Response of psoriasis to a lymphocyte-selective toxin (DAB389IL-2) suggests a primary immune, but not keratinocyte, pathogenic basis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1995-05

AUTHORS

S L Gottlieb, P Gilleaudeau, R Johnson, L Estes, T G Woodworth, A B Gottlieb, J G Krueger

ABSTRACT

Psoriasis is a hyperproliferative and inflammatory skin disorder of unknown aetiology. A fusion protein composed of human interleukin-2 and fragments of diphtheria toxin (DAB389IL-2), which selectively blocks the growth of activated lymphocytes but not keratinocytes, was administered systemically to ten patients to gauge the contribution of activated T cells to the disease. Four patients showed striking clinical improvement and four moderate improvement, after two cycle of low dose IL-2-toxin. The reversal of several molecular markers of epidermal dysfunction was associated with a marked reduction in intraepidermal CD3+ and CD8+ T cells, suggesting a primary immunological basis for this widespread disorder. More... »

PAGES

442-447

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nm0595-442

DOI

http://dx.doi.org/10.1038/nm0595-442

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049704206

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7585092


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