Limited CD4+ T-cell renewal in early HIV-1 infection: Effect of highly active antiretroviral therapy View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1998-07

AUTHORS

Sylvain Fleury, Rob J. De Boer, G. Paolo Rizzardi, Katja C. Wolthers, Sigrid A. Otto, Craig C. Welbon, Cecilia Graziosi, Christian Knabenhans, Hugo Soudeyns, Piere-Alexander Bart, Serge Gallant, Jean-Marc Corpataux, Michel Gillet, Pascal Meylan, Pierre Schnyder, Jean-Yves Meuwly, William Spreen, Michel P. Glauser, Frank Miedema, Giuseppe Pantaleo

ABSTRACT

We show that the fraction of proliferating CD4+ lymphocytes is similar in HIV-infected subjects in the early stage of disease and in HIV-negative subjects, whereas the fraction of proliferating CD8+ lymphocytes is increased 6.8-fold in HIV-infected subjects. After initiation of antiviral therapy, there is a late increase in proliferating CD4+ T cells associated with the restoration of CD4+ T-cell counts. These results provide strong support for the idea of limited CD4+ T-cell renewal in the early stage of HIV infection and indicate that after effective suppression of virus replication, the mechanisms of CD4+ T-cell production are still functional in early HIV infection. More... »

PAGES

794-801

Journal

TITLE

Nature Medicine

ISSUE

7

VOLUME

4

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nm0798-794

DOI

http://dx.doi.org/10.1038/nm0798-794

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049577209

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9662370


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