Cancer immunotherapy: moving beyond current vaccines View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2004-09

AUTHORS

Steven A Rosenberg, James C Yang, Nicholas P Restifo

ABSTRACT

Great progress has been made in the field of tumor immunology in the past decade, but optimism about the clinical application of currently available cancer vaccine approaches is based more on surrogate endpoints than on clinical tumor regression. In our cancer vaccine trials of 440 patients, the objective response rate was low (2.6%), and comparable to the results obtained by others. We consider here results in cancer vaccine trials and highlight alternate strategies that mediate cancer regression in preclinical and clinical models. More... »

PAGES

909-915

Journal

TITLE

Nature Medicine

ISSUE

9

VOLUME

10

Related Patents

  • Increased T-Cell Tumor Infiltration And Eradication Of Metastases By Mutant Light
  • Tumour-Specific Animal Proteins
  • Tumor Vaccination In Combination With Hematopoietic Cell Transplantation For Cancer Therapy
  • Modified Polynucleotides For The Production Of Secreted Proteins
  • Mart-1 T Cell Receptors
  • Composition Comprising Bacillus Calmette Guerin With Cox2 Selective/Preferential Inhibitor And Uses Thereof
  • Method Of Targeted Gene Delivery Using Viral Vectors
  • Method Of Immunotherapy For Treatment Of Human Papillomavirus Infection
  • Engineered Nucleic Acids Encoding A Modified Erythropoietin And Their Expression
  • Controlled Delivery Of Tlr Agonists In Structural Polymeric Devices
  • Methods For Treating Cancer By Administration Of Nucleic Acids Encoding Fap And Cancer Antigens
  • Application Of Mrna For Use As A Therapeutic Against Tumor Diseases
  • Targeted Gene Delivery For Dendritic Cell Vaccination
  • Injectable Cryogel Vaccine Devices And Methods Of Use Thereof
  • Method Of Immunotherapy For Treament Of Human Papillomavirus Infection
  • Agents And Methods To Elicit Anti-Tumor Immune Response
  • Vaccine Immunotherapy For Treating Lymphoma In Immune Suppressed Patients
  • High Affinity T Cell Receptor And Use Thereof
  • Modified Polynucleotides For The Production Of Biologics And Proteins Associated With Human Disease
  • Modified Polynucleotides For Treating Galactosylceramidase Protein Deficiency
  • Increased T-Cell Tumor Infiltration And Eradication Of Metastases By Mutant Light
  • Rab6kifl/Kif20a Epitope Peptide And Vaccines Containing The Same
  • Scaffolds For Cell Transplantation
  • Vaccine Immunotherapy
  • Modified Polynucleotides Encoding Granulysin
  • Cancer Peptide Vaccine
  • Mart-1 T Cell Receptors
  • Modified Nucleosides, Nucleotides, And Nucleic Acids, And Uses Thereof
  • Application Of Mrna For Use As A Therapeutic Against Tumour Diseases
  • Application Of Mrna For Use As A Therapeutic Against Tumour Diseases
  • Modified Polynucleotides Encoding Cited4
  • Modified Polynucleotides For The Production Of Nuclear Proteins
  • Modified Polynucleotides Encoding Septin-4
  • Therapeutic Agent For Cancer
  • Peptide Having 5 Linked Ctl Epitopes
  • Materials And Methods For Producing Improved Lentiviral Vector Particles
  • Method For Identifying Novel Minor Histocompatibility Antigens
  • Controlled Release Of Growth Factors And Signaling Molecules For Promoting Angiogenesis
  • Modified Polynucleotides For Treating Protein Deficiency
  • Novel Melanoma Antigen Peptide And Uses Thereof
  • High Affinity T Cell Receptor And Use Thereof
  • Scaffolds For Cell Transplantation
  • Scaffolds For Cell Transplantation
  • Sema5b Peptides And Vaccines Including The Same
  • Engineered Nucleic Acids And Methods Of Use Thereof
  • Modified Polynucleotides Encoding Apoptosis Inducing Factor 1
  • Vaccine Immunotherapy For Treating Hepatocellular Cancer In Immune Suppressed Patients
  • Materials Presenting Notch Signaling Molecules To Control Cell Behavior
  • Delivery And Formulation Of Engineered Nucleic Acids
  • Method Of Increasing Immunological Effect
  • Modulation Of Cytokine Signaling Regulators And Applications For Immunotherapy
  • Tumour-Specific Animal Proteins
  • Delivery And Formulation Of Engineered Nucleic Acids
  • Programming Of Cells For Tolerogenic Therapies
  • Injectable Preformed Macroscopic 3-Dimensional Scaffolds For Minimally Invasive Administration
  • Mesoporous Silica Compositions For Modulating Immune Responses
  • Engineered Nucleic Acids And Methods Of Use Thereof
  • Casb7439 Constructs
  • Composition For Eliciting A Specific Ctl Response, Comprising A Lympho-Ablative Compound And A Molecule That Contains Antigenic Sequences And Targets Professional Antigen Presenting Cells
  • Modified Polynucleotides For The Production Of Proteins Associated With Human Disease
  • Controlled Release Of Growth Factors And Signaling Molecules For Promoting Angiogenesis
  • Formulation And Delivery Of Plga Microspheres
  • Application Of Mrna For Use As A Therapeutic Against Tumour Diseases
  • Compositions And Methods Of Altering Cholesterol Levels
  • Compositions And Methods Of Identifying Tumor Specific Neoantigens
  • Novel Melanoma Antigen Peptide And Uses Thereof
  • Modified Polynucleotides Encoding Copper Metabolism (Murr1) Domain Containing 1
  • Rab6kifl/Kif20a Epitope Peptide And Vaccines Containing The Same
