Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell derived exosomes View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1998-05

AUTHORS

Laurence Zitvogel, Armelle Regnault, Anne Lozier, Joseph Wolfers, Caroline Flament, Danielle Tenza, Paola Ricciardi-Castagnoli, Graça Raposo, Sebastian Amigorena

ABSTRACT

Dendritic cells (DCs) are professional antigen presenting cells with the unique capacity to induce primary and secondary immune responses in vivo. Here, we show that DCs secrete antigen presenting vesicles, called exosomes, which express functional Major Histocompatibility Complex class I and class II, and T-cell costimulatory molecules. Tumor peptide-pulsed DC-derived exosomes prime specific cytotoxic T lymphocytes in vivo and eradicate or suppress growth of established murine tumors in a T cell-dependent manner. Exosome-based cell-free vaccines represent an alternative to DC adoptive therapy for suppressing tumor growth. More... »

PAGES

594-600

Journal

TITLE

Nature Medicine

ISSUE

5

VOLUME

4

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nm0598-594

    DOI

    http://dx.doi.org/10.1038/nm0598-594

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1001835763

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/9585234


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    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nm0598-594'

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    RDF/XML is a standard XML format for linked data.

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