Long-term protection of chimpanzees against high-dose HIV-1 challenge induced by immunization View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1997-06

AUTHORS

M D Lubeck, R Natuk, M Myagkikh, N Kalyan, K Aldrich, F Sinangil, S Alipanah, S C Murthy, P K Chanda, S M Nigida, P D Markham, S Zolla-Pazner, K Steimer, M Wade, M S Reitz, L O Arthur, S Mizutani, A Davis, P P Hung, R C Gallo, J Eichberg, M Robert-Guroff

ABSTRACT

A combination AIDS vaccine approach consisting of priming with adenovirus-HIV-1MN gp160 recombinants followed by boosting with HIV-1SF2 gp120 was evaluated in chimpanzees. Long-lasting protection, requiring only three immunizations, was achieved against a low-dose challenge with the SF2 strain of HIV-1 and a subsequent high-dose SF2 challenge administered 1 year later without an intervening boost. Notably, neutralizing antibody responses against both clinical and laboratory isolates developed in three chimpanzees and persisted until the time of high-dose challenge. The possibility that cytotoxic T-lymphocytes contribute to low-dose protection of a chimpanzee lacking neutralizing antibodies is suggested. Our results validate the live vector priming/subunit booster approach and should stimulate interest in assessing this combination vaccine approach in humans. More... »