  • Immunogenic Polypeptide Composed Of Hla-B7 Restricted Tumor Antigen-Derived Optimized Cryptic Peptides, And Uses Thereof
  • Modified Polynucleotides Encoding Basic Helix-Loop-Helix Family Member E41
  • Programming Of Cells For Tolerogenic Therapies
  • Hig2 And Urlc10 Epitope Peptide And Vaccines Containing The Same
  • Enhancement Of Skeletal Muscle Stem Cell Engraftment By Dual Delivery Of Vegf And Igf-1
  • Generation Of Antibodies To Tumor Antigens And Generation Of Tumor Specific Complement Dependent Cytotoxicity By Administration Of Oncolytic Vaccinia Virus
  • Engineered Nucleic Acids And Methods Of Use Thereof
  • Ctl Inducer Composition
  • Modified Polynucleotides For The Production Of Proteins
  • Methods And Compositions Concerning Poxviruses And Cancer
  • Co-Delivery Of Stimulatory And Inhibitory Factors To Create Temporally Stable And Spatially Restricted Zones
  • Compositions Of Tumor Specific Neoantigens
  • Vaccine Immunotherapy
  • Allogeneic Autophagosome-Enriched Composition For The Treatment Of Disease
  • Engineered Nucleic Acids And Methods Of Use Thereof
  • Engineered Nucleic Acids And Methods Of Use Thereof
  • Programming Of Cells For Tolerogenic Therapies
  • Light Targeting Molecules And Uses Thereof
  • Modified Polynucleotides For The Production Of Oncology-Related Proteins And Peptides
  • Ctl Inducer Composition
  • Modified Polynucleotides For The Production Of G-Csf
  • Engineered Nucleic Acids And Methods Of Use Thereof
  • Oncolytic Vaccinia Virus Cancer Therapy
  • Fcγriib Specific Antibodies And Methods Of Use Thereof
  • Terminally Modified Rna
  • Modified Nucleosides, Nucleotides, And Nucleic Acids, And Uses Thereof
  • Vaccine Immunotherapy
  • Modulation Of Negative Immune Regulators And Applications For Immunotherapy
  • Engineered Nucleic Acids And Methods Of Use Thereof
  • Modified Polynucleotides For The Production Of Cosmetic Proteins And Peptides
  • Application Of Mrna For Use As A Therapeutic Against Tumour Diseases
  • Modified Polynucleotides Encoding Siah E3 Ubiquitin Protein Ligase 1
  • Vaccine Immunotherapy
  • Dlin-Kc2-Dma Lipid Nanoparticle Delivery Of Modified Polynucleotides
  • Targeted Gene Delivery To Dendritic Cells
  • Application Of Mrna For Use As A Therapeutic Against Tumour Diseases
  • Modified Polynucleotides For The Production Of Secreted Proteins
  • Therapeutic Agent For Cancer
  • Modified Polynucleotides Encoding Hepatitis A Virus Cellular Receptor 2
  • In Vivo Production Of Proteins
  • Systemic Treatment Of Metastatic And/Or Systemically-Disseminated Cancers Using Gm-Csf-Expressing Poxviruses
  • Controlled Delivery Of Tlr3 Agonists In Structural Polymeric Devices
  • Methods Useful For Generating Highly Mannosylated Pseudotyped Lentiviral Vector Particles Comprising A Vpx Protein
  • Recombinant Retrovirus Pseudotyped With A E2 Alphavirus Glycoprotein
  • Modified Polynucleotides For The Production Of Proteins
  • Agents And Methods To Elicit Anti-Tumor Immune Response
  • Modified Nucleosides, Nucleotides, And Nucleic Acids, And Uses Thereof
  • Method Of Targeting Gene Delivery Using Viral Vectors
  • Method For Producing A Protein Of Interest In A Primate
  • Packaging Cells For Producing Retrovirus Pseudotyped With An E2 Alphavirus Glycoprotein
  • Modified Polynucleotides Encoding Aquaporin-5
  • Modified Polynucleotides For The Production Of Proteins Associated With Blood And Lymphatic Disorders
  • Modified Polynucleotides For The Production Of Cytoplasmic And Cytoskeletal Proteins
  • Method Of Stimulating An Immune Response Using A Pseudotyped Lentivirus
  • Modified Polynucleotides For The Production Of Cytoplasmic And Cytoskeletal Proteins
  • Allogeneic Autophagosome-Enriched Composition For The Treatment Of Disease
  • In Situ Antigen-Generating Cancer Vaccine
  • Antigen Specific Multi Epitope Vaccines
  • Recombiant Lentivirus Comprising An E2 Alphavirus Glycoprotein That Binds To Dc-Sign
  • Immunogenic Polypeptide Composed Of Hla-B7 Restricted Tumor Antigen-Derived Optimized Cryptic Peptides, And Uses Thereof
  • Compositions And Methods Relating To Treatment Of Cancer And Infectious Diseases
  • Split Dose Administration
  • Oncolytic Vaccinia Virus Combination Cancer Therapy
  • Harnessing Cell Dynamics To Engineer Materials
  • Vaccine Immunotherapy For Treating Cervical Cancer In Immune Suppressed Patients
  • Recombinant Retrovirus Pseudotyped With E2 Alphavirus Glycoprotein
  • Modified Polynucleotides Encoding Aryl Hydrocarbon Receptor Nuclear Translocator
  • Tumour-Specific Animal Proteins
  • T Cell Receptor And Uses Thereof
  • Modified Nucleosides, Nucleotides, And Nucleic Acids, And Uses Thereof
  • Modified Polynucleotides For The Production Of Proteins Associated With Blood And Lymphatic Disorders
  • Lentiviral Vectors Pseudotyped With A Sindbis Virus Envelope Glycoprotein
  • Methods And Compositions For Treating Cancer
  • Scaffolds For Cell Collection Or Elimination
  • Modified Polynucleotides For The Production Of Biologics And Proteins Associated With Human Disease
  • Formulation And Delivery Of Plga Microspheres
  • Immunogenic Compositions Comprising Progastrin And Uses Thereof
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nm1100

