cytotoxic ROS and thus protect against oxidative damage.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nm1577", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1113716", 
        "issn": [
          "1078-8956", 
          "1546-170X"
        ], 
        "name": "Nature Medicine", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "13"
      }
    ], 
    "name": "Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals", 
    "pagination": "688-694", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "9456bfd30e0aa3a2dd995f98aedfac2c977f0cee890f0742b16f8ba39ca4db2d"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "17486089"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9502015"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nm1577"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1031138180"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nm1577", 
      "https://app.dimensions.ai/details/publication/pub.1031138180"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T00:55", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8697_00000425.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/nm/journal/v13/n6/full/nm1577.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nm1577'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nm1577'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nm1577'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nm1577'


 

This table displays all metadata directly associated to this object as RDF triples.

282 TRIPLES      21 PREDICATES      76 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nm1577 schema:about N2ec29b4cfa9a4ed6b10caf1429e08374
2 N33c3cddea28a4d72a0e651b68d8e7706
3 N4af4ecdea0c3495381bc4507d497897a
4 N4ff1b858ad2642dfa9e6d621285f391d
5 N5a193d931803455f8c5148eb3986c790
6 N8970eaabd4f444c3beb516053dc97e78
7 N9a3fc08b12144b6bb66c33807ec19ad7
8 N9f330f89d2864c30ba27b4ae45cabddf
9 Nabfd6df2a91f40d1896c009a1265253a
10 Nafbb7306158e4667acf47313c79e885f
11 Nbe72c9e61a354a8aad98b080625c9cac
12 Nc8c3b2bf09564401a12a8b1a48536fd1
13 Nd30efd371b89405c8cd886084ed48b51
14 Ndd40664b498d42f79601499e04addcac
15 Nf2def849f1ce415fa1a22ec6e43fda5c
16 anzsrc-for:11
17 anzsrc-for:1109
18 schema:author Nb070b32f8d5f481096e5e54b29564281
19 schema:citation sg:pub.10.1007/s004210050050
20 sg:pub.10.1007/s10540-005-2741-8
21 sg:pub.10.1602/neurorx.1.1.46
22 https://doi.org/10.1001/jama.297.8.842
23 https://doi.org/10.1016/j.bbadis.2005.10.007
24 https://doi.org/10.1016/j.brainres.2004.02.031
25 https://doi.org/10.1016/j.freeradbiomed.2004.06.012
26 https://doi.org/10.1016/j.mad.2005.03.026
27 https://doi.org/10.1016/j.neures.2005.08.002
28 https://doi.org/10.1016/s0169-328x(98)00040-0
29 https://doi.org/10.1016/s0300-483x(02)00286-x
30 https://doi.org/10.1016/s0531-5565(02)00241-3
31 https://doi.org/10.1042/bst0340232
32 https://doi.org/10.1042/bst20060232
33 https://doi.org/10.1046/j.1471-4159.2003.01619.x
34 https://doi.org/10.1063/1.1696199
35 https://doi.org/10.1063/1.555805
36 https://doi.org/10.1073/pnas.262460299
37 https://doi.org/10.1074/jbc.m209264200
38 https://doi.org/10.1111/j.1368-5031.2006.00825.x
39 https://doi.org/10.1111/j.1471-4159.2005.03530.x
40 https://doi.org/10.1111/j.1742-4658.2005.05103.x
41 https://doi.org/10.1113/jphysiol.2003.049478
42 https://doi.org/10.1146/annurev.genet.39.110304.095751
43 https://doi.org/10.1152/physrev.1999.79.4.1431
44 https://doi.org/10.1159/000047804
45 https://doi.org/10.1161/01.res.0000188210.72062.10
46 https://doi.org/10.1161/01.str.0000182241.07096.06
47 https://doi.org/10.1248/bpb.27.475
48 https://doi.org/10.1523/jneurosci.18-01-00205.1998
49 https://doi.org/10.2174/0929867033456440
50 https://doi.org/10.2174/1381612043384718
51 schema:datePublished 2007-06
52 schema:datePublishedReg 2007-06-01
53 schema:description Acute oxidative stress induced by ischemia-reperfusion or inflammation causes serious damage to tissues, and persistent oxidative stress is accepted as one of the causes of many common diseases including cancer. We show here that hydrogen (H(2)) has potential as an antioxidant in preventive and therapeutic applications. We induced acute oxidative stress in cultured cells by three independent methods. H(2) selectively reduced the hydroxyl radical, the most cytotoxic of reactive oxygen species (ROS), and effectively protected cells; however, H(2) did not react with other ROS, which possess physiological roles. We used an acute rat model in which oxidative stress damage was induced in the brain by focal ischemia and reperfusion. The inhalation of H(2) gas markedly suppressed brain injury by buffering the effects of oxidative stress. Thus H(2) can be used as an effective antioxidant therapy; owing to its ability to rapidly diffuse across membranes, it can reach and react with cytotoxic ROS and thus protect against oxidative damage.