PAGES

651-658

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nm0697-651

DOI

http://dx.doi.org/10.1038/nm0697-651

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1035410393

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9176492


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenoviridae", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HIV Envelope Protein gp120", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HIV Envelope Protein gp160", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HIV Infections", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HIV-1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pan troglodytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Recombinant Fusion Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "T-Lymphocytes, Cytotoxic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vaccination", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vaccines", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Pfizer (United States)", 
          "id": "https://www.grid.ac/institutes/grid.410513.2", 
          "name": [
            "Wyeth-Ayerst Research, Radnor, PA 19087, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lubeck", 
        "givenName": "M D", 
        "id": "sg:person.0722060323.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0722060323.30"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Natuk", 
        "givenName": "R", 
        "id": "sg:person.0621102327.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0621102327.28"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Myagkikh", 
        "givenName": "M", 
        "id": "sg:person.0753513760.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753513760.96"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Kalyan", 
        "givenName": "N", 
        "id": "sg:person.01123125241.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123125241.46"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Aldrich", 
        "givenName": "K", 
        "type": "Person"
      }, 
      {
        "familyName": "Sinangil", 
        "givenName": "F", 
        "id": "sg:person.0777634164.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777634164.51"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Alipanah", 
        "givenName": "S", 
        "id": "sg:person.01256605551.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256605551.22"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Murthy", 
        "givenName": "S C", 
        "id": "sg:person.014176470712.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014176470712.11"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Chanda", 
        "givenName": "P K", 
        "id": "sg:person.0773706237.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773706237.51"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Nigida", 
        "givenName": "S M", 
        "id": "sg:person.014452467134.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014452467134.31"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Markham", 
        "givenName": "P D", 
        "id": "sg:person.016332524464.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016332524464.24"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Zolla-Pazner", 
        "givenName": "S", 
        "id": "sg:person.016015237357.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016015237357.08"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Steimer", 
        "givenName": "K", 
        "id": "sg:person.01342523335.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342523335.34"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Wade", 
        "givenName": "M", 
        "id": "sg:person.0777350446.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777350446.53"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Reitz", 
        "givenName": "M S", 
        "id": "sg:person.0633033445.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0633033445.91"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Arthur", 
        "givenName": "L O", 
        "id": "sg:person.0634201432.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634201432.39"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Mizutani", 
        "givenName": "S", 
        "id": "sg:person.0770223076.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0770223076.50"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Davis", 
        "givenName": "A", 
        "id": "sg:person.013775567627.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013775567627.17"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Hung", 
        "givenName": "P P", 
        "id": "sg:person.0657606223.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657606223.62"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Gallo", 
        "givenName": "R C", 
        "id": "sg:person.011012202251.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011012202251.12"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Eichberg", 
        "givenName": "J", 
        "id": "sg:person.07422741224.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07422741224.51"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Robert-Guroff", 
        "givenName": "M", 
        "id": "sg:person.0101332607.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0101332607.46"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/eji.1830241017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001752922"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0166-0934(91)90069-c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002025188"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0166-0934(91)90069-c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002025188"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.85.14.5200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003196408"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-349-11888-5_9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014426977", 
          "https://doi.org/10.1007/978-1-349-11888-5_9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm0495-321", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021805682", 
          "https://doi.org/10.1038/nm0495-321"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/infdis/173.1.52", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025331061"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/353393b0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025853338", 
          "https://doi.org/10.1038/353393b0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1195-1167", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029055040", 
          "https://doi.org/10.1038/nm1195-1167"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1195-1167", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029055040", 
          "https://doi.org/10.1038/nm1195-1167"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/19.14.3979", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029803898"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.86.17.6763", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030551728"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0042-6822(90)90438-w", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030940011"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/345622a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032293946", 
          "https://doi.org/10.1038/345622a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.5.12.3403", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036135474"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0264-410x(94)90185-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036477197"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0264-410x(94)90185-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036477197"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00002030-199405000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036591420"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00002030-199405000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036591420"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/353393a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040473271", 
          "https://doi.org/10.1038/353393a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/355728a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040588876", 
          "https://doi.org/10.1038/355728a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.85.9.3105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046819147"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.84.12.4249", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050027055"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0264-410x(93)90341-t", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050350757"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0264-410x(93)90341-t", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050350757"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00002030-199512000-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053547192"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00002030-199512000-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053547192"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.88.2.542", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053563793"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/328721a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056438836", 
          "https://doi.org/10.1038/328721a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/328721a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056438836", 
          "https://doi.org/10.1038/328721a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/aid.1990.6.855", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059223205"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/aid.1993.9.1233", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059223610"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/aid.1993.9.395", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059223660"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/aid.1994.10.1443", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059223815"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/aid.1995.11.1449", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059224062"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/aid.1996.12.1341", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059224231"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1470916", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062484882"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.256.5064.1687", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062544171"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.2789433", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062559107"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077604964", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078734984", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079023614", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079784718", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082457527", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082473917", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082712376", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082989588", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1997-06", 
    "datePublishedReg": "1997-06-01", 
    "description": "A combination AIDS vaccine approach consisting of priming with adenovirus-HIV-1MN gp160 recombinants followed by boosting with HIV-1SF2 gp120 was evaluated in chimpanzees. Long-lasting protection, requiring only three immunizations, was achieved against a low-dose challenge with the SF2 strain of HIV-1 and a subsequent high-dose SF2 challenge administered 1 year later without an intervening boost. Notably, neutralizing antibody responses against both clinical and laboratory isolates developed in three chimpanzees and persisted until the time of high-dose challenge. The possibility that cytotoxic T-lymphocytes contribute to low-dose protection of a chimpanzee lacking neutralizing antibodies is suggested. Our results validate the live vector priming/subunit booster approach and should stimulate interest in assessing this combination vaccine approach in humans.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nm0697-651", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2452405", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2453027", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1113716", 
        "issn": [
          "1078-8956", 
          "1546-170X"
        ], 
        "name": "Nature Medicine", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "3"
      }
    ], 
    "name": "Long-term protection of chimpanzees against high-dose HIV-1 challenge induced by immunization", 
    "pagination": "651-658", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "a8adccdbf0dbfd239d548fc00df9adf522f091904e7f02a60830d7e9e0314fc1"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "9176492"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9502015"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nm0697-651"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1035410393"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nm0697-651", 
      "https://app.dimensions.ai/details/publication/pub.1035410393"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T00:56", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8697_00000434.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/nm0697-651"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nm0697-651'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nm0697-651'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nm0697-651'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nm0697-651'


 

This table displays all metadata directly associated to this object as RDF triples.

