Protective mucosal immunity elicited by targeted iliac lymph node immunization with a subunit SIV envelope and core vaccine in macaques View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-07-01

AUTHORS

Thomas Lehner, Yufei Wang, Martin Cranage, Lesley A. Bergmeier, Elaine Mitchell, Louisa Tao, Graham Hall, Mike Dennis, Nicola Cook, Roger Brookes, Linda Klavinskis, Ian Jones, Carl Doyle, Robert Ward

ABSTRACT

Prevention of sexually transmitted HIV infection was investigated in macaques by immunization with a recombinant SIV (simian immunodeficiency virus) envelope gp120 and core p27 vaccine. In two independent series of experiments, we used the novel targeted iliac lymph node (TILN) route of immunization, aiming close to the iliac lymph nodes draining the genitorectal mucosa. Rectal challenge with the SIVmac 32H J5 molecular clone in two series induced total protection in four out of seven macaques immunized by TILN, compared with infection in 13 of 14 unimmunized macaques or immunized by other routes (P = 0.025). The remaining three macaques showed either a decrease in viral load (>90%) or transient viremia, indicating that all seven TILN–immunized macaques showed total or partial protection (P = 0.001). Protection was associated with significant increase in the iliac lymph nodes of lgA antibody–secreting cells to p27 (P < 0.02), CD8–suppressor factor (P< 0.01), and the chemokines RANTES and MIP–1β (P< 0.01). More... »