54 schema:genre research_article
55 schema:inLanguage en
56 schema:isAccessibleForFree false
57 schema:isPartOf N81e525224f1c47eba2d7d43356e0184f
58 Ndcfa6da01d4241f2a93096dc7cddfbcc
59 sg:journal.1113716
60 schema:name Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals
61 schema:pagination 688-694
62 schema:productId N38be5fbf7f0a439ab0c86002046723b6
63 N4835fccfa235449e929dc5aba0158e4d
64 N6bf1139b0d0c4284b8cac693d367e5d5
65 N7e057b8a44084a0b875b683f0c18e9b4
66 Nae5cc01318b54880969429a4f5ca9143
67 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031138180
68 https://doi.org/10.1038/nm1577
69 schema:sdDatePublished 2019-04-11T00:55
70 schema:sdLicense https://scigraph.springernature.com/explorer/license/
71 schema:sdPublisher N25b913a650394cd589bdec1900e9dba4
72 schema:url http://www.nature.com/nm/journal/v13/n6/full/nm1577.html
73 sgo:license sg:explorer/license/
74 sgo:sdDataset articles
75 rdf:type schema:ScholarlyArticle
76 N14ee4b3165c6466abea2850c1e782566 rdf:first sg:person.01115222151.03
77 rdf:rest Na797bee78bea4db3828a97defac6cd38
78 N25b913a650394cd589bdec1900e9dba4 schema:name Springer Nature - SN SciGraph project
79 rdf:type schema:Organization
80 N2ec29b4cfa9a4ed6b10caf1429e08374 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Rats, Sprague-Dawley
82 rdf:type schema:DefinedTerm
83 N33c3cddea28a4d72a0e651b68d8e7706 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Cerebral Infarction
85 rdf:type schema:DefinedTerm
86 N3547649ef905452da080bc7b9dd7c539 rdf:first sg:person.012113643732.70
87 rdf:rest rdf:nil
88 N38be5fbf7f0a439ab0c86002046723b6 schema:name readcube_id
89 schema:value 9456bfd30e0aa3a2dd995f98aedfac2c977f0cee890f0742b16f8ba39ca4db2d
90 rdf:type schema:PropertyValue
91 N46da072b2d1146bfbf1a0ae57cd3f19c rdf:first sg:person.01000773551.67
92 rdf:rest Nd2d1cff13d88491a9e4b763c2f0d8c1a
93 N4835fccfa235449e929dc5aba0158e4d schema:name pubmed_id
94 schema:value 17486089
95 rdf:type schema:PropertyValue
96 N4af4ecdea0c3495381bc4507d497897a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Administration, Inhalation
98 rdf:type schema:DefinedTerm
99 N4ff1b858ad2642dfa9e6d621285f391d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Hydroxyl Radical
101 rdf:type schema:DefinedTerm
102 N5a193d931803455f8c5148eb3986c790 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Membrane Potential, Mitochondrial
104 rdf:type schema:DefinedTerm
105 N6bf1139b0d0c4284b8cac693d367e5d5 schema:name dimensions_id
106 schema:value pub.1031138180
107 rdf:type schema:PropertyValue
108 N7e057b8a44084a0b875b683f0c18e9b4 schema:name doi
109 schema:value 10.1038/nm1577
110 rdf:type schema:PropertyValue
111 N81e525224f1c47eba2d7d43356e0184f schema:issueNumber 6
112 rdf:type schema:PublicationIssue
113 N8557897db91d49deab0587ee86c8d2f9 rdf:first sg:person.0602077541.76
114 rdf:rest N3547649ef905452da080bc7b9dd7c539
115 N8970eaabd4f444c3beb516053dc97e78 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Hydrogen
117 rdf:type schema:DefinedTerm
118 N916871c1aba64838b772aea1d2d38228 rdf:first sg:person.0721711403.34
119 rdf:rest Nc2dff175136b47b78b7339cf39696beb
120 N9a3fc08b12144b6bb66c33807ec19ad7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Antioxidants
122 rdf:type schema:DefinedTerm
123 N9f330f89d2864c30ba27b4ae45cabddf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Rats
125 rdf:type schema:DefinedTerm
126 Na797bee78bea4db3828a97defac6cd38 rdf:first sg:person.01173037501.13
127 rdf:rest Ne70090f1d8dd44e781789542b3cfc535
128 Nabfd6df2a91f40d1896c009a1265253a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Male
130 rdf:type schema:DefinedTerm
131 Nae5cc01318b54880969429a4f5ca9143 schema:name nlm_unique_id
132 schema:value 9502015
133 rdf:type schema:PropertyValue
134 Nafbb7306158e4667acf47313c79e885f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Reperfusion Injury
136 rdf:type schema:DefinedTerm
137 Nb070b32f8d5f481096e5e54b29564281 rdf:first sg:person.01250650327.09
138 rdf:rest N14ee4b3165c6466abea2850c1e782566
139 Nbe72c9e61a354a8aad98b080625c9cac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Humans