    DOI

    http://dx.doi.org/10.1038/nm1100

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1001965372

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/15340416


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Immunology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adolescent", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cancer Vaccines", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Child", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Clinical Trials as Topic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Immunotherapy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Models, Immunological", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasm Metastasis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "T-Lymphocytes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Treatment Outcome", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Vaccines, Subunit", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "name": [
                "Surgery Branch of the Center for Cancer Research at the National Cancer Institute, Building 10, Room 2B42, 10 Center Drive, MSC 1502 Bethesda, Maryland 20892-1502, USA. sar@mail.nih.gov"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rosenberg", 
            "givenName": "Steven A", 
            "id": "sg:person.0717624506.16", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717624506.16"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Yang", 
            "givenName": "James C", 
            "id": "sg:person.012577717744.21", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012577717744.21"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Restifo", 
            "givenName": "Nicholas P", 
            "id": "sg:person.01257633341.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257633341.37"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1093/jnci/djh028", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000132661"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1034/j.1600-065x.2001.1820104.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002371313"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1076514", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003163159"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.141226398", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003475218"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1081/cnv-120025091", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003572414"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00262-003-0429-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003881258", 
              "https://doi.org/10.1007/s00262-003-0429-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1074-7613(01)00093-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005554478"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.190.11.1669", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006040605"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00002371-199903000-00007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006458820"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00002371-199903000-00007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006458820"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0065-2776(08)60911-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006515864"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.immunol.21.120601.141126", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011053444"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00000658-199210000-00010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015014754"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00000658-199210000-00010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015014754"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00002371-200307000-00007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017663233"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00002371-200307000-00007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017663233"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0398-328", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017994921", 
              "https://doi.org/10.1038/nm0398-328"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0264-410x(01)00062-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020124664"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-0620-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022828236"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1074-7613(00)00026-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023461380"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35077246", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024176319", 
              "https://doi.org/10.1038/35077246"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35077246", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024176319", 
              "https://doi.org/10.1038/35077246"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00002371-200003000-00012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026974409"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00002371-200003000-00012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026974409"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20030590", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027648981"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/92.16.1336", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029590769"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/pros.10276", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029699686"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/90.24.1894", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029708491"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.220413497", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031863846"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/92.3.205", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032301848"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.95.22.13141", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034584852"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0065-2776(03)81008-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035945582"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0959-8049(99)00048-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036532413"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood.v99.5.1517", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036676498"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6601711", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036999668", 
              "https://doi.org/10.1038/sj.bjc.6601711"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6601711", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036999668", 
              "https://doi.org/10.1038/sj.bjc.6601711"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0307298101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038276939"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/pros.10130", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038756273"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20012100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038904580"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00002371-200107000-00012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041687681"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00002371-200107000-00012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041687681"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1533209100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042168438"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/91.6.523", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042322859"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0398-321", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042802949", 
              "https://doi.org/10.1038/nm0398-321"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.186.5.645", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044924423"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-0689-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047952119"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/1097-0142(19810101)47:1<207::aid-cncr2820470134>3.0.co;2-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049278910"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s002620000146", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050911568", 
              "https://doi.org/10.1007/s002620000146"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/1097-0215(20001015)88:2<232::aid-ijc14>3.0.co;2-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051399926"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00002371-200307000-00008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052926290"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00002371-200307000-00008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052926290"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00002371-200007000-00013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053087303"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00002371-200007000-00013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053087303"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1074-7613(09)00091-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054680334"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/104303403322124828", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059202548"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/104303403765255110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059202626"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2002.09.134", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064203136"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2003.02.135", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064203413"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2003.03.091", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064203460"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2003.06.041", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064203662"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2003.10.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064203880"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2003.12.144", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064204032"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074494579", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.1999.17.1.332", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074511246"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074526318", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074641638", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074660225", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2000.18.23.3964", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074733885"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074813212", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074870439", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074892325", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074961232", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075070903", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075189853", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075279929", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075316378", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075330705", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075344765", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082444072", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082972452", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083061979", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083344550", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2004-09", 
        "datePublishedReg": "2004-09-01", 
        "description": "Great progress has been made in the field of tumor immunology in the past decade, but optimism about the clinical application of currently available cancer vaccine approaches is based more on surrogate endpoints than on clinical tumor regression. In our cancer vaccine trials of 440 patients, the objective response rate was low (2.6%), and comparable to the results obtained by others. We consider here results in cancer vaccine trials and highlight alternate strategies that mediate cancer regression in preclinical and clinical models.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/nm1100", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2710714", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2722393", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1113716", 
            "issn": [
              "1078-8956", 
              "1546-170X"
            ], 
            "name": "Nature Medicine", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "9", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "10"
          }
        ], 
        "name": "Cancer immunotherapy: moving beyond current vaccines", 
        "pagination": "909-915", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "095c7235b4296a28bf024ad8a9b8c80a826eab62f71651efe0d05d6ac4be4df9"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "15340416"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9502015"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nm1100"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1001965372"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nm1100", 
          "https://app.dimensions.ai/details/publication/pub.1001965372"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T12:20", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000362_0000000362/records_87078_00000000.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/nm/journal/v10/n9/full/nm1100.html"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nm1100'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nm1100'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nm1100'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nm1100'


