Killed but metabolically active microbes: a new vaccine paradigm for eliciting effector T-cell responses and protective immunity View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-08

AUTHORS

D G Brockstedt, K S Bahjat, M A Giedlin, W Liu, M Leong, W Luckett, Y Gao, P Schnupf, D Kapadia, G Castro, J Y H Lim, A Sampson-Johannes, A A Herskovits, A Stassinopoulos, H G Archie Bouwer, J E Hearst, D A Portnoy, D N Cook, T W Dubensky

ABSTRACT

We developed a new class of vaccines, based on killed but metabolically active (KBMA) bacteria, that simultaneously takes advantage of the potency of live vaccines and the safety of killed vaccines. We removed genes required for nucleotide excision repair (uvrAB), rendering microbial-based vaccines exquisitely sensitive to photochemical inactivation with psoralen and long-wavelength ultraviolet light. Colony formation of the nucleotide excision repair mutants was blocked by infrequent, randomly distributed psoralen crosslinks, but the bacterial population was able to express its genes, synthesize and secrete proteins. Using the intracellular pathogen Listeria monocytogenes as a model platform, recombinant psoralen-inactivated Lm DeltauvrAB vaccines induced potent CD4(+) and CD8(+) T-cell responses and protected mice against virus challenge in an infectious disease model and provided therapeutic benefit in a mouse cancer model. Microbial KBMA vaccines used either as a recombinant vaccine platform or as a modified form of the pathogen itself may have broad use for the treatment of infectious disease and cancer. More... »

PAGES

853-860

References to SciGraph publications

  • 2004-11. From Pasteur to genomics: progress and challenges in infectious diseases in NATURE MEDICINE
  • 2000-09-15. Generation of Antigen-Specific, LacZ-Inducible T-Cell Hybrids in ANTIGEN PROCESSING AND PRESENTATION PROTOCOLS
  • 2004-10. Immune responses to Listeria monocytogenes in NATURE REVIEWS IMMUNOLOGY
  • Journal

    TITLE

    Nature Medicine

    ISSUE

    8

    VOLUME

    11

    Related Patents

  • Attenuated And Adapted Strain Of Pseudomonas For Delivering Antigens
  • Compositions Comprising Cyclic Purine Dinucleotides Having Defined Stereochemistries And Methods For Their Preparation And Use
  • Vaccination With Killed But Metabolically Active (Kbma) Protozoans With Toll-Like Receptor Agonists
  • Methods And Compositions Using Listeria For Enhancing Immunogenicity By Prime Boost
  • Attenuated And Adapted Strain Of Pseudomonas For Delivering Antigens
  • Compositions Comprising Prfa*Mutant Listeria And Methods Of Use Thereof
  • Compositions And Methods For Inhibiting “Stimulator Of Interferon Gene”—Dependent Signalling
  • Methods And Compositions Using Listeria For Adjuvant Treatment Of Cancer
  • Facultatively Attenuated Bacterial Species And Methods Of Preparation And Use Thereof
  • Signal Peptide Fusion Partners Facilitating Listerial Expression Of Antigenic Sequences And Methods Of Preparation And Use Thereof
  • Compositions And Methods For Cancer Immunotherapy
  • Cells For Chromatin Immunoprecipitation And Methods For Making
  • Engineered Listeria And Methods Of Use Thereof
  • Modified Free-Living Microbes, Vaccine Compositions And Methods Of Use Thereof
  • Modified Free-Living Microbes, Vaccine Compositions And Methods Of Use Thereof
  • Engineered Listeria And Methods Of Use Thereof
  • Methods And Compositions Using Listeria For Enhancing Immunogenicity By Prime Boost
  • Modified Free-Living Microbes, Vaccine Compositions And Methods Of Use Thereof
  • Recombinant Nucleic Acid Molecules, Expression Cassettes, And Bacteria, And Methods Of Use Thereof
  • Compositions And Methods For Altering Second Messenger Signaling
  • Cells For Chromatin Immunoprecipitation And Methods For Making
  • Listeria Attenuated For Entry Into Non-Phagocytic Cells, Vaccines Comprising The Listeria, And Methods Of Use Thereof
  • Methods And Compositions Using Listeria For Enhancing Immunogenicity By Prime Boost
  • Bacterial Rnas As Vaccine Adjuvants
  • Compositions And Methods For Activating Stimulator Of Interferon Gene-Dependent Signalling
  • Vaccination With Killed But Metabolically Active (Kbma) Protozoans With Toll-Like Receptor Agonists
  • Attenuated And Adapted Strain Of Pseudomonas For Delivering Antigens
  • Therapeutic Vaccine For Treating Or Preventing Merkel Cell Polyoma Virus-Associated Tumors
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nm1276