PAGES

767-775

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nm0796-767

DOI

http://dx.doi.org/10.1038/nm0796-767

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049289100

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8673922


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibodies, Viral", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibody-Producing Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "B-Lymphocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chemokines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fluorescent Dyes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ileum", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intestinal Mucosa", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymph Nodes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Macaca mulatta", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "SAIDS Vaccines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Simian Immunodeficiency Virus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Suppressor Factors, Immunologic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "T-Lymphocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vaccines, Synthetic", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Immunology, United Medical & Dental Schools of Guy's & St. Thomas' Hospital, SE1 9RT, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.425213.3", 
          "name": [
            "Department of Immunology, United Medical & Dental Schools of Guy's & St. Thomas' Hospital, SE1 9RT, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lehner", 
        "givenName": "Thomas", 
        "id": "sg:person.0733367200.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733367200.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Immunology, United Medical & Dental Schools of Guy's & St. Thomas' Hospital, SE1 9RT, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.425213.3", 
          "name": [
            "Department of Immunology, United Medical & Dental Schools of Guy's & St. Thomas' Hospital, SE1 9RT, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Yufei", 
        "id": "sg:person.0761130730.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761130730.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre for Applied Microbiology & Research, SP4 OJC, Porton Down, Salisbury, Wiltshire, UK", 
          "id": "http://www.grid.ac/institutes/grid.271308.f", 
          "name": [
            "Centre for Applied Microbiology & Research, SP4 OJC, Porton Down, Salisbury, Wiltshire, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cranage", 
        "givenName": "Martin", 
        "id": "sg:person.01227706612.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227706612.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Immunology, United Medical & Dental Schools of Guy's & St. Thomas' Hospital, SE1 9RT, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.425213.3", 
          "name": [
            "Department of Immunology, United Medical & Dental Schools of Guy's & St. Thomas' Hospital, SE1 9RT, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bergmeier", 
        "givenName": "Lesley A.", 
        "id": "sg:person.01100261732.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100261732.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Immunology, United Medical & Dental Schools of Guy's & St. Thomas' Hospital, SE1 9RT, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.425213.3", 
          "name": [
            "Department of Immunology, United Medical & Dental Schools of Guy's & St. Thomas' Hospital, SE1 9RT, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mitchell", 
        "givenName": "Elaine", 
        "id": "sg:person.01360220412.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01360220412.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Immunology, United Medical & Dental Schools of Guy's & St. Thomas' Hospital, SE1 9RT, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.425213.3", 
          "name": [
            "Department of Immunology, United Medical & Dental Schools of Guy's & St. Thomas' Hospital, SE1 9RT, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tao", 
        "givenName": "Louisa", 
        "id": "sg:person.01174326000.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174326000.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre for Applied Microbiology & Research, SP4 OJC, Porton Down, Salisbury, Wiltshire, UK", 
          "id": "http://www.grid.ac/institutes/grid.271308.f", 
          "name": [
            "Centre for Applied Microbiology & Research, SP4 OJC, Porton Down, Salisbury, Wiltshire, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hall", 
        "givenName": "Graham", 
        "id": "sg:person.01300272600.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300272600.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre for Applied Microbiology & Research, SP4 OJC, Porton Down, Salisbury, Wiltshire, UK", 
          "id": "http://www.grid.ac/institutes/grid.271308.f", 
          "name": [
            "Centre for Applied Microbiology & Research, SP4 OJC, Porton Down, Salisbury, Wiltshire, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dennis", 
        "givenName": "Mike", 
        "id": "sg:person.0662040514.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662040514.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre for Applied Microbiology & Research, SP4 OJC, Porton Down, Salisbury, Wiltshire, UK", 
          "id": "http://www.grid.ac/institutes/grid.271308.f", 
          "name": [
            "Centre for Applied Microbiology & Research, SP4 OJC, Porton Down, Salisbury, Wiltshire, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cook", 
        "givenName": "Nicola", 
        "id": "sg:person.01074273513.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074273513.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Immunology, United Medical & Dental Schools of Guy's & St. Thomas' Hospital, SE1 9RT, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.425213.3", 
          "name": [
            "Department of Immunology, United Medical & Dental Schools of Guy's & St. Thomas' Hospital, SE1 9RT, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Brookes", 
        "givenName": "Roger", 
        "id": "sg:person.01322544210.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322544210.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Immunology, United Medical & Dental Schools of Guy's & St. Thomas' Hospital, SE1 9RT, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.425213.3", 
          "name": [
            "Department of Immunology, United Medical & Dental Schools of Guy's & St. Thomas' Hospital, SE1 9RT, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Klavinskis", 
