VEGF modulates erythropoiesis through regulation of adult hepatic erythropoietin synthesis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-06-25

AUTHORS

Betty Y Y Tam, Kevin Wei, John S Rudge, Jana Hoffman, Joceyln Holash, Sang-ki Park, Jenny Yuan, Colleen Hefner, Cecile Chartier, Jeng-Shin Lee, Shelly Jiang, Nihar R Nayak, Frans A Kuypers, Lisa Ma, Uma Sundram, Grace Wu, Joseph A Garcia, Stanley L Schrier, Jacquelyn J Maher, Randall S Johnson, George D Yancopoulos, Richard C Mulligan, Calvin J Kuo

ABSTRACT

Vascular endothelial growth factor (VEGF) exerts crucial functions during pathological angiogenesis and normal physiology. We observed increased hematocrit (60–75%) after high-grade inhibition of VEGF by diverse methods, including adenoviral expression of soluble VEGF receptor (VEGFR) ectodomains, recombinant VEGF Trap protein and the VEGFR2-selective antibody DC101. Increased production of red blood cells (erythrocytosis) occurred in both mouse and primate models, and was associated with near-complete neutralization of VEGF corneal micropocket angiogenesis. High-grade inhibition of VEGF induced hepatic synthesis of erythropoietin (Epo, encoded by Epo) >40-fold through a HIF-1α–independent mechanism, in parallel with suppression of renal Epo mRNA. Studies using hepatocyte-specific deletion of the Vegfa gene and hepatocyte–endothelial cell cocultures indicated that blockade of VEGF induced hepatic Epo by interfering with homeostatic VEGFR2-dependent paracrine signaling involving interactions between hepatocytes and endothelial cells. These data indicate that VEGF is a previously unsuspected negative regulator of hepatic Epo synthesis and erythropoiesis and suggest that levels of Epo and erythrocytosis could represent noninvasive surrogate markers for stringent blockade of VEGF in vivo.NOTE: In the version of this article initially published, the name of one of the authors, Nihar R. Nayak, was misspelled as Nihar R. Niyak. The error has been corrected in the HTML and PDF versions of the article. More... »

