Ferredoxin reductase affects p53-dependent, 5-fluorouracil–induced apoptosis in colorectal cancer cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2001-10

AUTHORS

Paul M. Hwang, Fred Bunz, Jian Yu, Carlo Rago, Timothy A. Chan, Michael P. Murphy, Geoffry F. Kelso, Robin A. J. Smith, Kenneth W. Kinzler, Bert Vogelstein

ABSTRACT

Loss of p53 gene function, which occurs in most colon cancer cells, has been shown to abolish the apoptotic response to 5-fluorouracil (5-FU). To identify genes downstream of p53 that might mediate these effects, we assessed global patterns of gene expression following 5-FU treatment of isogenic cells differing only in their p53 status. The gene encoding mitochondrial ferredoxin reductase (protein, FR; gene, FDXR) was one of the few genes significantly induced by p53 after 5-FU treatment. The FR protein was localized to mitochondria and suppressed the growth of colon cancer cells when over-expressed. Targeted disruption of the FDXR gene in human colon cancer cells showed that it was essential for viability, and partial disruption of the gene resulted in decreased sensitivity to 5-FU-induced apoptosis. These data, coupled with the effects of pharmacologic inhibitors of reactive oxygen species, indicate that FR contributes to p53-mediated apoptosis through the generation of oxidative stress in mitochondria. More... »

PAGES

1111

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nm1001-1111

DOI

http://dx.doi.org/10.1038/nm1001-1111

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026657021

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11590433


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

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Turtle is a human-readable linked data format.

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RDF/XML is a standard XML format for linked data.

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