Pathogenesis of HIV infection: what the virus spares is as important as what it destroys View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-03

AUTHORS

Zvi Grossman, Martin Meier-Schellersheim, William E Paul, Louis J Picker

ABSTRACT

Upon transmission to a new host, HIV targets CCR5+ CD4+ effector memory T cells, resulting in acute, massive depletion of these cells from mucosal effector sites. This depletion does not initially compromise the regenerative capacity of the immune system because naive and most central memory T cells are spared. Here, we discuss evidence suggesting that frequent activation of these spared cells during the chronic phase of HIV infection supplies mucosal tissues with short-lived CCR5+ CD4+ effector cells that prevent life-threatening infections. This immune activation also facilitates continued viral replication, but infection and killing of target T cells by HIV are selective and the impact on effector-cell lifespan is limited. We propose, however, that persistent activation progressively disrupts the functional organization of the immune system, reducing its regenerative capacity and facilitating viral evolution that leads to loss of the exquisite target cell-sparing selectivity of viral replication, ultimately resulting in AIDS. More... »

PAGES

289-295

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nm1380

    DOI

    http://dx.doi.org/10.1038/nm1380

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1009865103

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/16520776


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