The cyclin-dependent kinase inhibitor p27Kip1 safeguards against inflammatory injury View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1998-05

AUTHORS

Vuddhidej Ophascharoensuk, Matthew L. Fero, Jeremy Hughes, James M. Roberts, Stuart J. Shankland

ABSTRACT

The cyclin-dependent kinase inhibitor p27Kip1 controls cell proliferation in response to normal mitogenic stimuli. We show here that p27Kip1 also safeguards against excessive cell proliferation in specific pathophysioiogic settings. We used experimental glomerulonephritis as a paradigm for immune mediated inflammation and ureteral obstruction as a model for non-immune mediated inflammation. Renal function was substantially decreased in nephritic p27−/− mice compared with control mice, and this was associated with increased glomerular cell proliferation, apoptosis and matrix protein accumulation. Tubular epithelial cell proliferation and apoptosis was also increased in p27−/− mice following ureteral obstruction. p27Kip1 may have a general role in protecting cells and tissues from inflammatory injury. More... »

PAGES

575-580

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nm0598-575

DOI

http://dx.doi.org/10.1038/nm0598-575

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1043972437

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9585231


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "CDC2-CDC28 Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Cycle Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Division", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclin-Dependent Kinase 2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclin-Dependent Kinase Inhibitor p27", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclin-Dependent Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glomerulonephritis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kidney", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kidney Function Tests", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kidney Glomerulus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kidney Tubules", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Mutant Strains", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microtubule-Associated Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Serine-Threonine Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Suppressor Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ureteral Obstruction", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Basic Sciences, 1100 Fairview Avenue North, 98109, Seattle, Washington, USA", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Basic Sciences, 1100 Fairview Avenue North, 98109, Seattle, Washington, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ophascharoensuk", 
        "givenName": "Vuddhidej", 
        "id": "sg:person.01071120760.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071120760.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Basic Sciences, 1100 Fairview Avenue North, 98109, Seattle, Washington, USA", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Basic Sciences, 1100 Fairview Avenue North, 98109, Seattle, Washington, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fero", 
        "givenName": "Matthew L.", 
        "id": "sg:person.01010146146.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010146146.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Basic Sciences, 1100 Fairview Avenue North, 98109, Seattle, Washington, USA", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Basic Sciences, 1100 Fairview Avenue North, 98109, Seattle, Washington, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hughes", 
        "givenName": "Jeremy", 
        "id": "sg:person.016636123627.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016636123627.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, 98109, Seattle, Washington, USA", 
          "id": "http://www.grid.ac/institutes/grid.270240.3", 
          "name": [
            "Department of Basic Sciences, 1100 Fairview Avenue North, 98109, Seattle, Washington, USA", 
            "Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, 98109, Seattle, Washington, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Roberts", 
        "givenName": "James M.", 
        "id": "sg:person.014177104362.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014177104362.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Nephrology, Department of Medicine, University of Washington School of Medicine, 1959 NE Pacific Avenue, Box 356521, 98195-6521, Seattle, Washington, USA", 
          "id": "http://www.grid.ac/institutes/grid.34477.33", 
          "name": [
            "Division of Nephrology, Department of Medicine, University of Washington School of Medicine, 1959 NE Pacific Avenue, Box 356521, 98195-6521, Seattle, Washington, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shankland", 
        "givenName": "Stuart J.", 
        "id": "sg:person.0740164607.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740164607.60"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nm0297-222", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045491685", 
          "https://doi.org/10.1038/nm0297-222"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/372570a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048925981", 
          "https://doi.org/10.1038/372570a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/374131a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029953704", 
          "https://doi.org/10.1038/374131a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm0297-227", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011434633", 
          "https://doi.org/10.1038/nm0297-227"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm0297-231", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003429757", 
          "https://doi.org/10.1038/nm0297-231"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1998-05", 
    "datePublishedReg": "1998-05-01", 
    "description": "The cyclin-dependent kinase inhibitor p27Kip1 controls cell proliferation in response to normal mitogenic stimuli. We show here that p27Kip1 also safeguards against excessive cell proliferation in specific pathophysioiogic settings. We used experimental glomerulonephritis as a paradigm for immune mediated inflammation and ureteral obstruction as a model for non-immune mediated inflammation. Renal function was substantially decreased in nephritic p27\u2212/\u2212 mice compared with control mice, and this was associated with increased glomerular cell proliferation, apoptosis and matrix protein accumulation. Tubular epithelial cell proliferation and apoptosis was also increased in p27\u2212/\u2212 mice following ureteral obstruction. p27Kip1 may have a general role in protecting cells and tissues from inflammatory injury.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/nm0598-575", 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2495660", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2495819", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1113716", 
        "issn": [
          "1078-8956", 
          "1546-170X"
        ], 
        "name": "Nature Medicine", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "4"
      }
    ], 
    "keywords": [
      "inflammatory injury", 
      "ureteral obstruction", 
      "cell proliferation", 
      "tubular epithelial cell proliferation", 
      "glomerular cell proliferation", 
      "matrix protein accumulation", 
      "epithelial cell proliferation", 
      "cyclin-dependent kinase inhibitor p27Kip1", 
      "renal function", 
      "control mice", 
      "experimental glomerulonephritis", 
      "excessive cell proliferation", 
      "mice", 
      "mitogenic stimuli", 
      "inflammation", 
      "obstruction", 
      "injury", 
      "p27Kip1", 
      "proliferation", 
      "apoptosis", 
      "protein accumulation", 
      "glomerulonephritis", 
      "tissue", 
      "general role", 
      "cells", 
      "stimuli", 
      "setting", 
      "response", 
      "role", 
      "accumulation", 
      "function", 
      "paradigm", 
      "model", 
      "safeguards"
    ], 
    "name": "The cyclin-dependent kinase inhibitor p27Kip1 safeguards against inflammatory injury", 
    "pagination": "575-580", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1043972437"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nm0598-575"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "9585231"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nm0598-575", 
      "https://app.dimensions.ai/details/publication/pub.1043972437"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-08-04T16:52", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_293.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/nm0598-575"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nm0598-575'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nm0598-575'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nm0598-575'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nm0598-575'


