Ontology type: schema:ScholarlyArticle Open Access: True
2005-11-27
AUTHORSElsa Kermorvant-Duchemin, Florian Sennlaub, Mirna Sirinyan, Sonia Brault, Gregor Andelfinger, Amna Kooli, Stéphane Germain, Huy Ong, Pedro d'Orleans-Juste, Fernand Gobeil, Tang Zhu, Chantal Boisvert, Pierre Hardy, Kavita Jain, J Russel Falck, Michael Balazy, Sylvain Chemtob
ABSTRACTNitrative stress has an important role in microvascular degeneration leading to ischemia in conditions such as diabetic retinopathy and retinopathy of prematurity. Thus far, mediators of nitrative stress have been poorly characterized. We recently described that trans-arachidonic acids are major products of NO2•-mediated isomerization of arachidonic acid within the cell membrane, but their biological relevance is unknown. Here we show that trans-arachidonic acids are generated in a model of retinal microangiopathy in vivo in a NO•-dependent manner. They induce a selective time- and concentration-dependent apoptosis of microvascular endothelial cells in vitro, and result in retinal microvascular degeneration ex vivo and in vivo. These effects are mediated by an upregulation of the antiangiogenic factor thrombospondin-1, independently of classical arachidonic acid metabolism. Our findings provide new insight into the molecular mechanisms of nitrative stress in microvascular injury and suggest new therapeutic avenues in the management of disorders involving nitrative stress, such as ischemic retinopathies and encephalopathies. More... »
PAGES1339-1345
http://scigraph.springernature.com/pub.10.1038/nm1336
DOIhttp://dx.doi.org/10.1038/nm1336
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/16311602
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"sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_401.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1038/nm1336"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nm1336'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nm1336'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nm1336'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nm1336'
This table displays all metadata directly associated to this object as RDF triples.
358 TRIPLES
22 PREDICATES
110 URIs
98 LITERALS
28 BLANK NODES