Immune responses to transgene–encoded proteins limit the stability of gene expression after injection of replication–defective adenovirus vectors View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-05

AUTHORS

S K Tripathy, H B Black, E Goldwasser, J M Leiden

ABSTRACT

The use of replication-defective adenoviruses (RDAd) for human gene therapy has been limited by host immune responses that result in transient recombinant gene expression in vivo. It remained unclear whether these immune responses were directed predominantly against viral proteins or, alternatively, against foreign transgene-encoded proteins. In this report, we have compared the stability of recombinant gene expression in adult immunocompetent mice following intramuscular (i.m.) injection with identical RDAd encoding self (murine) or foreign (human) erythropoietin. Our results demonstrate that immune responses direct against foreign transgene-encoded proteins are the major determinants of the stability of gene expression following i.m. injection of RDAd. Moreover, we demonstrate long-term recombinant gene expression in immunocompetent animals following a single i.m. injection of RDAd encoding a self protein. These findings are important for the design of future preclinical and clinical gene therapy trials. More... »

PAGES

545-550

Journal

TITLE

Nature Medicine

ISSUE

5

VOLUME

2

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nm0596-545

DOI

http://dx.doi.org/10.1038/nm0596-545

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1016176325

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8616713


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenoviridae", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenovirus E1 Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenovirus E3 Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Base Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Erythropoietin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Therapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Vectors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Injections, Intramuscular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Data", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Recombinant Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Species Specificity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transgenes", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Chicago", 
          "id": "https://www.grid.ac/institutes/grid.170205.1", 
          "name": [
            "Department of Pathology, University of Chicago, Illinois 60637, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tripathy", 
        "givenName": "S K", 
        "id": "sg:person.01072225030.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072225030.14"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Black", 
        "givenName": "H B", 
        "id": "sg:person.01140340230.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01140340230.18"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Goldwasser", 
        "givenName": "E", 
        "id": "sg:person.01246072271.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246072271.91"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Leiden", 
        "givenName": "J M", 
        "id": "sg:person.0600436375.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600436375.25"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1111/j.1749-6632.1994.tb21705.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000349439"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng0794-362", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001773368", 
          "https://doi.org/10.1038/ng0794-362"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.91.24.11557", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003754627"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.116.6.913", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005920543"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1095-191", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008212803", 
          "https://doi.org/10.1038/ng1095-191"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.91.10.4407", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008866016"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.173.6.1433", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009101403"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng0593-27", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010312039", 
          "https://doi.org/10.1038/ng0593-27"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1293-397", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012339522", 
          "https://doi.org/10.1038/ng1293-397"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0959-437x(93)90126-a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012445290"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.89.7.2581", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016265057"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.91.13.6196", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019406962"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.92.5.1401", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034986450"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/1074-7613(94)90074-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042449328"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(91)90164-t", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043665984"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/345068a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046473693", 
          "https://doi.org/10.1038/345068a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2141.1981.tb02726.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046487389"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(92)90213-v", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050047366"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.6.3.842", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053269427"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/hum.1993.4.6-759", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059271278"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/hum.1993.4.6-771", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059271279"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/hum.1994.5.10-1217", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059271312"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.2112266", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062522795"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075554177", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077608685", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082423905", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082478883", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/oxfordjournals.bmb.a072951", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082498917"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082550481", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082687142", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1996-05", 
    "datePublishedReg": "1996-05-01", 
    "description": "The use of replication-defective adenoviruses (RDAd) for human gene therapy has been limited by host immune responses that result in transient recombinant gene expression in vivo. It remained unclear whether these immune responses were directed predominantly against viral proteins or, alternatively, against foreign transgene-encoded proteins. In this report, we have compared the stability of recombinant gene expression in adult immunocompetent mice following intramuscular (i.m.) injection with identical RDAd encoding self (murine) or foreign (human) erythropoietin. Our results demonstrate that immune responses direct against foreign transgene-encoded proteins are the major determinants of the stability of gene expression following i.m. injection of RDAd. Moreover, we demonstrate long-term recombinant gene expression in immunocompetent animals following a single i.m. injection of RDAd encoding a self protein. These findings are important for the design of future preclinical and clinical gene therapy trials.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nm0596-545", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2495344", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2463494", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1113716", 
        "issn": [
          "1078-8956", 
          "1546-170X"
        ], 
        "name": "Nature Medicine", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "2"
      }
    ], 
    "name": "Immune responses to transgene\u2013encoded proteins limit the stability of gene expression after injection of replication\u2013defective adenovirus vectors", 
    "pagination": "545-550", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "4d139731d001146de49c0c7f9005166e453bc42335077106803274b8e641eb9f"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "8616713"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9502015"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nm0596-545"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1016176325"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nm0596-545", 
      "https://app.dimensions.ai/details/publication/pub.1016176325"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T21:25", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8687_00000434.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/nm/journal/v2/n5/full/nm0596-545.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nm0596-545'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nm0596-545'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nm0596-545'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nm0596-545'


 

This table displays all metadata directly associated to this object as RDF triples.

