Protective mucosal immunity elicited by targeted iliac lymph node immunization with a subunit SIV envelope and core vaccine in macaques View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-07-01

AUTHORS

Thomas Lehner, Yufei Wang, Martin Cranage, Lesley A. Bergmeier, Elaine Mitchell, Louisa Tao, Graham Hall, Mike Dennis, Nicola Cook, Roger Brookes, Linda Klavinskis, Ian Jones, Carl Doyle, Robert Ward

ABSTRACT

Prevention of sexually transmitted HIV infection was investigated in macaques by immunization with a recombinant SIV (simian immunodeficiency virus) envelope gp120 and core p27 vaccine. In two independent series of experiments, we used the novel targeted iliac lymph node (TILN) route of immunization, aiming close to the iliac lymph nodes draining the genitorectal mucosa. Rectal challenge with the SIVmac 32H J5 molecular clone in two series induced total protection in four out of seven macaques immunized by TILN, compared with infection in 13 of 14 unimmunized macaques or immunized by other routes (P = 0.025). The remaining three macaques showed either a decrease in viral load (>90%) or transient viremia, indicating that all seven TILN–immunized macaques showed total or partial protection (P = 0.001). Protection was associated with significant increase in the iliac lymph nodes of lgA antibody–secreting cells to p27 (P < 0.02), CD8–suppressor factor (P< 0.01), and the chemokines RANTES and MIP–1β (P< 0.01). More... »

