Molecular regulation of vessel maturation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-06

AUTHORS

Rakesh K Jain

ABSTRACT

The maturation of nascent vasculature, formed by vasculogenesis or angiogenesis, requires recruitment of mural cells, generation of an extracellular matrix and specialization of the vessel wall for structural support and regulation of vessel function. In addition, the vascular network must be organized so that all the parenchymal cells receive adequate nutrients. All of these processes are orchestrated by physical forces as well as by a constellation of ligands and receptors whose spatio-temporal patterns of expression and concentration are tightly regulated. Inappropriate levels of these physical forces or molecules produce an abnormal vasculature--a hallmark of various pathologies. Normalization of the abnormal vasculature can facilitate drug delivery to tumors and formation of a mature vasculature can help realize the promise of therapeutic angiogenesis and tissue engineering. More... »

PAGES

685-693

References to SciGraph publications

  • 2002-03. Tumour biology: Herceptin acts as an anti-angiogenic cocktail in NATURE
  • 2001-03. Telomerized human microvasculature is functional in vivo in NATURE BIOTECHNOLOGY
  • 2002-09. A reevaluation of integrins as regulators of angiogenesis in NATURE MEDICINE
  • 2001-09. Normalizing tumor vasculature with anti-angiogenic therapy: A new paradigm for combination therapy in NATURE MEDICINE
  • 2002-04. Dissecting tumour pathophysiology using intravital microscopy in NATURE REVIEWS CANCER
  • 2002-08. Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1 in NATURE MEDICINE
  • 1997-02. Interstitial pH and pO2 gradients in solid tumors in vivo: High-resolution measurements reveal a lack of correlation in NATURE MEDICINE
  • 2000-11. Flk1-positive cells derived from embryonic stem cells serve as vascular progenitors in NATURE
  • 2002-01. Myocardial gene therapy in NATURE
  • 2000-04. Mechanisms of angiogenesis and arteriogenesis in NATURE MEDICINE
  • 2001-11. Polymeric system for dual growth factor delivery in NATURE BIOTECHNOLOGY
  • 1999-10. Tumor–host interactions in the gallbladder suppress distal angiogenesis and tumor growth: Involvement of transforming growth factor β1 in NATURE MEDICINE
  • 2002-10. VEGF and the quest for tumour angiogenesis factors in NATURE REVIEWS CANCER
  • 2000-01. PR39, a peptide regulator of angiogenesis in NATURE MEDICINE
  • 2001-04. Neovascularization of ischemic myocardium by human bone-marrow–derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function in NATURE MEDICINE
  • 2000-09. Angiogenesis in cancer and other diseases in NATURE
  • 2003-06. Angiogenesis in health and disease in NATURE MEDICINE
  • 2001-03. TGFβ is required for the formation of capillary-like structures in three-dimensional cocultures of 10T1/2 and endothelial cells in ANGIOGENESIS
  • 2002-02. Specialization of tumour vasculature in NATURE REVIEWS CANCER
  • 2002-12. Inflammation and cancer in NATURE
  • 2001-07. In vivo measurement of gene expression, angiogenesis and physiological function in tumors using multiphoton laser scanning microscopy in NATURE MEDICINE
  • 2003-06. Imaging of angiogenesis: from microscope to clinic in NATURE MEDICINE
  • 2000-04. Angiopoietin-1 protects the adult vasculature against plasma leakage in NATURE MEDICINE
  • 1997-08. Solid stress inhibits the growth of multicellular tumor spheroids in NATURE BIOTECHNOLOGY
  • 2000-02. Leaky vessels? Call Ang1! in NATURE MEDICINE
  • 2003-04. Where a pill won't reach. in SCIENTIFIC AMERICAN
  • 2001-12. Vessels of death or life. in SCIENTIFIC AMERICAN
  • 2000-09. Vascular-specific growth factors and blood vessel formation in NATURE
  • 2002-05. Myofibroblasts and mechano-regulation of connective tissue remodelling in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 1996-09. During angiogenesis, vascular endothelial growth factor regulate natural killer cell adhesion to tumor endothelium in NATURE MEDICINE
  • Journal