244 TRIPLES      21 PREDICATES      75 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nm0596-545 schema:about N00e254440dff4128afdfe3d73ce61c51
2 N01170c72372f4ea7bd0232da02e55d50
3 N1615d74daf6744a29c035dac1c80a395
4 N2af965446e99491cb5bf4cb58d1780a2
5 N2b310280fba246b1a244ae10feb3ea83
6 N5aa3443fc5ca445d9d2b555fc39a6402
7 N99fbe81f68e24abdb78970b64470b839
8 N9ab1d4cf8cb04c9fadd3f37b47ae5748
9 Na3a3deb4a6194627aa847b47f6329a25
10 Na882834c3395448f84451ff48bae852c
11 Nc14eaa820589495591d30fd07e99ac2e
12 Nc975b6d6b3e24b5facb80c64de405c49
13 Nd5493714eec84683b5aa08c25cc2d08c
14 Nea3350c3ca2845a5b676e9217210a08d
15 Ned442d0809aa4311957cb4f914c079d1
16 Nfa9c091b5b7740f98efcb6e19ad27d31
17 anzsrc-for:11
18 anzsrc-for:1107
19 schema:author Nf7ca42c4f2484a0bacc7902e4b54550d
20 schema:citation sg:pub.10.1038/345068a0
21 sg:pub.10.1038/ng0593-27
22 sg:pub.10.1038/ng0794-362
23 sg:pub.10.1038/ng1095-191
24 sg:pub.10.1038/ng1293-397
25 https://app.dimensions.ai/details/publication/pub.1075554177
26 https://app.dimensions.ai/details/publication/pub.1077608685
27 https://app.dimensions.ai/details/publication/pub.1082423905
28 https://app.dimensions.ai/details/publication/pub.1082478883
29 https://app.dimensions.ai/details/publication/pub.1082550481
30 https://app.dimensions.ai/details/publication/pub.1082687142
31 https://doi.org/10.1016/0092-8674(91)90164-t
32 https://doi.org/10.1016/0092-8674(92)90213-v
33 https://doi.org/10.1016/0959-437x(93)90126-a
34 https://doi.org/10.1016/1074-7613(94)90074-4
35 https://doi.org/10.1073/pnas.89.7.2581
36 https://doi.org/10.1073/pnas.91.10.4407
37 https://doi.org/10.1073/pnas.91.13.6196
38 https://doi.org/10.1073/pnas.91.24.11557
39 https://doi.org/10.1073/pnas.92.5.1401
40 https://doi.org/10.1084/jem.116.6.913
41 https://doi.org/10.1084/jem.173.6.1433
42 https://doi.org/10.1089/hum.1993.4.6-759
43 https://doi.org/10.1089/hum.1993.4.6-771
44 https://doi.org/10.1089/hum.1994.5.10-1217
45 https://doi.org/10.1093/oxfordjournals.bmb.a072951
46 https://doi.org/10.1111/j.1365-2141.1981.tb02726.x
47 https://doi.org/10.1111/j.1749-6632.1994.tb21705.x
48 https://doi.org/10.1126/science.2112266
49 https://doi.org/10.1128/mcb.6.3.842
50 schema:datePublished 1996-05
51 schema:datePublishedReg 1996-05-01
52 schema:description The use of replication-defective adenoviruses (RDAd) for human gene therapy has been limited by host immune responses that result in transient recombinant gene expression in vivo. It remained unclear whether these immune responses were directed predominantly against viral proteins or, alternatively, against foreign transgene-encoded proteins. In this report, we have compared the stability of recombinant gene expression in adult immunocompetent mice following intramuscular (i.m.) injection with identical RDAd encoding self (murine) or foreign (human) erythropoietin. Our results demonstrate that immune responses direct against foreign transgene-encoded proteins are the major determinants of the stability of gene expression following i.m. injection of RDAd. Moreover, we demonstrate long-term recombinant gene expression in immunocompetent animals following a single i.m. injection of RDAd encoding a self protein. These findings are important for the design of future preclinical and clinical gene therapy trials.
53 schema:genre research_article
54 schema:inLanguage en
55 schema:isAccessibleForFree false
56 schema:isPartOf Ndaf925ddad7d4480bf3814c97a22f51a
57 Nf4770ea77c8943f796491bf8bec6c9ca
58 sg:journal.1113716
59 schema:name Immune responses to transgene–encoded proteins limit the stability of gene expression after injection of replication–defective adenovirus vectors
60 schema:pagination 545-550
61 schema:productId N10da64d3c8674821b03b197b7f30908d
62 N60e53bba08e14e1794c539707d27f8b5
63 N93fe0f2780e944c4a82eba76b1debf7c
64 Ncba83f9e896c47d39f10a85a3548a6f5
65 Nfa7c7d5c4686462f86b612be2f3667f4
66 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016176325
67 https://doi.org/10.1038/nm0596-545
68 schema:sdDatePublished 2019-04-10T21:25
69 schema:sdLicense https://scigraph.springernature.com/explorer/license/
70 schema:sdPublisher N31a7a935e3ea48389038772db3f9521e
71 schema:url http://www.nature.com/nm/journal/v2/n5/full/nm0596-545.html
72 sgo:license sg:explorer/license/
73 sgo:sdDataset articles
74 rdf:type schema:ScholarlyArticle
75 N00e254440dff4128afdfe3d73ce61c51 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name Adenovirus E1 Proteins
77 rdf:type schema:DefinedTerm