141 rdf:type schema:DefinedTerm
142 Nc2dff175136b47b78b7339cf39696beb rdf:first sg:person.01141355146.64
143 rdf:rest N8557897db91d49deab0587ee86c8d2f9
144 Nc8c3b2bf09564401a12a8b1a48536fd1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Disease Models, Animal
146 rdf:type schema:DefinedTerm
147 Nd2d1cff13d88491a9e4b763c2f0d8c1a rdf:first sg:person.01170315142.67
148 rdf:rest N916871c1aba64838b772aea1d2d38228
149 Nd30efd371b89405c8cd886084ed48b51 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Oxidation-Reduction
151 rdf:type schema:DefinedTerm
152 Ndcfa6da01d4241f2a93096dc7cddfbcc schema:volumeNumber 13
153 rdf:type schema:PublicationVolume
154 Ndd40664b498d42f79601499e04addcac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name PC12 Cells
156 rdf:type schema:DefinedTerm
157 Ne70090f1d8dd44e781789542b3cfc535 rdf:first sg:person.01307266101.51
158 rdf:rest N46da072b2d1146bfbf1a0ae57cd3f19c
159 Nf2def849f1ce415fa1a22ec6e43fda5c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Animals
161 rdf:type schema:DefinedTerm
162 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
163 schema:name Medical and Health Sciences
164 rdf:type schema:DefinedTerm
165 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
166 schema:name Neurosciences
167 rdf:type schema:DefinedTerm
168 sg:journal.1113716 schema:issn 1078-8956
169 1546-170X
170 schema:name Nature Medicine
171 rdf:type schema:Periodical
172 sg:person.01000773551.67 schema:familyName Nishimaki
173 schema:givenName Kiyomi
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000773551.67
175 rdf:type schema:Person
176 sg:person.01115222151.03 schema:familyName Ishikawa
177 schema:givenName Masahiro
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115222151.03
179 rdf:type schema:Person
180 sg:person.01141355146.64 schema:familyName Katayama
181 schema:givenName Yasuo
182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01141355146.64
183 rdf:type schema:Person
184 sg:person.01170315142.67 schema:familyName Yamagata
185 schema:givenName Kumi
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170315142.67
187 rdf:type schema:Person
188 sg:person.01173037501.13 schema:familyName Takahashi
189 schema:givenName Kumiko
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173037501.13
191 rdf:type schema:Person
192 sg:person.012113643732.70 schema:familyName Ohta
193 schema:givenName Shigeo
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012113643732.70
195 rdf:type schema:Person
196 sg:person.01250650327.09 schema:affiliation https://www.grid.ac/institutes/grid.410821.e
197 schema:familyName Ohsawa
198 schema:givenName Ikuroh
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01250650327.09
200 rdf:type schema:Person
201 sg:person.01307266101.51 schema:familyName Watanabe
202 schema:givenName Megumi
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307266101.51
204 rdf:type schema:Person
205 sg:person.0602077541.76 schema:familyName Asoh
206 schema:givenName Sadamitsu
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602077541.76
208 rdf:type schema:Person
209 sg:person.0721711403.34 schema:familyName Katsura
210 schema:givenName Ken-Ichiro
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721711403.34
212 rdf:type schema:Person
213 sg:pub.10.1007/s004210050050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011189293
214 https://doi.org/10.1007/s004210050050
215 rdf:type schema:CreativeWork
216 sg:pub.10.1007/s10540-005-2741-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038299351
217 https://doi.org/10.1007/s10540-005-2741-8
218 rdf:type schema:CreativeWork
219 sg:pub.10.1602/neurorx.1.1.46 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050398314
220 https://doi.org/10.1602/neurorx.1.1.46
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1001/jama.297.8.842 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054167645
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1016/j.bbadis.2005.10.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030374552