    DOI

    http://dx.doi.org/10.1038/nm1276

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1006723508

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/16041382


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0605", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Microbiology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Bacterial Vaccines", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Carbon Radioisotopes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA Repair", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Dendritic Cells", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Endodeoxyribonucleases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Escherichia coli Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Ficusin", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Flow Cytometry", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Immunity, Cellular", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Listeria monocytogenes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice, Inbred C57BL", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Ultraviolet Rays", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Vaccination", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Cerus (United States)", 
              "id": "https://www.grid.ac/institutes/grid.418416.e", 
              "name": [
                "Cerus Corporation, 2411 Stanwell Drive, Concord, California 94520, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Brockstedt", 
            "givenName": "D G", 
            "id": "sg:person.0745122036.60", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745122036.60"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cerus (United States)", 
              "id": "https://www.grid.ac/institutes/grid.418416.e", 
              "name": [
                "Cerus Corporation, 2411 Stanwell Drive, Concord, California 94520, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bahjat", 
            "givenName": "K S", 
            "id": "sg:person.01243522551.25", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243522551.25"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cerus (United States)", 
              "id": "https://www.grid.ac/institutes/grid.418416.e", 
              "name": [
                "Cerus Corporation, 2411 Stanwell Drive, Concord, California 94520, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Giedlin", 
            "givenName": "M A", 
            "id": "sg:person.0634111110.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634111110.15"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cerus (United States)", 
              "id": "https://www.grid.ac/institutes/grid.418416.e", 
              "name": [
                "Cerus Corporation, 2411 Stanwell Drive, Concord, California 94520, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Liu", 
            "givenName": "W", 
            "id": "sg:person.0637624663.70", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637624663.70"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cerus (United States)", 
              "id": "https://www.grid.ac/institutes/grid.418416.e", 
              "name": [
                "Cerus Corporation, 2411 Stanwell Drive, Concord, California 94520, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Leong", 
            "givenName": "M", 
            "id": "sg:person.01311635751.96", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311635751.96"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cerus (United States)", 
              "id": "https://www.grid.ac/institutes/grid.418416.e", 
              "name": [
                "Cerus Corporation, 2411 Stanwell Drive, Concord, California 94520, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Luckett", 
            "givenName": "W", 
            "id": "sg:person.0630673436.61", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630673436.61"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cerus (United States)", 
              "id": "https://www.grid.ac/institutes/grid.418416.e", 
              "name": [
                "Cerus Corporation, 2411 Stanwell Drive, Concord, California 94520, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gao", 
            "givenName": "Y", 
            "id": "sg:person.0654011112.92", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0654011112.92"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Oregon Health & Science University", 
              "id": "https://www.grid.ac/institutes/grid.5288.7", 
              "name": [
                "Department of Molecular and Cell Biology, Oregon Health Sciences University, 3710 SW US Veterans Hospital Road, Portland, Oregon 97201, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Schnupf", 
            "givenName": "P", 
            "id": "sg:person.01017310721.32", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017310721.32"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cerus (United States)", 
              "id": "https://www.grid.ac/institutes/grid.418416.e", 
              "name": [
                "Cerus Corporation, 2411 Stanwell Drive, Concord, California 94520, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kapadia", 
            "givenName": "D", 
            "id": "sg:person.0674113252.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0674113252.00"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cerus (United States)", 
              "id": "https://www.grid.ac/institutes/grid.418416.e", 
              "name": [
                "Cerus Corporation, 2411 Stanwell Drive, Concord, California 94520, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Castro", 
            "givenName": "G", 
            "id": "sg:person.0701047743.82", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701047743.82"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cerus (United States)", 
              "id": "https://www.grid.ac/institutes/grid.418416.e", 
              "name": [
                "Cerus Corporation, 2411 Stanwell Drive, Concord, California 94520, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lim", 
            "givenName": "J Y H", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cerus (United States)", 
              "id": "https://www.grid.ac/institutes/grid.418416.e", 
              "name": [
                "Cerus Corporation, 2411 Stanwell Drive, Concord, California 94520, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sampson-Johannes", 
            "givenName": "A", 
            "id": "sg:person.01167350325.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167350325.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Oregon Health & Science University", 
              "id": "https://www.grid.ac/institutes/grid.5288.7", 
              "name": [
                "Department of Molecular and Cell Biology, Oregon Health Sciences University, 3710 SW US Veterans Hospital Road, Portland, Oregon 97201, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Herskovits", 
            "givenName": "A A", 
            "id": "sg:person.0744115027.96", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744115027.96"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cerus (United States)", 
              "id": "https://www.grid.ac/institutes/grid.418416.e", 
              "name": [
                "Cerus Corporation, 2411 Stanwell Drive, Concord, California 94520, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Stassinopoulos", 
            "givenName": "A", 
            "id": "sg:person.01176017141.92", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176017141.92"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Oregon Health & Science University", 
              "id": "https://www.grid.ac/institutes/grid.5288.7", 
              "name": [
                "Department of Molecular and Cell Biology, Oregon Health Sciences University, 3710 SW US Veterans Hospital Road, Portland, Oregon 97201, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bouwer", 
            "givenName": "H G Archie", 
            "id": "sg:person.0616412763.76", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616412763.76"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cerus (United States)", 
              "id": "https://www.grid.ac/institutes/grid.418416.e", 
              "name": [
                "Cerus Corporation, 2411 Stanwell Drive, Concord, California 94520, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hearst", 
            "givenName": "J E", 
            "id": "sg:person.01273722422.40", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273722422.40"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of California, Berkeley", 
              "id": "https://www.grid.ac/institutes/grid.47840.3f", 
              "name": [
                "Department of Molecular and Cell Biology, Oregon Health Sciences University, 3710 SW US Veterans Hospital Road, Portland, Oregon 97201, USA.", 
                "School of Public Health, University of California, 508 Barker Hall, #3202, Berkeley, California, 94720-3202, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Portnoy", 
            "givenName": "D A", 
            "id": "sg:person.01204007054.60", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204007054.60"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cerus (United States)", 
              "id": "https://www.grid.ac/institutes/grid.418416.e", 
              "name": [