366 TRIPLES      21 PREDICATES      81 URIs      33 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nm0697-651 schema:about N33e029fced1c4b5bad35c6c99441fbb9
2 N340b649d75ee4176a2ad5ae3f1d963ae
3 N3bee116c70824d2dbde617087123fe4c
4 N3d7de452dc514ef2ac23a2701ecb4858
5 N44339fceb70448fd9eda8bd9f9015eaa
6 N6af127950587458f8acc03b9c4f12146
7 Na692d619f5ca402fb27869422b394ca6
8 Na8d0fea6c9214cd88e3d9982614f22a5
9 Nab9ebd9779f2490cb3b5b41285b76417
10 Nadfcd9f549bb4ba38b89d72f9412a647
11 Nd1beed3a986b4815882d4395255c3c0c
12 Nd732f20edcc04a029a00c397cc13ef97
13 anzsrc-for:11
14 anzsrc-for:1107
15 schema:author N1988b4c210b54471ae9b310dcfc686f0
16 schema:citation sg:pub.10.1007/978-1-349-11888-5_9
17 sg:pub.10.1038/328721a0
18 sg:pub.10.1038/345622a0
19 sg:pub.10.1038/353393a0
20 sg:pub.10.1038/353393b0
21 sg:pub.10.1038/355728a0
22 sg:pub.10.1038/nm0495-321
23 sg:pub.10.1038/nm1195-1167
24 https://app.dimensions.ai/details/publication/pub.1077604964
25 https://app.dimensions.ai/details/publication/pub.1078734984
26 https://app.dimensions.ai/details/publication/pub.1079023614
27 https://app.dimensions.ai/details/publication/pub.1079784718
28 https://app.dimensions.ai/details/publication/pub.1082457527
29 https://app.dimensions.ai/details/publication/pub.1082473917
30 https://app.dimensions.ai/details/publication/pub.1082712376
31 https://app.dimensions.ai/details/publication/pub.1082989588
32 https://doi.org/10.1002/eji.1830241017
33 https://doi.org/10.1016/0042-6822(90)90438-w
34 https://doi.org/10.1016/0166-0934(91)90069-c
35 https://doi.org/10.1016/0264-410x(93)90341-t
36 https://doi.org/10.1016/0264-410x(94)90185-6
37 https://doi.org/10.1073/pnas.84.12.4249
38 https://doi.org/10.1073/pnas.85.14.5200
39 https://doi.org/10.1073/pnas.85.9.3105
40 https://doi.org/10.1073/pnas.86.17.6763
41 https://doi.org/10.1073/pnas.88.2.542
42 https://doi.org/10.1089/aid.1990.6.855
43 https://doi.org/10.1089/aid.1993.9.1233
44 https://doi.org/10.1089/aid.1993.9.395
45 https://doi.org/10.1089/aid.1994.10.1443
46 https://doi.org/10.1089/aid.1995.11.1449
47 https://doi.org/10.1089/aid.1996.12.1341
48 https://doi.org/10.1093/infdis/173.1.52
49 https://doi.org/10.1093/nar/19.14.3979
50 https://doi.org/10.1097/00002030-199405000-00004
51 https://doi.org/10.1097/00002030-199512000-00003
52 https://doi.org/10.1126/science.1470916
53 https://doi.org/10.1126/science.256.5064.1687
54 https://doi.org/10.1126/science.2789433
55 https://doi.org/10.1128/mcb.5.12.3403
56 schema:datePublished 1997-06
57 schema:datePublishedReg 1997-06-01
58 schema:description A combination AIDS vaccine approach consisting of priming with adenovirus-HIV-1MN gp160 recombinants followed by boosting with HIV-1SF2 gp120 was evaluated in chimpanzees. Long-lasting protection, requiring only three immunizations, was achieved against a low-dose challenge with the SF2 strain of HIV-1 and a subsequent high-dose SF2 challenge administered 1 year later without an intervening boost. Notably, neutralizing antibody responses against both clinical and laboratory isolates developed in three chimpanzees and persisted until the time of high-dose challenge. The possibility that cytotoxic T-lymphocytes contribute to low-dose protection of a chimpanzee lacking neutralizing antibodies is suggested. Our results validate the live vector priming/subunit booster approach and should stimulate interest in assessing this combination vaccine approach in humans.
59 schema:genre research_article
60 schema:inLanguage en
61 schema:isAccessibleForFree false
62 schema:isPartOf N0f1298aafc2c4801a69797b8e1c13ec3
63 Na6f5f8a71d6641ba8f185f4a241c50b8
64 sg:journal.1113716
65 schema:name Long-term protection of chimpanzees against high-dose HIV-1 challenge induced by immunization
66 schema:pagination 651-658
67 schema:productId N252733a56d8e426e8dcabad1cd5da9f2
68 N46ed59dc605f4be08189924996ba6e55
69 N5b175232dabe4506a2c074d2ccdb0af1
70 N678a58b915754af28670081404e21a76
