Microsatellite alterations in plasma DNA of small cell lung cancer patients View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-09

AUTHORS

X Q Chen, M Stroun, J L Magnenat, L P Nicod, A M Kurt, J Lyautey, C Lederrey, P Anker

ABSTRACT

Microsatellite instability is an important characteristic of many tumor types especially those associated with hereditary non-polyposis colorectal carcinoma (HNPCC) syndrome. Microsatellite alterations in 50% of primary small cell lung carcinoma (SCLC) have been found. These alterations were also found in the sputum. Because neoplastic characteristics such as decreased strand stability9 and ras mutations have been found in the plasma DNA of cancer patients, we looked for microsatellite alterations in the plasma of SCLC patients. A microsatellite alteration was present in 16 out of 21 (76%) SCLC tumors and in 15 out of 21 (71%) plasma samples. In one case, the alteration was present only in the plasma DNA. If confirmed in larger studies, microsatellite analysis of plasma DNA might constitute a new tool for tumor staging, management and, possibly, detection. More... »

PAGES

1033-1035

References to SciGraph publications

Journal

TITLE

Nature Medicine

ISSUE

9

VOLUME

2

Related Patents

  • Evaluation Of Diseases And Conditions Associated With Translocated Genes Using Plasma Or Serum Dna
  • Genetically Modified Cells Expressing A Tgf Beta Inhibitor, The Cells Being Lung Cancer Cells
  • Normalizing Chromosomes For The Determination And Verification Of Common And Rare Chromosomal Aneuploidies
  • Methods For Non-Invasive Prenatal Ploidy Calling
  • Detection Of Extracellular Tumor-Associated Nucleic Acid In Blood Plasma Or Serum Using Nucleic Acid Amplification Assays
  • Detection Of Extracellular Tumor-Associated Nucleic Acid In Blood Plasma Or Serum Using Nucleic Acid Amplification Assays
  • Detection Of Extracellular Tumor-Associated Nucleic Acid In Blood Plasma Or Serum
  • Methods For Non-Invasive Prenatal Ploidy Calling
  • Methods For Determining Fraction Of Fetal Nucleic Acids In Maternal Samples
  • Methods For Detecting Papillomavirus Dna In Blood Plasma And Serum
  • Detection Of Extracellular Tumor-Associated Nucleic Acid In Blood Plasma Or Serum Using Nucleic Acid Amplification Assays
  • Materials And Methods For Prevention And Treatment Of Rna Viral Diseases
  • Rapid Analysis Of Variations In A Genome
  • Methods For Selecting Cancer Vaccine Therapies Using Extracellular Dna
  • Resolving Genome Fractions Using Polymorphism Counts
  • Method Of Detecting Tumor-Associated Dna In Plasma Or Serum From Humans Without Cancer
  • Detection Of Loss Of Heterozygosity In Tumor And Serum Of Melanoma Patients
  • Nucleic Acid Detection
  • System And Method For Cleaning Noisy Genetic Data And Determining Chromosome Copy Number
  • System And Method For Cleaning Noisy Genetic Data And Determining Chromosome Copy Number
  • Detection Of Extracellular Translocated Tumor-Associated Nucleic Acid In Blood Plasma Or Serum Using Nucleic Acid Amplification Assays
  • Microfluidic-Based Lab-On-A-Test Card For A Point-Of-Care Analyzer
  • Materials And Methods For Prevention And Treatment Of Rna Viral Diseases
  • Detection Of Extracellular Tumor-Associated Nucleic Acid In Blood Plasma Or Serum Using Nucleic Acid Amplification Assay
  • Detection Of Microsatellite Instability And Its Use In Diagnosis Of Tumors
  • Methods For Detection Of Genetic Disorders
  • Detection Of Extracellular Tumor-Associated Nucleic Acid In Blood Plasma Or Serum Using Nucleic Acid Amplification Assays
  • Methods For Detecting Papillomavirus Dna In Blood Plasma And Serum
  • Circulating Epstein-Barr Virus Dna In The Serum Of Patients With Gastric Carcinoma
  • Detection Of Extracellular Tumor-Associated Nucleic Acid In Blood Plasma Or Serum Using Nucleic Acid Amplification Assays
  • Rapid Analysis Of Variations In A Genome
  • Detection Of Extracellular Tumor-Associated Nucleic Acid In Blood Plasma Or Serum Using Nucleic Acid Amplification Assays
  • Methods For Detection Of Genetic Disorders
  • Methods For Selecting Monoclonal Antibody Therapies Using Extracellular Dna
  • Method Of Detecting Tumor-Associated Dna In Plasma Or Serum With A Premalignant Solid Tumor
  • Detection Of Extracellular Tumor-Associated Nucleic Acid In Blood Plasma Or Serum
  • Methods For Evaluating Stroke Or Cardiac Ischemia By Nucleic Acid Detection
  • Detection Of Extracellular Tumor-Associated Nucleic Acid In Blood Plasma Or Serum Using Nucleic Acid Amplification Assay
  • Detection Of Extracellular Tumor-Associated Nucleic Acid In Blood Plasma Or Serum Using Nucleic Acid Amplification Assays
  • Determination Of 17q Gain In Neuroblastoma Patients By Analysis Of Circulating Dna
  • Methods For Detection Of Genetic Disorders
  • Detection Of Microsatellite Instability And Its Use In Diagnosis Of Tumors
  • Detecting And Classifying Copy Number Variation
  • Rapid And Efficient Capture Of Dna From Sample Without Using Cell Lysing Reagent
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nm0996-1033