    TITLE

    Nature Medicine

    ISSUE

    6

    VOLUME

    9

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nm0603-685

    DOI

    http://dx.doi.org/10.1038/nm0603-685

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1023460594

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/12778167


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Blood Vessels", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Endothelium, Vascular", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Extracellular Matrix", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neovascularization, Pathologic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neovascularization, Physiologic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Signal Transduction", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "name": [
                "E.L. Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 100 Blossom Street, Boston, Massachusetts 02114, USA. jain@steele.mgh.harvard.edu"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jain", 
            "givenName": "Rakesh K", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1159/000025622", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000110775"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/71527", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000556369", 
              "https://doi.org/10.1038/71527"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/71527", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000556369", 
              "https://doi.org/10.1038/71527"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1359-6101(99)00028-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001946883"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1359-6101(96)00048-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005221718"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.153.3.543", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008050371"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0603-713", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008659620", 
              "https://doi.org/10.1038/nm0603-713"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0603-713", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008659620", 
              "https://doi.org/10.1038/nm0603-713"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35025215", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009409437", 
              "https://doi.org/10.1038/35025215"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35025215", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009409437", 
              "https://doi.org/10.1038/35025215"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1388-1981(02)00139-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009530335"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/72212", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009758949", 
              "https://doi.org/10.1038/72212"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0074-7696(01)04002-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009876833"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.cir.102.18.2255", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010087968"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0955-0674(00)00143-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010139482"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0603-653", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010143012", 
              "https://doi.org/10.1038/nm0603-653"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0603-653", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010143012", 
              "https://doi.org/10.1038/nm0603-653"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.95.8.4607", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010786456"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0026-2862(81)90003-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012024497"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/sj.mn.7800173", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012489831"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/94.6.417", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012756649"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/74651", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013330715", 
              "https://doi.org/10.1038/74651"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/74651", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013330715", 
              "https://doi.org/10.1038/74651"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0002-9440(10)63847-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013423475"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1469-7793.1999.001af.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014017819"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.res.84.3.298", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014990839"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0955-0674(00)00194-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015200698"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/89997", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015354678", 
              "https://doi.org/10.1038/89997"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/89997", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015354678", 
              "https://doi.org/10.1038/89997"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/89997", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015354678", 
              "https://doi.org/10.1038/89997"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0902-918", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015536783", 
              "https://doi.org/10.1038/nm0902-918"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0902-918", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015536783", 
              "https://doi.org/10.1038/nm0902-918"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/415234a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015714386", 
              "https://doi.org/10.1038/415234a"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/415234a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015714386", 
              "https://doi.org/10.1038/415234a"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0002-9440(10)64920-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016535980"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0014-5793(02)03742-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016923506"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/excr.2000.5133", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017438163"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)81731-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017592303"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc778", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017974354", 
              "https://doi.org/10.1038/nrc778"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc778", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017974354", 
              "https://doi.org/10.1038/nrc778"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.97.26.14608", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018416746"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01322", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019336134", 
              "https://doi.org/10.1038/nature01322"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01322", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019336134", 
              "https://doi.org/10.1038/nature01322"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35040568", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019378335", 
              "https://doi.org/10.1038/35040568"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35040568", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019378335", 
              "https://doi.org/10.1038/35040568"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0996-992", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020266312", 
              "https://doi.org/10.1038/nm0996-992"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci5028", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022103776"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/emboj/21.7.1535", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022411044"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc724", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022623295", 
              "https://doi.org/10.1038/nrc724"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc724", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022623295", 
              "https://doi.org/10.1038/nrc724"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.cir.97.12.1114", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022909671"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.150242297", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023323215"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2002-06-1877", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023436191"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.cir.0000031525.61826.a8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024701052"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0297-177", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025563287", 
              "https://doi.org/10.1038/nm0297-177"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci16157", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026200638"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/85655", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027298856", 
              "https://doi.org/10.1038/85655"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/85655", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027298856", 
              "https://doi.org/10.1038/85655"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1535-6108(02)00051-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029815551"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.cellbio.18.012502.105825", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032623557"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0945-053x(01)00149-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033259796"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0301-472x(02)00869-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034217844"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/hh2401.100844", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034253793"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt1101-1029", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034690773", 