71 N7c521ce1e44e4c2391bd7267bfae0c84
72 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035410393
73 https://doi.org/10.1038/nm0697-651
74 schema:sdDatePublished 2019-04-11T00:56
75 schema:sdLicense https://scigraph.springernature.com/explorer/license/
76 schema:sdPublisher N4edd5cb34c3f4bdb81e2512cb0e8f54a
77 schema:url http://www.nature.com/articles/nm0697-651
78 sgo:license sg:explorer/license/
79 sgo:sdDataset articles
80 rdf:type schema:ScholarlyArticle
81 N02b8fc80971949499ff0a5d7fdaa2c10 rdf:first sg:person.01342523335.34
82 rdf:rest Nb5ccc0154a184c8eb9a7ee60cb203cd4
83 N0bbba90e075b45839b7bee52a1fd2015 rdf:first sg:person.013775567627.17
84 rdf:rest N696a730b09dc4fc48b2f0dff4151d688
85 N0f1298aafc2c4801a69797b8e1c13ec3 schema:volumeNumber 3
86 rdf:type schema:PublicationVolume
87 N10c076a7df8045e1949fbc1d71aaee3d rdf:first sg:person.0770223076.50
88 rdf:rest N0bbba90e075b45839b7bee52a1fd2015
89 N11620d0bd2ef4025a547342015bbe540 rdf:first sg:person.016332524464.24
90 rdf:rest N712af03352284c7fac29a5dffa143e27
91 N1988b4c210b54471ae9b310dcfc686f0 rdf:first sg:person.0722060323.30
92 rdf:rest N897d4da21dc140b68d2e212db61bded4
93 N24077df383fc4e9f9057545d0af5f14e rdf:first sg:person.0753513760.96
94 rdf:rest Nddde232c92ba43daa840ff405b7136c6
95 N252733a56d8e426e8dcabad1cd5da9f2 schema:name nlm_unique_id
96 schema:value 9502015
97 rdf:type schema:PropertyValue
98 N28374bcf6a5149a3a9e8a7630e725236 rdf:first sg:person.0777634164.51
99 rdf:rest N40b170b85d21458b8ea40c09cff92e12
100 N2d0a8a5d38a6450d8687452ff36f1ba3 rdf:first sg:person.0633033445.91
101 rdf:rest N7d58bc4da5d4488a892f519814508404
102 N33e029fced1c4b5bad35c6c99441fbb9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name HIV Infections
104 rdf:type schema:DefinedTerm
105 N340b649d75ee4176a2ad5ae3f1d963ae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Adenoviridae
107 rdf:type schema:DefinedTerm
108 N3632a151ce364a478907fe14a2aa106d rdf:first N52814062735f4f9599025ca81eaa97be
109 rdf:rest N28374bcf6a5149a3a9e8a7630e725236
110 N3bee116c70824d2dbde617087123fe4c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Recombinant Fusion Proteins
112 rdf:type schema:DefinedTerm
113 N3d7de452dc514ef2ac23a2701ecb4858 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Animals
115 rdf:type schema:DefinedTerm
116 N40b170b85d21458b8ea40c09cff92e12 rdf:first sg:person.01256605551.22
117 rdf:rest N5c3c908f631c457e8e24011850a73e9d
118 N44339fceb70448fd9eda8bd9f9015eaa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name HIV-1
120 rdf:type schema:DefinedTerm
121 N46ed59dc605f4be08189924996ba6e55 schema:name doi
122 schema:value 10.1038/nm0697-651
123 rdf:type schema:PropertyValue
124 N4edd5cb34c3f4bdb81e2512cb0e8f54a schema:name Springer Nature - SN SciGraph project
125 rdf:type schema:Organization
126 N52814062735f4f9599025ca81eaa97be schema:familyName Aldrich
127 schema:givenName K
128 rdf:type schema:Person
129 N5b175232dabe4506a2c074d2ccdb0af1 schema:name pubmed_id
130 schema:value 9176492
131 rdf:type schema:PropertyValue
132 N5c3c908f631c457e8e24011850a73e9d rdf:first sg:person.014176470712.11
133 rdf:rest Nbb095b0731ae4e0abda4fdb2e36b9047
134 N5dffacdb9f03437b91baf6ed2287a6e8 rdf:first sg:person.014452467134.31
135 rdf:rest N11620d0bd2ef4025a547342015bbe540
136 N678a58b915754af28670081404e21a76 schema:name dimensions_id
137 schema:value pub.1035410393
138 rdf:type schema:PropertyValue
139 N696a730b09dc4fc48b2f0dff4151d688 rdf:first sg:person.0657606223.62
140 rdf:rest Nb90303a50ddb4663aa3024d6add8a0ea
141 N6af127950587458f8acc03b9c4f12146 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name HIV Envelope Protein gp160
143 rdf:type schema:DefinedTerm
144 N712af03352284c7fac29a5dffa143e27 rdf:first sg:person.016015237357.08
145 rdf:rest N02b8fc80971949499ff0a5d7fdaa2c10
146 N7c521ce1e44e4c2391bd7267bfae0c84 schema:name readcube_id
147 schema:value a8adccdbf0dbfd239d548fc00df9adf522f091904e7f02a60830d7e9e0314fc1