PAGES

793-800

Journal

TITLE

Nature Medicine

ISSUE

7

VOLUME

12

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nm1428

DOI

http://dx.doi.org/10.1038/nm1428

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1015883708

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16799557


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Erythropoietin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hematocrit", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hypoxia-Inducible Factor 1, alpha Subunit", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, SCID", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Transgenic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polycythemia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Vascular Endothelial Growth Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retinal Vessels", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vascular Endothelial Growth Factor A", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "TargeGen Inc., 9380 Judicial Drive, 92121, San Diego, California, USA", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Division of Hematology, Stanford University School of Medicine, 269 Campus Drive, CCSR 1155, 94305, Stanford, California, USA", 
            "TargeGen Inc., 9380 Judicial Drive, 92121, San Diego, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tam", 
        "givenName": "Betty Y Y", 
        "id": "sg:person.016571307217.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016571307217.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Hematology, Stanford University School of Medicine, 269 Campus Drive, CCSR 1155, 94305, Stanford, California, USA", 
          "id": "http://www.grid.ac/institutes/grid.168010.e", 
          "name": [
            "Division of Hematology, Stanford University School of Medicine, 269 Campus Drive, CCSR 1155, 94305, Stanford, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wei", 
        "givenName": "Kevin", 
        "id": "sg:person.01065047561.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065047561.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Regeneron Pharmaceuticals, Incorporated, 777 Old Saw Mill River Road, 10591, Tarrytown, New York, USA", 
          "id": "http://www.grid.ac/institutes/grid.418961.3", 
          "name": [
            "Regeneron Pharmaceuticals, Incorporated, 777 Old Saw Mill River Road, 10591, Tarrytown, New York, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rudge", 
        "givenName": "John S", 
        "id": "sg:person.0763115533.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0763115533.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Hematology, Stanford University School of Medicine, 269 Campus Drive, CCSR 1155, 94305, Stanford, California, USA", 
          "id": "http://www.grid.ac/institutes/grid.168010.e", 
          "name": [
            "Division of Hematology, Stanford University School of Medicine, 269 Campus Drive, CCSR 1155, 94305, Stanford, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hoffman", 
        "givenName": "Jana", 
        "id": "sg:person.0654474704.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0654474704.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Regeneron Pharmaceuticals, Incorporated, 777 Old Saw Mill River Road, 10591, Tarrytown, New York, USA", 
          "id": "http://www.grid.ac/institutes/grid.418961.3", 
          "name": [
            "Regeneron Pharmaceuticals, Incorporated, 777 Old Saw Mill River Road, 10591, Tarrytown, New York, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Holash", 
        "givenName": "Joceyln", 
        "id": "sg:person.0627165220.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627165220.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "TargeGen Inc., 9380 Judicial Drive, 92121, San Diego, California, USA", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Division of Biological Sciences, University of California, San Diego, Molecular Biology Section, 9500 Gilman Drive, 92093, La Jolla, California, USA", 
            "TargeGen Inc., 9380 Judicial Drive, 92121, San Diego, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Park", 
        "givenName": "Sang-ki", 
        "id": "sg:person.0735131276.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735131276.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Hematology, Stanford University School of Medicine, 269 Campus Drive, CCSR 1155, 94305, Stanford, California, USA", 
          "id": "http://www.grid.ac/institutes/grid.168010.e", 
          "name": [
            "Division of Hematology, Stanford University School of Medicine, 269 Campus Drive, CCSR 1155, 94305, Stanford, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yuan", 
        "givenName": "Jenny", 
        "id": "sg:person.01201276161.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201276161.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Liver Center and Department of Medicine, S-357 University of California, 94143, San Francisco, California, USA", 
          "id": "http://www.grid.ac/institutes/grid.266102.1", 
          "name": [
            "Liver Center and Department of Medicine, S-357 University of California, 94143, San Francisco, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hefner", 
        "givenName": "Colleen", 
        "id": "sg:person.01236307654.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01236307654.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Hematology, Stanford University School of Medicine, 269 Campus Drive, CCSR 1155, 94305, Stanford, California, USA", 
          "id": "http://www.grid.ac/institutes/grid.168010.e", 
          "name": [
            "Division of Hematology, Stanford University School of Medicine, 269 Campus Drive, CCSR 1155, 94305, Stanford, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chartier", 
        "givenName": "Cecile", 
        "id": "sg:person.0733150427.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733150427.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Genetics, Division of Molecular Medicine, Harvard Medical School, Children's Hospital, 300 Longwood Avenue, 02115, Boston, Massachusetts, USA", 
          "id": "http://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Department of Genetics, Division of Molecular Medicine, Harvard Medical School, Children's Hospital, 300 Longwood Avenue, 02115, Boston, Massachusetts, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Jeng-Shin", 
        "id": "sg:person.0713215032.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713215032.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Regeneron Pharmaceuticals, Incorporated, 777 Old Saw Mill River Road, 10591, Tarrytown, New York, USA", 
