Microsatellite alterations in plasma DNA of small cell lung cancer patients View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-09

AUTHORS

X Q Chen, M Stroun, J L Magnenat, L P Nicod, A M Kurt, J Lyautey, C Lederrey, P Anker

ABSTRACT

Microsatellite instability is an important characteristic of many tumor types especially those associated with hereditary non-polyposis colorectal carcinoma (HNPCC) syndrome. Microsatellite alterations in 50% of primary small cell lung carcinoma (SCLC) have been found. These alterations were also found in the sputum. Because neoplastic characteristics such as decreased strand stability9 and ras mutations have been found in the plasma DNA of cancer patients, we looked for microsatellite alterations in the plasma of SCLC patients. A microsatellite alteration was present in 16 out of 21 (76%) SCLC tumors and in 15 out of 21 (71%) plasma samples. In one case, the alteration was present only in the plasma DNA. If confirmed in larger studies, microsatellite analysis of plasma DNA might constitute a new tool for tumor staging, management and, possibly, detection. More... »

PAGES

1033-1035

References to SciGraph publications

Journal

TITLE

Nature Medicine

ISSUE

9

VOLUME

2

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nm0996-1033

    DOI

    http://dx.doi.org/10.1038/nm0996-1033

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1004802843

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/8782463


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