A chemokine receptor CCR2 allele delays HIV-1 disease progression and is associated with a CCR5 promoter mutation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1998-03

AUTHORS

L G Kostrikis, Y Huang, J P Moore, S M Wolinsky, L Zhang, Y Guo, L Deutsch, J Phair, A U Neumann, D D Ho

ABSTRACT

Viral and host factors influence the rate of HIV-1 disease progression. For HIV-1 to fuse, a CD4+ cell must express a co-receptor that the virus can use. The chemokine receptors CCR5 and CXCR4 are used by R5 and X4 viruses, respectively. Most new infections involve transmission of R5 viruses, but variants can arise later that also use CXCR4 (R5-X4 or X4 viruses). This is associated with an increased rate of CD4+ T-cell loss and poor prognosis. The ability of host cells to support HIV-1 entry also influences progression. The absence of CCR5 in approximately 1% of the Caucasian population, due to homozygosity for a 32-nucleotide deletion in the coding region (delta32-CCR5 allele), very strongly protects against HIV-1 transmission. Heterozygosity for the delta32-CCR5 allele delays progression typically by 2 years. A recent study showed that a conservative substitution (V64I) in the coding region of CCR2 also has a significant impact on disease progression, but not on HIV-1 transmission. This was unexpected, since CCR2 is rarely used as a co-receptor in vitro and the V64I change is in a transmembrane region. Because a subsequent study did not confirm this effect on progression to disease, we analyzed CCR2-V64I using subjects in the Chicago MACS. We show that CCR2-V64I is indeed protective against disease progression and go on to show that the CCR2-V64I allele is in complete linkage disequilibrium with a point mutation in the CCR5 regulatory region. More... »

PAGES

350-353

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nm0398-350

DOI

http://dx.doi.org/10.1038/nm0398-350

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1032260358

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9500612


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1108", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Microbiology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Alleles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "CD4 Lymphocyte Count", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cohort Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Progression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genotype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HIV Infections", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HIV Seropositivity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HIV Seroprevalence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HIV-1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heterozygote", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Homozygote", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Data", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Promoter Regions, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, CCR2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, CCR5", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Chemokine", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Rockefeller University", 
          "id": "https://www.grid.ac/institutes/grid.134907.8", 
          "name": [
            "The Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York 10016, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kostrikis", 
        "givenName": "L G", 
        "id": "sg:person.011766633667.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011766633667.48"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Huang", 
        "givenName": "Y", 
        "id": "sg:person.01316621751.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316621751.77"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Moore", 
        "givenName": "J P", 
        "id": "sg:person.010315044462.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010315044462.97"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Wolinsky", 
        "givenName": "S M", 
        "id": "sg:person.015620773504.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015620773504.51"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Zhang", 
        "givenName": "L", 
        "id": "sg:person.015027462407.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015027462407.75"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Guo", 
        "givenName": "Y", 
        "id": "sg:person.01206234451.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206234451.30"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Deutsch", 
        "givenName": "L", 
        "id": "sg:person.01322463051.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322463051.26"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Phair", 
        "givenName": "J", 
        "id": "sg:person.0703504620.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703504620.54"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Neumann", 
        "givenName": "A U", 
        "id": "sg:person.015363106637.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015363106637.43"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Ho", 
        "givenName": "D D", 
        "id": "sg:person.01342202624.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342202624.34"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)80110-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003314512"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0952-7915(97)80110-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006400499"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1196-1174", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008364449", 