     

    This table displays all metadata directly associated to this object as RDF triples.

    359 TRIPLES      21 PREDICATES      119 URIs      38 LITERALS      26 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nm1100 schema:about N0adb71a353384acaae43c14b1dae8973
    2 N103b340add4c4e848bcc556831835b40
    3 N21022ae44bc84b14b3b9b6b7154bc4f5
    4 N24921a7e9ce542788db626c56d2f754c
    5 N2ada67ea51e242c4bdb0a0c94eef70c4
    6 N3f9908277990473b9c27685109041e7e
    7 N493bb48e57104d8cb548764066025c34
    8 N4a95afdde38646c1ac4717f867c34b33
    9 N8bddcab3a135425f8311c5fc8c679030
    10 Nae52ec13bb1f46e59360644c1a9caff3
    11 Nc87d0cca9a5f4a2a8297d5ba7d3e70bd
    12 Ncbb8bcf5e68e4fb79a69b3aa7abf6d89
    13 Nd8ab3fc3a89b4b1ea16b8b4fdba4c33d
    14 Nddc0838023c544938550950f2cfad790
    15 Nde78217ccfed480fb5f33e5fd97a9d5b
    16 Ne4407bc7d4d74d2bb1097cab09aebe61
    17 Nfb93e8ed98de4379ad40d9ac2dbb1adb
    18 anzsrc-for:11
    19 anzsrc-for:1107
    20 schema:author N7cb98f8a7fa2436382feeb73debc8246
    21 schema:citation sg:pub.10.1007/s00262-003-0429-0
    22 sg:pub.10.1007/s002620000146
    23 sg:pub.10.1038/35077246
    24 sg:pub.10.1038/nm0398-321
    25 sg:pub.10.1038/nm0398-328
    26 sg:pub.10.1038/sj.bjc.6601711
    27 https://app.dimensions.ai/details/publication/pub.1074494579
    28 https://app.dimensions.ai/details/publication/pub.1074526318
    29 https://app.dimensions.ai/details/publication/pub.1074641638
    30 https://app.dimensions.ai/details/publication/pub.1074660225
    31 https://app.dimensions.ai/details/publication/pub.1074813212
    32 https://app.dimensions.ai/details/publication/pub.1074870439
    33 https://app.dimensions.ai/details/publication/pub.1074892325
    34 https://app.dimensions.ai/details/publication/pub.1074961232
    35 https://app.dimensions.ai/details/publication/pub.1075070903
    36 https://app.dimensions.ai/details/publication/pub.1075189853
    37 https://app.dimensions.ai/details/publication/pub.1075279929
    38 https://app.dimensions.ai/details/publication/pub.1075316378
    39 https://app.dimensions.ai/details/publication/pub.1075330705
    40 https://app.dimensions.ai/details/publication/pub.1075344765
    41 https://app.dimensions.ai/details/publication/pub.1082444072
    42 https://app.dimensions.ai/details/publication/pub.1082972452
    43 https://app.dimensions.ai/details/publication/pub.1083061979
    44 https://app.dimensions.ai/details/publication/pub.1083344550
    45 https://doi.org/10.1002/1097-0142(19810101)47:1<207::aid-cncr2820470134>3.0.co;2-6
    46 https://doi.org/10.1002/1097-0215(20001015)88:2<232::aid-ijc14>3.0.co;2-8
    47 https://doi.org/10.1002/pros.10130
    48 https://doi.org/10.1002/pros.10276
    49 https://doi.org/10.1016/s0065-2776(03)81008-8
    50 https://doi.org/10.1016/s0065-2776(08)60911-6
    51 https://doi.org/10.1016/s0264-410x(01)00062-7
    52 https://doi.org/10.1016/s0959-8049(99)00048-9
    53 https://doi.org/10.1016/s1074-7613(00)00026-1
    54 https://doi.org/10.1016/s1074-7613(01)00093-0
    55 https://doi.org/10.1016/s1074-7613(09)00091-0
    56 https://doi.org/10.1034/j.1600-065x.2001.1820104.x
    57 https://doi.org/10.1073/pnas.0307298101
    58 https://doi.org/10.1073/pnas.141226398
    59 https://doi.org/10.1073/pnas.1533209100
    60 https://doi.org/10.1073/pnas.220413497
    61 https://doi.org/10.1073/pnas.95.22.13141
    62 https://doi.org/10.1081/cnv-120025091
    63 https://doi.org/10.1084/jem.186.5.645
    64 https://doi.org/10.1084/jem.190.11.1669
    65 https://doi.org/10.1084/jem.20012100
    66 https://doi.org/10.1084/jem.20030590
    67 https://doi.org/10.1089/104303403322124828
    68 https://doi.org/10.1089/104303403765255110
    69 https://doi.org/10.1093/jnci/90.24.1894
    70 https://doi.org/10.1093/jnci/91.6.523
    71 https://doi.org/10.1093/jnci/92.16.1336
    72 https://doi.org/10.1093/jnci/92.3.205
    73 https://doi.org/10.1093/jnci/djh028
    74 https://doi.org/10.1097/00000658-199210000-00010
    75 https://doi.org/10.1097/00002371-199903000-00007
    76 https://doi.org/10.1097/00002371-200003000-00012
    77 https://doi.org/10.1097/00002371-200007000-00013
    78 https://doi.org/10.1097/00002371-200107000-00012
    79 https://doi.org/10.1097/00002371-200307000-00007
    80 https://doi.org/10.1097/00002371-200307000-00008
    81 https://doi.org/10.1126/science.1076514
    82 https://doi.org/10.1146/annurev.immunol.21.120601.141126
    83 https://doi.org/10.1158/1078-0432.ccr-0620-3