PAGES

767-775

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nm0796-767

DOI

http://dx.doi.org/10.1038/nm0796-767

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049289100

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8673922


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibodies, Viral", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibody-Producing Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "B-Lymphocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chemokines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fluorescent Dyes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ileum", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intestinal Mucosa", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymph Nodes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Macaca mulatta", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "SAIDS Vaccines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Simian Immunodeficiency Virus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Suppressor Factors, Immunologic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "T-Lymphocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vaccines, Synthetic", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Immunology, United Medical & Dental Schools of Guy's & St. Thomas' Hospital, SE1 9RT, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.425213.3", 
          "name": [
            "Department of Immunology, United Medical & Dental Schools of Guy's & St. Thomas' Hospital, SE1 9RT, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lehner", 
        "givenName": "Thomas", 
        "id": "sg:person.0733367200.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733367200.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Immunology, United Medical & Dental Schools of Guy's & St. Thomas' Hospital, SE1 9RT, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.425213.3", 
          "name": [
            "Department of Immunology, United Medical & Dental Schools of Guy's & St. Thomas' Hospital, SE1 9RT, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Yufei", 
        "id": "sg:person.0761130730.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761130730.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre for Applied Microbiology & Research, SP4 OJC, Porton Down, Salisbury, Wiltshire, UK", 
          "id": "http://www.grid.ac/institutes/grid.271308.f", 
          "name": [
            "Centre for Applied Microbiology & Research, SP4 OJC, Porton Down, Salisbury, Wiltshire, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cranage", 
        "givenName": "Martin", 
        "id": "sg:person.01227706612.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227706612.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Immunology, United Medical & Dental Schools of Guy's & St. Thomas' Hospital, SE1 9RT, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.425213.3", 
          "name": [
            "Department of Immunology, United Medical & Dental Schools of Guy's & St. Thomas' Hospital, SE1 9RT, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bergmeier", 
        "givenName": "Lesley A.", 
        "id": "sg:person.01100261732.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100261732.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Immunology, United Medical & Dental Schools of Guy's & St. Thomas' Hospital, SE1 9RT, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.425213.3", 
          "name": [
            "Department of Immunology, United Medical & Dental Schools of Guy's & St. Thomas' Hospital, SE1 9RT, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mitchell", 
        "givenName": "Elaine", 
        "id": "sg:person.01360220412.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01360220412.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Immunology, United Medical & Dental Schools of Guy's & St. Thomas' Hospital, SE1 9RT, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.425213.3", 
          "name": [
            "Department of Immunology, United Medical & Dental Schools of Guy's & St. Thomas' Hospital, SE1 9RT, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tao", 
        "givenName": "Louisa", 
        "id": "sg:person.01174326000.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174326000.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre for Applied Microbiology & Research, SP4 OJC, Porton Down, Salisbury, Wiltshire, UK", 
          "id": "http://www.grid.ac/institutes/grid.271308.f", 
          "name": [
            "Centre for Applied Microbiology & Research, SP4 OJC, Porton Down, Salisbury, Wiltshire, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hall", 
        "givenName": "Graham", 
        "id": "sg:person.01300272600.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300272600.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre for Applied Microbiology & Research, SP4 OJC, Porton Down, Salisbury, Wiltshire, UK", 
          "id": "http://www.grid.ac/institutes/grid.271308.f", 
          "name": [
            "Centre for Applied Microbiology & Research, SP4 OJC, Porton Down, Salisbury, Wiltshire, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dennis", 
        "givenName": "Mike", 
        "id": "sg:person.0662040514.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662040514.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre for Applied Microbiology & Research, SP4 OJC, Porton Down, Salisbury, Wiltshire, UK", 
          "id": "http://www.grid.ac/institutes/grid.271308.f", 
          "name": [
            "Centre for Applied Microbiology & Research, SP4 OJC, Porton Down, Salisbury, Wiltshire, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cook", 
        "givenName": "Nicola", 
        "id": "sg:person.01074273513.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074273513.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Immunology, United Medical & Dental Schools of Guy's & St. Thomas' Hospital, SE1 9RT, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.425213.3", 
          "name": [
            "Department of Immunology, United Medical & Dental Schools of Guy's & St. Thomas' Hospital, SE1 9RT, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Brookes", 
        "givenName": "Roger", 
        "id": "sg:person.01322544210.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322544210.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Immunology, United Medical & Dental Schools of Guy's & St. Thomas' Hospital, SE1 9RT, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.425213.3", 
          "name": [
            "Department of Immunology, United Medical & Dental Schools of Guy's & St. Thomas' Hospital, SE1 9RT, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Klavinskis", 
        "givenName": "Linda", 
        "id": "sg:person.01133562263.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133562263.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Virology and Environmental Microbiology, Mansfield Road, OX1 3SR, Oxford, UK", 