                "Cerus Corporation, 2411 Stanwell Drive, Concord, California 94520, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cook", 
            "givenName": "D N", 
            "id": "sg:person.013306262652.04", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013306262652.04"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Dubensky", 
            "givenName": "T W", 
            "id": "sg:person.0630700305.07", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630700305.07"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1073/pnas.93.9.4102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000183927"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.202476699", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002680506"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.93.18.9730", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004357203"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/jb.184.15.4177-4186.2002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005568798"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1074-7613(00)00052-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006801851"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1365-2958.2002.03072.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010391951"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.200205009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012008252"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1600-065x.1997.tb00988.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012154317"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.175.6.1531", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013274658"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/iai.68.6.3680-3688.2000", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014041368"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20040712", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014765958"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.immunol.18.1.275", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019051896"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.030528397", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021110326"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20040769", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025520991"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0952-7915(96)80083-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025912918"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0406035101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026955438"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.167.11.6471", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030071382"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.92.9.3987", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030835472"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/clim.1999.4724", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031338753"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0022-1759(98)00204-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033648033"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri1461", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033865745", 
              "https://doi.org/10.1038/nri1461"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri1461", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033865745", 
              "https://doi.org/10.1038/nri1461"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0928-8244(02)00470-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037985491"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20040976", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040741147"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/0471142727.mb0204s56", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040923428"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/0471142727.mb0204s56", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040923428"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/iai.69.5.2888-2893.2001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041020895"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2958.1993.tb01211.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044039866"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.bi.57.070188.000333", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045816488"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1365-2958.2003.03639.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046149869"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0037-1963(01)90118-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047008254"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0037-1963(01)90118-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047008254"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1385/1-59259-062-4:265", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047802023", 
              "https://doi.org/10.1385/1-59259-062-4:265"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1129", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050946104", 
              "https://doi.org/10.1038/nm1129"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1129", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050946104", 
              "https://doi.org/10.1038/nm1129"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/shem.2001.20861", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1057077911"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1064571", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062445425"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1082305", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062447916"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.166.3.1877", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074751404"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074995141", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075034111", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.170.10.5176", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1075282170"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.173.1.420", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1076855528"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078378459", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078715038", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079557310", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082424514", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083056569", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083163736", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2005-08", 
        "datePublishedReg": "2005-08-01", 
        "description": "We developed a new class of vaccines, based on killed but metabolically active (KBMA) bacteria, that simultaneously takes advantage of the potency of live vaccines and the safety of killed vaccines. We removed genes required for nucleotide excision repair (uvrAB), rendering microbial-based vaccines exquisitely sensitive to photochemical inactivation with psoralen and long-wavelength ultraviolet light. Colony formation of the nucleotide excision repair mutants was blocked by infrequent, randomly distributed psoralen crosslinks, but the bacterial population was able to express its genes, synthesize and secrete proteins. Using the intracellular pathogen Listeria monocytogenes as a model platform, recombinant psoralen-inactivated Lm DeltauvrAB vaccines induced potent CD4(+) and CD8(+) T-cell responses and protected mice against virus challenge in an infectious disease model and provided therapeutic benefit in a mouse cancer model. Microbial KBMA vaccines used either as a recombinant vaccine platform or as a modified form of the pathogen itself may have broad use for the treatment of infectious disease and cancer.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/nm1276", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1113716", 
            "issn": [
              "1078-8956", 
              "1546-170X"
            ], 
            "name": "Nature Medicine", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "8", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "11"
          }
        ], 
        "name": "Killed but metabolically active microbes: a new vaccine paradigm for eliciting effector T-cell responses and protective immunity", 
        "pagination": "853-860", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "2006c1fd0e592a037d34ae3d0449307dba33b7e67c5d62a359dc356f4dc0e942"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "16041382"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9502015"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nm1276"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1006723508"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nm1276", 
          "https://app.dimensions.ai/details/publication/pub.1006723508"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T12:20", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000362_0000000362/records_87078_00000000.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/articles/nm1276"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nm1276'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nm1276'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nm1276'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nm1276'


     

    This table displays all metadata directly associated to this object as RDF triples.