          "id": "http://www.grid.ac/institutes/grid.418961.3", 
          "name": [
            "Regeneron Pharmaceuticals, Incorporated, 777 Old Saw Mill River Road, 10591, Tarrytown, New York, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jiang", 
        "givenName": "Shelly", 
        "id": "sg:person.01047377027.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01047377027.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Gynecology and Obstetrics, Stanford University School of Medicine, 300 Pasteur Drive, 94305, Stanford, California, USA", 
          "id": "http://www.grid.ac/institutes/grid.168010.e", 
          "name": [
            "Division of Gynecology and Obstetrics, Stanford University School of Medicine, 300 Pasteur Drive, 94305, Stanford, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nayak", 
        "givenName": "Nihar R", 
        "id": "sg:person.01126651206.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01126651206.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Children's Hospital Oakland Research Institute, 5700 Martin Luther King Jr. Way, 94609, Oakland, California, USA", 
          "id": "http://www.grid.ac/institutes/grid.414016.6", 
          "name": [
            "Children's Hospital Oakland Research Institute, 5700 Martin Luther King Jr. Way, 94609, Oakland, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kuypers", 
        "givenName": "Frans A", 
        "id": "sg:person.01105175730.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105175730.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Hematology, Stanford University School of Medicine, 269 Campus Drive, CCSR 1155, 94305, Stanford, California, USA", 
          "id": "http://www.grid.ac/institutes/grid.168010.e", 
          "name": [
            "Division of Hematology, Stanford University School of Medicine, 269 Campus Drive, CCSR 1155, 94305, Stanford, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ma", 
        "givenName": "Lisa", 
        "id": "sg:person.01300054027.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300054027.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, 94305, Stanford, California, USA", 
          "id": "http://www.grid.ac/institutes/grid.168010.e", 
          "name": [
            "Division of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, 94305, Stanford, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sundram", 
        "givenName": "Uma", 
        "id": "sg:person.0746560173.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746560173.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Hematology, Stanford University School of Medicine, 269 Campus Drive, CCSR 1155, 94305, Stanford, California, USA", 
          "id": "http://www.grid.ac/institutes/grid.168010.e", 
          "name": [
            "Division of Hematology, Stanford University School of Medicine, 269 Campus Drive, CCSR 1155, 94305, Stanford, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wu", 
        "givenName": "Grace", 
        "id": "sg:person.0606361504.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606361504.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Cardiology MC8573, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, 75390, Dallas, Texas, USA", 
          "id": "http://www.grid.ac/institutes/grid.267313.2", 
          "name": [
            "Division of Cardiology MC8573, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, 75390, Dallas, Texas, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Garcia", 
        "givenName": "Joseph A", 
        "id": "sg:person.0615256620.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615256620.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Hematology, Stanford University School of Medicine, 269 Campus Drive, CCSR 1155, 94305, Stanford, California, USA", 
          "id": "http://www.grid.ac/institutes/grid.168010.e", 
          "name": [
            "Division of Hematology, Stanford University School of Medicine, 269 Campus Drive, CCSR 1155, 94305, Stanford, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schrier", 
        "givenName": "Stanley L", 
        "id": "sg:person.01124526016.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124526016.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Liver Center and Department of Medicine, S-357 University of California, 94143, San Francisco, California, USA", 
          "id": "http://www.grid.ac/institutes/grid.266102.1", 
          "name": [
            "Liver Center and Department of Medicine, S-357 University of California, 94143, San Francisco, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Maher", 
        "givenName": "Jacquelyn J", 
        "id": "sg:person.01304423054.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304423054.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Biological Sciences, University of California, San Diego, Molecular Biology Section, 9500 Gilman Drive, 92093, La Jolla, California, USA", 
          "id": "http://www.grid.ac/institutes/grid.266100.3", 
          "name": [
            "Division of Biological Sciences, University of California, San Diego, Molecular Biology Section, 9500 Gilman Drive, 92093, La Jolla, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Johnson", 
        "givenName": "Randall S", 
        "id": "sg:person.015356443364.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015356443364.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Regeneron Pharmaceuticals, Incorporated, 777 Old Saw Mill River Road, 10591, Tarrytown, New York, USA", 
          "id": "http://www.grid.ac/institutes/grid.418961.3", 
          "name": [
            "Regeneron Pharmaceuticals, Incorporated, 777 Old Saw Mill River Road, 10591, Tarrytown, New York, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yancopoulos", 
        "givenName": "George D", 
        "id": "sg:person.01274702531.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274702531.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Genetics, Division of Molecular Medicine, Harvard Medical School, Children's Hospital, 300 Longwood Avenue, 02115, Boston, Massachusetts, USA", 
          "id": "http://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Department of Genetics, Division of Molecular Medicine, Harvard Medical School, Children's Hospital, 300 Longwood Avenue, 02115, Boston, Massachusetts, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mulligan", 
        "givenName": "Richard C", 
        "id": "sg:person.01301244232.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301244232.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Hematology, Stanford University School of Medicine, 269 Campus Drive, CCSR 1155, 94305, Stanford, California, USA", 
