Myelomonocytic cells are sufficient for therapeutic cell fusion in liver View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2004-06-13

AUTHORS

Holger Willenbring, Alexis S Bailey, Mark Foster, Yassmine Akkari, Craig Dorrell, Susan Olson, Milton Finegold, William H Fleming, Markus Grompe

ABSTRACT

Liver repopulation with bone marrow–derived hepatocytes (BMHs) can cure the genetic liver disease fumarylacetoacetate hydrolase (Fah) deficiency1. BMHs emerge from fusion between donor bone marrow–derived cells and host hepatocytes2. To use such in vivo cell fusion efficiently for therapy requires knowing the nature of the hematopoietic cells that fuse with hepatocytes. Here we show that the transplantation into Fah−/− mice of hematopoietic stem cells (HSCs) from lymphocyte-deficient Rag1−/− mice, lineage-committed granulocyte-macrophage progenitors (GMPs) or bone marrow–derived macrophages (BMMs) results in the robust production of BMHs. These results provide direct evidence that committed myelomonocytic cells such as macrophages can produce functional epithelial cells by in vivo fusion. Because stable bone marrow engraftment or HSCs are not required for this process, macrophages or their highly proliferative progenitors provide potential for targeted and well-tolerated cell therapy aimed at organ regeneration. More... »

PAGES

744-748

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nm1062

DOI

http://dx.doi.org/10.1038/nm1062

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1048852622

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15195088


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