              "https://doi.org/10.1038/nbt1101-1029"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt1101-1029", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034690773", 
              "https://doi.org/10.1038/nbt1101-1029"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.032074999", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035295182"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/416279b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035406433", 
              "https://doi.org/10.1038/416279b"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/416279b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035406433", 
              "https://doi.org/10.1038/416279b"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/scdb.2001.0285", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035763054"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m108347200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036076719"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt0897-778", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037588020", 
              "https://doi.org/10.1038/nbt0897-778"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1050-1738(01)00140-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038687578"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.res.0000065621.69843.49", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038816630"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.res.0000065621.69843.49", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038816630"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/86498", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039983093", 
              "https://doi.org/10.1038/86498"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2337/diabetes.50.3.667", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040256432"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc909", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040662917", 
              "https://doi.org/10.1038/nrc909"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc909", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040662917", 
              "https://doi.org/10.1038/nrc909"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm809", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040709899", 
              "https://doi.org/10.1038/nrm809"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm809", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040709899", 
              "https://doi.org/10.1038/nrm809"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1357-4310(98)01372-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040773848"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1096/fj.02-0586fje", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041343559"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1096/fj.00-0490fje", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041506638"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/jcs.00071", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041675144"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.914801", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042219163"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/13524", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042429861", 
              "https://doi.org/10.1038/13524"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/13524", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042429861", 
              "https://doi.org/10.1038/13524"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35025220", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043028620", 
              "https://doi.org/10.1038/35025220"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35025220", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043028620", 
              "https://doi.org/10.1038/35025220"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1016611824696", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043268994", 
              "https://doi.org/10.1023/a:1016611824696"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm731", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043669041", 
              "https://doi.org/10.1038/nm731"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm731", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043669041", 
              "https://doi.org/10.1038/nm731"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2002-03-0755", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046430552"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0002-9440(10)65006-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048305964"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.95.18.10820", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049541248"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1096/fj.02-0340fje", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050520691"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/emboj/21.7.1743", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051391684"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(02)00757-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052405097"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3109/10739689709146803", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053244823"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/74725", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053268935", 
              "https://doi.org/10.1038/74725"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/74725", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053268935", 
              "https://doi.org/10.1038/74725"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0901-987", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053699875", 
              "https://doi.org/10.1038/nm0901-987"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0901-987", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053699875", 
              "https://doi.org/10.1038/nm0901-987"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0008-6363(02)00259-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054578061"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/scientificamerican0403-50", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056514606", 
              "https://doi.org/10.1038/scientificamerican0403-50"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/scientificamerican1201-38", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056630771", 
              "https://doi.org/10.1038/scientificamerican1201-38"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/15396850360495664", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059215508"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/15396850360495673", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059215509"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1071420", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062446516"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1081345", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062447834"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.284.5413.489", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062564945"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci14327", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063415261"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci15621", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063415410"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci17929", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063416312"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpcell.1999.277.1.c1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074492005"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074608463", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074677014", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074795141", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082427072", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082909414", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2003-06", 
        "datePublishedReg": "2003-06-01", 
        "description": "The maturation of nascent vasculature, formed by vasculogenesis or angiogenesis, requires recruitment of mural cells, generation of an extracellular matrix and specialization of the vessel wall for structural support and regulation of vessel function. In addition, the vascular network must be organized so that all the parenchymal cells receive adequate nutrients. All of these processes are orchestrated by physical forces as well as by a constellation of ligands and receptors whose spatio-temporal patterns of expression and concentration are tightly regulated. Inappropriate levels of these physical forces or molecules produce an abnormal vasculature--a hallmark of various pathologies. Normalization of the abnormal vasculature can facilitate drug delivery to tumors and formation of a mature vasculature can help realize the promise of therapeutic angiogenesis and tissue engineering.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/nm0603-685", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1113716", 
            "issn": [
              "1078-8956", 
              "1546-170X"
            ], 
            "name": "Nature Medicine", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "6", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "9"
          }
        ], 
        "name": "Molecular regulation of vessel maturation", 
        "pagination": "685-693", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "6fc5def23cf70a72f011c7270eb7c836bddf51feb31ee9077960224951b19b5f"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "12778167"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9502015"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nm0603-685"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1023460594"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nm0603-685", 
          "https://app.dimensions.ai/details/publication/pub.1023460594"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T12:22", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000362_0000000362/records_87088_00000000.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/articles/nm0603-685"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nm0603-685'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nm0603-685'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nm0603-685'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nm0603-685'