          "id": "http://www.grid.ac/institutes/grid.168010.e", 
          "name": [
            "Division of Hematology, Stanford University School of Medicine, 269 Campus Drive, CCSR 1155, 94305, Stanford, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kuo", 
        "givenName": "Calvin J", 
        "id": "sg:person.0764422637.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764422637.10"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/35025215", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009409437", 
          "https://doi.org/10.1038/35025215"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm740", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011527446", 
          "https://doi.org/10.1038/nm740"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm0603-669", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031340920", 
          "https://doi.org/10.1038/nm0603-669"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature00821", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017873888", 
          "https://doi.org/10.1038/nature00821"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/5007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030839891", 
          "https://doi.org/10.1038/5007"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gt.3302162", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019998222", 
          "https://doi.org/10.1038/sj.gt.3302162"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/380439a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004384986", 
          "https://doi.org/10.1038/380439a0"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2006-06-25", 
    "datePublishedReg": "2006-06-25", 
    "description": "Vascular endothelial growth factor (VEGF) exerts crucial functions during pathological angiogenesis and normal physiology. We observed increased hematocrit (60\u201375%) after high-grade inhibition of VEGF by diverse methods, including adenoviral expression of soluble VEGF receptor (VEGFR) ectodomains, recombinant VEGF Trap protein and the VEGFR2-selective antibody DC101. Increased production of red blood cells (erythrocytosis) occurred in both mouse and primate models, and was associated with near-complete neutralization of VEGF corneal micropocket angiogenesis. High-grade inhibition of VEGF induced hepatic synthesis of erythropoietin (Epo, encoded by Epo) >40-fold through a HIF-1\u03b1\u2013independent mechanism, in parallel with suppression of renal Epo mRNA. Studies using hepatocyte-specific deletion of the Vegfa gene and hepatocyte\u2013endothelial cell cocultures indicated that blockade of VEGF induced hepatic Epo by interfering with homeostatic VEGFR2-dependent paracrine signaling involving interactions between hepatocytes and endothelial cells. These data indicate that VEGF is a previously unsuspected negative regulator of hepatic Epo synthesis and erythropoiesis and suggest that levels of Epo and erythrocytosis could represent noninvasive surrogate markers for stringent blockade of VEGF in vivo.NOTE: In the version of this article initially published, the name of one of the authors, Nihar R. Nayak, was misspelled as Nihar R. Niyak. The error has been corrected in the HTML and PDF versions of the article.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/nm1428", 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2539526", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2438977", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.7142624", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2413949", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2476089", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1113716", 
        "issn": [
          "1078-8956", 
          "1546-170X"
        ], 
        "name": "Nature Medicine", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "12"
      }
    ], 
    "keywords": [
      "vascular endothelial growth factor", 
      "hepatic EPO synthesis", 
      "receptor ectodomain", 
      "negative regulator", 
      "adenoviral expression", 
      "crucial function", 
      "TRAP protein", 
      "pathological angiogenesis", 
      "normal physiology", 
      "hepatocyte-specific deletion", 
      "independent mechanisms", 
      "blockade of VEGF", 
      "renal EPO mRNA", 
      "EPO mRNA", 
      "EPO synthesis", 
      "growth factor", 
      "HIF-1\u03b1", 
      "VEGFA gene", 
      "endothelial cells", 
      "endothelial growth factor", 
      "cell cocultures", 
      "antibody DC101", 
      "levels of EPO", 
      "angiogenesis", 
      "cells", 
      "PDF version", 
      "EPO", 
      "genes", 
      "ectodomain", 
      "regulator", 
      "inhibition", 
      "protein", 
      "deletion", 
      "mRNA", 
      "physiology", 
      "regulation", 
      "paracrine", 
      "expression", 
      "red blood cells", 
      "erythropoietin synthesis", 
      "blood cells", 
      "erythropoiesis", 
      "modulates", 
      "vivo", 
      "coculture", 
      "synthesis", 
      "hepatocytes", 
      "markers", 
      "erythropoietin", 
      "mechanism", 
      "production", 
      "mice", 
      "suppression", 
      "interaction", 
      "function", 
      "diverse methods", 
      "primate model", 
      "complete neutralization", 
      "hepatic synthesis", 
      "levels", 
      "erythrocytosis", 
      "factors", 
      "blockade", 
      "name", 
      "parallel", 
      "study", 
      "neutralization", 
      "data", 
      "DC101", 
      "surrogate marker", 
      "model", 
      "HTML", 
      "method", 
      "version", 
      "hematocrit", 
      "article", 
      "noninvasive surrogate marker", 
      "authors", 
      "Nayak", 
      "error"
    ], 
    "name": "VEGF modulates erythropoiesis through regulation of adult hepatic erythropoietin synthesis", 
    "pagination": "793-800", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1015883708"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nm1428"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "16799557"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nm1428", 
      "https://app.dimensions.ai/details/publication/pub.1015883708"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-10-01T06:33", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_429.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/nm1428"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nm1428'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nm1428'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nm1428'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nm1428'