          "https://doi.org/10.1038/nm1196-1174"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1097-1160", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014801043", 
          "https://doi.org/10.1038/nm1097-1160"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm0496-412", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019706003", 
          "https://doi.org/10.1038/nm0496-412"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/384529a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020733467", 
          "https://doi.org/10.1038/384529a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1196-1240", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026944069", 
          "https://doi.org/10.1038/nm1196-1240"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/384184a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036628325", 
          "https://doi.org/10.1038/384184a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.272.49.30662", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037130066"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.185.9.1681", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041581293"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/34571", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042683516", 
          "https://doi.org/10.1038/34571"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/34571", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042683516", 
          "https://doi.org/10.1038/34571"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/382722a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050488632", 
          "https://doi.org/10.1038/382722a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1097-1052c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051084444", 
          "https://doi.org/10.1038/nm1097-1052c"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/infdis/169.5.968", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059704481"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.273.5283.1856", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062554224"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.276.5309.51", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062556256"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.277.5328.959", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062557687"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.8356453", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062654813"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1998-03", 
    "datePublishedReg": "1998-03-01", 
    "description": "Viral and host factors influence the rate of HIV-1 disease progression. For HIV-1 to fuse, a CD4+ cell must express a co-receptor that the virus can use. The chemokine receptors CCR5 and CXCR4 are used by R5 and X4 viruses, respectively. Most new infections involve transmission of R5 viruses, but variants can arise later that also use CXCR4 (R5-X4 or X4 viruses). This is associated with an increased rate of CD4+ T-cell loss and poor prognosis. The ability of host cells to support HIV-1 entry also influences progression. The absence of CCR5 in approximately 1% of the Caucasian population, due to homozygosity for a 32-nucleotide deletion in the coding region (delta32-CCR5 allele), very strongly protects against HIV-1 transmission. Heterozygosity for the delta32-CCR5 allele delays progression typically by 2 years. A recent study showed that a conservative substitution (V64I) in the coding region of CCR2 also has a significant impact on disease progression, but not on HIV-1 transmission. This was unexpected, since CCR2 is rarely used as a co-receptor in vitro and the V64I change is in a transmembrane region. Because a subsequent study did not confirm this effect on progression to disease, we analyzed CCR2-V64I using subjects in the Chicago MACS. We show that CCR2-V64I is indeed protective against disease progression and go on to show that the CCR2-V64I allele is in complete linkage disequilibrium with a point mutation in the CCR5 regulatory region.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nm0398-350", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2687333", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2453592", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2424636", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1113716", 
        "issn": [
          "1078-8956", 
          "1546-170X"
        ], 
        "name": "Nature Medicine", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "4"
      }
    ], 
    "name": "A chemokine receptor CCR2 allele delays HIV-1 disease progression and is associated with a CCR5 promoter mutation", 
    "pagination": "350-353", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "99aeb8a100f2db8f62d9ed5ff92b79f6533f0d1f780ade1d7461e3599e6febcb"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "9500612"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9502015"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nm0398-350"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1032260358"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nm0398-350", 
      "https://app.dimensions.ai/details/publication/pub.1032260358"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T15:39", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8664_00000434.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/nm/journal/v4/n3/full/nm0398-350.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nm0398-350'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nm0398-350'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nm0398-350'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nm0398-350'