     

    This table displays all metadata directly associated to this object as RDF triples.

    416 TRIPLES      21 PREDICATES      134 URIs      30 LITERALS      18 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nm0603-685 schema:about N1e9d1094ec9a44998e21a35ce6233102
    2 N53073ad0eff04b109dd4f20060d0ec8d
    3 N5f81b72e438b4d35a12ca569eceef38a
    4 N6088777ca1c94ad8907a6caaecae92f5
    5 N753c273e14d6417f94619b853415e84a
    6 Nb0eb4abddf6d4ce4ba637a938a4455ec
    7 Nceba512a7a4043088dfe3a95a19bc8cb
    8 Nd871ed3451fa424f9ab1a9dd3adc4e63
    9 Nd926a6627a4a40d695b852f2ec5fafd3
    10 anzsrc-for:06
    11 anzsrc-for:0601
    12 schema:author Nacbf6e38c20f4f2b85f09489064f4115
    13 schema:citation sg:pub.10.1023/a:1016611824696
    14 sg:pub.10.1038/13524
    15 sg:pub.10.1038/35025215
    16 sg:pub.10.1038/35025220
    17 sg:pub.10.1038/35040568
    18 sg:pub.10.1038/415234a
    19 sg:pub.10.1038/416279b
    20 sg:pub.10.1038/71527
    21 sg:pub.10.1038/72212
    22 sg:pub.10.1038/74651
    23 sg:pub.10.1038/74725
    24 sg:pub.10.1038/85655
    25 sg:pub.10.1038/86498
    26 sg:pub.10.1038/89997
    27 sg:pub.10.1038/nature01322
    28 sg:pub.10.1038/nbt0897-778
    29 sg:pub.10.1038/nbt1101-1029
    30 sg:pub.10.1038/nm0297-177
    31 sg:pub.10.1038/nm0603-653
    32 sg:pub.10.1038/nm0603-713
    33 sg:pub.10.1038/nm0901-987
    34 sg:pub.10.1038/nm0902-918
    35 sg:pub.10.1038/nm0996-992
    36 sg:pub.10.1038/nm731
    37 sg:pub.10.1038/nrc724
    38 sg:pub.10.1038/nrc778
    39 sg:pub.10.1038/nrc909
    40 sg:pub.10.1038/nrm809
    41 sg:pub.10.1038/scientificamerican0403-50
    42 sg:pub.10.1038/scientificamerican1201-38
    43 https://app.dimensions.ai/details/publication/pub.1074608463
    44 https://app.dimensions.ai/details/publication/pub.1074677014
    45 https://app.dimensions.ai/details/publication/pub.1074795141
    46 https://app.dimensions.ai/details/publication/pub.1082427072
    47 https://app.dimensions.ai/details/publication/pub.1082909414
    48 https://doi.org/10.1006/excr.2000.5133
    49 https://doi.org/10.1006/scdb.2001.0285
    50 https://doi.org/10.1016/0026-2862(81)90003-0
    51 https://doi.org/10.1016/s0002-9440(10)63847-3
    52 https://doi.org/10.1016/s0002-9440(10)64920-6
    53 https://doi.org/10.1016/s0002-9440(10)65006-7
    54 https://doi.org/10.1016/s0008-6363(02)00259-6
    55 https://doi.org/10.1016/s0014-5793(02)03742-0
    56 https://doi.org/10.1016/s0074-7696(01)04002-5
    57 https://doi.org/10.1016/s0092-8674(00)81731-6
    58 https://doi.org/10.1016/s0092-8674(02)00757-2
    59 https://doi.org/10.1016/s0301-472x(02)00869-x
    60 https://doi.org/10.1016/s0945-053x(01)00149-4
    61 https://doi.org/10.1016/s0955-0674(00)00143-5
    62 https://doi.org/10.1016/s0955-0674(00)00194-0
    63 https://doi.org/10.1016/s1050-1738(01)00140-2
    64 https://doi.org/10.1016/s1357-4310(98)01372-0
    65 https://doi.org/10.1016/s1359-6101(96)00048-2
    66 https://doi.org/10.1016/s1359-6101(99)00028-3
    67 https://doi.org/10.1016/s1388-1981(02)00139-7
    68 https://doi.org/10.1016/s1535-6108(02)00051-x
    69 https://doi.org/10.1038/sj.mn.7800173
    70 https://doi.org/10.1073/pnas.032074999
    71 https://doi.org/10.1073/pnas.150242297
    72 https://doi.org/10.1073/pnas.95.18.10820
    73 https://doi.org/10.1073/pnas.95.8.4607
    74 https://doi.org/10.1073/pnas.97.26.14608
    75 https://doi.org/10.1074/jbc.m108347200
    76 https://doi.org/10.1083/jcb.153.3.543
    77 https://doi.org/10.1089/15396850360495664
    78 https://doi.org/10.1089/15396850360495673
    79 https://doi.org/10.1093/emboj/21.7.1535
    80 https://doi.org/10.1093/emboj/21.7.1743
    81 https://doi.org/10.1093/jnci/94.6.417
    82 https://doi.org/10.1096/fj.00-0490fje
    83 https://doi.org/10.1096/fj.02-0340fje
    84 https://doi.org/10.1096/fj.02-0586fje
    85 https://doi.org/10.1101/gad.914801
    86 https://doi.org/10.1111/j.1469-7793.1999.001af.x
    87 https://doi.org/10.1126/science.1071420
    88 https://doi.org/10.1126/science.1081345
    89 https://doi.org/10.1126/science.284.5413.489
    90 https://doi.org/10.1146/annurev.cellbio.18.012502.105825
    91 https://doi.org/10.1152/ajpcell.1999.277.1.c1
    92 https://doi.org/10.1159/000025622
    93 https://doi.org/10.1161/01.cir.0000031525.61826.a8
    94 https://doi.org/10.1161/01.cir.102.18.2255
    95 https://doi.org/10.1161/01.cir.97.12.1114
    96 https://doi.org/10.1161/01.res.0000065621.69843.49
    97 https://doi.org/10.1161/01.res.84.3.298
    98 https://doi.org/10.1161/hh2401.100844
    99 https://doi.org/10.1172/jci14327
    100 https://doi.org/10.1172/jci15621
    101 https://doi.org/10.1172/jci16157
    102 https://doi.org/10.1172/jci17929
    103 https://doi.org/10.1172/jci5028
    104 https://doi.org/10.1182/blood-2002-03-0755
    105 https://doi.org/10.1182/blood-2002-06-1877
    106 https://doi.org/10.1242/jcs.00071
    107 https://doi.org/10.2337/diabetes.50.3.667
    108 https://doi.org/10.3109/10739689709146803
    109 schema:datePublished 2003-06