 

This table displays all metadata directly associated to this object as RDF triples.

412 TRIPLES      21 PREDICATES      124 URIs      110 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nm1428 schema:about N2e9583955d4542569b5d7058906432f1
2 N333eb19fa9d24a43b1f7fad46d08cc69
3 N3fc41de6bf124935b684b8aa5a25074d
4 N4e50e2a561144d299a5c353695dfc0db
5 N50225713c8d54660ba2acbddf543a4e8
6 N65ed689bc38948d7996fb4637eef5833
7 N93b8defba9ca44d09cfc5f282f242934
8 N93be39a8932746b3bf8216d89887d3f3
9 N9729bb8ddbb24bdb92ae480f72b34e1a
10 Na4f86532be3a4e6882bfa61ef203df0d
11 Na69d178574ca487c872b0e3db88b8441
12 Nab08981b0d5f4b36bb6c5b61119a9495
13 Nc552c1909e50466da306c1e83b4b5cdb
14 Nefc27ea0aaa141669e142951a8fa3ec0
15 anzsrc-for:11
16 schema:author Nc1ea8cf85a7047e79a9111e9369908eb
17 schema:citation sg:pub.10.1038/35025215
18 sg:pub.10.1038/380439a0
19 sg:pub.10.1038/5007
20 sg:pub.10.1038/nature00821
21 sg:pub.10.1038/nm0603-669
22 sg:pub.10.1038/nm740
23 sg:pub.10.1038/sj.gt.3302162
24 schema:datePublished 2006-06-25
25 schema:datePublishedReg 2006-06-25
26 schema:description Vascular endothelial growth factor (VEGF) exerts crucial functions during pathological angiogenesis and normal physiology. We observed increased hematocrit (60–75%) after high-grade inhibition of VEGF by diverse methods, including adenoviral expression of soluble VEGF receptor (VEGFR) ectodomains, recombinant VEGF Trap protein and the VEGFR2-selective antibody DC101. Increased production of red blood cells (erythrocytosis) occurred in both mouse and primate models, and was associated with near-complete neutralization of VEGF corneal micropocket angiogenesis. High-grade inhibition of VEGF induced hepatic synthesis of erythropoietin (Epo, encoded by Epo) >40-fold through a HIF-1α–independent mechanism, in parallel with suppression of renal Epo mRNA. Studies using hepatocyte-specific deletion of the Vegfa gene and hepatocyte–endothelial cell cocultures indicated that blockade of VEGF induced hepatic Epo by interfering with homeostatic VEGFR2-dependent paracrine signaling involving interactions between hepatocytes and endothelial cells. These data indicate that VEGF is a previously unsuspected negative regulator of hepatic Epo synthesis and erythropoiesis and suggest that levels of Epo and erythrocytosis could represent noninvasive surrogate markers for stringent blockade of VEGF in vivo.NOTE: In the version of this article initially published, the name of one of the authors, Nihar R. Nayak, was misspelled as Nihar R. Niyak. The error has been corrected in the HTML and PDF versions of the article.
27 schema:genre article
28 schema:isAccessibleForFree false
29 schema:isPartOf N3db45ecb341a40208ffe24bbf5ac2aa1
30 Nca35ef847b6d40328492a1f0121cc128
31 sg:journal.1113716
32 schema:keywords DC101
33 EPO
34 EPO mRNA
35 EPO synthesis
36 HIF-1α
37 HTML
38 Nayak
39 PDF version
40 TRAP protein
41 VEGFA gene
42 adenoviral expression
43 angiogenesis
44 antibody DC101
45 article
46 authors
47 blockade
48 blockade of VEGF
49 blood cells
50 cell cocultures
51 cells
52 coculture
53 complete neutralization
54 crucial function
55 data
56 deletion
57 diverse methods
58 ectodomain
59 endothelial cells
60 endothelial growth factor
61 error
62 erythrocytosis
63 erythropoiesis
64 erythropoietin
65 erythropoietin synthesis
66 expression
67 factors
68 function
69 genes
70 growth factor
71 hematocrit
72 hepatic EPO synthesis
73 hepatic synthesis
74 hepatocyte-specific deletion
75 hepatocytes
76 independent mechanisms
77 inhibition
78 interaction
79 levels
80 levels of EPO
81 mRNA
82 markers
83 mechanism
84 method
85 mice
86 model
87 modulates
88 name
89 negative regulator
90 neutralization
91 noninvasive surrogate marker
92 normal physiology
93 paracrine
94 parallel
95 pathological angiogenesis
96 physiology
97 primate model
98 production
99 protein
100 receptor ectodomain
101 red blood cells
102 regulation
103 regulator
104 renal EPO mRNA
105 study
106 suppression
107 surrogate marker
108 synthesis
109 vascular endothelial growth factor
110 version
111 vivo
112 schema:name VEGF modulates erythropoiesis through regulation of adult hepatic erythropoietin synthesis
113 schema:pagination 793-800
114 schema:productId N93c97d30b0f740c7825dd6a3816b5878
115 Nc130aecb074545f48c9ed3fd05be8202
116 Nf96ef8325d5442a8aa8d6414b0c6144a
117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015883708
118 https://doi.org/10.1038/nm1428
119 schema:sdDatePublished 2022-10-01T06:33
120 schema:sdLicense https://scigraph.springernature.com/explorer/license/
121 schema:sdPublisher N33a0da80201c47e99b892447f7b10098
122 schema:url https://doi.org/10.1038/nm1428
123 sgo:license sg:explorer/license/
124 sgo:sdDataset articles
125 rdf:type schema:ScholarlyArticle
126 N064a460c861b424ba85c536fd4094c0d rdf:first sg:person.01047377027.00
127 rdf:rest Nde6a9b3e09ea4891bd9a2fc8bc8d80f6
128 N27306f42e7fa4a65bfeffe1f13a33ff2 rdf:first sg:person.01300054027.39
129 rdf:rest N73a11329fc064e83a9ebf99c8920e825
130 N2e9583955d4542569b5d7058906432f1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Hematocrit
132 rdf:type schema:DefinedTerm
133 N30ea25dd41cf4176891dad72c2ce0d65 rdf:first sg:person.01274702531.47
134 rdf:rest N5ef869351a424143a5675032a603f18b