148 rdf:type schema:PropertyValue
149 N7d58bc4da5d4488a892f519814508404 rdf:first sg:person.0634201432.39
150 rdf:rest N10c076a7df8045e1949fbc1d71aaee3d
151 N897d4da21dc140b68d2e212db61bded4 rdf:first sg:person.0621102327.28
152 rdf:rest N24077df383fc4e9f9057545d0af5f14e
153 N8eb6b685e3974a7d8b97c7c4ed6e4bf0 rdf:first sg:person.07422741224.51
154 rdf:rest Na2649d4826ee409c8f5f1da89b8cf60e
155 Na2649d4826ee409c8f5f1da89b8cf60e rdf:first sg:person.0101332607.46
156 rdf:rest rdf:nil
157 Na692d619f5ca402fb27869422b394ca6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name T-Lymphocytes, Cytotoxic
159 rdf:type schema:DefinedTerm
160 Na6f5f8a71d6641ba8f185f4a241c50b8 schema:issueNumber 6
161 rdf:type schema:PublicationIssue
162 Na8d0fea6c9214cd88e3d9982614f22a5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Vaccination
164 rdf:type schema:DefinedTerm
165 Nab9ebd9779f2490cb3b5b41285b76417 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Vaccines
167 rdf:type schema:DefinedTerm
168 Nadfcd9f549bb4ba38b89d72f9412a647 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Pan troglodytes
170 rdf:type schema:DefinedTerm
171 Nb5ccc0154a184c8eb9a7ee60cb203cd4 rdf:first sg:person.0777350446.53
172 rdf:rest N2d0a8a5d38a6450d8687452ff36f1ba3
173 Nb90303a50ddb4663aa3024d6add8a0ea rdf:first sg:person.011012202251.12
174 rdf:rest N8eb6b685e3974a7d8b97c7c4ed6e4bf0
175 Nbb095b0731ae4e0abda4fdb2e36b9047 rdf:first sg:person.0773706237.51
176 rdf:rest N5dffacdb9f03437b91baf6ed2287a6e8
177 Nd1beed3a986b4815882d4395255c3c0c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Female
179 rdf:type schema:DefinedTerm
180 Nd732f20edcc04a029a00c397cc13ef97 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name HIV Envelope Protein gp120
182 rdf:type schema:DefinedTerm
183 Nddde232c92ba43daa840ff405b7136c6 rdf:first sg:person.01123125241.46
184 rdf:rest N3632a151ce364a478907fe14a2aa106d
185 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
186 schema:name Medical and Health Sciences
187 rdf:type schema:DefinedTerm
188 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
189 schema:name Immunology
190 rdf:type schema:DefinedTerm
191 sg:grant.2452405 http://pending.schema.org/fundedItem sg:pub.10.1038/nm0697-651
192 rdf:type schema:MonetaryGrant
193 sg:grant.2453027 http://pending.schema.org/fundedItem sg:pub.10.1038/nm0697-651
194 rdf:type schema:MonetaryGrant
195 sg:journal.1113716 schema:issn 1078-8956
196 1546-170X
197 schema:name Nature Medicine
198 rdf:type schema:Periodical
199 sg:person.0101332607.46 schema:familyName Robert-Guroff
200 schema:givenName M
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0101332607.46
202 rdf:type schema:Person
203 sg:person.011012202251.12 schema:familyName Gallo
204 schema:givenName R C
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011012202251.12
206 rdf:type schema:Person
207 sg:person.01123125241.46 schema:familyName Kalyan
208 schema:givenName N
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123125241.46
210 rdf:type schema:Person
211 sg:person.01256605551.22 schema:familyName Alipanah
212 schema:givenName S
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256605551.22
214 rdf:type schema:Person
215 sg:person.01342523335.34 schema:familyName Steimer
216 schema:givenName K
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342523335.34
218 rdf:type schema:Person
219 sg:person.013775567627.17 schema:familyName Davis
220 schema:givenName A
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013775567627.17
222 rdf:type schema:Person
223 sg:person.014176470712.11 schema:familyName Murthy
224 schema:givenName S C
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014176470712.11
226 rdf:type schema:Person
227 sg:person.014452467134.31 schema:familyName Nigida
228 schema:givenName S M
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014452467134.31
230 rdf:type schema:Person
