Possible new role for NF-κB in the resolution of inflammation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-12

AUTHORS

Toby Lawrence, Derek W. Gilroy, Paul R. Colville-Nash, Derek A. Willoughby

ABSTRACT

Inflammation involves the sequential activation of signaling pathways leading to the production of both pro- and anti-inflammatory mediators. Although much attention has focused on pro-inflammatory pathways that initiate inflammation, relatively little is known about the mechanisms that switch off inflammation and resolve the inflammatory response. The transcription factor NF-κB is thought to have a central role in the induction of pro-inflammatory gene expression and has attracted interest as a new target for the treatment of inflammatory disease. We show here that NF-κB activation in leukocytes recruited during the onset of inflammation is associated with pro-inflammatory gene expression, whereas such activation during the resolution of inflammation is associated with the expression of anti-inflammatory genes and the induction of apoptosis. Inhibition of NF-κB during the resolution of inflammation protracts the inflammatory response and prevents apoptosis. This suggests that NF-κB has an anti-inflammatory role in vivo involving the regulation of inflammatory resolution. More... »

PAGES

1291-1297

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nm1201-1291

DOI

http://dx.doi.org/10.1038/nm1201-1291

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042511547

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11726968


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