Polyvalent vaccines for optimal coverage of potential T-cell epitopes in global HIV-1 variants View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-01

AUTHORS

Will Fischer, Simon Perkins, James Theiler, Tanmoy Bhattacharya, Karina Yusim, Robert Funkhouser, Carla Kuiken, Barton Haynes, Norman L Letvin, Bruce D Walker, Beatrice H Hahn, Bette T Korber

ABSTRACT

HIV-1/AIDS vaccines must address the extreme diversity of HIV-1. We have designed new polyvalent vaccine antigens comprised of sets of 'mosaic' proteins, assembled from fragments of natural sequences via a computational optimization method. Mosaic proteins resemble natural proteins, and a mosaic set maximizes the coverage of potential T-cell epitopes (peptides of nine amino acids) for a viral population. We found that coverage of viral diversity using mosaics was greatly increased compared to coverage by natural-sequence vaccine candidates, for both variable and conserved proteins; for conserved HIV-1 proteins, global coverage may be feasible. For example, four mosaic proteins perfectly matched 74% of 9-amino-acid potential epitopes in global Gag sequences; 87% of potential epitopes matched at least 8 of 9 positions. In contrast, a single natural Gag protein covered only 37% (9 of 9) and 67% (8 of 9). Mosaics provide diversity coverage comparable to that afforded by thousands of separate peptides, but, because the fragments of natural proteins are compressed into a small number of native-like proteins, they are tractable for vaccines. More... »

PAGES

100-106

References to SciGraph publications

Journal

TITLE

Nature Medicine

ISSUE

1

VOLUME

13

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nm1461

DOI

http://dx.doi.org/10.1038/nm1461

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013466904

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17187074


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

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Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nm1461'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nm1461'


 

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