    84 https://doi.org/10.1158/1078-0432.ccr-0689-3
    85 https://doi.org/10.1182/blood.v99.5.1517
    86 https://doi.org/10.1200/jco.1999.17.1.332
    87 https://doi.org/10.1200/jco.2000.18.23.3964
    88 https://doi.org/10.1200/jco.2002.09.134
    89 https://doi.org/10.1200/jco.2003.02.135
    90 https://doi.org/10.1200/jco.2003.03.091
    91 https://doi.org/10.1200/jco.2003.06.041
    92 https://doi.org/10.1200/jco.2003.10.005
    93 https://doi.org/10.1200/jco.2003.12.144
    94 schema:datePublished 2004-09
    95 schema:datePublishedReg 2004-09-01
    96 schema:description Great progress has been made in the field of tumor immunology in the past decade, but optimism about the clinical application of currently available cancer vaccine approaches is based more on surrogate endpoints than on clinical tumor regression. In our cancer vaccine trials of 440 patients, the objective response rate was low (2.6%), and comparable to the results obtained by others. We consider here results in cancer vaccine trials and highlight alternate strategies that mediate cancer regression in preclinical and clinical models.
    97 schema:genre research_article
    98 schema:inLanguage en
    99 schema:isAccessibleForFree true
    100 schema:isPartOf N8c63862415254ca4908c066b69042053
    101 Ndb8d1219acff44a7907fe348c5e9d26c
    102 sg:journal.1113716
    103 schema:name Cancer immunotherapy: moving beyond current vaccines
    104 schema:pagination 909-915
    105 schema:productId N47d4d02d1f6e4513ac95e0c819b03766
    106 N4eecc048855343dc89d8599b9b689105
    107 N54a86960a7f94bb888dcd3171622ba88
    108 N65270a5beb36499f9356913bf4771a8f
    109 Nf1a4daeccdb74cf6b47d1e706641fe51
    110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001965372
    111 https://doi.org/10.1038/nm1100
    112 schema:sdDatePublished 2019-04-11T12:20
    113 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    114 schema:sdPublisher N0a43ae9c6aaa4afb965eb7929e4dd502
    115 schema:url http://www.nature.com/nm/journal/v10/n9/full/nm1100.html
    116 sgo:license sg:explorer/license/
    117 sgo:sdDataset articles
    118 rdf:type schema:ScholarlyArticle
    119 N0a43ae9c6aaa4afb965eb7929e4dd502 schema:name Springer Nature - SN SciGraph project
    120 rdf:type schema:Organization
    121 N0adb71a353384acaae43c14b1dae8973 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    122 schema:name Clinical Trials as Topic
    123 rdf:type schema:DefinedTerm
    124 N103b340add4c4e848bcc556831835b40 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    125 schema:name Male
    126 rdf:type schema:DefinedTerm
    127 N1c58472044ee418b99551829a5f0d384 schema:name Surgery Branch of the Center for Cancer Research at the National Cancer Institute, Building 10, Room 2B42, 10 Center Drive, MSC 1502 Bethesda, Maryland 20892-1502, USA. sar@mail.nih.gov
    128 rdf:type schema:Organization
    129 N21022ae44bc84b14b3b9b6b7154bc4f5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    130 schema:name Adult
    131 rdf:type schema:DefinedTerm
    132 N24921a7e9ce542788db626c56d2f754c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    133 schema:name Adolescent
    134 rdf:type schema:DefinedTerm
    135 N2ada67ea51e242c4bdb0a0c94eef70c4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    136 schema:name Models, Immunological
    137 rdf:type schema:DefinedTerm
    138 N2feb19013a064d9d9173080c3db86e0a rdf:first sg:person.01257633341.37
    139 rdf:rest rdf:nil
    140 N3f9908277990473b9c27685109041e7e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    141 schema:name Vaccines, Subunit
    142 rdf:type schema:DefinedTerm
    143 N47d4d02d1f6e4513ac95e0c819b03766 schema:name nlm_unique_id
    144 schema:value 9502015
    145 rdf:type schema:PropertyValue
    146 N493bb48e57104d8cb548764066025c34 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    147 schema:name Treatment Outcome
    148 rdf:type schema:DefinedTerm
    149 N4a95afdde38646c1ac4717f867c34b33 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    150 schema:name Female
    151 rdf:type schema:DefinedTerm
    152 N4eecc048855343dc89d8599b9b689105 schema:name pubmed_id
    153 schema:value 15340416
    154 rdf:type schema:PropertyValue
    155 N54a86960a7f94bb888dcd3171622ba88 schema:name readcube_id
    156 schema:value 095c7235b4296a28bf024ad8a9b8c80a826eab62f71651efe0d05d6ac4be4df9
    157 rdf:type schema:PropertyValue
    158 N65270a5beb36499f9356913bf4771a8f schema:name doi
    159 schema:value 10.1038/nm1100