          "id": "http://www.grid.ac/institutes/grid.494924.6", 
          "name": [
            "Institute of Virology and Environmental Microbiology, Mansfield Road, OX1 3SR, Oxford, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jones", 
        "givenName": "Ian", 
        "id": "sg:person.0721567750.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721567750.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Virology and Environmental Microbiology, Mansfield Road, OX1 3SR, Oxford, UK", 
          "id": "http://www.grid.ac/institutes/grid.494924.6", 
          "name": [
            "Institute of Virology and Environmental Microbiology, Mansfield Road, OX1 3SR, Oxford, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Doyle", 
        "givenName": "Carl", 
        "id": "sg:person.01053456700.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053456700.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Immunology, United Medical & Dental Schools of Guy's & St. Thomas' Hospital, SE1 9RT, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.425213.3", 
          "name": [
            "Department of Immunology, United Medical & Dental Schools of Guy's & St. Thomas' Hospital, SE1 9RT, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ward", 
        "givenName": "Robert", 
        "id": "sg:person.0721561232.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721561232.15"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/336484a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014534456", 
          "https://doi.org/10.1038/336484a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm0496-412", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019706003", 
          "https://doi.org/10.1038/nm0496-412"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/373123a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014949926", 
          "https://doi.org/10.1038/373123a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/353393a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040473271", 
          "https://doi.org/10.1038/353393a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/378563a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013565921", 
          "https://doi.org/10.1038/378563a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/373117a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025418642", 
          "https://doi.org/10.1038/373117a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/328345a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022500911", 
          "https://doi.org/10.1038/328345a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/362355a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041590783", 
          "https://doi.org/10.1038/362355a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/340167a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046466369", 
          "https://doi.org/10.1038/340167a0"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1996-07-01", 
    "datePublishedReg": "1996-07-01", 
    "description": "Prevention of sexually transmitted HIV infection was investigated in macaques by immunization with a recombinant SIV (simian immunodeficiency virus) envelope gp120 and core p27 vaccine. In two independent series of experiments, we used the novel targeted iliac lymph node (TILN) route of immunization, aiming close to the iliac lymph nodes draining the genitorectal mucosa. Rectal challenge with the SIVmac 32H J5 molecular clone in two series induced total protection in four out of seven macaques immunized by TILN, compared with infection in 13 of 14 unimmunized macaques or immunized by other routes (P = 0.025). The remaining three macaques showed either a decrease in viral load (>90%) or transient viremia, indicating that all seven TILN\u2013immunized macaques showed total or partial protection (P = 0.001). Protection was associated with significant increase in the iliac lymph nodes of lgA antibody\u2013secreting cells to p27 (P < 0.02), CD8\u2013suppressor factor (P< 0.01), and the chemokines RANTES and MIP\u20131\u03b2 (P< 0.01).", 
    "genre": "article", 
    "id": "sg:pub.10.1038/nm0796-767", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1113716", 
        "issn": [
          "1078-8956", 
          "1546-170X"
        ], 
        "name": "Nature Medicine", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "2"
      }
    ], 
    "keywords": [
      "iliac lymph nodes", 
      "lymph nodes", 
      "iliac lymph node (TILN) route", 
      "CD8-suppressor factor", 
      "protective mucosal immunity", 
      "antibody-secreting cells", 
      "unimmunized macaques", 
      "iliac lymph", 
      "core vaccines", 
      "rectal challenge", 
      "HIV infection", 
      "transient viremia", 
      "envelope gp120", 
      "viral load", 
      "MIP-1\u03b2", 
      "mucosal immunity", 
      "SIV envelope", 
      "chemokine RANTES", 
      "immunization", 
      "partial protection", 
      "molecular clone", 
      "macaques", 
      "significant increase", 
      "independent series", 
      "vaccine", 
      "infection", 
      "total protection", 
      "viremia", 
      "lymph", 
      "RANTES", 
      "mucosa", 
      "gp120", 
      "TILN", 
      "immunity", 
      "prevention", 
      "p27", 
      "protection", 
      "cells", 
      "node route", 
      "decrease", 
      "factors", 
      "clones", 
      "increase", 
      "nodes", 
      "series", 
      "route", 
      "challenges", 
      "novel", 
      "envelope", 
      "load", 
      "experiments", 
      "recombinant SIV (simian immunodeficiency virus) envelope gp120", 
      "SIV (simian immunodeficiency virus) envelope gp120", 
      "core p27 vaccine", 
      "p27 vaccine", 
      "lymph node (TILN) route", 
      "genitorectal mucosa", 
      "SIVmac 32H J5 molecular clone", 
      "J5 molecular clone", 
      "TILN\u2013immunized macaques", 
      "lgA antibody\u2013secreting cells", 
      "subunit SIV envelope"
    ], 
    "name": "Protective mucosal immunity elicited by targeted iliac lymph node immunization with a subunit SIV envelope and core vaccine in macaques", 
    "pagination": "767-775", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1049289100"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nm0796-767"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "8673922"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nm0796-767", 
      "https://app.dimensions.ai/details/publication/pub.1049289100"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:08", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_289.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/nm0796-767"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nm0796-767'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nm0796-767'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nm0796-767'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nm0796-767'