 

This table displays all metadata directly associated to this object as RDF triples.

272 TRIPLES      21 PREDICATES      67 URIs      41 LITERALS      29 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nm0398-350 schema:about N06dac438ef664921a023bd3d3c1c732e
2 N0e621f648a0743baa33102663c81a2be
3 N308d925040f442668dc88a10fdfc0898
4 N38c476e67f3e42e18103f26474492a55
5 N46420c77fd4c43fd9f04a5b0eb8f39cc
6 N53c5927cfc704f62a5e0050ff79f49b8
7 N58f793bf1c0a4f718eb5c9cd6fb3f7a4
8 N5d18f6d9d4674be5b1031afd3b8a8c29
9 N5d8801991a694236af55272ccc48af5f
10 N7eef9f00eb464a5ea2708adc6efe5fca
11 N7f0b4fc8cb4f44feb99bbbde76ec7102
12 N7f1c68045d5648ef8548bd890237deb9
13 N82e1908a34f24860baae6abd3af5f688
14 N86f22afd92b74ca9b8cab3f6af0f1aec
15 N894116d4c65b4df5939093695381e4b9
16 N94c2ab7eaeb34403850574283dbdd191
17 N98381824bb4743999744e43765b330be
18 N9a6aa769d5454085a773fd7fc111ddaa
19 Ndb303c5e3ded426cb9ba411a05ed5b5f
20 Nf9fabe86252e4f0ba3c996c286b53c37
21 anzsrc-for:11
22 anzsrc-for:1108
23 schema:author Nea05c0d0fb7942f3b8952331ba9f8cb3
24 schema:citation sg:pub.10.1038/34571
25 sg:pub.10.1038/382722a0
26 sg:pub.10.1038/384184a0
27 sg:pub.10.1038/384529a0
28 sg:pub.10.1038/nm0496-412
29 sg:pub.10.1038/nm1097-1052c
30 sg:pub.10.1038/nm1097-1160
31 sg:pub.10.1038/nm1196-1174
32 sg:pub.10.1038/nm1196-1240
33 https://doi.org/10.1016/s0092-8674(00)80110-5
34 https://doi.org/10.1016/s0952-7915(97)80110-0
35 https://doi.org/10.1074/jbc.272.49.30662
36 https://doi.org/10.1084/jem.185.9.1681
37 https://doi.org/10.1093/infdis/169.5.968
38 https://doi.org/10.1126/science.273.5283.1856
39 https://doi.org/10.1126/science.276.5309.51
40 https://doi.org/10.1126/science.277.5328.959
41 https://doi.org/10.1126/science.8356453
42 schema:datePublished 1998-03
43 schema:datePublishedReg 1998-03-01
44 schema:description Viral and host factors influence the rate of HIV-1 disease progression. For HIV-1 to fuse, a CD4+ cell must express a co-receptor that the virus can use. The chemokine receptors CCR5 and CXCR4 are used by R5 and X4 viruses, respectively. Most new infections involve transmission of R5 viruses, but variants can arise later that also use CXCR4 (R5-X4 or X4 viruses). This is associated with an increased rate of CD4+ T-cell loss and poor prognosis. The ability of host cells to support HIV-1 entry also influences progression. The absence of CCR5 in approximately 1% of the Caucasian population, due to homozygosity for a 32-nucleotide deletion in the coding region (delta32-CCR5 allele), very strongly protects against HIV-1 transmission. Heterozygosity for the delta32-CCR5 allele delays progression typically by 2 years. A recent study showed that a conservative substitution (V64I) in the coding region of CCR2 also has a significant impact on disease progression, but not on HIV-1 transmission. This was unexpected, since CCR2 is rarely used as a co-receptor in vitro and the V64I change is in a transmembrane region. Because a subsequent study did not confirm this effect on progression to disease, we analyzed CCR2-V64I using subjects in the Chicago MACS. We show that CCR2-V64I is indeed protective against disease progression and go on to show that the CCR2-V64I allele is in complete linkage disequilibrium with a point mutation in the CCR5 regulatory region.
45 schema:genre research_article
46 schema:inLanguage en
47 schema:isAccessibleForFree false
48 schema:isPartOf N253210296f834eab86127529fea61f71
49 N8771b86b433c4f7e9cbb1b2919a04c2f
50 sg:journal.1113716
51 schema:name A chemokine receptor CCR2 allele delays HIV-1 disease progression and is associated with a CCR5 promoter mutation
52 schema:pagination 350-353
53 schema:productId N548152d060dd4272bda309dcb08fe820
54 N62354fe12184404aa712569576dfa353
55 N72732fbad602474ea059a642aa334c86
56 N945ff80f32944aa3ba83096d8832e732
57 Nd20aae29ff4d4883b2633d9a50139ce8
58 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032260358
59 https://doi.org/10.1038/nm0398-350
60 schema:sdDatePublished 2019-04-10T15:39
61 schema:sdLicense https://scigraph.springernature.com/explorer/license/
62 schema:sdPublisher N6384b129989e44c9a34016ca8f05a4f8
63 schema:url http://www.nature.com/nm/journal/v4/n3/full/nm0398-350.html
64 sgo:license sg:explorer/license/
65 sgo:sdDataset articles
66 rdf:type schema:ScholarlyArticle
67 N06dac438ef664921a023bd3d3c1c732e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
68 schema:name HIV Infections
69 rdf:type schema:DefinedTerm
70 N0e621f648a0743baa33102663c81a2be schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
71 schema:name HIV Seropositivity
72 rdf:type schema:DefinedTerm
73 N1a106e2dcba545f394c5dd4a18f2e625 rdf:first sg:person.01342202624.34
74 rdf:rest rdf:nil
75 N253210296f834eab86127529fea61f71 schema:issueNumber 3
76 rdf:type schema:PublicationIssue
77 N2900dc28506743f29e0e4c5405db18a7 rdf:first sg:person.015363106637.43
78 rdf:rest N1a106e2dcba545f394c5dd4a18f2e625