 

This table displays all metadata directly associated to this object as RDF triples.

230 TRIPLES      21 PREDICATES      84 URIs      71 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nm0598-575 schema:about N0ff96b23e02e4be6842c8ae64450dbe7
2 N22eb322d4a944754803e2ad370cd4cdd
3 N34d4d903509c470596211dd90a417a8a
4 N3fb4485406304e2ba8b1494244f8bf2a
5 N428432a83bf0411e9321e486ecae6de4
6 N440183f1848441bb8b082a105bdb1885
7 N5925f88f980b440ca95a45f95b109810
8 N5b7a5d5d14f048f48683e7a71f8bc426
9 N5daba62852fb493185d11a1f7d38bc18
10 N6379d177e39046c39701bd51316650f0
11 N853dfaac5ecc4360b8c9c41b06f972dd
12 N93bc184c75d94c26924e789076068f64
13 N9a0cd263d3244e63a8afb902570f9bdb
14 N9fc34e608f4b4d808610a09d9ee0ef14
15 Na10882941f8f40bfa62d59babafcf8b8
16 Nbd63f09bf4b247bcb77726e809745f6a
17 Nd788a3b422654122b0ab37fd9d073048
18 Ndba97140177f441fa9dfba3068f85868
19 Ne6f28ed9af7640b4abecabd8c1d7ddaa
20 anzsrc-for:11
21 anzsrc-for:1107
22 schema:author Nff8d191c5e474ffea28e7686f3bb4e1e
23 schema:citation sg:pub.10.1038/372570a0
24 sg:pub.10.1038/374131a0
25 sg:pub.10.1038/nm0297-222
26 sg:pub.10.1038/nm0297-227
27 sg:pub.10.1038/nm0297-231
28 schema:datePublished 1998-05
29 schema:datePublishedReg 1998-05-01
30 schema:description The cyclin-dependent kinase inhibitor p27Kip1 controls cell proliferation in response to normal mitogenic stimuli. We show here that p27Kip1 also safeguards against excessive cell proliferation in specific pathophysioiogic settings. We used experimental glomerulonephritis as a paradigm for immune mediated inflammation and ureteral obstruction as a model for non-immune mediated inflammation. Renal function was substantially decreased in nephritic p27−/− mice compared with control mice, and this was associated with increased glomerular cell proliferation, apoptosis and matrix protein accumulation. Tubular epithelial cell proliferation and apoptosis was also increased in p27−/− mice following ureteral obstruction. p27Kip1 may have a general role in protecting cells and tissues from inflammatory injury.
31 schema:genre article
32 schema:isAccessibleForFree false
33 schema:isPartOf N43b67e6b3ec44ebb8d54c658ffa12926
34 N9cb9966e52634f6ba98a9d411126cc74
35 sg:journal.1113716
36 schema:keywords accumulation
37 apoptosis
38 cell proliferation
39 cells
40 control mice
41 cyclin-dependent kinase inhibitor p27Kip1
42 epithelial cell proliferation
43 excessive cell proliferation
44 experimental glomerulonephritis
45 function
46 general role
47 glomerular cell proliferation
48 glomerulonephritis
49 inflammation
50 inflammatory injury
51 injury
52 matrix protein accumulation
53 mice
54 mitogenic stimuli
55 model
56 obstruction
57 p27Kip1
58 paradigm
59 proliferation
60 protein accumulation
61 renal function
62 response
63 role
64 safeguards
65 setting
66 stimuli
67 tissue
68 tubular epithelial cell proliferation
69 ureteral obstruction
70 schema:name The cyclin-dependent kinase inhibitor p27Kip1 safeguards against inflammatory injury
71 schema:pagination 575-580
72 schema:productId N2c64869a980543feb7d12d7261bc451c
73 N850a9d5ebeeb45fa890c4f9261a0f20a
74 Nb198b744da214b8d80c6f0f2a04a79f4
75 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043972437
76 https://doi.org/10.1038/nm0598-575
77 schema:sdDatePublished 2022-08-04T16:52
78 schema:sdLicense https://scigraph.springernature.com/explorer/license/
79 schema:sdPublisher N758ebe9b36e14a80b370c58ef8452095
80 schema:url https://doi.org/10.1038/nm0598-575
81 sgo:license sg:explorer/license/
82 sgo:sdDataset articles
83 rdf:type schema:ScholarlyArticle
84 N0ff96b23e02e4be6842c8ae64450dbe7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Apoptosis
86 rdf:type schema:DefinedTerm
87 N1fe96e6e48794fc9b6fca9e7b78277f1 rdf:first sg:person.016636123627.34