        "givenName": "Linda", 
        "id": "sg:person.01133562263.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133562263.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Virology and Environmental Microbiology, Mansfield Road, OX1 3SR, Oxford, UK", 
          "id": "http://www.grid.ac/institutes/grid.494924.6", 
          "name": [
            "Institute of Virology and Environmental Microbiology, Mansfield Road, OX1 3SR, Oxford, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jones", 
        "givenName": "Ian", 
        "id": "sg:person.0721567750.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721567750.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Virology and Environmental Microbiology, Mansfield Road, OX1 3SR, Oxford, UK", 
          "id": "http://www.grid.ac/institutes/grid.494924.6", 
          "name": [
            "Institute of Virology and Environmental Microbiology, Mansfield Road, OX1 3SR, Oxford, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Doyle", 
        "givenName": "Carl", 
        "id": "sg:person.01053456700.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053456700.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Immunology, United Medical & Dental Schools of Guy's & St. Thomas' Hospital, SE1 9RT, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.425213.3", 
          "name": [
            "Department of Immunology, United Medical & Dental Schools of Guy's & St. Thomas' Hospital, SE1 9RT, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ward", 
        "givenName": "Robert", 
        "id": "sg:person.0721561232.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721561232.15"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/336484a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014534456", 
          "https://doi.org/10.1038/336484a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/328345a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022500911", 
          "https://doi.org/10.1038/328345a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/353393a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040473271", 
          "https://doi.org/10.1038/353393a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/340167a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046466369", 
          "https://doi.org/10.1038/340167a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm0496-412", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019706003", 
          "https://doi.org/10.1038/nm0496-412"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/373117a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025418642", 
          "https://doi.org/10.1038/373117a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/378563a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013565921", 
          "https://doi.org/10.1038/378563a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/362355a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041590783", 
          "https://doi.org/10.1038/362355a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/373123a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014949926", 
          "https://doi.org/10.1038/373123a0"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1996-07-01", 
    "datePublishedReg": "1996-07-01", 
    "description": "Prevention of sexually transmitted HIV infection was investigated in macaques by immunization with a recombinant SIV (simian immunodeficiency virus) envelope gp120 and core p27 vaccine. In two independent series of experiments, we used the novel targeted iliac lymph node (TILN) route of immunization, aiming close to the iliac lymph nodes draining the genitorectal mucosa. Rectal challenge with the SIVmac 32H J5 molecular clone in two series induced total protection in four out of seven macaques immunized by TILN, compared with infection in 13 of 14 unimmunized macaques or immunized by other routes (P = 0.025). The remaining three macaques showed either a decrease in viral load (>90%) or transient viremia, indicating that all seven TILN\u2013immunized macaques showed total or partial protection (P = 0.001). Protection was associated with significant increase in the iliac lymph nodes of lgA antibody\u2013secreting cells to p27 (P < 0.02), CD8\u2013suppressor factor (P< 0.01), and the chemokines RANTES and MIP\u20131\u03b2 (P< 0.01).", 
    "genre": "article", 
    "id": "sg:pub.10.1038/nm0796-767", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1113716", 
        "issn": [
          "1078-8956", 
          "1546-170X"
        ], 
        "name": "Nature Medicine", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "2"
      }
    ], 
    "keywords": [
      "iliac lymph nodes", 
      "lymph nodes", 
      "iliac lymph node (TILN) route", 
      "CD8-suppressor factor", 
      "protective mucosal immunity", 
      "antibody-secreting cells", 
      "unimmunized macaques", 
      "iliac lymph", 
      "core vaccines", 
      "rectal challenge", 
      "transient viremia", 
      "HIV infection", 
      "envelope gp120", 
      "viral load", 
      "MIP-1\u03b2", 
      "mucosal immunity", 
      "SIV envelope", 
      "chemokine RANTES", 
      "partial protection", 
      "immunization", 
      "molecular clone", 
      "macaques", 
      "independent series", 
      "significant increase", 
      "vaccine", 
      "infection", 
      "total protection", 
      "viremia", 
      "lymph", 
      "RANTES", 
      "mucosa", 
      "gp120", 
      "TILN", 
      "immunity", 
      "prevention", 
      "p27", 
      "protection", 
      "cells", 
      "node route", 
      "factors", 
      "decrease", 
      "clones", 
      "increase", 
      "nodes", 
      "series", 
      "route", 
      "challenges", 
      "novel", 
      "envelope", 
      "load", 
      "experiments"
    ], 
    "name": "Protective mucosal immunity elicited by targeted iliac lymph node immunization with a subunit SIV envelope and core vaccine in macaques", 
    "pagination": "767-775", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1049289100"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nm0796-767"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "8673922"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nm0796-767", 
      "https://app.dimensions.ai/details/publication/pub.1049289100"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-05-10T09:45", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220509/entities/gbq_results/article/article_293.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/nm0796-767"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nm0796-767'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nm0796-767'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nm0796-767'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nm0796-767'