231 sg:person.016015237357.08 schema:familyName Zolla-Pazner
232 schema:givenName S
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016015237357.08
234 rdf:type schema:Person
235 sg:person.016332524464.24 schema:familyName Markham
236 schema:givenName P D
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016332524464.24
238 rdf:type schema:Person
239 sg:person.0621102327.28 schema:familyName Natuk
240 schema:givenName R
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0621102327.28
242 rdf:type schema:Person
243 sg:person.0633033445.91 schema:familyName Reitz
244 schema:givenName M S
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0633033445.91
246 rdf:type schema:Person
247 sg:person.0634201432.39 schema:familyName Arthur
248 schema:givenName L O
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634201432.39
250 rdf:type schema:Person
251 sg:person.0657606223.62 schema:familyName Hung
252 schema:givenName P P
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657606223.62
254 rdf:type schema:Person
255 sg:person.0722060323.30 schema:affiliation https://www.grid.ac/institutes/grid.410513.2
256 schema:familyName Lubeck
257 schema:givenName M D
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0722060323.30
259 rdf:type schema:Person
260 sg:person.07422741224.51 schema:familyName Eichberg
261 schema:givenName J
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07422741224.51
263 rdf:type schema:Person
264 sg:person.0753513760.96 schema:familyName Myagkikh
265 schema:givenName M
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753513760.96
267 rdf:type schema:Person
268 sg:person.0770223076.50 schema:familyName Mizutani
269 schema:givenName S
270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0770223076.50
271 rdf:type schema:Person
272 sg:person.0773706237.51 schema:familyName Chanda
273 schema:givenName P K
274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773706237.51
275 rdf:type schema:Person
276 sg:person.0777350446.53 schema:familyName Wade
277 schema:givenName M
278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777350446.53
279 rdf:type schema:Person
280 sg:person.0777634164.51 schema:familyName Sinangil
281 schema:givenName F
282 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777634164.51
283 rdf:type schema:Person
284 sg:pub.10.1007/978-1-349-11888-5_9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014426977
285 https://doi.org/10.1007/978-1-349-11888-5_9
286 rdf:type schema:CreativeWork
287 sg:pub.10.1038/328721a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056438836
288 https://doi.org/10.1038/328721a0
289 rdf:type schema:CreativeWork
290 sg:pub.10.1038/345622a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032293946
291 https://doi.org/10.1038/345622a0
292 rdf:type schema:CreativeWork
293 sg:pub.10.1038/353393a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040473271
294 https://doi.org/10.1038/353393a0
295 rdf:type schema:CreativeWork
296 sg:pub.10.1038/353393b0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025853338
297 https://doi.org/10.1038/353393b0
298 rdf:type schema:CreativeWork
299 sg:pub.10.1038/355728a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040588876
300 https://doi.org/10.1038/355728a0
301 rdf:type schema:CreativeWork
302 sg:pub.10.1038/nm0495-321 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021805682
303 https://doi.org/10.1038/nm0495-321
304 rdf:type schema:CreativeWork
305 sg:pub.10.1038/nm1195-1167 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029055040
306 https://doi.org/10.1038/nm1195-1167
307 rdf:type schema:CreativeWork
308 https://app.dimensions.ai/details/publication/pub.1077604964 schema:CreativeWork
309 https://app.dimensions.ai/details/publication/pub.1078734984 schema:CreativeWork
310 https://app.dimensions.ai/details/publication/pub.1079023614 schema:CreativeWork
311 https://app.dimensions.ai/details/publication/pub.1079784718 schema:CreativeWork
