Progression of metastatic human prostate cancer to androgen independence in immunodeficient SCID mice View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1997-04

AUTHORS

K A Klein, R E Reiter, J Redula, H Moradi, X L Zhu, A R Brothman, D J Lamb, M Marcelli, A Belldegrun, O N Witte, C L Sawyers

ABSTRACT

Prostate cancer mortality results from metastasis to bone and hormone-independent tumor growth. Models to study these progressive changes are lacking. Here we describe the propagation of advanced human prostate cancer by direct transfer of surgical samples from patients into immune-deficient male SCID mice. Explants from six of eight patients formed prostate tumors and two showed unique cytogenetic, biologic and molecular features that were retained through six or more passages. One grew in an androgen-independent fashion, whereas the second formed tumors that regressed following castration then regrew. Micrometastatic disease was detected in the hematopoietic tissues of half of the recipient mice. Thus selected specimens of advanced human prostate cancer can be propagated in SCID mice in a manner that recapitulates the clinical transition from androgen-sensitive to androgen-independent growth, accompanied by micrometastasis. More... »

PAGES

402-408

References to SciGraph publications

Journal

TITLE

Nature Medicine

ISSUE

4

VOLUME

3

From Grant

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nm0497-402

    DOI

    http://dx.doi.org/10.1038/nm0497-402

    DIMENSIONS

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    https://www.ncbi.nlm.nih.gov/pubmed/9095173


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