Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1995-10

AUTHORS

Tamar Alon, Itzhak Hemo, Ahuva Itin, Jacob Pe'er, Jonathan Stone, Eli Keshet

ABSTRACT

Retinopathy of prematurity (ROP) is initiated by hyperoxia–induced obliteration of newly formed blood vessels in the retina of the premature newborn. We propose that vessel regression is a consequence of hyperoxia–induced withdrawal of a critical vascular survival factor. We show that regression of retinal capillaries in neonatal rats exposed to high oxygen, is preceded by a shut–off of vascular endothelial growth factor (VEGF) production by nearby neuroglial cells. Vessel regression occurs via selective apoptosis of endothelial cells. Intraocular injection of VEGF at the onset of experimental hyperoxia prevents apoptotic death of endothelial cells and rescues the retinal vasculature. These findings provide evidence for a specific angiogenic factor acting as a vascular survival factor in vivo. The system also provides a paradigm for vascular remodelling as an adaptive response to an increase in oxygen tension and suggests a novel approach to prevention of ROP. More... »

PAGES

1024-1028

Journal

TITLE

Nature Medicine

ISSUE

10

VOLUME

1

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nm1095-1024

    DOI

    http://dx.doi.org/10.1038/nm1095-1024

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1011626141

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/7489357


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