    110 schema:datePublishedReg 2003-06-01
    111 schema:description The maturation of nascent vasculature, formed by vasculogenesis or angiogenesis, requires recruitment of mural cells, generation of an extracellular matrix and specialization of the vessel wall for structural support and regulation of vessel function. In addition, the vascular network must be organized so that all the parenchymal cells receive adequate nutrients. All of these processes are orchestrated by physical forces as well as by a constellation of ligands and receptors whose spatio-temporal patterns of expression and concentration are tightly regulated. Inappropriate levels of these physical forces or molecules produce an abnormal vasculature--a hallmark of various pathologies. Normalization of the abnormal vasculature can facilitate drug delivery to tumors and formation of a mature vasculature can help realize the promise of therapeutic angiogenesis and tissue engineering.
    112 schema:genre research_article
    113 schema:inLanguage en
    114 schema:isAccessibleForFree false
    115 schema:isPartOf N4ac3e584dc1c4a319259c1c6f6c09dda
    116 Nf1ff09026cc64dad908b97aad792aa30
    117 sg:journal.1113716
    118 schema:name Molecular regulation of vessel maturation
    119 schema:pagination 685-693
    120 schema:productId N13130b3311554a1188d295598069cde2
    121 N319e43c226164fe88eacc2c754d1c7fe
    122 N32624c2c19ce4749961cad9e2ba82438
    123 N52135b862760440fb4d253441d984611
    124 N76ba1172e72f4ad7b4e9ed7ddc947ba2
    125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023460594
    126 https://doi.org/10.1038/nm0603-685
    127 schema:sdDatePublished 2019-04-11T12:22
    128 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    129 schema:sdPublisher Na50dc6b6572647a3a2742e0a88356fee
    130 schema:url http://www.nature.com/articles/nm0603-685
    131 sgo:license sg:explorer/license/
    132 sgo:sdDataset articles
    133 rdf:type schema:ScholarlyArticle
    134 N13130b3311554a1188d295598069cde2 schema:name readcube_id
    135 schema:value 6fc5def23cf70a72f011c7270eb7c836bddf51feb31ee9077960224951b19b5f
    136 rdf:type schema:PropertyValue
    137 N1e9d1094ec9a44998e21a35ce6233102 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    138 schema:name Signal Transduction
    139 rdf:type schema:DefinedTerm
    140 N319e43c226164fe88eacc2c754d1c7fe schema:name pubmed_id
    141 schema:value 12778167
    142 rdf:type schema:PropertyValue
    143 N32624c2c19ce4749961cad9e2ba82438 schema:name dimensions_id
    144 schema:value pub.1023460594
    145 rdf:type schema:PropertyValue
    146 N4ac3e584dc1c4a319259c1c6f6c09dda schema:issueNumber 6
    147 rdf:type schema:PublicationIssue
    148 N52135b862760440fb4d253441d984611 schema:name nlm_unique_id
    149 schema:value 9502015
    150 rdf:type schema:PropertyValue
    151 N53073ad0eff04b109dd4f20060d0ec8d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    152 schema:name Extracellular Matrix
    153 rdf:type schema:DefinedTerm
    154 N5f81b72e438b4d35a12ca569eceef38a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    155 schema:name Animals
    156 rdf:type schema:DefinedTerm
    157 N6088777ca1c94ad8907a6caaecae92f5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    158 schema:name Blood Vessels
    159 rdf:type schema:DefinedTerm
    160 N65a78eba825d41c3ae9a243d163b5119 schema:affiliation N860a97727a8c4eb488b789698d0b71c1
    161 schema:familyName Jain
    162 schema:givenName Rakesh K
    163 rdf:type schema:Person
    164 N753c273e14d6417f94619b853415e84a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    165 schema:name Humans
    166 rdf:type schema:DefinedTerm
    167 N76ba1172e72f4ad7b4e9ed7ddc947ba2 schema:name doi
    168 schema:value 10.1038/nm0603-685
    169 rdf:type schema:PropertyValue
    170 N860a97727a8c4eb488b789698d0b71c1 schema:name E.L. Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 100 Blossom Street, Boston, Massachusetts 02114, USA. jain@steele.mgh.harvard.edu
    171 rdf:type schema:Organization
    172 Na50dc6b6572647a3a2742e0a88356fee schema:name Springer Nature - SN SciGraph project
    173 rdf:type schema:Organization
    174 Nacbf6e38c20f4f2b85f09489064f4115 rdf:first N65a78eba825d41c3ae9a243d163b5119
    175 rdf:rest rdf:nil
    176 Nb0eb4abddf6d4ce4ba637a938a4455ec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    177 schema:name Neovascularization, Pathologic
    178 rdf:type schema:DefinedTerm
    179 Nceba512a7a4043088dfe3a95a19bc8cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    180 schema:name Neoplasms
    181 rdf:type schema:DefinedTerm
    182 Nd871ed3451fa424f9ab1a9dd3adc4e63 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    183 schema:name Endothelium, Vascular
    184 rdf:type schema:DefinedTerm
    185 Nd926a6627a4a40d695b852f2ec5fafd3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    186 schema:name Neovascularization, Physiologic
    187 rdf:type schema:DefinedTerm
    188 Nf1ff09026cc64dad908b97aad792aa30 schema:volumeNumber 9