78 N01170c72372f4ea7bd0232da02e55d50 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Genetic Vectors
80 rdf:type schema:DefinedTerm
81 N10da64d3c8674821b03b197b7f30908d schema:name doi
82 schema:value 10.1038/nm0596-545
83 rdf:type schema:PropertyValue
84 N1615d74daf6744a29c035dac1c80a395 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Molecular Sequence Data
86 rdf:type schema:DefinedTerm
87 N242723753db04ef1bfc4a1e6df1edee4 rdf:first sg:person.01246072271.91
88 rdf:rest Na5047b6d89924f43ac283078a58ad49c
89 N2af965446e99491cb5bf4cb58d1780a2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Animals
91 rdf:type schema:DefinedTerm
92 N2b310280fba246b1a244ae10feb3ea83 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Injections, Intramuscular
94 rdf:type schema:DefinedTerm
95 N31a7a935e3ea48389038772db3f9521e schema:name Springer Nature - SN SciGraph project
96 rdf:type schema:Organization
97 N5aa3443fc5ca445d9d2b555fc39a6402 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Humans
99 rdf:type schema:DefinedTerm
100 N60e53bba08e14e1794c539707d27f8b5 schema:name nlm_unique_id
101 schema:value 9502015
102 rdf:type schema:PropertyValue
103 N93fe0f2780e944c4a82eba76b1debf7c schema:name pubmed_id
104 schema:value 8616713
105 rdf:type schema:PropertyValue
106 N99fbe81f68e24abdb78970b64470b839 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Species Specificity
108 rdf:type schema:DefinedTerm
109 N9ab1d4cf8cb04c9fadd3f37b47ae5748 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Base Sequence
111 rdf:type schema:DefinedTerm
112 N9d114a6150d743f99c3bc3a9a1a42ed6 rdf:first sg:person.01140340230.18
113 rdf:rest N242723753db04ef1bfc4a1e6df1edee4
114 Na3a3deb4a6194627aa847b47f6329a25 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Recombinant Proteins
116 rdf:type schema:DefinedTerm
117 Na5047b6d89924f43ac283078a58ad49c rdf:first sg:person.0600436375.25
118 rdf:rest rdf:nil
119 Na882834c3395448f84451ff48bae852c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Mice
121 rdf:type schema:DefinedTerm
122 Nc14eaa820589495591d30fd07e99ac2e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Transgenes
124 rdf:type schema:DefinedTerm
125 Nc975b6d6b3e24b5facb80c64de405c49 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Adenoviridae
127 rdf:type schema:DefinedTerm
128 Ncba83f9e896c47d39f10a85a3548a6f5 schema:name readcube_id
129 schema:value 4d139731d001146de49c0c7f9005166e453bc42335077106803274b8e641eb9f
130 rdf:type schema:PropertyValue
131 Nd5493714eec84683b5aa08c25cc2d08c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Gene Expression
133 rdf:type schema:DefinedTerm
134 Ndaf925ddad7d4480bf3814c97a22f51a schema:issueNumber 5
135 rdf:type schema:PublicationIssue
136 Nea3350c3ca2845a5b676e9217210a08d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Genetic Therapy
138 rdf:type schema:DefinedTerm
139 Ned442d0809aa4311957cb4f914c079d1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Adenovirus E3 Proteins
141 rdf:type schema:DefinedTerm
142 Nf4770ea77c8943f796491bf8bec6c9ca schema:volumeNumber 2
143 rdf:type schema:PublicationVolume
144 Nf7ca42c4f2484a0bacc7902e4b54550d rdf:first sg:person.01072225030.14
145 rdf:rest N9d114a6150d743f99c3bc3a9a1a42ed6
146 Nfa7c7d5c4686462f86b612be2f3667f4 schema:name dimensions_id
147 schema:value pub.1016176325
148 rdf:type schema:PropertyValue
149 Nfa9c091b5b7740f98efcb6e19ad27d31 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Erythropoietin
151 rdf:type schema:DefinedTerm
152 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
153 schema:name Medical and Health Sciences
154 rdf:type schema:DefinedTerm
155 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
156 schema:name Immunology
157 rdf:type schema:DefinedTerm
158 sg:grant.2463494 http://pending.schema.org/fundedItem sg:pub.10.1038/nm0596-545
159 rdf:type schema:MonetaryGrant
160 sg:grant.2495344 http://pending.schema.org/fundedItem sg:pub.10.1038/nm0596-545
161 rdf:type schema:MonetaryGrant
162 sg:journal.1113716 schema:issn 1078-8956
163 1546-170X
164 schema:name Nature Medicine
165 rdf:type schema:Periodical
166 sg:person.01072225030.14 schema:affiliation https://www.grid.ac/institutes/grid.170205.1
167 schema:familyName Tripathy
168 schema:givenName S K
169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072225030.14
170 rdf:type schema:Person
171 sg:person.01140340230.18 schema:familyName Black
172 schema:givenName H B
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01140340230.18
174 rdf:type schema:Person
175 sg:person.01246072271.91 schema:familyName Goldwasser