    390 TRIPLES      21 PREDICATES      89 URIs      36 LITERALS      24 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nm1276 schema:about N00e5e834d341416fa7d9d68024b63179
    2 N26566545982c4a8a930445670313a353
    3 N4102fcaee2f5446ca05c395a5a8395ee
    4 N43c6f4e13d4a47779eed01d61dc722b9
    5 N4f1bde7da47848da936210105eb824b7
    6 N58b581f9c732417d9b60c7f55e8d7fd5
    7 N5ac0b7776df84921b5bb348a141703cb
    8 N6c370424c36e44baa6da9f08a4ad07f1
    9 N73e37fdf8faf4cd5b2a41963b991b764
    10 Na953c87e00dc41d7a088e50573c3e028
    11 Nb46c491a4e914a76a1240c8e0b760529
    12 Nc051ad1c2c644e4085952e056b56b55f
    13 Ncf973e2fae904aaba82ac802adbf3987
    14 Nd1429b93d66e425a88bcde77009ff665
    15 Ne5ebb784f8674b008bb4015dda00d167
    16 anzsrc-for:06
    17 anzsrc-for:0605
    18 schema:author Nd31373ac43234c7ab10ecc74a04f1449
    19 schema:citation sg:pub.10.1038/nm1129
    20 sg:pub.10.1038/nri1461
    21 sg:pub.10.1385/1-59259-062-4:265
    22 https://app.dimensions.ai/details/publication/pub.1074995141
    23 https://app.dimensions.ai/details/publication/pub.1075034111
    24 https://app.dimensions.ai/details/publication/pub.1078378459
    25 https://app.dimensions.ai/details/publication/pub.1078715038
    26 https://app.dimensions.ai/details/publication/pub.1079557310
    27 https://app.dimensions.ai/details/publication/pub.1082424514
    28 https://app.dimensions.ai/details/publication/pub.1083056569
    29 https://app.dimensions.ai/details/publication/pub.1083163736
    30 https://doi.org/10.1002/0471142727.mb0204s56
    31 https://doi.org/10.1006/clim.1999.4724
    32 https://doi.org/10.1016/s0022-1759(98)00204-x
    33 https://doi.org/10.1016/s0037-1963(01)90118-0
    34 https://doi.org/10.1016/s0928-8244(02)00470-4
    35 https://doi.org/10.1016/s0952-7915(96)80083-5
    36 https://doi.org/10.1016/s1074-7613(00)00052-2
    37 https://doi.org/10.1046/j.1365-2958.2002.03072.x
    38 https://doi.org/10.1046/j.1365-2958.2003.03639.x
    39 https://doi.org/10.1053/shem.2001.20861
    40 https://doi.org/10.1073/pnas.030528397
    41 https://doi.org/10.1073/pnas.0406035101
    42 https://doi.org/10.1073/pnas.202476699
    43 https://doi.org/10.1073/pnas.92.9.3987
    44 https://doi.org/10.1073/pnas.93.18.9730
    45 https://doi.org/10.1073/pnas.93.9.4102
    46 https://doi.org/10.1083/jcb.200205009
    47 https://doi.org/10.1084/jem.175.6.1531
    48 https://doi.org/10.1084/jem.20040712
    49 https://doi.org/10.1084/jem.20040769
    50 https://doi.org/10.1084/jem.20040976
    51 https://doi.org/10.1111/j.1365-2958.1993.tb01211.x
    52 https://doi.org/10.1111/j.1600-065x.1997.tb00988.x
    53 https://doi.org/10.1126/science.1064571
    54 https://doi.org/10.1126/science.1082305
    55 https://doi.org/10.1128/iai.68.6.3680-3688.2000
    56 https://doi.org/10.1128/iai.69.5.2888-2893.2001
    57 https://doi.org/10.1128/jb.184.15.4177-4186.2002
    58 https://doi.org/10.1146/annurev.bi.57.070188.000333
    59 https://doi.org/10.1146/annurev.immunol.18.1.275
    60 https://doi.org/10.4049/jimmunol.166.3.1877
    61 https://doi.org/10.4049/jimmunol.167.11.6471
    62 https://doi.org/10.4049/jimmunol.170.10.5176
    63 https://doi.org/10.4049/jimmunol.173.1.420
    64 schema:datePublished 2005-08
    65 schema:datePublishedReg 2005-08-01
    66 schema:description We developed a new class of vaccines, based on killed but metabolically active (KBMA) bacteria, that simultaneously takes advantage of the potency of live vaccines and the safety of killed vaccines. We removed genes required for nucleotide excision repair (uvrAB), rendering microbial-based vaccines exquisitely sensitive to photochemical inactivation with psoralen and long-wavelength ultraviolet light. Colony formation of the nucleotide excision repair mutants was blocked by infrequent, randomly distributed psoralen crosslinks, but the bacterial population was able to express its genes, synthesize and secrete proteins. Using the intracellular pathogen Listeria monocytogenes as a model platform, recombinant psoralen-inactivated Lm DeltauvrAB vaccines induced potent CD4(+) and CD8(+) T-cell responses and protected mice against virus challenge in an infectious disease model and provided therapeutic benefit in a mouse cancer model. Microbial KBMA vaccines used either as a recombinant vaccine platform or as a modified form of the pathogen itself may have broad use for the treatment of infectious disease and cancer.
    67 schema:genre research_article
    68 schema:inLanguage en
    69 schema:isAccessibleForFree false
    70 schema:isPartOf N13634670f4b74058b7f5b55a7ae74565
    71 N2dec1d1e1bfe40d5883f9edd7e235432
    72 sg:journal.1113716
    73 schema:name Killed but metabolically active microbes: a new vaccine paradigm for eliciting effector T-cell responses and protective immunity