    189 rdf:type schema:PublicationVolume
    190 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    191 schema:name Biological Sciences
    192 rdf:type schema:DefinedTerm
    193 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    194 schema:name Biochemistry and Cell Biology
    195 rdf:type schema:DefinedTerm
    196 sg:journal.1113716 schema:issn 1078-8956
    197 1546-170X
    198 schema:name Nature Medicine
    199 rdf:type schema:Periodical
    200 sg:pub.10.1023/a:1016611824696 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043268994
    201 https://doi.org/10.1023/a:1016611824696
    202 rdf:type schema:CreativeWork
    203 sg:pub.10.1038/13524 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042429861
    204 https://doi.org/10.1038/13524
    205 rdf:type schema:CreativeWork
    206 sg:pub.10.1038/35025215 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009409437
    207 https://doi.org/10.1038/35025215
    208 rdf:type schema:CreativeWork
    209 sg:pub.10.1038/35025220 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043028620
    210 https://doi.org/10.1038/35025220
    211 rdf:type schema:CreativeWork
    212 sg:pub.10.1038/35040568 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019378335
    213 https://doi.org/10.1038/35040568
    214 rdf:type schema:CreativeWork
    215 sg:pub.10.1038/415234a schema:sameAs https://app.dimensions.ai/details/publication/pub.1015714386
    216 https://doi.org/10.1038/415234a
    217 rdf:type schema:CreativeWork
    218 sg:pub.10.1038/416279b schema:sameAs https://app.dimensions.ai/details/publication/pub.1035406433
    219 https://doi.org/10.1038/416279b
    220 rdf:type schema:CreativeWork
    221 sg:pub.10.1038/71527 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000556369
    222 https://doi.org/10.1038/71527
    223 rdf:type schema:CreativeWork
    224 sg:pub.10.1038/72212 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009758949
    225 https://doi.org/10.1038/72212
    226 rdf:type schema:CreativeWork
    227 sg:pub.10.1038/74651 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013330715
    228 https://doi.org/10.1038/74651
    229 rdf:type schema:CreativeWork
    230 sg:pub.10.1038/74725 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053268935
    231 https://doi.org/10.1038/74725
    232 rdf:type schema:CreativeWork
    233 sg:pub.10.1038/85655 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027298856
    234 https://doi.org/10.1038/85655
    235 rdf:type schema:CreativeWork
    236 sg:pub.10.1038/86498 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039983093
    237 https://doi.org/10.1038/86498
    238 rdf:type schema:CreativeWork
    239 sg:pub.10.1038/89997 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015354678
    240 https://doi.org/10.1038/89997
    241 rdf:type schema:CreativeWork
    242 sg:pub.10.1038/nature01322 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019336134
    243 https://doi.org/10.1038/nature01322
    244 rdf:type schema:CreativeWork
    245 sg:pub.10.1038/nbt0897-778 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037588020
    246 https://doi.org/10.1038/nbt0897-778
    247 rdf:type schema:CreativeWork
    248 sg:pub.10.1038/nbt1101-1029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034690773
    249 https://doi.org/10.1038/nbt1101-1029
    250 rdf:type schema:CreativeWork
    251 sg:pub.10.1038/nm0297-177 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025563287
    252 https://doi.org/10.1038/nm0297-177
    253 rdf:type schema:CreativeWork
    254 sg:pub.10.1038/nm0603-653 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010143012
    255 https://doi.org/10.1038/nm0603-653
    256 rdf:type schema:CreativeWork
    257 sg:pub.10.1038/nm0603-713 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008659620
    258 https://doi.org/10.1038/nm0603-713
    259 rdf:type schema:CreativeWork
    260 sg:pub.10.1038/nm0901-987 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053699875
    261 https://doi.org/10.1038/nm0901-987
    262 rdf:type schema:CreativeWork
    263 sg:pub.10.1038/nm0902-918 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015536783
    264 https://doi.org/10.1038/nm0902-918
    265 rdf:type schema:CreativeWork
    266 sg:pub.10.1038/nm0996-992 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020266312
    267 https://doi.org/10.1038/nm0996-992
    268 rdf:type schema:CreativeWork
    269 sg:pub.10.1038/nm731 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043669041
    270 https://doi.org/10.1038/nm731
    271 rdf:type schema:CreativeWork
    272 sg:pub.10.1038/nrc724 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022623295
    273 https://doi.org/10.1038/nrc724
    274 rdf:type schema:CreativeWork
    275 sg:pub.10.1038/nrc778 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017974354
    276 https://doi.org/10.1038/nrc778
    277 rdf:type schema:CreativeWork
    278 sg:pub.10.1038/nrc909 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040662917