    160 rdf:type schema:PropertyValue
    161 N7cb98f8a7fa2436382feeb73debc8246 rdf:first sg:person.0717624506.16
    162 rdf:rest N92a03f2b777e4ded9252878b7ff73c6b
    163 N8bddcab3a135425f8311c5fc8c679030 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    164 schema:name Immunotherapy
    165 rdf:type schema:DefinedTerm
    166 N8c63862415254ca4908c066b69042053 schema:issueNumber 9
    167 rdf:type schema:PublicationIssue
    168 N92a03f2b777e4ded9252878b7ff73c6b rdf:first sg:person.012577717744.21
    169 rdf:rest N2feb19013a064d9d9173080c3db86e0a
    170 Nae52ec13bb1f46e59360644c1a9caff3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    171 schema:name Neoplasm Metastasis
    172 rdf:type schema:DefinedTerm
    173 Nc87d0cca9a5f4a2a8297d5ba7d3e70bd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    174 schema:name T-Lymphocytes
    175 rdf:type schema:DefinedTerm
    176 Ncbb8bcf5e68e4fb79a69b3aa7abf6d89 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    177 schema:name Humans
    178 rdf:type schema:DefinedTerm
    179 Nd8ab3fc3a89b4b1ea16b8b4fdba4c33d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    180 schema:name Neoplasms
    181 rdf:type schema:DefinedTerm
    182 Ndb8d1219acff44a7907fe348c5e9d26c schema:volumeNumber 10
    183 rdf:type schema:PublicationVolume
    184 Nddc0838023c544938550950f2cfad790 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    185 schema:name Middle Aged
    186 rdf:type schema:DefinedTerm
    187 Nde78217ccfed480fb5f33e5fd97a9d5b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    188 schema:name Child
    189 rdf:type schema:DefinedTerm
    190 Ne4407bc7d4d74d2bb1097cab09aebe61 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    191 schema:name Cancer Vaccines
    192 rdf:type schema:DefinedTerm
    193 Nf1a4daeccdb74cf6b47d1e706641fe51 schema:name dimensions_id
    194 schema:value pub.1001965372
    195 rdf:type schema:PropertyValue
    196 Nfb93e8ed98de4379ad40d9ac2dbb1adb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    197 schema:name Aged
    198 rdf:type schema:DefinedTerm
    199 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    200 schema:name Medical and Health Sciences
    201 rdf:type schema:DefinedTerm
    202 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
    203 schema:name Immunology
    204 rdf:type schema:DefinedTerm
    205 sg:grant.2710714 http://pending.schema.org/fundedItem sg:pub.10.1038/nm1100
    206 rdf:type schema:MonetaryGrant
    207 sg:grant.2722393 http://pending.schema.org/fundedItem sg:pub.10.1038/nm1100
    208 rdf:type schema:MonetaryGrant
    209 sg:journal.1113716 schema:issn 1078-8956
    210 1546-170X
    211 schema:name Nature Medicine
    212 rdf:type schema:Periodical
    213 sg:person.01257633341.37 schema:familyName Restifo
    214 schema:givenName Nicholas P
    215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257633341.37
    216 rdf:type schema:Person
    217 sg:person.012577717744.21 schema:familyName Yang
    218 schema:givenName James C
    219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012577717744.21
    220 rdf:type schema:Person
    221 sg:person.0717624506.16 schema:affiliation N1c58472044ee418b99551829a5f0d384
    222 schema:familyName Rosenberg
    223 schema:givenName Steven A
    224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717624506.16
    225 rdf:type schema:Person
    226 sg:pub.10.1007/s00262-003-0429-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003881258
    227 https://doi.org/10.1007/s00262-003-0429-0
    228 rdf:type schema:CreativeWork
    229 sg:pub.10.1007/s002620000146 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050911568
    230 https://doi.org/10.1007/s002620000146
    231 rdf:type schema:CreativeWork
    232 sg:pub.10.1038/35077246 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024176319
    233 https://doi.org/10.1038/35077246
    234 rdf:type schema:CreativeWork
    235 sg:pub.10.1038/nm0398-321 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042802949
    236 https://doi.org/10.1038/nm0398-321
    237 rdf:type schema:CreativeWork
    238 sg:pub.10.1038/nm0398-328 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017994921
    239 https://doi.org/10.1038/nm0398-328
    240 rdf:type schema:CreativeWork
    241 sg:pub.10.1038/sj.bjc.6601711 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036999668
    242 https://doi.org/10.1038/sj.bjc.6601711
    243 rdf:type schema:CreativeWork