312 https://app.dimensions.ai/details/publication/pub.1082457527 schema:CreativeWork
313 https://app.dimensions.ai/details/publication/pub.1082473917 schema:CreativeWork
314 https://app.dimensions.ai/details/publication/pub.1082712376 schema:CreativeWork
315 https://app.dimensions.ai/details/publication/pub.1082989588 schema:CreativeWork
316 https://doi.org/10.1002/eji.1830241017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001752922
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1016/0042-6822(90)90438-w schema:sameAs https://app.dimensions.ai/details/publication/pub.1030940011
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1016/0166-0934(91)90069-c schema:sameAs https://app.dimensions.ai/details/publication/pub.1002025188
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1016/0264-410x(93)90341-t schema:sameAs https://app.dimensions.ai/details/publication/pub.1050350757
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1016/0264-410x(94)90185-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036477197
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1073/pnas.84.12.4249 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050027055
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1073/pnas.85.14.5200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003196408
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1073/pnas.85.9.3105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046819147
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1073/pnas.86.17.6763 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030551728
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1073/pnas.88.2.542 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053563793
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1089/aid.1990.6.855 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059223205
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1089/aid.1993.9.1233 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059223610
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1089/aid.1993.9.395 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059223660
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1089/aid.1994.10.1443 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059223815
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1089/aid.1995.11.1449 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059224062
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1089/aid.1996.12.1341 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059224231
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1093/infdis/173.1.52 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025331061
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1093/nar/19.14.3979 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029803898
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1097/00002030-199405000-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036591420
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1097/00002030-199512000-00003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053547192
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1126/science.1470916 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062484882
357 rdf:type schema:CreativeWork
358 https://doi.org/10.1126/science.256.5064.1687 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062544171
359 rdf:type schema:CreativeWork
360 https://doi.org/10.1126/science.2789433 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062559107
361 rdf:type schema:CreativeWork
362 https://doi.org/10.1128/mcb.5.12.3403 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036135474
363 rdf:type schema:CreativeWork
364 https://www.grid.ac/institutes/grid.410513.2 schema:alternateName Pfizer (United States)
365 schema:name Wyeth-Ayerst Research, Radnor, PA 19087, USA.
366 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...