    DOI

    http://dx.doi.org/10.1038/nm0996-1033

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1004802843

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/8782463


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged, 80 and over", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Base Sequence", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Biomarkers, Tumor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Carcinoma, Small Cell", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA Primers", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA, Neoplasm", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA, Satellite", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lung Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Microsatellite Repeats", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Molecular Sequence Data", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Plasmids", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "name": [
                "Laboratory of Plant Biochemistry and Physiology, Faculty of Science, Geneva, Switzerland."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chen", 
            "givenName": "X Q", 
            "id": "sg:person.012206211374.82", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012206211374.82"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Stroun", 
            "givenName": "M", 
            "id": "sg:person.0100473020.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0100473020.38"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Magnenat", 
            "givenName": "J L", 
            "id": "sg:person.01263576636.58", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263576636.58"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Nicod", 
            "givenName": "L P", 
            "id": "sg:person.01074342407.25", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074342407.25"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Kurt", 
            "givenName": "A M", 
            "id": "sg:person.01255762224.70", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255762224.70"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Lyautey", 
            "givenName": "J", 
            "id": "sg:person.01017227563.27", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017227563.27"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Lederrey", 
            "givenName": "C", 
            "id": "sg:person.01046417525.36", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046417525.36"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Anker", 
            "givenName": "P", 
            "id": "sg:person.01312727150.74", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01312727150.74"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1126/science.271.5249.659", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001850296"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0016-5085(93)90368-m", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024783054"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000226740", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033559486"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0996-1035", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042449680", 
              "https://doi.org/10.1038/nm0996-1035"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2141.1994.tb04828.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048395071"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.91.21.9871", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049769933"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.2565047", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062544226"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.8484122", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062655780"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082511549", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082519343", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082659349", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082727077", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "1996-09", 
        "datePublishedReg": "1996-09-01", 
        "description": "Microsatellite instability is an important characteristic of many tumor types especially those associated with hereditary non-polyposis colorectal carcinoma (HNPCC) syndrome. Microsatellite alterations in 50% of primary small cell lung carcinoma (SCLC) have been found. These alterations were also found in the sputum. Because neoplastic characteristics such as decreased strand stability9 and ras mutations have been found in the plasma DNA of cancer patients, we looked for microsatellite alterations in the plasma of SCLC patients. A microsatellite alteration was present in 16 out of 21 (76%) SCLC tumors and in 15 out of 21 (71%) plasma samples. In one case, the alteration was present only in the plasma DNA. If confirmed in larger studies, microsatellite analysis of plasma DNA might constitute a new tool for tumor staging, management and, possibly, detection.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/nm0996-1033", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1113716", 
            "issn": [
              "1078-8956", 
              "1546-170X"
            ], 
            "name": "Nature Medicine", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "9", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "2"
          }
        ], 
        "name": "Microsatellite alterations in plasma DNA of small cell lung cancer patients", 
        "pagination": "1033-1035", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "16e29513c62eaf001dde345931aa7085c168ebd91cc594669cd324f912e433b9"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "8782463"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9502015"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nm0996-1033"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1004802843"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nm0996-1033", 
          "https://app.dimensions.ai/details/publication/pub.1004802843"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T17:20", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8672_00000434.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/articles/nm0996-1033"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nm0996-1033'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nm0996-1033'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nm0996-1033'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nm0996-1033'


     

    This table displays all metadata directly associated to this object as RDF triples.