    74 schema:pagination 853-860
    75 schema:productId N0eeb765977614bc0863dee19bb067147
    76 N2f446c6844a9416f91458b5a47106820
    77 N3f95864ab80d49598c7e1a2a923d4924
    78 N8aaab871cae74949986ffcb7ac54029b
    79 Nc2a589d1cc394a63a478abaced084f47
    80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006723508
    81 https://doi.org/10.1038/nm1276
    82 schema:sdDatePublished 2019-04-11T12:20
    83 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    84 schema:sdPublisher N20925daaa26a476888c8cefdf1db2bc7
    85 schema:url http://www.nature.com/articles/nm1276
    86 sgo:license sg:explorer/license/
    87 sgo:sdDataset articles
    88 rdf:type schema:ScholarlyArticle
    89 N00e5e834d341416fa7d9d68024b63179 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    90 schema:name Vaccination
    91 rdf:type schema:DefinedTerm
    92 N0eeb765977614bc0863dee19bb067147 schema:name dimensions_id
    93 schema:value pub.1006723508
    94 rdf:type schema:PropertyValue
    95 N13634670f4b74058b7f5b55a7ae74565 schema:issueNumber 8
    96 rdf:type schema:PublicationIssue
    97 N153c874f4fe64016b7e3acf5f433483a schema:affiliation https://www.grid.ac/institutes/grid.418416.e
    98 schema:familyName Lim
    99 schema:givenName J Y H
    100 rdf:type schema:Person
    101 N20925daaa26a476888c8cefdf1db2bc7 schema:name Springer Nature - SN SciGraph project
    102 rdf:type schema:Organization
    103 N26566545982c4a8a930445670313a353 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    104 schema:name DNA Repair
    105 rdf:type schema:DefinedTerm
    106 N28f4bd9acc6a4a2597b53e0117950e5b rdf:first sg:person.01311635751.96
    107 rdf:rest N67c71256acfa485a95e27e1254f517e2
    108 N2dec1d1e1bfe40d5883f9edd7e235432 schema:volumeNumber 11
    109 rdf:type schema:PublicationVolume
    110 N2f446c6844a9416f91458b5a47106820 schema:name nlm_unique_id
    111 schema:value 9502015
    112 rdf:type schema:PropertyValue
    113 N39ff5564aa0741e0906d9b9c888ea4a4 rdf:first sg:person.01273722422.40
    114 rdf:rest Nc8cbc4f491584557b49485e05396b36d
    115 N3d723cd0750b43f18d3a7f3af6a87b17 rdf:first sg:person.01243522551.25
    116 rdf:rest Nf58ca04c32914cff92be3364fb2977a6
    117 N3f95864ab80d49598c7e1a2a923d4924 schema:name pubmed_id
    118 schema:value 16041382
    119 rdf:type schema:PropertyValue
    120 N4102fcaee2f5446ca05c395a5a8395ee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    121 schema:name Escherichia coli Proteins
    122 rdf:type schema:DefinedTerm
    123 N43c6f4e13d4a47779eed01d61dc722b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    124 schema:name Listeria monocytogenes
    125 rdf:type schema:DefinedTerm
    126 N44590be5e1b34136bad26596ae15d2e6 rdf:first sg:person.01017310721.32
    127 rdf:rest N62852dfca1634f4594fb5fd333ed387c
    128 N4f1bde7da47848da936210105eb824b7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    129 schema:name Immunity, Cellular
    130 rdf:type schema:DefinedTerm
    131 N54c3674fdb6a40d5be9025ac8c6dcc66 rdf:first sg:person.0630700305.07
    132 rdf:rest rdf:nil
    133 N55713f8f29424a0aa6427090fa67280b rdf:first sg:person.0637624663.70
    134 rdf:rest N28f4bd9acc6a4a2597b53e0117950e5b
    135 N585e0ea13fdb4778b253ec960b24197d rdf:first sg:person.01176017141.92
    136 rdf:rest N6bbd690846814efeb8458ea35b1ebf4c
    137 N58b581f9c732417d9b60c7f55e8d7fd5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    138 schema:name Endodeoxyribonucleases
    139 rdf:type schema:DefinedTerm
    140 N59777c17b1054478b0c007d7f4a07e53 rdf:first N153c874f4fe64016b7e3acf5f433483a
    141 rdf:rest Ncee002ac77fa4a9ab104f0a60d579815
    142 N5ac0b7776df84921b5bb348a141703cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    143 schema:name Flow Cytometry
    144 rdf:type schema:DefinedTerm
    145 N5b07afa78b664700a198130661da3749 rdf:first sg:person.0701047743.82
    146 rdf:rest N59777c17b1054478b0c007d7f4a07e53
    147 N62852dfca1634f4594fb5fd333ed387c rdf:first sg:person.0674113252.00
    148 rdf:rest N5b07afa78b664700a198130661da3749
    149 N67c71256acfa485a95e27e1254f517e2 rdf:first sg:person.0630673436.61
    150 rdf:rest N946714bbdb6648938f66ed186c9b0b38
    151 N6bbd690846814efeb8458ea35b1ebf4c rdf:first sg:person.0616412763.76
    152 rdf:rest N39ff5564aa0741e0906d9b9c888ea4a4
    153 N6c370424c36e44baa6da9f08a4ad07f1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    154 schema:name Bacterial Vaccines
    155 rdf:type schema:DefinedTerm
    156 N73e37fdf8faf4cd5b2a41963b991b764 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    157 schema:name Dendritic Cells
    158 rdf:type schema:DefinedTerm
    159 N8aaab871cae74949986ffcb7ac54029b schema:name readcube_id