    279 https://doi.org/10.1038/nrc909
    280 rdf:type schema:CreativeWork
    281 sg:pub.10.1038/nrm809 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040709899
    282 https://doi.org/10.1038/nrm809
    283 rdf:type schema:CreativeWork
    284 sg:pub.10.1038/scientificamerican0403-50 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056514606
    285 https://doi.org/10.1038/scientificamerican0403-50
    286 rdf:type schema:CreativeWork
    287 sg:pub.10.1038/scientificamerican1201-38 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056630771
    288 https://doi.org/10.1038/scientificamerican1201-38
    289 rdf:type schema:CreativeWork
    290 https://app.dimensions.ai/details/publication/pub.1074608463 schema:CreativeWork
    291 https://app.dimensions.ai/details/publication/pub.1074677014 schema:CreativeWork
    292 https://app.dimensions.ai/details/publication/pub.1074795141 schema:CreativeWork
    293 https://app.dimensions.ai/details/publication/pub.1082427072 schema:CreativeWork
    294 https://app.dimensions.ai/details/publication/pub.1082909414 schema:CreativeWork
    295 https://doi.org/10.1006/excr.2000.5133 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017438163
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1006/scdb.2001.0285 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035763054
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1016/0026-2862(81)90003-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012024497
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1016/s0002-9440(10)63847-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013423475
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1016/s0002-9440(10)64920-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016535980
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1016/s0002-9440(10)65006-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048305964
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1016/s0008-6363(02)00259-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054578061
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1016/s0014-5793(02)03742-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016923506
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1016/s0074-7696(01)04002-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009876833
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1016/s0092-8674(00)81731-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017592303
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1016/s0092-8674(02)00757-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052405097
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1016/s0301-472x(02)00869-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1034217844
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1016/s0945-053x(01)00149-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033259796
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1016/s0955-0674(00)00143-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010139482
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1016/s0955-0674(00)00194-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015200698
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1016/s1050-1738(01)00140-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038687578
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1016/s1357-4310(98)01372-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040773848
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1016/s1359-6101(96)00048-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005221718
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1016/s1359-6101(99)00028-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001946883
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.1016/s1388-1981(02)00139-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009530335
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.1016/s1535-6108(02)00051-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1029815551
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1038/sj.mn.7800173 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012489831
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.1073/pnas.032074999 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035295182
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.1073/pnas.150242297 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023323215
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.1073/pnas.95.18.10820 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049541248
    344 rdf:type schema:CreativeWork
    345 https://doi.org/10.1073/pnas.95.8.4607 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010786456
    346 rdf:type schema:CreativeWork
    347 https://doi.org/10.1073/pnas.97.26.14608 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018416746
    348 rdf:type schema:CreativeWork
    349 https://doi.org/10.1074/jbc.m108347200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036076719