176 schema:givenName E
177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246072271.91
178 rdf:type schema:Person
179 sg:person.0600436375.25 schema:familyName Leiden
180 schema:givenName J M
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600436375.25
182 rdf:type schema:Person
183 sg:pub.10.1038/345068a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046473693
184 https://doi.org/10.1038/345068a0
185 rdf:type schema:CreativeWork
186 sg:pub.10.1038/ng0593-27 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010312039
187 https://doi.org/10.1038/ng0593-27
188 rdf:type schema:CreativeWork
189 sg:pub.10.1038/ng0794-362 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001773368
190 https://doi.org/10.1038/ng0794-362
191 rdf:type schema:CreativeWork
192 sg:pub.10.1038/ng1095-191 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008212803
193 https://doi.org/10.1038/ng1095-191
194 rdf:type schema:CreativeWork
195 sg:pub.10.1038/ng1293-397 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012339522
196 https://doi.org/10.1038/ng1293-397
197 rdf:type schema:CreativeWork
198 https://app.dimensions.ai/details/publication/pub.1075554177 schema:CreativeWork
199 https://app.dimensions.ai/details/publication/pub.1077608685 schema:CreativeWork
200 https://app.dimensions.ai/details/publication/pub.1082423905 schema:CreativeWork
201 https://app.dimensions.ai/details/publication/pub.1082478883 schema:CreativeWork
202 https://app.dimensions.ai/details/publication/pub.1082550481 schema:CreativeWork
203 https://app.dimensions.ai/details/publication/pub.1082687142 schema:CreativeWork
204 https://doi.org/10.1016/0092-8674(91)90164-t schema:sameAs https://app.dimensions.ai/details/publication/pub.1043665984
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1016/0092-8674(92)90213-v schema:sameAs https://app.dimensions.ai/details/publication/pub.1050047366
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1016/0959-437x(93)90126-a schema:sameAs https://app.dimensions.ai/details/publication/pub.1012445290
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1016/1074-7613(94)90074-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042449328
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1073/pnas.89.7.2581 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016265057
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1073/pnas.91.10.4407 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008866016
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1073/pnas.91.13.6196 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019406962
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1073/pnas.91.24.11557 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003754627
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1073/pnas.92.5.1401 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034986450
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1084/jem.116.6.913 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005920543
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1084/jem.173.6.1433 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009101403
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1089/hum.1993.4.6-759 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059271278
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1089/hum.1993.4.6-771 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059271279
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1089/hum.1994.5.10-1217 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059271312
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1093/oxfordjournals.bmb.a072951 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082498917
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1111/j.1365-2141.1981.tb02726.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1046487389
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1111/j.1749-6632.1994.tb21705.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1000349439
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1126/science.2112266 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062522795
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1128/mcb.6.3.842 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053269427
241 rdf:type schema:CreativeWork
242 https://www.grid.ac/institutes/grid.170205.1 schema:alternateName University of Chicago
243 schema:name Department of Pathology, University of Chicago, Illinois 60637, USA.
244 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...