    160 schema:value 2006c1fd0e592a037d34ae3d0449307dba33b7e67c5d62a359dc356f4dc0e942
    161 rdf:type schema:PropertyValue
    162 N946714bbdb6648938f66ed186c9b0b38 rdf:first sg:person.0654011112.92
    163 rdf:rest N44590be5e1b34136bad26596ae15d2e6
    164 Na953c87e00dc41d7a088e50573c3e028 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    165 schema:name Ultraviolet Rays
    166 rdf:type schema:DefinedTerm
    167 Nb46c491a4e914a76a1240c8e0b760529 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    168 schema:name Mice, Inbred C57BL
    169 rdf:type schema:DefinedTerm
    170 Nc051ad1c2c644e4085952e056b56b55f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    171 schema:name Mice
    172 rdf:type schema:DefinedTerm
    173 Nc2a589d1cc394a63a478abaced084f47 schema:name doi
    174 schema:value 10.1038/nm1276
    175 rdf:type schema:PropertyValue
    176 Nc3a59c59602a4e3281f347eecda6b291 rdf:first sg:person.013306262652.04
    177 rdf:rest N54c3674fdb6a40d5be9025ac8c6dcc66
    178 Nc8cbc4f491584557b49485e05396b36d rdf:first sg:person.01204007054.60
    179 rdf:rest Nc3a59c59602a4e3281f347eecda6b291
    180 Ncee002ac77fa4a9ab104f0a60d579815 rdf:first sg:person.01167350325.23
    181 rdf:rest Nd2dab7ed490d402faaf87ab09cbfc9ee
    182 Ncf973e2fae904aaba82ac802adbf3987 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    183 schema:name Carbon Radioisotopes
    184 rdf:type schema:DefinedTerm
    185 Nd1429b93d66e425a88bcde77009ff665 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    186 schema:name Animals
    187 rdf:type schema:DefinedTerm
    188 Nd2dab7ed490d402faaf87ab09cbfc9ee rdf:first sg:person.0744115027.96
    189 rdf:rest N585e0ea13fdb4778b253ec960b24197d
    190 Nd31373ac43234c7ab10ecc74a04f1449 rdf:first sg:person.0745122036.60
    191 rdf:rest N3d723cd0750b43f18d3a7f3af6a87b17
    192 Ne5ebb784f8674b008bb4015dda00d167 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    193 schema:name Ficusin
    194 rdf:type schema:DefinedTerm
    195 Nf58ca04c32914cff92be3364fb2977a6 rdf:first sg:person.0634111110.15
    196 rdf:rest N55713f8f29424a0aa6427090fa67280b
    197 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    198 schema:name Biological Sciences
    199 rdf:type schema:DefinedTerm
    200 anzsrc-for:0605 schema:inDefinedTermSet anzsrc-for:
    201 schema:name Microbiology
    202 rdf:type schema:DefinedTerm
    203 sg:journal.1113716 schema:issn 1078-8956
    204 1546-170X
    205 schema:name Nature Medicine
    206 rdf:type schema:Periodical
    207 sg:person.01017310721.32 schema:affiliation https://www.grid.ac/institutes/grid.5288.7
    208 schema:familyName Schnupf
    209 schema:givenName P
    210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017310721.32
    211 rdf:type schema:Person
    212 sg:person.01167350325.23 schema:affiliation https://www.grid.ac/institutes/grid.418416.e
    213 schema:familyName Sampson-Johannes
    214 schema:givenName A
    215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167350325.23
    216 rdf:type schema:Person
    217 sg:person.01176017141.92 schema:affiliation https://www.grid.ac/institutes/grid.418416.e
    218 schema:familyName Stassinopoulos
    219 schema:givenName A
    220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176017141.92
    221 rdf:type schema:Person
    222 sg:person.01204007054.60 schema:affiliation https://www.grid.ac/institutes/grid.47840.3f
    223 schema:familyName Portnoy
    224 schema:givenName D A
    225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204007054.60
    226 rdf:type schema:Person
    227 sg:person.01243522551.25 schema:affiliation https://www.grid.ac/institutes/grid.418416.e
    228 schema:familyName Bahjat
    229 schema:givenName K S
    230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243522551.25
    231 rdf:type schema:Person
    232 sg:person.01273722422.40 schema:affiliation https://www.grid.ac/institutes/grid.418416.e
    233 schema:familyName Hearst
    234 schema:givenName J E
    235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273722422.40
    236 rdf:type schema:Person
    237 sg:person.01311635751.96 schema:affiliation https://www.grid.ac/institutes/grid.418416.e
    238 schema:familyName Leong
    239 schema:givenName M
    240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311635751.96
    241 rdf:type schema:Person
    242 sg:person.013306262652.04 schema:affiliation https://www.grid.ac/institutes/grid.418416.e
    243 schema:familyName Cook
    244 schema:givenName D N
    245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013306262652.04
    246 rdf:type schema:Person
    247 sg:person.0616412763.76 schema:affiliation https://www.grid.ac/institutes/grid.5288.7
    248 schema:familyName Bouwer
    249 schema:givenName H G Archie