    244 https://app.dimensions.ai/details/publication/pub.1074494579 schema:CreativeWork
    245 https://app.dimensions.ai/details/publication/pub.1074526318 schema:CreativeWork
    246 https://app.dimensions.ai/details/publication/pub.1074641638 schema:CreativeWork
    247 https://app.dimensions.ai/details/publication/pub.1074660225 schema:CreativeWork
    248 https://app.dimensions.ai/details/publication/pub.1074813212 schema:CreativeWork
    249 https://app.dimensions.ai/details/publication/pub.1074870439 schema:CreativeWork
    250 https://app.dimensions.ai/details/publication/pub.1074892325 schema:CreativeWork
    251 https://app.dimensions.ai/details/publication/pub.1074961232 schema:CreativeWork
    252 https://app.dimensions.ai/details/publication/pub.1075070903 schema:CreativeWork
    253 https://app.dimensions.ai/details/publication/pub.1075189853 schema:CreativeWork
    254 https://app.dimensions.ai/details/publication/pub.1075279929 schema:CreativeWork
    255 https://app.dimensions.ai/details/publication/pub.1075316378 schema:CreativeWork
    256 https://app.dimensions.ai/details/publication/pub.1075330705 schema:CreativeWork
    257 https://app.dimensions.ai/details/publication/pub.1075344765 schema:CreativeWork
    258 https://app.dimensions.ai/details/publication/pub.1082444072 schema:CreativeWork
    259 https://app.dimensions.ai/details/publication/pub.1082972452 schema:CreativeWork
    260 https://app.dimensions.ai/details/publication/pub.1083061979 schema:CreativeWork
    261 https://app.dimensions.ai/details/publication/pub.1083344550 schema:CreativeWork
    262 https://doi.org/10.1002/1097-0142(19810101)47:1<207::aid-cncr2820470134>3.0.co;2-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049278910
    263 rdf:type schema:CreativeWork
    264 https://doi.org/10.1002/1097-0215(20001015)88:2<232::aid-ijc14>3.0.co;2-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051399926
    265 rdf:type schema:CreativeWork
    266 https://doi.org/10.1002/pros.10130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038756273
    267 rdf:type schema:CreativeWork
    268 https://doi.org/10.1002/pros.10276 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029699686
    269 rdf:type schema:CreativeWork
    270 https://doi.org/10.1016/s0065-2776(03)81008-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035945582
    271 rdf:type schema:CreativeWork
    272 https://doi.org/10.1016/s0065-2776(08)60911-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006515864
    273 rdf:type schema:CreativeWork
    274 https://doi.org/10.1016/s0264-410x(01)00062-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020124664
    275 rdf:type schema:CreativeWork
    276 https://doi.org/10.1016/s0959-8049(99)00048-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036532413
    277 rdf:type schema:CreativeWork
    278 https://doi.org/10.1016/s1074-7613(00)00026-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023461380
    279 rdf:type schema:CreativeWork
    280 https://doi.org/10.1016/s1074-7613(01)00093-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005554478
    281 rdf:type schema:CreativeWork
    282 https://doi.org/10.1016/s1074-7613(09)00091-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054680334
    283 rdf:type schema:CreativeWork
    284 https://doi.org/10.1034/j.1600-065x.2001.1820104.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1002371313
    285 rdf:type schema:CreativeWork
    286 https://doi.org/10.1073/pnas.0307298101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038276939
    287 rdf:type schema:CreativeWork
    288 https://doi.org/10.1073/pnas.141226398 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003475218
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.1073/pnas.1533209100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042168438
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.1073/pnas.220413497 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031863846
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.1073/pnas.95.22.13141 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034584852
    295 rdf:type schema:CreativeWork
    296 https://doi.org/10.1081/cnv-120025091 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003572414
    297 rdf:type schema:CreativeWork
    298 https://doi.org/10.1084/jem.186.5.645 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044924423
    299 rdf:type schema:CreativeWork
    300 https://doi.org/10.1084/jem.190.11.1669 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006040605