79 N308d925040f442668dc88a10fdfc0898 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name HIV Seroprevalence
81 rdf:type schema:DefinedTerm
82 N36f16f780a30439a963f00f9dce0ff97 rdf:first sg:person.015027462407.75
83 rdf:rest Nfe089a8de91d4cab902c3bf580260f69
84 N38c476e67f3e42e18103f26474492a55 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Receptors, CCR2
86 rdf:type schema:DefinedTerm
87 N46420c77fd4c43fd9f04a5b0eb8f39cc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Mutation
89 rdf:type schema:DefinedTerm
90 N53c5927cfc704f62a5e0050ff79f49b8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Disease Progression
92 rdf:type schema:DefinedTerm
93 N548152d060dd4272bda309dcb08fe820 schema:name doi
94 schema:value 10.1038/nm0398-350
95 rdf:type schema:PropertyValue
96 N58f793bf1c0a4f718eb5c9cd6fb3f7a4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Homozygote
98 rdf:type schema:DefinedTerm
99 N5d18f6d9d4674be5b1031afd3b8a8c29 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name HIV-1
101 rdf:type schema:DefinedTerm
102 N5d8801991a694236af55272ccc48af5f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Male
104 rdf:type schema:DefinedTerm
105 N62354fe12184404aa712569576dfa353 schema:name nlm_unique_id
106 schema:value 9502015
107 rdf:type schema:PropertyValue
108 N6384b129989e44c9a34016ca8f05a4f8 schema:name Springer Nature - SN SciGraph project
109 rdf:type schema:Organization
110 N72732fbad602474ea059a642aa334c86 schema:name readcube_id
111 schema:value 99aeb8a100f2db8f62d9ed5ff92b79f6533f0d1f780ade1d7461e3599e6febcb
112 rdf:type schema:PropertyValue
113 N75b9dc8b3afc42da9abc7c8e1b8227b9 rdf:first sg:person.015620773504.51
114 rdf:rest N36f16f780a30439a963f00f9dce0ff97
115 N78fb70e061d6421f8874e4964cb28728 rdf:first sg:person.01316621751.77
116 rdf:rest N8571960c2d7d4e5cb220165922256457
117 N7eef9f00eb464a5ea2708adc6efe5fca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Prognosis
119 rdf:type schema:DefinedTerm
120 N7f0b4fc8cb4f44feb99bbbde76ec7102 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Promoter Regions, Genetic
122 rdf:type schema:DefinedTerm
123 N7f1c68045d5648ef8548bd890237deb9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Humans
125 rdf:type schema:DefinedTerm
126 N82e1908a34f24860baae6abd3af5f688 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Molecular Sequence Data
128 rdf:type schema:DefinedTerm
129 N8571960c2d7d4e5cb220165922256457 rdf:first sg:person.010315044462.97
130 rdf:rest N75b9dc8b3afc42da9abc7c8e1b8227b9
131 N86f22afd92b74ca9b8cab3f6af0f1aec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Cohort Studies
133 rdf:type schema:DefinedTerm
134 N8771b86b433c4f7e9cbb1b2919a04c2f schema:volumeNumber 4
135 rdf:type schema:PublicationVolume
136 N894116d4c65b4df5939093695381e4b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Genotype
138 rdf:type schema:DefinedTerm
139 N945ff80f32944aa3ba83096d8832e732 schema:name pubmed_id
140 schema:value 9500612
141 rdf:type schema:PropertyValue
142 N94c2ab7eaeb34403850574283dbdd191 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Alleles
144 rdf:type schema:DefinedTerm
145 N98381824bb4743999744e43765b330be schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Heterozygote
147 rdf:type schema:DefinedTerm
148 N9a6aa769d5454085a773fd7fc111ddaa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Receptors, Chemokine
150 rdf:type schema:DefinedTerm
151 Nd20aae29ff4d4883b2633d9a50139ce8 schema:name dimensions_id
152 schema:value pub.1032260358
153 rdf:type schema:PropertyValue
154 Ndb303c5e3ded426cb9ba411a05ed5b5f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Receptors, CCR5
156 rdf:type schema:DefinedTerm
157 Nea05c0d0fb7942f3b8952331ba9f8cb3 rdf:first sg:person.011766633667.48
158 rdf:rest N78fb70e061d6421f8874e4964cb28728
159 Nf547905ad5d64b66bc5f7dfca826a9a1 rdf:first sg:person.0703504620.54
160 rdf:rest N2900dc28506743f29e0e4c5405db18a7
161 Nf96123f88d1248e6a135c2a4be6aa482 rdf:first sg:person.01322463051.26
162 rdf:rest Nf547905ad5d64b66bc5f7dfca826a9a1
163 Nf9fabe86252e4f0ba3c996c286b53c37 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name CD4 Lymphocyte Count
165 rdf:type schema:DefinedTerm
166 Nfe089a8de91d4cab902c3bf580260f69 rdf:first sg:person.01206234451.30
167 rdf:rest Nf96123f88d1248e6a135c2a4be6aa482
168 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
169 schema:name Medical and Health Sciences
170 rdf:type schema:DefinedTerm
171 anzsrc-for:1108 schema:inDefinedTermSet anzsrc-for:
172 schema:name Medical Microbiology
173 rdf:type schema:DefinedTerm
174 sg:grant.2424636 http://pending.schema.org/fundedItem sg:pub.10.1038/nm0398-350
175 rdf:type schema:MonetaryGrant
176 sg:grant.2453592 http://pending.schema.org/fundedItem sg:pub.10.1038/nm0398-350
177 rdf:type schema:MonetaryGrant
178 sg:grant.2687333 http://pending.schema.org/fundedItem sg:pub.10.1038/nm0398-350