88 rdf:rest N6278b5acd00d41c3aa41f23744a74437
89 N22eb322d4a944754803e2ad370cd4cdd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Kidney
91 rdf:type schema:DefinedTerm
92 N2c64869a980543feb7d12d7261bc451c schema:name pubmed_id
93 schema:value 9585231
94 rdf:type schema:PropertyValue
95 N34d4d903509c470596211dd90a417a8a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Animals
97 rdf:type schema:DefinedTerm
98 N3fb4485406304e2ba8b1494244f8bf2a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Microtubule-Associated Proteins
100 rdf:type schema:DefinedTerm
101 N428432a83bf0411e9321e486ecae6de4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Cell Cycle Proteins
103 rdf:type schema:DefinedTerm
104 N43b67e6b3ec44ebb8d54c658ffa12926 schema:volumeNumber 4
105 rdf:type schema:PublicationVolume
106 N440183f1848441bb8b082a105bdb1885 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name CDC2-CDC28 Kinases
108 rdf:type schema:DefinedTerm
109 N5925f88f980b440ca95a45f95b109810 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Ureteral Obstruction
111 rdf:type schema:DefinedTerm
112 N5b7a5d5d14f048f48683e7a71f8bc426 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Kidney Tubules
114 rdf:type schema:DefinedTerm
115 N5daba62852fb493185d11a1f7d38bc18 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Kidney Glomerulus
117 rdf:type schema:DefinedTerm
118 N6278b5acd00d41c3aa41f23744a74437 rdf:first sg:person.014177104362.78
119 rdf:rest Nfe13a5ca15c0454482dc63e6aa3303ca
120 N6379d177e39046c39701bd51316650f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Cell Division
122 rdf:type schema:DefinedTerm
123 N758ebe9b36e14a80b370c58ef8452095 schema:name Springer Nature - SN SciGraph project
124 rdf:type schema:Organization
125 N7ad935ba163b4f68bd1e2db522167a8f rdf:first sg:person.01010146146.20
126 rdf:rest N1fe96e6e48794fc9b6fca9e7b78277f1
127 N850a9d5ebeeb45fa890c4f9261a0f20a schema:name doi
128 schema:value 10.1038/nm0598-575
129 rdf:type schema:PropertyValue
130 N853dfaac5ecc4360b8c9c41b06f972dd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Cyclin-Dependent Kinases
132 rdf:type schema:DefinedTerm
133 N93bc184c75d94c26924e789076068f64 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Cyclin-Dependent Kinase Inhibitor p27
135 rdf:type schema:DefinedTerm
136 N9a0cd263d3244e63a8afb902570f9bdb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Mice, Mutant Strains
138 rdf:type schema:DefinedTerm
139 N9cb9966e52634f6ba98a9d411126cc74 schema:issueNumber 5
140 rdf:type schema:PublicationIssue
141 N9fc34e608f4b4d808610a09d9ee0ef14 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Glomerulonephritis
143 rdf:type schema:DefinedTerm
144 Na10882941f8f40bfa62d59babafcf8b8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Protein Serine-Threonine Kinases
146 rdf:type schema:DefinedTerm
147 Nb198b744da214b8d80c6f0f2a04a79f4 schema:name dimensions_id
148 schema:value pub.1043972437
149 rdf:type schema:PropertyValue
150 Nbd63f09bf4b247bcb77726e809745f6a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Tumor Suppressor Proteins
152 rdf:type schema:DefinedTerm
153 Nd788a3b422654122b0ab37fd9d073048 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Cyclin-Dependent Kinase 2
155 rdf:type schema:DefinedTerm
156 Ndba97140177f441fa9dfba3068f85868 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Kidney Function Tests
158 rdf:type schema:DefinedTerm
159 Ne6f28ed9af7640b4abecabd8c1d7ddaa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Mice
161 rdf:type schema:DefinedTerm
162 Nfe13a5ca15c0454482dc63e6aa3303ca rdf:first sg:person.0740164607.60
163 rdf:rest rdf:nil
164 Nff8d191c5e474ffea28e7686f3bb4e1e rdf:first sg:person.01071120760.55