    301 rdf:type schema:CreativeWork
    302 https://doi.org/10.1084/jem.20012100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038904580
    303 rdf:type schema:CreativeWork
    304 https://doi.org/10.1084/jem.20030590 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027648981
    305 rdf:type schema:CreativeWork
    306 https://doi.org/10.1089/104303403322124828 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059202548
    307 rdf:type schema:CreativeWork
    308 https://doi.org/10.1089/104303403765255110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059202626
    309 rdf:type schema:CreativeWork
    310 https://doi.org/10.1093/jnci/90.24.1894 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029708491
    311 rdf:type schema:CreativeWork
    312 https://doi.org/10.1093/jnci/91.6.523 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042322859
    313 rdf:type schema:CreativeWork
    314 https://doi.org/10.1093/jnci/92.16.1336 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029590769
    315 rdf:type schema:CreativeWork
    316 https://doi.org/10.1093/jnci/92.3.205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032301848
    317 rdf:type schema:CreativeWork
    318 https://doi.org/10.1093/jnci/djh028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000132661
    319 rdf:type schema:CreativeWork
    320 https://doi.org/10.1097/00000658-199210000-00010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015014754
    321 rdf:type schema:CreativeWork
    322 https://doi.org/10.1097/00002371-199903000-00007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006458820
    323 rdf:type schema:CreativeWork
    324 https://doi.org/10.1097/00002371-200003000-00012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026974409
    325 rdf:type schema:CreativeWork
    326 https://doi.org/10.1097/00002371-200007000-00013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053087303
    327 rdf:type schema:CreativeWork
    328 https://doi.org/10.1097/00002371-200107000-00012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041687681
    329 rdf:type schema:CreativeWork
    330 https://doi.org/10.1097/00002371-200307000-00007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017663233
    331 rdf:type schema:CreativeWork
    332 https://doi.org/10.1097/00002371-200307000-00008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052926290
    333 rdf:type schema:CreativeWork
    334 https://doi.org/10.1126/science.1076514 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003163159
    335 rdf:type schema:CreativeWork
    336 https://doi.org/10.1146/annurev.immunol.21.120601.141126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011053444
    337 rdf:type schema:CreativeWork
    338 https://doi.org/10.1158/1078-0432.ccr-0620-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022828236
    339 rdf:type schema:CreativeWork
    340 https://doi.org/10.1158/1078-0432.ccr-0689-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047952119
    341 rdf:type schema:CreativeWork
    342 https://doi.org/10.1182/blood.v99.5.1517 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036676498
    343 rdf:type schema:CreativeWork
    344 https://doi.org/10.1200/jco.1999.17.1.332 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074511246
    345 rdf:type schema:CreativeWork
    346 https://doi.org/10.1200/jco.2000.18.23.3964 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074733885
    347 rdf:type schema:CreativeWork
    348 https://doi.org/10.1200/jco.2002.09.134 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064203136
    349 rdf:type schema:CreativeWork
    350 https://doi.org/10.1200/jco.2003.02.135 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064203413
    351 rdf:type schema:CreativeWork
    352 https://doi.org/10.1200/jco.2003.03.091 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064203460
    353 rdf:type schema:CreativeWork
    354 https://doi.org/10.1200/jco.2003.06.041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064203662
    355 rdf:type schema:CreativeWork
    356 https://doi.org/10.1200/jco.2003.10.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064203880
    357 rdf:type schema:CreativeWork
    358 https://doi.org/10.1200/jco.2003.12.144 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064204032
    359 rdf:type schema:CreativeWork
     




    Preview window. Press ESC to close (or click here)


    ...