 

This table displays all metadata directly associated to this object as RDF triples.

321 TRIPLES      22 PREDICATES      113 URIs      96 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nm0796-767 schema:about N1052addfce894ff89199d8984d984333
2 N23051e7889ab47acb8c0645e8bf720dd
3 N29ec115ef9ec4099b876703908f6ea98
4 N30be4aa82122475ea2507396358139d7
5 N31647fb67e1a4e43a41d6d061bef9bb4
6 N34d1604dea63425a9fdf60b4ddae5d8d
7 N424ceb69db9b47048ae25fe1df8db2fe
8 N626137fa13ed48a2902b06a83eeab287
9 N708244ae66414d9ab0a31ddb4073b1f5
10 N80798d19c69d458abdf320080050ce61
11 N9ae06d5aeba24ca5917b665275e3c229
12 Naf5733f5b3114717ab568782176c367b
13 Nb1d30cf174874899baa34332135db1e5
14 Nbca7bc5f90294f19bab1f827b3af0220
15 Nc387950114a2478ab9edd192cf9f94c2
16 Ned6f592d752c409ebfaaffd903536341
17 anzsrc-for:11
18 anzsrc-for:1107
19 schema:author N39aa9560e17f44e0a09b1742dc2df096
20 schema:citation sg:pub.10.1038/328345a0
21 sg:pub.10.1038/336484a0
22 sg:pub.10.1038/340167a0
23 sg:pub.10.1038/353393a0
24 sg:pub.10.1038/362355a0
25 sg:pub.10.1038/373117a0
26 sg:pub.10.1038/373123a0
27 sg:pub.10.1038/378563a0
28 sg:pub.10.1038/nm0496-412
29 schema:datePublished 1996-07-01
30 schema:datePublishedReg 1996-07-01
31 schema:description Prevention of sexually transmitted HIV infection was investigated in macaques by immunization with a recombinant SIV (simian immunodeficiency virus) envelope gp120 and core p27 vaccine. In two independent series of experiments, we used the novel targeted iliac lymph node (TILN) route of immunization, aiming close to the iliac lymph nodes draining the genitorectal mucosa. Rectal challenge with the SIVmac 32H J5 molecular clone in two series induced total protection in four out of seven macaques immunized by TILN, compared with infection in 13 of 14 unimmunized macaques or immunized by other routes (P = 0.025). The remaining three macaques showed either a decrease in viral load (>90%) or transient viremia, indicating that all seven TILN–immunized macaques showed total or partial protection (P = 0.001). Protection was associated with significant increase in the iliac lymph nodes of lgA antibody–secreting cells to p27 (P < 0.02), CD8–suppressor factor (P< 0.01), and the chemokines RANTES and MIP–1β (P< 0.01).
32 schema:genre article
33 schema:inLanguage en
34 schema:isAccessibleForFree false
35 schema:isPartOf N228e0357d0434147a7bf5ccec9f6bdaa
36 Na5d42b58dc1f45f78dfb01f5c3dd82e0
37 sg:journal.1113716
38 schema:keywords CD8-suppressor factor
39 HIV infection
40 J5 molecular clone
41 MIP-1β
42 RANTES
43 SIV (simian immunodeficiency virus) envelope gp120
44 SIV envelope
45 SIVmac 32H J5 molecular clone
46 TILN
47 TILN–immunized macaques
48 antibody-secreting cells
49 cells
50 challenges
51 chemokine RANTES
52 clones
53 core p27 vaccine
54 core vaccines
55 decrease
56 envelope
57 envelope gp120
58 experiments
59 factors
60 genitorectal mucosa
61 gp120
62 iliac lymph
63 iliac lymph node (TILN) route
64 iliac lymph nodes
65 immunity
66 immunization
67 increase
68 independent series
69 infection
70 lgA antibody–secreting cells
71 load
72 lymph
73 lymph node (TILN) route
74 lymph nodes
75 macaques
76 molecular clone
77 mucosa
78 mucosal immunity
79 node route
80 nodes
81 novel
82 p27
83 p27 vaccine
84 partial protection
85 prevention
86 protection
87 protective mucosal immunity
88 recombinant SIV (simian immunodeficiency virus) envelope gp120
89 rectal challenge
90 route
91 series
92 significant increase
93 subunit SIV envelope
94 total protection
95 transient viremia
96 unimmunized macaques
97 vaccine
98 viral load
99 viremia
100 schema:name Protective mucosal immunity elicited by targeted iliac lymph node immunization with a subunit SIV envelope and core vaccine in macaques