135 N333eb19fa9d24a43b1f7fad46d08cc69 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Liver
137 rdf:type schema:DefinedTerm
138 N33a0da80201c47e99b892447f7b10098 schema:name Springer Nature - SN SciGraph project
139 rdf:type schema:Organization
140 N3db45ecb341a40208ffe24bbf5ac2aa1 schema:issueNumber 7
141 rdf:type schema:PublicationIssue
142 N3fc41de6bf124935b684b8aa5a25074d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Vascular Endothelial Growth Factor A
144 rdf:type schema:DefinedTerm
145 N41c10e9d267f41f0b010544e18d3fb85 rdf:first sg:person.0606361504.20
146 rdf:rest N427ba8d1faeb44a3aa144ee054679e99
147 N427ba8d1faeb44a3aa144ee054679e99 rdf:first sg:person.0615256620.75
148 rdf:rest Nf9a7925a45314c2296e7c132170572d1
149 N4e50e2a561144d299a5c353695dfc0db schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Mice
151 rdf:type schema:DefinedTerm
152 N4f99aff70cc8421f874de58da9551740 rdf:first sg:person.01065047561.41
153 rdf:rest N8ae257075ff243aab5e6abbf09190838
154 N4fbe22c0303b4ed7b4932c4e3945803a rdf:first sg:person.0627165220.59
155 rdf:rest N75c04dc145ff475e8f3ece7e9f20c638
156 N50225713c8d54660ba2acbddf543a4e8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Retinal Vessels
158 rdf:type schema:DefinedTerm
159 N54829ae8ca554434a7af8d8d2136e2b0 rdf:first sg:person.0733150427.11
160 rdf:rest Nf5fffcddaa38455ba244fa81ed270ca3
161 N5ef869351a424143a5675032a603f18b rdf:first sg:person.01301244232.44
162 rdf:rest N828854ee35b94eaaa22c6ed69b604bba
163 N60aece307643418ab78650ba812ad336 rdf:first sg:person.01201276161.12
164 rdf:rest Nba73e4f6a9f94797a274d27dcb188e3b
165 N65ed689bc38948d7996fb4637eef5833 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Models, Animal
167 rdf:type schema:DefinedTerm
168 N6ad79608b00042ddbf27bf8553963614 rdf:first sg:person.01105175730.70
169 rdf:rest N27306f42e7fa4a65bfeffe1f13a33ff2
170 N6c1c30347bba4d7abd55984984dfa06b rdf:first sg:person.01304423054.00
171 rdf:rest Ne48a4f96051d4699935761601d872ece
172 N6dcff6d74da6489cafd0ea7a94a82cc5 rdf:first sg:person.0654474704.80
173 rdf:rest N4fbe22c0303b4ed7b4932c4e3945803a
174 N73a11329fc064e83a9ebf99c8920e825 rdf:first sg:person.0746560173.81
175 rdf:rest N41c10e9d267f41f0b010544e18d3fb85
176 N75c04dc145ff475e8f3ece7e9f20c638 rdf:first sg:person.0735131276.85
177 rdf:rest N60aece307643418ab78650ba812ad336
178 N828854ee35b94eaaa22c6ed69b604bba rdf:first sg:person.0764422637.10
179 rdf:rest rdf:nil
180 N8ae257075ff243aab5e6abbf09190838 rdf:first sg:person.0763115533.00
181 rdf:rest N6dcff6d74da6489cafd0ea7a94a82cc5
182 N93b8defba9ca44d09cfc5f282f242934 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Mice, SCID
184 rdf:type schema:DefinedTerm
185 N93be39a8932746b3bf8216d89887d3f3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Receptors, Vascular Endothelial Growth Factor
187 rdf:type schema:DefinedTerm
188 N93c97d30b0f740c7825dd6a3816b5878 schema:name pubmed_id
189 schema:value 16799557
190 rdf:type schema:PropertyValue
191 N9729bb8ddbb24bdb92ae480f72b34e1a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name Hypoxia-Inducible Factor 1, alpha Subunit
193 rdf:type schema:DefinedTerm
194 Na4f86532be3a4e6882bfa61ef203df0d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Animals
196 rdf:type schema:DefinedTerm
197 Na69d178574ca487c872b0e3db88b8441 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name Mice, Inbred C57BL
199 rdf:type schema:DefinedTerm
200 Nab08981b0d5f4b36bb6c5b61119a9495 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
201 schema:name Mice, Transgenic
202 rdf:type schema:DefinedTerm
203 Nba73e4f6a9f94797a274d27dcb188e3b rdf:first sg:person.01236307654.42
204 rdf:rest N54829ae8ca554434a7af8d8d2136e2b0
205 Nc130aecb074545f48c9ed3fd05be8202 schema:name doi
206 schema:value 10.1038/nm1428
207 rdf:type schema:PropertyValue
208 Nc1ea8cf85a7047e79a9111e9369908eb rdf:first sg:person.016571307217.62
209 rdf:rest N4f99aff70cc8421f874de58da9551740
210 Nc552c1909e50466da306c1e83b4b5cdb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
211 schema:name Erythropoietin
212 rdf:type schema:DefinedTerm
213 Nca35ef847b6d40328492a1f0121cc128 schema:volumeNumber 12
214 rdf:type schema:PublicationVolume
215 Nde6a9b3e09ea4891bd9a2fc8bc8d80f6 rdf:first sg:person.01126651206.91
216 rdf:rest N6ad79608b00042ddbf27bf8553963614
217 Ne48a4f96051d4699935761601d872ece rdf:first sg:person.015356443364.36
218 rdf:rest N30ea25dd41cf4176891dad72c2ce0d65
219 Nefc27ea0aaa141669e142951a8fa3ec0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
220 schema:name Polycythemia
221 rdf:type schema:DefinedTerm
222 Nf5fffcddaa38455ba244fa81ed270ca3 rdf:first sg:person.0713215032.51
223 rdf:rest N064a460c861b424ba85c536fd4094c0d
224 Nf96ef8325d5442a8aa8d6414b0c6144a schema:name dimensions_id
225 schema:value pub.1015883708
226 rdf:type schema:PropertyValue
227 Nf9a7925a45314c2296e7c132170572d1 rdf:first sg:person.01124526016.69
228 rdf:rest N6c1c30347bba4d7abd55984984dfa06b
229 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
230 schema:name Medical and Health Sciences
231 rdf:type schema:DefinedTerm
232 sg:grant.2413949 http://pending.schema.org/fundedItem sg:pub.10.1038/nm1428
233 rdf:type schema:MonetaryGrant
234 sg:grant.2438977 http://pending.schema.org/fundedItem sg:pub.10.1038/nm1428
