Cell-cycle arrest versus cell death in cancer therapy View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1997-09

AUTHORS

T Waldman, Y Zhang, L Dillehay, J Yu, K Kinzler, B Vogelstein, J Williams

ABSTRACT

In response to anticancer therapeutics, human colon cancer cells growing in vitro either enter into a stable arrest or die, depending on the integrity of their cell-cycle checkpoints. To test whether altered checkpoints can modulate sensitivity to treatment in vivo, xenografts were established from isogenic lines differing only in their p21 checkpoint status. Although all tumors with intact checkpoint function underwent regrowth after treatment with gamma-radiation, a significant fraction of checkpoint-deficient tumors were completely cured. This difference in sensitivity was not detected by the clonogenic survival assay, because both arrest and death preclude outgrowth of colonies. These results demonstrate that checkpoint status affects sensitivity to anticancer treatments in vivo, and these findings have important implications for identifying and testing new therapeutic compounds. More... »

PAGES

1034-1036

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nm0997-1034

DOI

http://dx.doi.org/10.1038/nm0997-1034

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1027964878

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9288734


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