 

This table displays all metadata directly associated to this object as RDF triples.

310 TRIPLES      22 PREDICATES      102 URIs      85 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nm0796-767 schema:about N00c1ef5e5fc24053b06fde64b38bd8e0
2 N00d33b6033604f0a892df0020e3b7c0a
3 N3f638875897447179632050e7735b70d
4 N5296161867644b1fb6a4e504db685775
5 N59797251e58345ebb3c217124e0e827a
6 N6ad70cd500e747aab0239643230355f3
7 N6c1b5bf317094e41bb944936d2360bc1
8 N846f2741bb7a4d37aee4e4cc18e2394e
9 N9b19411983394048821a07bec768e290
10 Nab1939ffd1494144ae9f03cb2758e2e6
11 Nd6a2cb09bb7b474ba54144bcb0bed06c
12 Ndbc574135f3b49b79c6b30ec4596eb23
13 Ned0ba28639c843a8bfee2f15cece6b12
14 Neddf68b77d614818a22d75d1ca20bbf2
15 Nf2ffdd2b4262444d9b6dcd48f04c9c57
16 Nfaf0eb121c3b45e682c5c643af36f9f2
17 anzsrc-for:11
18 anzsrc-for:1107
19 schema:author Nc0be390b8c304ea6b461a15f0ca523db
20 schema:citation sg:pub.10.1038/328345a0
21 sg:pub.10.1038/336484a0
22 sg:pub.10.1038/340167a0
23 sg:pub.10.1038/353393a0
24 sg:pub.10.1038/362355a0
25 sg:pub.10.1038/373117a0
26 sg:pub.10.1038/373123a0
27 sg:pub.10.1038/378563a0
28 sg:pub.10.1038/nm0496-412
29 schema:datePublished 1996-07-01
30 schema:datePublishedReg 1996-07-01
31 schema:description Prevention of sexually transmitted HIV infection was investigated in macaques by immunization with a recombinant SIV (simian immunodeficiency virus) envelope gp120 and core p27 vaccine. In two independent series of experiments, we used the novel targeted iliac lymph node (TILN) route of immunization, aiming close to the iliac lymph nodes draining the genitorectal mucosa. Rectal challenge with the SIVmac 32H J5 molecular clone in two series induced total protection in four out of seven macaques immunized by TILN, compared with infection in 13 of 14 unimmunized macaques or immunized by other routes (P = 0.025). The remaining three macaques showed either a decrease in viral load (>90%) or transient viremia, indicating that all seven TILN–immunized macaques showed total or partial protection (P = 0.001). Protection was associated with significant increase in the iliac lymph nodes of lgA antibody–secreting cells to p27 (P < 0.02), CD8–suppressor factor (P< 0.01), and the chemokines RANTES and MIP–1β (P< 0.01).
32 schema:genre article
33 schema:inLanguage en
34 schema:isAccessibleForFree false
35 schema:isPartOf N0fef0a2e99bc4b18ac5d157000320b90
36 Na7fe447b09a44ec783968674586543c2
37 sg:journal.1113716
38 schema:keywords CD8-suppressor factor
39 HIV infection
40 MIP-1β
41 RANTES
42 SIV envelope
43 TILN
44 antibody-secreting cells
45 cells
46 challenges
47 chemokine RANTES
48 clones
49 core vaccines
50 decrease
51 envelope
52 envelope gp120
53 experiments
54 factors
55 gp120
56 iliac lymph
57 iliac lymph node (TILN) route
58 iliac lymph nodes
59 immunity
60 immunization
61 increase
62 independent series
63 infection
64 load
65 lymph
66 lymph nodes
67 macaques
68 molecular clone
69 mucosa
70 mucosal immunity
71 node route
72 nodes
73 novel
74 p27
75 partial protection
76 prevention
77 protection
78 protective mucosal immunity
79 rectal challenge
80 route
81 series
82 significant increase
83 total protection
84 transient viremia
85 unimmunized macaques
86 vaccine
87 viral load
88 viremia
89 schema:name Protective mucosal immunity elicited by targeted iliac lymph node immunization with a subunit SIV envelope and core vaccine in macaques
90 schema:pagination 767-775
91 schema:productId N045b600ace9143859ffaa85f67eba04b
92 N9af2e80e06ca48a9b889a453355a592e
93 Ne0bb1d1b5fba434c84ef6b9f0c0069d2
94 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049289100
95 https://doi.org/10.1038/nm0796-767
96 schema:sdDatePublished 2022-05-10T09:45
97 schema:sdLicense https://scigraph.springernature.com/explorer/license/
98 schema:sdPublisher Na1d4578d446a422a94046e989c256ce7
99 schema:url https://doi.org/10.1038/nm0796-767
100 sgo:license sg:explorer/license/
101 sgo:sdDataset articles
102 rdf:type schema:ScholarlyArticle
103 N00c1ef5e5fc24053b06fde64b38bd8e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name SAIDS Vaccines
105 rdf:type schema:DefinedTerm
106 N00d33b6033604f0a892df0020e3b7c0a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Animals
108 rdf:type schema:DefinedTerm
109 N045b600ace9143859ffaa85f67eba04b schema:name doi
110 schema:value 10.1038/nm0796-767
111 rdf:type schema:PropertyValue
112 N0fef0a2e99bc4b18ac5d157000320b90 schema:volumeNumber 2
113 rdf:type schema:PublicationVolume
114 N19877bdc29ce47f58e19123c23a399ec rdf:first sg:person.01133562263.23
115 rdf:rest Ne031e973c7a8485c862826a8ed0a14b0
116 N1a56677c3ea945f29076cdcf5b72a0e0 rdf:first sg:person.01053456700.39
117 rdf:rest N3d02c3b342534df282e56984236e35a7
118 N1ecafebced3c417697261170280eace5 rdf:first sg:person.01322544210.31
119 rdf:rest N19877bdc29ce47f58e19123c23a399ec