    350 rdf:type schema:CreativeWork
    351 https://doi.org/10.1083/jcb.153.3.543 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008050371
    352 rdf:type schema:CreativeWork
    353 https://doi.org/10.1089/15396850360495664 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059215508
    354 rdf:type schema:CreativeWork
    355 https://doi.org/10.1089/15396850360495673 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059215509
    356 rdf:type schema:CreativeWork
    357 https://doi.org/10.1093/emboj/21.7.1535 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022411044
    358 rdf:type schema:CreativeWork
    359 https://doi.org/10.1093/emboj/21.7.1743 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051391684
    360 rdf:type schema:CreativeWork
    361 https://doi.org/10.1093/jnci/94.6.417 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012756649
    362 rdf:type schema:CreativeWork
    363 https://doi.org/10.1096/fj.00-0490fje schema:sameAs https://app.dimensions.ai/details/publication/pub.1041506638
    364 rdf:type schema:CreativeWork
    365 https://doi.org/10.1096/fj.02-0340fje schema:sameAs https://app.dimensions.ai/details/publication/pub.1050520691
    366 rdf:type schema:CreativeWork
    367 https://doi.org/10.1096/fj.02-0586fje schema:sameAs https://app.dimensions.ai/details/publication/pub.1041343559
    368 rdf:type schema:CreativeWork
    369 https://doi.org/10.1101/gad.914801 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042219163
    370 rdf:type schema:CreativeWork
    371 https://doi.org/10.1111/j.1469-7793.1999.001af.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1014017819
    372 rdf:type schema:CreativeWork
    373 https://doi.org/10.1126/science.1071420 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062446516
    374 rdf:type schema:CreativeWork
    375 https://doi.org/10.1126/science.1081345 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062447834
    376 rdf:type schema:CreativeWork
    377 https://doi.org/10.1126/science.284.5413.489 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062564945
    378 rdf:type schema:CreativeWork
    379 https://doi.org/10.1146/annurev.cellbio.18.012502.105825 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032623557
    380 rdf:type schema:CreativeWork
    381 https://doi.org/10.1152/ajpcell.1999.277.1.c1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074492005
    382 rdf:type schema:CreativeWork
    383 https://doi.org/10.1159/000025622 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000110775
    384 rdf:type schema:CreativeWork
    385 https://doi.org/10.1161/01.cir.0000031525.61826.a8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024701052
    386 rdf:type schema:CreativeWork
    387 https://doi.org/10.1161/01.cir.102.18.2255 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010087968
    388 rdf:type schema:CreativeWork
    389 https://doi.org/10.1161/01.cir.97.12.1114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022909671
    390 rdf:type schema:CreativeWork
    391 https://doi.org/10.1161/01.res.0000065621.69843.49 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038816630
    392 rdf:type schema:CreativeWork
    393 https://doi.org/10.1161/01.res.84.3.298 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014990839
    394 rdf:type schema:CreativeWork
    395 https://doi.org/10.1161/hh2401.100844 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034253793
    396 rdf:type schema:CreativeWork
    397 https://doi.org/10.1172/jci14327 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063415261
    398 rdf:type schema:CreativeWork
    399 https://doi.org/10.1172/jci15621 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063415410
    400 rdf:type schema:CreativeWork
    401 https://doi.org/10.1172/jci16157 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026200638
    402 rdf:type schema:CreativeWork
    403 https://doi.org/10.1172/jci17929 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063416312
    404 rdf:type schema:CreativeWork
    405 https://doi.org/10.1172/jci5028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022103776
    406 rdf:type schema:CreativeWork
    407 https://doi.org/10.1182/blood-2002-03-0755 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046430552
    408 rdf:type schema:CreativeWork
    409 https://doi.org/10.1182/blood-2002-06-1877 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023436191
    410 rdf:type schema:CreativeWork
    411 https://doi.org/10.1242/jcs.00071 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041675144
    412 rdf:type schema:CreativeWork
    413 https://doi.org/10.2337/diabetes.50.3.667 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040256432
    414 rdf:type schema:CreativeWork
    415 https://doi.org/10.3109/10739689709146803 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053244823
    416 rdf:type schema:CreativeWork
     




    Preview window. Press ESC to close (or click here)


    ...