    250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616412763.76
    251 rdf:type schema:Person
    252 sg:person.0630673436.61 schema:affiliation https://www.grid.ac/institutes/grid.418416.e
    253 schema:familyName Luckett
    254 schema:givenName W
    255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630673436.61
    256 rdf:type schema:Person
    257 sg:person.0630700305.07 schema:familyName Dubensky
    258 schema:givenName T W
    259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630700305.07
    260 rdf:type schema:Person
    261 sg:person.0634111110.15 schema:affiliation https://www.grid.ac/institutes/grid.418416.e
    262 schema:familyName Giedlin
    263 schema:givenName M A
    264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634111110.15
    265 rdf:type schema:Person
    266 sg:person.0637624663.70 schema:affiliation https://www.grid.ac/institutes/grid.418416.e
    267 schema:familyName Liu
    268 schema:givenName W
    269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637624663.70
    270 rdf:type schema:Person
    271 sg:person.0654011112.92 schema:affiliation https://www.grid.ac/institutes/grid.418416.e
    272 schema:familyName Gao
    273 schema:givenName Y
    274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0654011112.92
    275 rdf:type schema:Person
    276 sg:person.0674113252.00 schema:affiliation https://www.grid.ac/institutes/grid.418416.e
    277 schema:familyName Kapadia
    278 schema:givenName D
    279 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0674113252.00
    280 rdf:type schema:Person
    281 sg:person.0701047743.82 schema:affiliation https://www.grid.ac/institutes/grid.418416.e
    282 schema:familyName Castro
    283 schema:givenName G
    284 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701047743.82
    285 rdf:type schema:Person
    286 sg:person.0744115027.96 schema:affiliation https://www.grid.ac/institutes/grid.5288.7
    287 schema:familyName Herskovits
    288 schema:givenName A A
    289 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744115027.96
    290 rdf:type schema:Person
    291 sg:person.0745122036.60 schema:affiliation https://www.grid.ac/institutes/grid.418416.e
    292 schema:familyName Brockstedt
    293 schema:givenName D G
    294 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745122036.60
    295 rdf:type schema:Person
    296 sg:pub.10.1038/nm1129 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050946104
    297 https://doi.org/10.1038/nm1129
    298 rdf:type schema:CreativeWork
    299 sg:pub.10.1038/nri1461 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033865745
    300 https://doi.org/10.1038/nri1461
    301 rdf:type schema:CreativeWork
    302 sg:pub.10.1385/1-59259-062-4:265 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047802023
    303 https://doi.org/10.1385/1-59259-062-4:265
    304 rdf:type schema:CreativeWork
    305 https://app.dimensions.ai/details/publication/pub.1074995141 schema:CreativeWork
    306 https://app.dimensions.ai/details/publication/pub.1075034111 schema:CreativeWork
    307 https://app.dimensions.ai/details/publication/pub.1078378459 schema:CreativeWork
    308 https://app.dimensions.ai/details/publication/pub.1078715038 schema:CreativeWork
    309 https://app.dimensions.ai/details/publication/pub.1079557310 schema:CreativeWork
    310 https://app.dimensions.ai/details/publication/pub.1082424514 schema:CreativeWork
    311 https://app.dimensions.ai/details/publication/pub.1083056569 schema:CreativeWork
    312 https://app.dimensions.ai/details/publication/pub.1083163736 schema:CreativeWork
    313 https://doi.org/10.1002/0471142727.mb0204s56 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040923428
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1006/clim.1999.4724 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031338753
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1016/s0022-1759(98)00204-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1033648033
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1016/s0037-1963(01)90118-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047008254
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1016/s0928-8244(02)00470-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037985491
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1016/s0952-7915(96)80083-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025912918
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1016/s1074-7613(00)00052-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006801851
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1046/j.1365-2958.2002.03072.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010391951
