Imaging human epithelial properties with polarized light-scattering spectroscopy View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-11

AUTHORS

R S Gurjar, V Backman, L T Perelman, I Georgakoudi, K Badizadegan, I Itzkan, R R Dasari, M S Feld

ABSTRACT

Biomedical imaging with light-scattering spectroscopy (LSS) is a novel optical technology developed to probe the structure of living epithelial cells in situ without need for tissue removal. LSS makes it possible to distinguish between single backscattering from epithelial-cell nuclei and multiply scattered light. The spectrum of the single backscattering component is further analyzed to provide quantitative information about the epithelial-cell nuclei such as nuclear size, degree of pleomorphism, degree of hyperchromasia and amount of chromatin. LSS imaging allows mapping these histological properties over wide areas of epithelial lining. Because nuclear enlargement, pleomorphism and hyperchromasia are principal features of nuclear atypia associated with precancerous and cancerous changes in virtually all epithelia, LSS imaging can be used to detect precancerous lesions in optically accessible organs. More... »

PAGES

1245-1248

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nm1101-1245

DOI

http://dx.doi.org/10.1038/nm1101-1245

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1019798836

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11689891


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