A genetic Xenopus laevis tadpole model to study lymphangiogenesis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-09

AUTHORS

Annelii Ny, Marta Koch, Martin Schneider, Elke Neven, Ricky T Tong, Sunit Maity, Christian Fischer, Stephane Plaisance, Diether Lambrechts, Christophe Héligon, Sven Terclavers, Malgorzata Ciesiolka, Roland Kälin, Yan Man, Irena Senn, Sabine Wyns, Florea Lupu, André Brändli, Kris Vleminckx, Désiré Collen, Mieke Dewerchin, Edward M Conway, Lieve Moons, Rakesh K Jain, Peter Carmeliet

ABSTRACT

Lymph vessels control fluid homeostasis, immunity and metastasis. Unraveling the molecular basis of lymphangiogenesis has been hampered by the lack of a small animal model that can be genetically manipulated. Here, we show that Xenopus tadpoles develop lymph vessels from lymphangioblasts or, through transdifferentiation, from venous endothelial cells. Lymphangiography showed that these lymph vessels drain lymph, through the lymph heart, to the venous circulation. Morpholino-mediated knockdown of the lymphangiogenic factor Prox1 caused lymph vessel defects and lymphedema by impairing lymphatic commitment. Knockdown of vascular endothelial growth factor C (VEGF-C) also induced lymph vessel defects and lymphedema, but primarily by affecting migration of lymphatic endothelial cells. Knockdown of VEGF-C also resulted in aberrant blood vessel formation in tadpoles. This tadpole model offers opportunities for the discovery of new regulators of lymphangiogenesis. More... »

PAGES

998-1004

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nm1285

DOI

http://dx.doi.org/10.1038/nm1285

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004418120

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16116431


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