165 rdf:rest N7ad935ba163b4f68bd1e2db522167a8f
166 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
167 schema:name Medical and Health Sciences
168 rdf:type schema:DefinedTerm
169 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
170 schema:name Immunology
171 rdf:type schema:DefinedTerm
172 sg:grant.2495660 http://pending.schema.org/fundedItem sg:pub.10.1038/nm0598-575
173 rdf:type schema:MonetaryGrant
174 sg:grant.2495819 http://pending.schema.org/fundedItem sg:pub.10.1038/nm0598-575
175 rdf:type schema:MonetaryGrant
176 sg:journal.1113716 schema:issn 1078-8956
177 1546-170X
178 schema:name Nature Medicine
179 schema:publisher Springer Nature
180 rdf:type schema:Periodical
181 sg:person.01010146146.20 schema:affiliation grid-institutes:None
182 schema:familyName Fero
183 schema:givenName Matthew L.
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010146146.20
185 rdf:type schema:Person
186 sg:person.01071120760.55 schema:affiliation grid-institutes:None
187 schema:familyName Ophascharoensuk
188 schema:givenName Vuddhidej
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071120760.55
190 rdf:type schema:Person
191 sg:person.014177104362.78 schema:affiliation grid-institutes:grid.270240.3
192 schema:familyName Roberts
193 schema:givenName James M.
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014177104362.78
195 rdf:type schema:Person
196 sg:person.016636123627.34 schema:affiliation grid-institutes:None
197 schema:familyName Hughes
198 schema:givenName Jeremy
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016636123627.34
200 rdf:type schema:Person
201 sg:person.0740164607.60 schema:affiliation grid-institutes:grid.34477.33
202 schema:familyName Shankland
203 schema:givenName Stuart J.
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740164607.60
205 rdf:type schema:Person
206 sg:pub.10.1038/372570a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048925981
207 https://doi.org/10.1038/372570a0
208 rdf:type schema:CreativeWork
209 sg:pub.10.1038/374131a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029953704
210 https://doi.org/10.1038/374131a0
211 rdf:type schema:CreativeWork
212 sg:pub.10.1038/nm0297-222 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045491685
213 https://doi.org/10.1038/nm0297-222
214 rdf:type schema:CreativeWork
215 sg:pub.10.1038/nm0297-227 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011434633
216 https://doi.org/10.1038/nm0297-227
217 rdf:type schema:CreativeWork
218 sg:pub.10.1038/nm0297-231 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003429757
219 https://doi.org/10.1038/nm0297-231
220 rdf:type schema:CreativeWork
221 grid-institutes:None schema:alternateName Department of Basic Sciences, 1100 Fairview Avenue North, 98109, Seattle, Washington, USA
222 schema:name Department of Basic Sciences, 1100 Fairview Avenue North, 98109, Seattle, Washington, USA
223 rdf:type schema:Organization
224 grid-institutes:grid.270240.3 schema:alternateName Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, 98109, Seattle, Washington, USA
225 schema:name Department of Basic Sciences, 1100 Fairview Avenue North, 98109, Seattle, Washington, USA
226 Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, 98109, Seattle, Washington, USA
227 rdf:type schema:Organization
228 grid-institutes:grid.34477.33 schema:alternateName Division of Nephrology, Department of Medicine, University of Washington School of Medicine, 1959 NE Pacific Avenue, Box 356521, 98195-6521, Seattle, Washington, USA
229 schema:name Division of Nephrology, Department of Medicine, University of Washington School of Medicine, 1959 NE Pacific Avenue, Box 356521, 98195-6521, Seattle, Washington, USA
230 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...