235 rdf:type schema:MonetaryGrant
236 sg:grant.2476089 http://pending.schema.org/fundedItem sg:pub.10.1038/nm1428
237 rdf:type schema:MonetaryGrant
238 sg:grant.2539526 http://pending.schema.org/fundedItem sg:pub.10.1038/nm1428
239 rdf:type schema:MonetaryGrant
240 sg:grant.7142624 http://pending.schema.org/fundedItem sg:pub.10.1038/nm1428
241 rdf:type schema:MonetaryGrant
242 sg:journal.1113716 schema:issn 1078-8956
243 1546-170X
244 schema:name Nature Medicine
245 schema:publisher Springer Nature
246 rdf:type schema:Periodical
247 sg:person.01047377027.00 schema:affiliation grid-institutes:grid.418961.3
248 schema:familyName Jiang
249 schema:givenName Shelly
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01047377027.00
251 rdf:type schema:Person
252 sg:person.01065047561.41 schema:affiliation grid-institutes:grid.168010.e
253 schema:familyName Wei
254 schema:givenName Kevin
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065047561.41
256 rdf:type schema:Person
257 sg:person.01105175730.70 schema:affiliation grid-institutes:grid.414016.6
258 schema:familyName Kuypers
259 schema:givenName Frans A
260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105175730.70
261 rdf:type schema:Person
262 sg:person.01124526016.69 schema:affiliation grid-institutes:grid.168010.e
263 schema:familyName Schrier
264 schema:givenName Stanley L
265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124526016.69
266 rdf:type schema:Person
267 sg:person.01126651206.91 schema:affiliation grid-institutes:grid.168010.e
268 schema:familyName Nayak
269 schema:givenName Nihar R
270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01126651206.91
271 rdf:type schema:Person
272 sg:person.01201276161.12 schema:affiliation grid-institutes:grid.168010.e
273 schema:familyName Yuan
274 schema:givenName Jenny
275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201276161.12
276 rdf:type schema:Person
277 sg:person.01236307654.42 schema:affiliation grid-institutes:grid.266102.1
278 schema:familyName Hefner
279 schema:givenName Colleen
280 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01236307654.42
281 rdf:type schema:Person
282 sg:person.01274702531.47 schema:affiliation grid-institutes:grid.418961.3
283 schema:familyName Yancopoulos
284 schema:givenName George D
285 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274702531.47
286 rdf:type schema:Person
287 sg:person.01300054027.39 schema:affiliation grid-institutes:grid.168010.e
288 schema:familyName Ma
289 schema:givenName Lisa
290 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300054027.39
291 rdf:type schema:Person
292 sg:person.01301244232.44 schema:affiliation grid-institutes:grid.38142.3c
293 schema:familyName Mulligan
294 schema:givenName Richard C
295 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301244232.44
296 rdf:type schema:Person
297 sg:person.01304423054.00 schema:affiliation grid-institutes:grid.266102.1
298 schema:familyName Maher
299 schema:givenName Jacquelyn J
300 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304423054.00
301 rdf:type schema:Person
302 sg:person.015356443364.36 schema:affiliation grid-institutes:grid.266100.3
303 schema:familyName Johnson
304 schema:givenName Randall S
305 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015356443364.36
306 rdf:type schema:Person
307 sg:person.016571307217.62 schema:affiliation grid-institutes:None
308 schema:familyName Tam
309 schema:givenName Betty Y Y
310 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016571307217.62
311 rdf:type schema:Person
312 sg:person.0606361504.20 schema:affiliation grid-institutes:grid.168010.e
313 schema:familyName Wu
314 schema:givenName Grace
315 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606361504.20
316 rdf:type schema:Person
317 sg:person.0615256620.75 schema:affiliation grid-institutes:grid.267313.2
318 schema:familyName Garcia
319 schema:givenName Joseph A
320 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615256620.75
321 rdf:type schema:Person
322 sg:person.0627165220.59 schema:affiliation grid-institutes:grid.418961.3
323 schema:familyName Holash
324 schema:givenName Joceyln
325 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627165220.59
326 rdf:type schema:Person
327 sg:person.0654474704.80 schema:affiliation grid-institutes:grid.168010.e
328 schema:familyName Hoffman
329 schema:givenName Jana
330 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0654474704.80
331 rdf:type schema:Person
332 sg:person.0713215032.51 schema:affiliation grid-institutes:grid.38142.3c
333 schema:familyName Lee
334 schema:givenName Jeng-Shin
335 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713215032.51
336 rdf:type schema:Person
337 sg:person.0733150427.11 schema:affiliation grid-institutes:grid.168010.e
338 schema:familyName Chartier
339 schema:givenName Cecile
340 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733150427.11
341 rdf:type schema:Person
342 sg:person.0735131276.85 schema:affiliation grid-institutes:None
343 schema:familyName Park
344 schema:givenName Sang-ki
345 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735131276.85
346 rdf:type schema:Person
347 sg:person.0746560173.81 schema:affiliation grid-institutes:grid.168010.e
