Absence of host plasminogen activator inhibitor 1 prevents cancer invasion and vascularization View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1998-08

AUTHORS

K Bajou, A Noël, R D Gerard, V Masson, N Brunner, C Holst-Hansen, M Skobe, N E Fusenig, P Carmeliet, D Collen, J M Foidart

ABSTRACT

Acquisition of invasive/metastatic potential through protease expression is an essential event in tumor progression. High levels of components of the plasminogen activation system, including urokinase, but paradoxically also its inhibitor, plasminogen activator inhibitor 1 (PAI1), have been correlated with a poor prognosis for some cancers. We report here that deficient PAI1 expression in host mice prevented local invasion and tumor vascularization of transplanted malignant keratinocytes. When this PAI1 deficiency was circumvented by intravenous injection of a replication-defective adenoviral vector expressing human PAI1, invasion and associated angiogenesis were restored. This experimental evidence demonstrates that host-produced PAI is essential for cancer cell invasion and angiogenesis. More... »

PAGES

923-928

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nm0898-923

DOI

http://dx.doi.org/10.1038/nm0898-923

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046573440

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9701244


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