5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1995-07

AUTHORS

Adrian Merlo, James G. Herman, Li Mao, Daniel J. Lee, Edward Gabrielson, Peter C. Burger, Stephen B. Baylin, David Sidransky

ABSTRACT

Loss of heterozygosity on chromosome 9p21 is one of the most frequent genetic alterations identified in human cancer. The rate of point mutations of p16, a candidate suppressor gene of this area, is low in most primary tumours with allelic loss of 9p21. Monosomic cell lines with structurally unaltered p16 show methylation of the 5′ CpG island of p16. This distinct methylation pattern was associated with a complete transcriptional block that was reversible upon treatment with 5-deoxyazacytidine. Moreover, de novo methylation of the 5′ CpG island of p16 was also found in approximately 20% of different primary neoplasms, but not in normal tissues, potentially representing a common pathway of tumour suppressor gene inactivation in human cancers. More... »

PAGES

686-692

Journal

TITLE

Nature Medicine

ISSUE

7

VOLUME

1

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nm0795-686

    DOI

    http://dx.doi.org/10.1038/nm0795-686

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1016345098

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/7585152


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    43 schema:description Loss of heterozygosity on chromosome 9p21 is one of the most frequent genetic alterations identified in human cancer. The rate of point mutations of p16, a candidate suppressor gene of this area, is low in most primary tumours with allelic loss of 9p21. Monosomic cell lines with structurally unaltered p16 show methylation of the 5′ CpG island of p16. This distinct methylation pattern was associated with a complete transcriptional block that was reversible upon treatment with 5-deoxyazacytidine. Moreover, de novo methylation of the 5′ CpG island of p16 was also found in approximately 20% of different primary neoplasms, but not in normal tissues, potentially representing a common pathway of tumour suppressor gene inactivation in human cancers.
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