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1046/j.1365-2958.2003.03639.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1046149869
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1053/shem.2001.20861 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057077911
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.1073/pnas.030528397 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021110326
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.1073/pnas.0406035101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026955438
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1073/pnas.202476699 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002680506
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.1073/pnas.92.9.3987 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030835472
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.1073/pnas.93.18.9730 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004357203
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.1073/pnas.93.9.4102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000183927
    344 rdf:type schema:CreativeWork
    345 https://doi.org/10.1083/jcb.200205009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012008252
    346 rdf:type schema:CreativeWork
    347 https://doi.org/10.1084/jem.175.6.1531 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013274658
    348 rdf:type schema:CreativeWork
    349 https://doi.org/10.1084/jem.20040712 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014765958
    350 rdf:type schema:CreativeWork
    351 https://doi.org/10.1084/jem.20040769 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025520991
    352 rdf:type schema:CreativeWork
    353 https://doi.org/10.1084/jem.20040976 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040741147
    354 rdf:type schema:CreativeWork
    355 https://doi.org/10.1111/j.1365-2958.1993.tb01211.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044039866
    356 rdf:type schema:CreativeWork
    357 https://doi.org/10.1111/j.1600-065x.1997.tb00988.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1012154317
    358 rdf:type schema:CreativeWork
    359 https://doi.org/10.1126/science.1064571 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062445425
    360 rdf:type schema:CreativeWork
    361 https://doi.org/10.1126/science.1082305 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062447916
    362 rdf:type schema:CreativeWork
    363 https://doi.org/10.1128/iai.68.6.3680-3688.2000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014041368
    364 rdf:type schema:CreativeWork
    365 https://doi.org/10.1128/iai.69.5.2888-2893.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041020895
    366 rdf:type schema:CreativeWork
    367 https://doi.org/10.1128/jb.184.15.4177-4186.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005568798
    368 rdf:type schema:CreativeWork
    369 https://doi.org/10.1146/annurev.bi.57.070188.000333 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045816488
    370 rdf:type schema:CreativeWork
    371 https://doi.org/10.1146/annurev.immunol.18.1.275 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019051896
    372 rdf:type schema:CreativeWork
    373 https://doi.org/10.4049/jimmunol.166.3.1877 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074751404
    374 rdf:type schema:CreativeWork
    375 https://doi.org/10.4049/jimmunol.167.11.6471 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030071382
    376 rdf:type schema:CreativeWork
    377 https://doi.org/10.4049/jimmunol.170.10.5176 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075282170
    378 rdf:type schema:CreativeWork
    379 https://doi.org/10.4049/jimmunol.173.1.420 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076855528
    380 rdf:type schema:CreativeWork
    381 https://www.grid.ac/institutes/grid.418416.e schema:alternateName Cerus (United States)
    382 schema:name Cerus Corporation, 2411 Stanwell Drive, Concord, California 94520, USA.
    383 rdf:type schema:Organization
    384 https://www.grid.ac/institutes/grid.47840.3f schema:alternateName University of California, Berkeley
    385 schema:name Department of Molecular and Cell Biology, Oregon Health Sciences University, 3710 SW US Veterans Hospital Road, Portland, Oregon 97201, USA.
    386 School of Public Health, University of California, 508 Barker Hall, #3202, Berkeley, California, 94720-3202, USA.
    387 rdf:type schema:Organization
    388 https://www.grid.ac/institutes/grid.5288.7 schema:alternateName Oregon Health & Science University
    389 schema:name Department of Molecular and Cell Biology, Oregon Health Sciences University, 3710 SW US Veterans Hospital Road, Portland, Oregon 97201, USA.
    390 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...