Extensive polymorphisms observed in HIV–1 clade B protease gene using high–density oligonucleotide arrays View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-07

AUTHORS

M J Kozal, N Shah, N Shen, R Yang, R Fucini, T C Merigan, D D Richman, D Morris, E Hubbell, M Chee, T R Gingeras

ABSTRACT

Naturally occurring mutations in HIV-1-infected patients have important implications for therapy and the outcome of clinical studies. However, little is known about the prevalence of mutations that confer resistance to HIV-1 protease inhibitors in isolates derived from patients naive for such inhibitors. In the first clinical application of high-density oligonucleotide array sequencing, the sequences of 167 viral isolates from 102 patients have been determined. The DNA sequence of USA HIV-1 clade B proteases was found to be extremely variable and 47.5% of the 99 amino acid positions varied. This level of amino acid diversity is greater than that previously known for all worldwide HIV-1 clades combined (40%). Many of the amino acid changes that are known to contribute to drug resistance occurred as natural polymorphisms in isolates from patients who had never received protease inhibitors. More... »

PAGES

753-759

Journal

TITLE

Nature Medicine

ISSUE

7

VOLUME

2

Author Affiliations

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    URI

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    DOI

    http://dx.doi.org/10.1038/nm0796-753

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/8673920


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