Ontology type: schema:ScholarlyArticle Open Access: True
1998-02
AUTHORSNadine G. Pakker, Daan W. Notermans, Rob J. De Boer, Marijke T.L. Roos, Frank De Wolf, Andrew Hill, John M. Leonard, Sven A. Danner, Frank Miedema, Peter T.A. Schellekens
ABSTRACTThe origin of CD4+ T cells reappearing in the blood following antiretroviral therapy in human immunodeficiency virus type-1 (HIV-1) infection is still controversial. Here we show, using mathematical modeling, that redistribution of T cells to the blood can explain the striking correlation between the initial CD4+ and CD8+ memory T-cell repopulation and the observation that 3 weeks after the start of treatment memory CD4+ T-cell numbers reach a plateau. The increase in CD4+ T cells following therapy most likely is a composite of initial redistribution, accompanied by a continuous slow repopulation with newly produced naive T cells. More... »
PAGES208-214
http://scigraph.springernature.com/pub.10.1038/nm0298-208
DOIhttp://dx.doi.org/10.1038/nm0298-208
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/9461195
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