5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1995-07

AUTHORS

A Merlo, J G Herman, L Mao, D J Lee, E Gabrielson, P C Burger, S B Baylin, D Sidransky

ABSTRACT

Loss of heterozygosity on chromosome 9p21 is one of the most frequent genetic alterations identified in human cancer. The rate of point mutations of p16, a candidate suppressor gene of this area, is low in most primary tumours with allelic loss of 9p21. Monosomic cell lines with structurally unaltered p16 show methylation of the 5' CpG island of p16. This distinct methylation pattern was associated with a complete transcriptional block that was reversible upon treatment with 5-deoxyazacytidine. Moreover, de novo methylation of the 5' CpG island of p16 was also found in approximately 20% of different primary neoplasms, but not in normal tissues, potentially representing a common pathway of tumour suppressor gene inactivation in human cancers. More... »

PAGES

686-692

Journal

TITLE

Nature Medicine

ISSUE

7

VOLUME

1

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nm0795-686

DOI

http://dx.doi.org/10.1038/nm0795-686

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1016345098

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7585152


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curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nm0795-686'

RDF/XML is a standard XML format for linked data.

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