The transcription factor SNAIL represses vitamin D receptor expression and responsiveness in human colon cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2004-09

AUTHORS

Héctor G Pálmer, María Jesús Larriba, José Miguel García, Paloma Ordóñez-Morán, Cristina Peña, Sandra Peiró, Isabel Puig, Rufo Rodríguez, Ricardo de la Fuente, Antonio Bernad, Marina Pollán, Félix Bonilla, Carlos Gamallo, Antonio García de Herreros, Alberto Muñoz

ABSTRACT

Several non-hypercalcemic analogs of 1alpha,25-dihydroxyvitamin D3 (1,25(OH)(2)D(3)) show antitumor activity in a subset of cancer patients. High vitamin D receptor (VDR) expression, which is associated with good prognosis but is lost during tumor progression. We show that the SNAIL transcription factor represses VDR gene expression in human colon cancer cells and blocks the antitumor action of EB1089, a 1,25(OH)(2)D(3) analog, in xenografted mice. In human colon cancers, elevated SNAIL expression correlates with downregulation of VDR. More... »

PAGES

917

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nm1095

DOI

http://dx.doi.org/10.1038/nm1095

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1001975394

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15322538


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