101 schema:pagination 767-775
102 schema:productId N2491c8a647d24c71aa1022a43525774b
103 N7b01069a9fe342518a034bf17226e52f
104 Ncfbbbc0250c44a0bac1d143312091148
105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049289100
106 https://doi.org/10.1038/nm0796-767
107 schema:sdDatePublished 2022-01-01T18:08
108 schema:sdLicense https://scigraph.springernature.com/explorer/license/
109 schema:sdPublisher Nc80e4ab49f0c45ec81cbb418d0cbe3f2
110 schema:url https://doi.org/10.1038/nm0796-767
111 sgo:license sg:explorer/license/
112 sgo:sdDataset articles
113 rdf:type schema:ScholarlyArticle
114 N058f75cd6d6740afa5602682858dc782 rdf:first sg:person.01322544210.31
115 rdf:rest Na94b47a2c19d48aabe04c96c30e8da83
116 N0a7f05a433b24125a965896c9449707d rdf:first sg:person.01100261732.04
117 rdf:rest N64dc37eee416422eb174215fe50b45d4
118 N0ff9c5f08269422486b7e2efb5fd2d38 rdf:first sg:person.0721561232.15
119 rdf:rest rdf:nil
120 N1052addfce894ff89199d8984d984333 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Male
122 rdf:type schema:DefinedTerm
123 N228e0357d0434147a7bf5ccec9f6bdaa schema:volumeNumber 2
124 rdf:type schema:PublicationVolume
125 N23051e7889ab47acb8c0645e8bf720dd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Fluorescent Dyes
127 rdf:type schema:DefinedTerm
128 N2491c8a647d24c71aa1022a43525774b schema:name pubmed_id
129 schema:value 8673922
130 rdf:type schema:PropertyValue
131 N29ec115ef9ec4099b876703908f6ea98 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Vaccines, Synthetic
133 rdf:type schema:DefinedTerm
134 N30be4aa82122475ea2507396358139d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Lymph Nodes
136 rdf:type schema:DefinedTerm
137 N31647fb67e1a4e43a41d6d061bef9bb4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Chemokines
139 rdf:type schema:DefinedTerm
140 N34d1604dea63425a9fdf60b4ddae5d8d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name SAIDS Vaccines
142 rdf:type schema:DefinedTerm
143 N39aa9560e17f44e0a09b1742dc2df096 rdf:first sg:person.0733367200.21
144 rdf:rest N88a0beff0bbe4d739aa5e8d86df150cb
145 N424ceb69db9b47048ae25fe1df8db2fe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Antibody-Producing Cells
147 rdf:type schema:DefinedTerm
148 N56e0d1bcb5504de886f118d32bff5feb rdf:first sg:person.0721567750.06
149 rdf:rest N661c55fa8ffb4011b9b53544f56f5ff7
150 N626137fa13ed48a2902b06a83eeab287 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Suppressor Factors, Immunologic
152 rdf:type schema:DefinedTerm
153 N64dc37eee416422eb174215fe50b45d4 rdf:first sg:person.01360220412.06
154 rdf:rest Nabfde08cfdbc4c8ba5d1316c7b6f2ff3
155 N661c55fa8ffb4011b9b53544f56f5ff7 rdf:first sg:person.01053456700.39
156 rdf:rest N0ff9c5f08269422486b7e2efb5fd2d38
157 N708244ae66414d9ab0a31ddb4073b1f5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Simian Immunodeficiency Virus
159 rdf:type schema:DefinedTerm
160 N7b01069a9fe342518a034bf17226e52f schema:name doi
161 schema:value 10.1038/nm0796-767
162 rdf:type schema:PropertyValue
163 N80798d19c69d458abdf320080050ce61 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Macaca mulatta
165 rdf:type schema:DefinedTerm
166 N876b1cec3d8b44c0978a2ad64e88b616 rdf:first sg:person.0662040514.00
167 rdf:rest Ncd7e84d8b12241018b1b5ccea35e6abd
168 N88a0beff0bbe4d739aa5e8d86df150cb rdf:first sg:person.0761130730.45
169 rdf:rest N9335a26225774f5883e5f0234fc245b5
170 N9335a26225774f5883e5f0234fc245b5 rdf:first sg:person.01227706612.03
171 rdf:rest N0a7f05a433b24125a965896c9449707d
172 N9ae06d5aeba24ca5917b665275e3c229 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Antibodies, Viral
174 rdf:type schema:DefinedTerm
175 Na5d42b58dc1f45f78dfb01f5c3dd82e0 schema:issueNumber 7