348 schema:familyName Sundram
349 schema:givenName Uma
350 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746560173.81
351 rdf:type schema:Person
352 sg:person.0763115533.00 schema:affiliation grid-institutes:grid.418961.3
353 schema:familyName Rudge
354 schema:givenName John S
355 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0763115533.00
356 rdf:type schema:Person
357 sg:person.0764422637.10 schema:affiliation grid-institutes:grid.168010.e
358 schema:familyName Kuo
359 schema:givenName Calvin J
360 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764422637.10
361 rdf:type schema:Person
362 sg:pub.10.1038/35025215 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009409437
363 https://doi.org/10.1038/35025215
364 rdf:type schema:CreativeWork
365 sg:pub.10.1038/380439a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004384986
366 https://doi.org/10.1038/380439a0
367 rdf:type schema:CreativeWork
368 sg:pub.10.1038/5007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030839891
369 https://doi.org/10.1038/5007
370 rdf:type schema:CreativeWork
371 sg:pub.10.1038/nature00821 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017873888
372 https://doi.org/10.1038/nature00821
373 rdf:type schema:CreativeWork
374 sg:pub.10.1038/nm0603-669 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031340920
375 https://doi.org/10.1038/nm0603-669
376 rdf:type schema:CreativeWork
377 sg:pub.10.1038/nm740 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011527446
378 https://doi.org/10.1038/nm740
379 rdf:type schema:CreativeWork
380 sg:pub.10.1038/sj.gt.3302162 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019998222
381 https://doi.org/10.1038/sj.gt.3302162
382 rdf:type schema:CreativeWork
383 grid-institutes:None schema:alternateName TargeGen Inc., 9380 Judicial Drive, 92121, San Diego, California, USA
384 schema:name Division of Biological Sciences, University of California, San Diego, Molecular Biology Section, 9500 Gilman Drive, 92093, La Jolla, California, USA
385 Division of Hematology, Stanford University School of Medicine, 269 Campus Drive, CCSR 1155, 94305, Stanford, California, USA
386 TargeGen Inc., 9380 Judicial Drive, 92121, San Diego, California, USA
387 rdf:type schema:Organization
388 grid-institutes:grid.168010.e schema:alternateName Division of Gynecology and Obstetrics, Stanford University School of Medicine, 300 Pasteur Drive, 94305, Stanford, California, USA
389 Division of Hematology, Stanford University School of Medicine, 269 Campus Drive, CCSR 1155, 94305, Stanford, California, USA
390 Division of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, 94305, Stanford, California, USA
391 schema:name Division of Gynecology and Obstetrics, Stanford University School of Medicine, 300 Pasteur Drive, 94305, Stanford, California, USA
392 Division of Hematology, Stanford University School of Medicine, 269 Campus Drive, CCSR 1155, 94305, Stanford, California, USA
393 Division of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, 94305, Stanford, California, USA
394 rdf:type schema:Organization
395 grid-institutes:grid.266100.3 schema:alternateName Division of Biological Sciences, University of California, San Diego, Molecular Biology Section, 9500 Gilman Drive, 92093, La Jolla, California, USA
396 schema:name Division of Biological Sciences, University of California, San Diego, Molecular Biology Section, 9500 Gilman Drive, 92093, La Jolla, California, USA
397 rdf:type schema:Organization
398 grid-institutes:grid.266102.1 schema:alternateName Liver Center and Department of Medicine, S-357 University of California, 94143, San Francisco, California, USA
399 schema:name Liver Center and Department of Medicine, S-357 University of California, 94143, San Francisco, California, USA
400 rdf:type schema:Organization
401 grid-institutes:grid.267313.2 schema:alternateName Division of Cardiology MC8573, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, 75390, Dallas, Texas, USA
402 schema:name Division of Cardiology MC8573, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, 75390, Dallas, Texas, USA
403 rdf:type schema:Organization
404 grid-institutes:grid.38142.3c schema:alternateName Department of Genetics, Division of Molecular Medicine, Harvard Medical School, Children's Hospital, 300 Longwood Avenue, 02115, Boston, Massachusetts, USA
405 schema:name Department of Genetics, Division of Molecular Medicine, Harvard Medical School, Children's Hospital, 300 Longwood Avenue, 02115, Boston, Massachusetts, USA
406 rdf:type schema:Organization
407 grid-institutes:grid.414016.6 schema:alternateName Children's Hospital Oakland Research Institute, 5700 Martin Luther King Jr. Way, 94609, Oakland, California, USA
408 schema:name Children's Hospital Oakland Research Institute, 5700 Martin Luther King Jr. Way, 94609, Oakland, California, USA
409 rdf:type schema:Organization
410 grid-institutes:grid.418961.3 schema:alternateName Regeneron Pharmaceuticals, Incorporated, 777 Old Saw Mill River Road, 10591, Tarrytown, New York, USA
411 schema:name Regeneron Pharmaceuticals, Incorporated, 777 Old Saw Mill River Road, 10591, Tarrytown, New York, USA
412 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...