Regulation of pancreatic β-cell growth and survival by the serine/threonine protein kinase Akt1/PKBα View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-10

AUTHORS

Robyn L. Tuttle, Navdeep S. Gill, William Pugh, Jean-Pyo Lee, Brigitte Koeberlein, Emma E. Furth, Kenneth S. Polonsky, Ali Naji, Morris J. Birnbaum

ABSTRACT

The physiological performance of an organ depends on an interplay between changes in cellular function and organ size, determined by cell growth, proliferation and death. Nowhere is this more evident than in the endocrine pancreas, where disturbances in function or mass result in severe disease. Recently, the insulin signal-transduction pathway has been implicated in both the regulation of hormone secretion from beta cells in mammals as well as the determination of cell and organ size in Drosophila melanogaster. A prominent mediator of the actions of insulin and insulin-like growth factor 1 (IGF-1) is the 3'-phosphoinositide-dependent protein kinase Akt, also known as protein kinase B (PKB). Here we report that overexpression of active Akt1 in the mouse beta cell substantially affects compartment size and function. There was a significant increase in both beta-cell size and total islet mass, accompanied by improved glucose tolerance and complete resistance to experimental diabetes. More... »

PAGES

1133

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nm1001-1133

DOI

http://dx.doi.org/10.1038/nm1001-1133

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046760980

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11590437


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RDF/XML is a standard XML format for linked data.

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