176 rdf:type schema:PublicationIssue
177 Na94b47a2c19d48aabe04c96c30e8da83 rdf:first sg:person.01133562263.23
178 rdf:rest N56e0d1bcb5504de886f118d32bff5feb
179 Nabfde08cfdbc4c8ba5d1316c7b6f2ff3 rdf:first sg:person.01174326000.02
180 rdf:rest Ncdef966a0c1f497fb06aa3059246d7fa
181 Naf5733f5b3114717ab568782176c367b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Ileum
183 rdf:type schema:DefinedTerm
184 Nb1d30cf174874899baa34332135db1e5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Animals
186 rdf:type schema:DefinedTerm
187 Nbca7bc5f90294f19bab1f827b3af0220 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name T-Lymphocytes
189 rdf:type schema:DefinedTerm
190 Nc387950114a2478ab9edd192cf9f94c2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name B-Lymphocytes
192 rdf:type schema:DefinedTerm
193 Nc80e4ab49f0c45ec81cbb418d0cbe3f2 schema:name Springer Nature - SN SciGraph project
194 rdf:type schema:Organization
195 Ncd7e84d8b12241018b1b5ccea35e6abd rdf:first sg:person.01074273513.38
196 rdf:rest N058f75cd6d6740afa5602682858dc782
197 Ncdef966a0c1f497fb06aa3059246d7fa rdf:first sg:person.01300272600.28
198 rdf:rest N876b1cec3d8b44c0978a2ad64e88b616
199 Ncfbbbc0250c44a0bac1d143312091148 schema:name dimensions_id
200 schema:value pub.1049289100
201 rdf:type schema:PropertyValue
202 Ned6f592d752c409ebfaaffd903536341 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
203 schema:name Intestinal Mucosa
204 rdf:type schema:DefinedTerm
205 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
206 schema:name Medical and Health Sciences
207 rdf:type schema:DefinedTerm
208 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
209 schema:name Immunology
210 rdf:type schema:DefinedTerm
211 sg:journal.1113716 schema:issn 1078-8956
212 1546-170X
213 schema:name Nature Medicine
214 schema:publisher Springer Nature
215 rdf:type schema:Periodical
216 sg:person.01053456700.39 schema:affiliation grid-institutes:grid.494924.6
217 schema:familyName Doyle
218 schema:givenName Carl
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053456700.39
220 rdf:type schema:Person
221 sg:person.01074273513.38 schema:affiliation grid-institutes:grid.271308.f
222 schema:familyName Cook
223 schema:givenName Nicola
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074273513.38
225 rdf:type schema:Person
226 sg:person.01100261732.04 schema:affiliation grid-institutes:grid.425213.3
227 schema:familyName Bergmeier
228 schema:givenName Lesley A.
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100261732.04
230 rdf:type schema:Person
231 sg:person.01133562263.23 schema:affiliation grid-institutes:grid.425213.3
232 schema:familyName Klavinskis
233 schema:givenName Linda
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133562263.23
235 rdf:type schema:Person
236 sg:person.01174326000.02 schema:affiliation grid-institutes:grid.425213.3
237 schema:familyName Tao
238 schema:givenName Louisa
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174326000.02
240 rdf:type schema:Person
241 sg:person.01227706612.03 schema:affiliation grid-institutes:grid.271308.f
242 schema:familyName Cranage
243 schema:givenName Martin
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227706612.03
245 rdf:type schema:Person
246 sg:person.01300272600.28 schema:affiliation grid-institutes:grid.271308.f
247 schema:familyName Hall
248 schema:givenName Graham
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300272600.28
250 rdf:type schema:Person
251 sg:person.01322544210.31 schema:affiliation grid-institutes:grid.425213.3
252 schema:familyName Brookes
253 schema:givenName Roger
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322544210.31
255 rdf:type schema:Person
