A novel dendritic cell subset involved in tumor immunosurveillance View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-02

AUTHORS

Julien Taieb, Nathalie Chaput, Cédric Ménard, Lionel Apetoh, Evelyn Ullrich, Mathieu Bonmort, Marie Péquignot, Noelia Casares, Magali Terme, Caroline Flament, Paule Opolon, Yann Lecluse, Didier Métivier, Elena Tomasello, Eric Vivier, François Ghiringhelli, François Martin, David Klatzmann, Thierry Poynard, Thomas Tursz, Graça Raposo, Hideo Yagita, Bernard Ryffel, Guido Kroemer, Laurence Zitvogel

ABSTRACT

The interferon (IFN)-gamma-induced TRAIL effector mechanism is a vital component of cancer immunosurveillance by natural killer (NK) cells in mice. Here we show that the main source of IFN-gamma is not the conventional NK cell but a subset of B220(+)Ly6C(-) dendritic cells, which are atypical insofar as they express NK cell-surface molecules. Upon contact with a variety of tumor cells that are poorly recognized by NK cells, B220(+)NK1.1(+) dendritic cells secrete high levels of IFN-gamma and mediate TRAIL-dependent lysis of tumor cells. Adoptive transfer of these IFN-producing killer dendritic cells (IKDCs) into tumor-bearing Rag2(-/-)Il2rg(-/-) mice prevented tumor outgrowth, whereas transfer of conventional NK cells did not. In conclusion, we identified IKDCs as pivotal sensors and effectors of the innate antitumor immune response. More... »

PAGES

214-219

Journal

TITLE

Nature Medicine

ISSUE

2

VOLUME

12

Clinical Trials linked to this publication

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nm1356

DOI

http://dx.doi.org/10.1038/nm1356

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1016783900

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16444265


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