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1016/j.brainres.2004.02.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008864749
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1016/j.freeradbiomed.2004.06.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017819454
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1016/j.mad.2005.03.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050968469
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1016/j.neures.2005.08.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029091749
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1016/s0169-328x(98)00040-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049039009
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1016/s0300-483x(02)00286-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1053421354
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1016/s0531-5565(02)00241-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050111928
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1042/bst0340232 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022933989
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1042/bst20060232 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056717499
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1046/j.1471-4159.2003.01619.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049957920
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1063/1.1696199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057767415
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1063/1.555805 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058109677
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1073/pnas.262460299 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051056202
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1074/jbc.m209264200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049337439
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1111/j.1368-5031.2006.00825.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1039658064
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1111/j.1471-4159.2005.03530.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1014748469
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1111/j.1742-4658.2005.05103.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1009805946
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1113/jphysiol.2003.049478 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018334362
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1146/annurev.genet.39.110304.095751 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053197411
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1152/physrev.1999.79.4.1431 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074529426
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1159/000047804 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016874296
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1161/01.res.0000188210.72062.10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008614623
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1161/01.str.0000182241.07096.06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030214659
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1248/bpb.27.475 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030026087
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1523/jneurosci.18-01-00205.1998 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083190460
275 rdf:type schema:CreativeWork
276 https://doi.org/10.2174/0929867033456440 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069160041
277 rdf:type schema:CreativeWork
278 https://doi.org/10.2174/1381612043384718 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069165254
279 rdf:type schema:CreativeWork
280 https://www.grid.ac/institutes/grid.410821.e schema:alternateName Nippon Medical School
281 schema:name Department of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Graduate School of Medicine, Nippon Medical School, 1-396 Kosugi-cho, Nakahara-ku, Kawasaki City 211-8533, Japan.
282 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...