256 sg:person.01360220412.06 schema:affiliation grid-institutes:grid.425213.3
257 schema:familyName Mitchell
258 schema:givenName Elaine
259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01360220412.06
260 rdf:type schema:Person
261 sg:person.0662040514.00 schema:affiliation grid-institutes:grid.271308.f
262 schema:familyName Dennis
263 schema:givenName Mike
264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662040514.00
265 rdf:type schema:Person
266 sg:person.0721561232.15 schema:affiliation grid-institutes:grid.425213.3
267 schema:familyName Ward
268 schema:givenName Robert
269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721561232.15
270 rdf:type schema:Person
271 sg:person.0721567750.06 schema:affiliation grid-institutes:grid.494924.6
272 schema:familyName Jones
273 schema:givenName Ian
274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721567750.06
275 rdf:type schema:Person
276 sg:person.0733367200.21 schema:affiliation grid-institutes:grid.425213.3
277 schema:familyName Lehner
278 schema:givenName Thomas
279 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733367200.21
280 rdf:type schema:Person
281 sg:person.0761130730.45 schema:affiliation grid-institutes:grid.425213.3
282 schema:familyName Wang
283 schema:givenName Yufei
284 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761130730.45
285 rdf:type schema:Person
286 sg:pub.10.1038/328345a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022500911
287 https://doi.org/10.1038/328345a0
288 rdf:type schema:CreativeWork
289 sg:pub.10.1038/336484a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014534456
290 https://doi.org/10.1038/336484a0
291 rdf:type schema:CreativeWork
292 sg:pub.10.1038/340167a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046466369
293 https://doi.org/10.1038/340167a0
294 rdf:type schema:CreativeWork
295 sg:pub.10.1038/353393a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040473271
296 https://doi.org/10.1038/353393a0
297 rdf:type schema:CreativeWork
298 sg:pub.10.1038/362355a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041590783
299 https://doi.org/10.1038/362355a0
300 rdf:type schema:CreativeWork
301 sg:pub.10.1038/373117a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025418642
302 https://doi.org/10.1038/373117a0
303 rdf:type schema:CreativeWork
304 sg:pub.10.1038/373123a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014949926
305 https://doi.org/10.1038/373123a0
306 rdf:type schema:CreativeWork
307 sg:pub.10.1038/378563a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013565921
308 https://doi.org/10.1038/378563a0
309 rdf:type schema:CreativeWork
310 sg:pub.10.1038/nm0496-412 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019706003
311 https://doi.org/10.1038/nm0496-412
312 rdf:type schema:CreativeWork
313 grid-institutes:grid.271308.f schema:alternateName Centre for Applied Microbiology & Research, SP4 OJC, Porton Down, Salisbury, Wiltshire, UK
314 schema:name Centre for Applied Microbiology & Research, SP4 OJC, Porton Down, Salisbury, Wiltshire, UK
315 rdf:type schema:Organization
316 grid-institutes:grid.425213.3 schema:alternateName Department of Immunology, United Medical & Dental Schools of Guy's & St. Thomas' Hospital, SE1 9RT, London, UK
317 schema:name Department of Immunology, United Medical & Dental Schools of Guy's & St. Thomas' Hospital, SE1 9RT, London, UK
318 rdf:type schema:Organization
319 grid-institutes:grid.494924.6 schema:alternateName Institute of Virology and Environmental Microbiology, Mansfield Road, OX1 3SR, Oxford, UK
320 schema:name Institute of Virology and Environmental Microbiology, Mansfield Road, OX1 3SR, Oxford, UK
321 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...