Ontology type: schema:ScholarlyArticle
1995-10
AUTHORSTamar Alon, Itzhak Hemo, Ahuva Itin, Jacob Pe'er, Jonathan Stone, Eli Keshet
ABSTRACTRetinopathy of prematurity (ROP) is initiated by hyperoxia–induced obliteration of newly formed blood vessels in the retina of the premature newborn. We propose that vessel regression is a consequence of hyperoxia–induced withdrawal of a critical vascular survival factor. We show that regression of retinal capillaries in neonatal rats exposed to high oxygen, is preceded by a shut–off of vascular endothelial growth factor (VEGF) production by nearby neuroglial cells. Vessel regression occurs via selective apoptosis of endothelial cells. Intraocular injection of VEGF at the onset of experimental hyperoxia prevents apoptotic death of endothelial cells and rescues the retinal vasculature. These findings provide evidence for a specific angiogenic factor acting as a vascular survival factor in vivo. The system also provides a paradigm for vascular remodelling as an adaptive response to an increase in oxygen tension and suggests a novel approach to prevention of ROP. More... »
PAGES1024-1028
http://scigraph.springernature.com/pub.10.1038/nm1095-1024
DOIhttp://dx.doi.org/10.1038/nm1095-1024
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/7489357
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