120 N2dabe6911b24410f834c58416f683a44 rdf:first sg:person.01174326000.02
121 rdf:rest Nabb57b959aa54f899bdc527250b6b2bd
122 N3d02c3b342534df282e56984236e35a7 rdf:first sg:person.0721561232.15
123 rdf:rest rdf:nil
124 N3f638875897447179632050e7735b70d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name B-Lymphocytes
126 rdf:type schema:DefinedTerm
127 N4a36c457b3ee475b985ddc933aff5581 rdf:first sg:person.01074273513.38
128 rdf:rest N1ecafebced3c417697261170280eace5
129 N5296161867644b1fb6a4e504db685775 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Ileum
131 rdf:type schema:DefinedTerm
132 N579d4037db054bfeae3c0b1a6b05589a rdf:first sg:person.0662040514.00
133 rdf:rest N4a36c457b3ee475b985ddc933aff5581
134 N59797251e58345ebb3c217124e0e827a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Male
136 rdf:type schema:DefinedTerm
137 N6199915c575c4545b53c80029c422127 rdf:first sg:person.0761130730.45
138 rdf:rest Na3a6710ecef64de58521d00e3ae69d68
139 N6ad70cd500e747aab0239643230355f3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Intestinal Mucosa
141 rdf:type schema:DefinedTerm
142 N6c1b5bf317094e41bb944936d2360bc1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Chemokines
144 rdf:type schema:DefinedTerm
145 N846f2741bb7a4d37aee4e4cc18e2394e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name T-Lymphocytes
147 rdf:type schema:DefinedTerm
148 N9433cac35bbc497e9650942a16dad9fb rdf:first sg:person.01100261732.04
149 rdf:rest Ne1351c7136d9412080e580cd3d652df5
150 N9af2e80e06ca48a9b889a453355a592e schema:name dimensions_id
151 schema:value pub.1049289100
152 rdf:type schema:PropertyValue
153 N9b19411983394048821a07bec768e290 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Macaca mulatta
155 rdf:type schema:DefinedTerm
156 Na1d4578d446a422a94046e989c256ce7 schema:name Springer Nature - SN SciGraph project
157 rdf:type schema:Organization
158 Na3a6710ecef64de58521d00e3ae69d68 rdf:first sg:person.01227706612.03
159 rdf:rest N9433cac35bbc497e9650942a16dad9fb
160 Na7fe447b09a44ec783968674586543c2 schema:issueNumber 7
161 rdf:type schema:PublicationIssue
162 Nab1939ffd1494144ae9f03cb2758e2e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Vaccines, Synthetic
164 rdf:type schema:DefinedTerm
165 Nabb57b959aa54f899bdc527250b6b2bd rdf:first sg:person.01300272600.28
166 rdf:rest N579d4037db054bfeae3c0b1a6b05589a
167 Nc0be390b8c304ea6b461a15f0ca523db rdf:first sg:person.0733367200.21
168 rdf:rest N6199915c575c4545b53c80029c422127
169 Nd6a2cb09bb7b474ba54144bcb0bed06c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Suppressor Factors, Immunologic
171 rdf:type schema:DefinedTerm
172 Ndbc574135f3b49b79c6b30ec4596eb23 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Lymph Nodes
174 rdf:type schema:DefinedTerm
175 Ne031e973c7a8485c862826a8ed0a14b0 rdf:first sg:person.0721567750.06
176 rdf:rest N1a56677c3ea945f29076cdcf5b72a0e0
177 Ne0bb1d1b5fba434c84ef6b9f0c0069d2 schema:name pubmed_id
178 schema:value 8673922
179 rdf:type schema:PropertyValue
180 Ne1351c7136d9412080e580cd3d652df5 rdf:first sg:person.01360220412.06
181 rdf:rest N2dabe6911b24410f834c58416f683a44
182 Ned0ba28639c843a8bfee2f15cece6b12 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Fluorescent Dyes
184 rdf:type schema:DefinedTerm
185 Neddf68b77d614818a22d75d1ca20bbf2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Antibody-Producing Cells
187 rdf:type schema:DefinedTerm
188 Nf2ffdd2b4262444d9b6dcd48f04c9c57 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Antibodies, Viral
190 rdf:type schema:DefinedTerm
191 Nfaf0eb121c3b45e682c5c643af36f9f2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name Simian Immunodeficiency Virus
193 rdf:type schema:DefinedTerm
194 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
195 schema:name Medical and Health Sciences
196 rdf:type schema:DefinedTerm
197 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
198 schema:name Immunology
199 rdf:type schema:DefinedTerm
200 sg:journal.1113716 schema:issn 1078-8956
201 1546-170X
202 schema:name Nature Medicine
203 schema:publisher Springer Nature
204 rdf:type schema:Periodical
205 sg:person.01053456700.39 schema:affiliation grid-institutes:grid.494924.6
206 schema:familyName Doyle
207 schema:givenName Carl
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053456700.39
209 rdf:type schema:Person
210 sg:person.01074273513.38 schema:affiliation grid-institutes:grid.271308.f
211 schema:familyName Cook
212 schema:givenName Nicola
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074273513.38
214 rdf:type schema:Person
215 sg:person.01100261732.04 schema:affiliation grid-institutes:grid.425213.3
216 schema:familyName Bergmeier
217 schema:givenName Lesley A.
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100261732.04
219 rdf:type schema:Person
