Humanization of autoantigen View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-02-25

AUTHORS

Wataru Nishie, Daisuke Sawamura, Maki Goto, Kei Ito, Akihiko Shibaki, James R McMillan, Kaori Sakai, Hideki Nakamura, Edit Olasz, Kim B Yancey, Masashi Akiyama, Hiroshi Shimizu

ABSTRACT

Transmissibility of characteristic lesions to experimental animals may help us understand the pathomechanism of human autoimmune disease. Here we show that human autoimmune disease can be reproduced using genetically engineered model mice. Bullous pemphigoid (BP) is the most common serious autoimmune blistering skin disease, with a considerable body of indirect evidence indicating that the underlying autoantigen is collagen XVII (COL17). Passive transfer of human BP autoantibodies into mice does not induce skin lesions, probably because of differences between humans and mice in the amino acid sequence of the COL17 pathogenic epitope. We injected human BP autoantibody into Col17-knockout mice rescued by the human ortholog. This resulted in BP-like skin lesions and a human disease phenotype. Humanization of autoantigens is a new approach to the study of human autoimmune diseases. More... »

PAGES

378-383

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nm1496

DOI

http://dx.doi.org/10.1038/nm1496

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025652921

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17322897


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