    211 TRIPLES      21 PREDICATES      58 URIs      38 LITERALS      26 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nm0996-1033 schema:about N0ddf30cd19064d21861e3b0ae9b3bea0
    2 N1269601c27c94383a7c5a1ff36021c84
    3 N2c154079775b4ba197d5f8040f3e85cd
    4 N40a0d8a40e614864a5f41b65ca90a161
    5 N5832bbda57e94abab690770f7739711e
    6 N59d4671ed8d84b78b36ff99b1380e5f5
    7 N5a1485d1fbca44c1a0ec5577bf64c1bb
    8 N645d7e9cae96489790226bea6f95da1a
    9 N7bc8977c634a474baee72abdd0346085
    10 Nacff46a617544cc4bf9d8f1c4ec25888
    11 Nb2e31528af9d43009a78f81f4da7f7f8
    12 Nb49eb536886a49e99714ce99777c1cc2
    13 Nbd7228a63c7c4f4b902f0d024bc3a07e
    14 Nbf5fce0340854bfcbee544f45a347f32
    15 Nc48f5fe9b13a4614a99a0d48f1b84cee
    16 Nf5ed59c17a044081a89fc2aee3a339a4
    17 Nf5f3cfe7af614e07b0b4a74570e4c5cd
    18 anzsrc-for:11
    19 anzsrc-for:1112
    20 schema:author Nb793ec17783f431b93ac4b9c70698720
    21 schema:citation sg:pub.10.1038/nm0996-1035
    22 https://app.dimensions.ai/details/publication/pub.1082511549
    23 https://app.dimensions.ai/details/publication/pub.1082519343
    24 https://app.dimensions.ai/details/publication/pub.1082659349
    25 https://app.dimensions.ai/details/publication/pub.1082727077
    26 https://doi.org/10.1016/0016-5085(93)90368-m
    27 https://doi.org/10.1073/pnas.91.21.9871
    28 https://doi.org/10.1111/j.1365-2141.1994.tb04828.x
    29 https://doi.org/10.1126/science.2565047
    30 https://doi.org/10.1126/science.271.5249.659
    31 https://doi.org/10.1126/science.8484122
    32 https://doi.org/10.1159/000226740
    33 schema:datePublished 1996-09
    34 schema:datePublishedReg 1996-09-01
    35 schema:description Microsatellite instability is an important characteristic of many tumor types especially those associated with hereditary non-polyposis colorectal carcinoma (HNPCC) syndrome. Microsatellite alterations in 50% of primary small cell lung carcinoma (SCLC) have been found. These alterations were also found in the sputum. Because neoplastic characteristics such as decreased strand stability9 and ras mutations have been found in the plasma DNA of cancer patients, we looked for microsatellite alterations in the plasma of SCLC patients. A microsatellite alteration was present in 16 out of 21 (76%) SCLC tumors and in 15 out of 21 (71%) plasma samples. In one case, the alteration was present only in the plasma DNA. If confirmed in larger studies, microsatellite analysis of plasma DNA might constitute a new tool for tumor staging, management and, possibly, detection.
    36 schema:genre research_article
    37 schema:inLanguage en
    38 schema:isAccessibleForFree false
    39 schema:isPartOf N6e1917bee6524c6589dae8374530fccb
    40 N7fe18df5343e47ee8011b15b2fd477e9
    41 sg:journal.1113716
    42 schema:name Microsatellite alterations in plasma DNA of small cell lung cancer patients
    43 schema:pagination 1033-1035
    44 schema:productId N21a19728df4c4667b128d12bceef22f9
    45 N3e14acb07739499fb4c9808ed5863cb1
    46 N7399df9f493f4f8ab0c8fbda9dcfab0a
    47 N9fc6cae3907c451aa30bcc472b119bba
    48 Nb58ec5a852f64c54881c7866601d05ea
    49 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004802843
    50 https://doi.org/10.1038/nm0996-1033
    51 schema:sdDatePublished 2019-04-10T17:20
    52 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    53 schema:sdPublisher N4966d3c283834a2fbc937e9a79baac1c
    54 schema:url http://www.nature.com/articles/nm0996-1033
    55 sgo:license sg:explorer/license/
    56 sgo:sdDataset articles
    57 rdf:type schema:ScholarlyArticle
    58 N0ddf30cd19064d21861e3b0ae9b3bea0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    59 schema:name Aged, 80 and over
    60 rdf:type schema:DefinedTerm
    61 N1269601c27c94383a7c5a1ff36021c84 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    62 schema:name DNA, Neoplasm
    63 rdf:type schema:DefinedTerm
    64 N19f6d821ee2c415d8873f7f7baf5199b rdf:first sg:person.01017227563.27
    65 rdf:rest Nb4d17fc75bef48c5a13a0b6daa1c1852
    66 N21a19728df4c4667b128d12bceef22f9 schema:name pubmed_id