220 sg:person.01133562263.23 schema:affiliation grid-institutes:grid.425213.3
221 schema:familyName Klavinskis
222 schema:givenName Linda
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133562263.23
224 rdf:type schema:Person
225 sg:person.01174326000.02 schema:affiliation grid-institutes:grid.425213.3
226 schema:familyName Tao
227 schema:givenName Louisa
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174326000.02
229 rdf:type schema:Person
230 sg:person.01227706612.03 schema:affiliation grid-institutes:grid.271308.f
231 schema:familyName Cranage
232 schema:givenName Martin
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227706612.03
234 rdf:type schema:Person
235 sg:person.01300272600.28 schema:affiliation grid-institutes:grid.271308.f
236 schema:familyName Hall
237 schema:givenName Graham
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300272600.28
239 rdf:type schema:Person
240 sg:person.01322544210.31 schema:affiliation grid-institutes:grid.425213.3
241 schema:familyName Brookes
242 schema:givenName Roger
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322544210.31
244 rdf:type schema:Person
245 sg:person.01360220412.06 schema:affiliation grid-institutes:grid.425213.3
246 schema:familyName Mitchell
247 schema:givenName Elaine
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01360220412.06
249 rdf:type schema:Person
250 sg:person.0662040514.00 schema:affiliation grid-institutes:grid.271308.f
251 schema:familyName Dennis
252 schema:givenName Mike
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662040514.00
254 rdf:type schema:Person
255 sg:person.0721561232.15 schema:affiliation grid-institutes:grid.425213.3
256 schema:familyName Ward
257 schema:givenName Robert
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721561232.15
259 rdf:type schema:Person
260 sg:person.0721567750.06 schema:affiliation grid-institutes:grid.494924.6
261 schema:familyName Jones
262 schema:givenName Ian
263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721567750.06
264 rdf:type schema:Person
265 sg:person.0733367200.21 schema:affiliation grid-institutes:grid.425213.3
266 schema:familyName Lehner
267 schema:givenName Thomas
268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733367200.21
269 rdf:type schema:Person
270 sg:person.0761130730.45 schema:affiliation grid-institutes:grid.425213.3
271 schema:familyName Wang
272 schema:givenName Yufei
273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761130730.45
274 rdf:type schema:Person
275 sg:pub.10.1038/328345a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022500911
276 https://doi.org/10.1038/328345a0
277 rdf:type schema:CreativeWork
278 sg:pub.10.1038/336484a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014534456
279 https://doi.org/10.1038/336484a0
280 rdf:type schema:CreativeWork
281 sg:pub.10.1038/340167a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046466369
282 https://doi.org/10.1038/340167a0
283 rdf:type schema:CreativeWork
284 sg:pub.10.1038/353393a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040473271
285 https://doi.org/10.1038/353393a0
286 rdf:type schema:CreativeWork
287 sg:pub.10.1038/362355a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041590783
288 https://doi.org/10.1038/362355a0
289 rdf:type schema:CreativeWork
290 sg:pub.10.1038/373117a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025418642
291 https://doi.org/10.1038/373117a0
292 rdf:type schema:CreativeWork
293 sg:pub.10.1038/373123a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014949926
294 https://doi.org/10.1038/373123a0
295 rdf:type schema:CreativeWork
296 sg:pub.10.1038/378563a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013565921
297 https://doi.org/10.1038/378563a0
298 rdf:type schema:CreativeWork
299 sg:pub.10.1038/nm0496-412 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019706003
300 https://doi.org/10.1038/nm0496-412
301 rdf:type schema:CreativeWork
302 grid-institutes:grid.271308.f schema:alternateName Centre for Applied Microbiology & Research, SP4 OJC, Porton Down, Salisbury, Wiltshire, UK
303 schema:name Centre for Applied Microbiology & Research, SP4 OJC, Porton Down, Salisbury, Wiltshire, UK
304 rdf:type schema:Organization
305 grid-institutes:grid.425213.3 schema:alternateName Department of Immunology, United Medical & Dental Schools of Guy's & St. Thomas' Hospital, SE1 9RT, London, UK
306 schema:name Department of Immunology, United Medical & Dental Schools of Guy's & St. Thomas' Hospital, SE1 9RT, London, UK
307 rdf:type schema:Organization
308 grid-institutes:grid.494924.6 schema:alternateName Institute of Virology and Environmental Microbiology, Mansfield Road, OX1 3SR, Oxford, UK
309 schema:name Institute of Virology and Environmental Microbiology, Mansfield Road, OX1 3SR, Oxford, UK
310 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...