179 rdf:type schema:MonetaryGrant
180 sg:journal.1113716 schema:issn 1078-8956
181 1546-170X
182 schema:name Nature Medicine
183 rdf:type schema:Periodical
184 sg:person.010315044462.97 schema:familyName Moore
185 schema:givenName J P
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010315044462.97
187 rdf:type schema:Person
188 sg:person.011766633667.48 schema:affiliation https://www.grid.ac/institutes/grid.134907.8
189 schema:familyName Kostrikis
190 schema:givenName L G
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011766633667.48
192 rdf:type schema:Person
193 sg:person.01206234451.30 schema:familyName Guo
194 schema:givenName Y
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206234451.30
196 rdf:type schema:Person
197 sg:person.01316621751.77 schema:familyName Huang
198 schema:givenName Y
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316621751.77
200 rdf:type schema:Person
201 sg:person.01322463051.26 schema:familyName Deutsch
202 schema:givenName L
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322463051.26
204 rdf:type schema:Person
205 sg:person.01342202624.34 schema:familyName Ho
206 schema:givenName D D
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342202624.34
208 rdf:type schema:Person
209 sg:person.015027462407.75 schema:familyName Zhang
210 schema:givenName L
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015027462407.75
212 rdf:type schema:Person
213 sg:person.015363106637.43 schema:familyName Neumann
214 schema:givenName A U
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015363106637.43
216 rdf:type schema:Person
217 sg:person.015620773504.51 schema:familyName Wolinsky
218 schema:givenName S M
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015620773504.51
220 rdf:type schema:Person
221 sg:person.0703504620.54 schema:familyName Phair
222 schema:givenName J
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703504620.54
224 rdf:type schema:Person
225 sg:pub.10.1038/34571 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042683516
226 https://doi.org/10.1038/34571
227 rdf:type schema:CreativeWork
228 sg:pub.10.1038/382722a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050488632
229 https://doi.org/10.1038/382722a0
230 rdf:type schema:CreativeWork
231 sg:pub.10.1038/384184a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036628325
232 https://doi.org/10.1038/384184a0
233 rdf:type schema:CreativeWork
234 sg:pub.10.1038/384529a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020733467
235 https://doi.org/10.1038/384529a0
236 rdf:type schema:CreativeWork
237 sg:pub.10.1038/nm0496-412 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019706003
238 https://doi.org/10.1038/nm0496-412
239 rdf:type schema:CreativeWork
240 sg:pub.10.1038/nm1097-1052c schema:sameAs https://app.dimensions.ai/details/publication/pub.1051084444
241 https://doi.org/10.1038/nm1097-1052c
242 rdf:type schema:CreativeWork
243 sg:pub.10.1038/nm1097-1160 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014801043
244 https://doi.org/10.1038/nm1097-1160
245 rdf:type schema:CreativeWork
246 sg:pub.10.1038/nm1196-1174 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008364449
247 https://doi.org/10.1038/nm1196-1174
248 rdf:type schema:CreativeWork
249 sg:pub.10.1038/nm1196-1240 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026944069
250 https://doi.org/10.1038/nm1196-1240
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1016/s0092-8674(00)80110-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003314512
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1016/s0952-7915(97)80110-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006400499
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1074/jbc.272.49.30662 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037130066
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1084/jem.185.9.1681 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041581293
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1093/infdis/169.5.968 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059704481
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1126/science.273.5283.1856 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062554224
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1126/science.276.5309.51 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062556256
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1126/science.277.5328.959 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062557687
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1126/science.8356453 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062654813
269 rdf:type schema:CreativeWork
270 https://www.grid.ac/institutes/grid.134907.8 schema:alternateName Rockefeller University
271 schema:name The Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York 10016, USA.
272 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...