Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr–Abl positive cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-05

AUTHORS

B J Druker, S Tamura, E Buchdunger, S Ohno, G M Segal, S Fanning, J Zimmermann, N B Lydon

ABSTRACT

The bcr-abl oncogene, present in 95% of patients with chronic myelogenous leukemia (CML), has been implicated as the cause of this disease. A compound, designed to inhibit the Abl protein tyrosine kinase, was evaluated for its effects on cells containing the Bcr-Abl fusion protein. Cellular proliferation and tumor formation by Bcr-Abl-expressing cells were specifically inhibited by this compound. In colony-forming assays of peripheral blood or bone marrow from patients with CML, there was a 92-98% decrease in the number of bcr-abl colonies formed but no inhibition of normal colony formation. This compound may be useful in the treatment of bcr-abl-positive leukemias. More... »

PAGES

561-566

Journal

TITLE

Nature Medicine

ISSUE

5

VOLUME

2

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nm0596-561

    DOI

    http://dx.doi.org/10.1038/nm0596-561

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1051513257

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/8616716


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    RDF/XML is a standard XML format for linked data.

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