Long-term protection of chimpanzees against high-dose HIV-1 challenge induced by immunization View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1997-06

AUTHORS

M D Lubeck, R Natuk, M Myagkikh, N Kalyan, K Aldrich, F Sinangil, S Alipanah, S C Murthy, P K Chanda, S M Nigida, P D Markham, S Zolla-Pazner, K Steimer, M Wade, M S Reitz, L O Arthur, S Mizutani, A Davis, P P Hung, R C Gallo, J Eichberg, M Robert-Guroff

ABSTRACT

A combination AIDS vaccine approach consisting of priming with adenovirus-HIV-1MN gp160 recombinants followed by boosting with HIV-1SF2 gp120 was evaluated in chimpanzees. Long-lasting protection, requiring only three immunizations, was achieved against a low-dose challenge with the SF2 strain of HIV-1 and a subsequent high-dose SF2 challenge administered 1 year later without an intervening boost. Notably, neutralizing antibody responses against both clinical and laboratory isolates developed in three chimpanzees and persisted until the time of high-dose challenge. The possibility that cytotoxic T-lymphocytes contribute to low-dose protection of a chimpanzee lacking neutralizing antibodies is suggested. Our results validate the live vector priming/subunit booster approach and should stimulate interest in assessing this combination vaccine approach in humans. More... »

PAGES

651-658

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nm0697-651

DOI

http://dx.doi.org/10.1038/nm0697-651

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1035410393

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9176492


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