    67 schema:value 8782463
    68 rdf:type schema:PropertyValue
    69 N2c154079775b4ba197d5f8040f3e85cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    70 schema:name Carcinoma, Small Cell
    71 rdf:type schema:DefinedTerm
    72 N3e14acb07739499fb4c9808ed5863cb1 schema:name nlm_unique_id
    73 schema:value 9502015
    74 rdf:type schema:PropertyValue
    75 N40a0d8a40e614864a5f41b65ca90a161 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    76 schema:name Adult
    77 rdf:type schema:DefinedTerm
    78 N4966d3c283834a2fbc937e9a79baac1c schema:name Springer Nature - SN SciGraph project
    79 rdf:type schema:Organization
    80 N5832bbda57e94abab690770f7739711e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    81 schema:name DNA, Satellite
    82 rdf:type schema:DefinedTerm
    83 N59d4671ed8d84b78b36ff99b1380e5f5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    84 schema:name Humans
    85 rdf:type schema:DefinedTerm
    86 N5a1485d1fbca44c1a0ec5577bf64c1bb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    87 schema:name Male
    88 rdf:type schema:DefinedTerm
    89 N645d7e9cae96489790226bea6f95da1a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    90 schema:name Lung Neoplasms
    91 rdf:type schema:DefinedTerm
    92 N6e1917bee6524c6589dae8374530fccb schema:volumeNumber 2
    93 rdf:type schema:PublicationVolume
    94 N7399df9f493f4f8ab0c8fbda9dcfab0a schema:name doi
    95 schema:value 10.1038/nm0996-1033
    96 rdf:type schema:PropertyValue
    97 N7bc8977c634a474baee72abdd0346085 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    98 schema:name Microsatellite Repeats
    99 rdf:type schema:DefinedTerm
    100 N7dd8ad2f9d8f40b29a29be7b57cb4dfd rdf:first sg:person.01312727150.74
    101 rdf:rest rdf:nil
    102 N7fe18df5343e47ee8011b15b2fd477e9 schema:issueNumber 9
    103 rdf:type schema:PublicationIssue
    104 N9a795cccf99e4e87be82b2926c85bc44 rdf:first sg:person.0100473020.38
    105 rdf:rest Na98c90c0c85f4f85b7d98d26875f6b13
    106 N9fc6cae3907c451aa30bcc472b119bba schema:name readcube_id
    107 schema:value 16e29513c62eaf001dde345931aa7085c168ebd91cc594669cd324f912e433b9
    108 rdf:type schema:PropertyValue
    109 Na98c90c0c85f4f85b7d98d26875f6b13 rdf:first sg:person.01263576636.58
    110 rdf:rest Nc4cdfef675e443599fdcc3be72b94945
    111 Nacff46a617544cc4bf9d8f1c4ec25888 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    112 schema:name Molecular Sequence Data
    113 rdf:type schema:DefinedTerm
    114 Nb2e31528af9d43009a78f81f4da7f7f8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    115 schema:name Female
    116 rdf:type schema:DefinedTerm
    117 Nb49eb536886a49e99714ce99777c1cc2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    118 schema:name Plasmids
    119 rdf:type schema:DefinedTerm
    120 Nb4d17fc75bef48c5a13a0b6daa1c1852 rdf:first sg:person.01046417525.36
    121 rdf:rest N7dd8ad2f9d8f40b29a29be7b57cb4dfd
    122 Nb52084ff347c4f948637e527d5b95a00 schema:name Laboratory of Plant Biochemistry and Physiology, Faculty of Science, Geneva, Switzerland.
    123 rdf:type schema:Organization
    124 Nb58ec5a852f64c54881c7866601d05ea schema:name dimensions_id
    125 schema:value pub.1004802843
    126 rdf:type schema:PropertyValue
    127 Nb61aaa4cdab04fcc9565461af06d9b0d rdf:first sg:person.01255762224.70
    128 rdf:rest N19f6d821ee2c415d8873f7f7baf5199b
    129 Nb793ec17783f431b93ac4b9c70698720 rdf:first sg:person.012206211374.82
    130 rdf:rest N9a795cccf99e4e87be82b2926c85bc44
    131 Nbd7228a63c7c4f4b902f0d024bc3a07e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    132 schema:name DNA Primers
    133 rdf:type schema:DefinedTerm
    134 Nbf5fce0340854bfcbee544f45a347f32 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    135 schema:name Middle Aged
    136 rdf:type schema:DefinedTerm
    137 Nc48f5fe9b13a4614a99a0d48f1b84cee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    138 schema:name Aged
    139 rdf:type schema:DefinedTerm
    140 Nc4cdfef675e443599fdcc3be72b94945 rdf:first sg:person.01074342407.25
    141 rdf:rest Nb61aaa4cdab04fcc9565461af06d9b0d
    142 Nf5ed59c17a044081a89fc2aee3a339a4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    143 schema:name Base Sequence
    144 rdf:type schema:DefinedTerm
    145 Nf5f3cfe7af614e07b0b4a74570e4c5cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    146 schema:name Biomarkers, Tumor
    147 rdf:type schema:DefinedTerm
    148 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    149 schema:name Medical and Health Sciences
    150 rdf:type schema:DefinedTerm
    151 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    152 schema:name Oncology and Carcinogenesis
    153 rdf:type schema:DefinedTerm
    154 sg:journal.1113716 schema:issn 1078-8956
    155 1546-170X
    156 schema:name Nature Medicine
    157 rdf:type schema:Periodical
    158 sg:person.0100473020.38 schema:familyName Stroun
    159 schema:givenName M
    160 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0100473020.38
    161 rdf:type schema:Person
    162 sg:person.01017227563.27 schema:familyName Lyautey
    163 schema:givenName J
    164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017227563.27
    165 rdf:type schema:Person
    166 sg:person.01046417525.36 schema:familyName Lederrey
    167 schema:givenName C
    168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046417525.36
    169 rdf:type schema:Person
    170 sg:person.01074342407.25 schema:familyName Nicod
    171 schema:givenName L P
    172 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074342407.25
    173 rdf:type schema:Person
    174 sg:person.012206211374.82 schema:affiliation Nb52084ff347c4f948637e527d5b95a00
    175 schema:familyName Chen
    176 schema:givenName X Q
    177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012206211374.82
    178 rdf:type schema:Person
    179 sg:person.01255762224.70 schema:familyName Kurt
    180 schema:givenName A M
    181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255762224.70
    182 rdf:type schema:Person
    183 sg:person.01263576636.58 schema:familyName Magnenat
    184 schema:givenName J L
    185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263576636.58
    186 rdf:type schema:Person
    187 sg:person.01312727150.74 schema:familyName Anker
    188 schema:givenName P
    189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01312727150.74
    190 rdf:type schema:Person
    191 sg:pub.10.1038/nm0996-1035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042449680
    192 https://doi.org/10.1038/nm0996-1035
    193 rdf:type schema:CreativeWork
    194 https://app.dimensions.ai/details/publication/pub.1082511549 schema:CreativeWork
    195 https://app.dimensions.ai/details/publication/pub.1082519343 schema:CreativeWork
    196 https://app.dimensions.ai/details/publication/pub.1082659349 schema:CreativeWork
    197 https://app.dimensions.ai/details/publication/pub.1082727077 schema:CreativeWork
    198 https://doi.org/10.1016/0016-5085(93)90368-m schema:sameAs https://app.dimensions.ai/details/publication/pub.1024783054
    199 rdf:type schema:CreativeWork
    200 https://doi.org/10.1073/pnas.91.21.9871 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049769933
    201 rdf:type schema:CreativeWork
    202 https://doi.org/10.1111/j.1365-2141.1994.tb04828.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1048395071
    203 rdf:type schema:CreativeWork
    204 https://doi.org/10.1126/science.2565047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062544226
    205 rdf:type schema:CreativeWork
    206 https://doi.org/10.1126/science.271.5249.659 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001850296
    207 rdf:type schema:CreativeWork
    208 https://doi.org/10.1126/science.8484122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062655780
    209 rdf:type schema:CreativeWork
    210 https://doi.org/10.1159/000226740 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033559486
    211 rdf:type schema:CreativeWork
     




    Preview window. Press ESC to close (or click here)


    ...