Biphasic kinetics of peripheral blood T cells after triple combination therapy in HIV-1 infection: A composite of redistribution and proliferation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1998-02

AUTHORS

Nadine G. Pakker, Daan W. Notermans, Rob J. De Boer, Marijke T.L. Roos, Frank De Wolf, Andrew Hill, John M. Leonard, Sven A. Danner, Frank Miedema, Peter T.A. Schellekens

ABSTRACT

The origin of CD4+ T cells reappearing in the blood following antiretroviral therapy in human immunodeficiency virus type-1 (HIV-1) infection is still controversial. Here we show, using mathematical modeling, that redistribution of T cells to the blood can explain the striking correlation between the initial CD4+ and CD8+ memory T-cell repopulation and the observation that 3 weeks after the start of treatment memory CD4+ T-cell numbers reach a plateau. The increase in CD4+ T cells following therapy most likely is a composite of initial redistribution, accompanied by a continuous slow repopulation with newly produced naive T cells. More... »

PAGES

208-214

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nm0298-208

DOI

http://dx.doi.org/10.1038/nm0298-208

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046625046

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9461195


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anti-HIV Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "CD4-Positive T-Lymphocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "CD8-Positive T-Lymphocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Division", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Therapy, Combination", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HIV Infections", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HIV-1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Immunological", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Viral", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "T-Lymphocytes", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Laboratory for Experimental and Clinical Immunology, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands", 
          "id": "http://www.grid.ac/institutes/grid.7177.6", 
          "name": [
            "Department of Clinical Viro-Immunology, Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Plesmanlaan 125, 1066 CX, Amsterdam, The Netherlands", 
            "Laboratory for Experimental and Clinical Immunology, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pakker", 
        "givenName": "Nadine G.", 
        "id": "sg:person.0736206324.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736206324.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Infectious Diseases, Tropical Medicine and AIDS and National AIDS Therapy Evaluation Center, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands", 
          "id": "http://www.grid.ac/institutes/grid.7177.6", 
          "name": [
            "Division of Infectious Diseases, Tropical Medicine and AIDS and National AIDS Therapy Evaluation Center, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Notermans", 
        "givenName": "Daan W.", 
        "id": "sg:person.0732260043.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732260043.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Theoretical Biology, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands", 
          "id": "http://www.grid.ac/institutes/grid.5477.1", 
          "name": [
            "Theoretical Biology, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "De Boer", 
        "givenName": "Rob J.", 
        "id": "sg:person.0774503452.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774503452.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratory for Experimental and Clinical Immunology, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands", 
          "id": "http://www.grid.ac/institutes/grid.7177.6", 
          "name": [
            "Department of Clinical Viro-Immunology, Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Plesmanlaan 125, 1066 CX, Amsterdam, The Netherlands", 
            "Laboratory for Experimental and Clinical Immunology, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Roos", 
        "givenName": "Marijke T.L.", 
        "id": "sg:person.012745551202.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012745551202.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Human Retrovirology, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands", 
          "id": "http://www.grid.ac/institutes/grid.7177.6", 
          "name": [
            "Department of Human Retrovirology, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wolf", 
        "givenName": "Frank De", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Abbott Laboratories, 60064, Abbott Park, Illinois, USA", 
          "id": "http://www.grid.ac/institutes/grid.417574.4", 
          "name": [
            "Abbott Laboratories, 60064, Abbott Park, Illinois, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hill", 
        "givenName": "Andrew", 
        "id": "sg:person.01002031561.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002031561.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Glaxo-Wellcome Research and Development, Greenford-Middlesex, UB6 0HE, United Kingdom", 
          "id": "http://www.grid.ac/institutes/grid.418236.a", 
          "name": [
            "Glaxo-Wellcome Research and Development, Greenford-Middlesex, UB6 0HE, United Kingdom"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Leonard", 
        "givenName": "John M.", 
        "id": "sg:person.01342544700.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342544700.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands", 
          "id": "http://www.grid.ac/institutes/grid.5650.6", 
          "name": [
            "Division of Infectious Diseases, Tropical Medicine and AIDS and National AIDS Therapy Evaluation Center, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands", 
            "Department of Internal Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Danner", 
        "givenName": "Sven A.", 
        "id": "sg:person.01303761254.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303761254.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Human Retrovirology, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands", 
          "id": "http://www.grid.ac/institutes/grid.7177.6", 
          "name": [
            "Department of Clinical Viro-Immunology, Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Plesmanlaan 125, 1066 CX, Amsterdam, The Netherlands", 
            "Laboratory for Experimental and Clinical Immunology, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands", 
            "Department of Human Retrovirology, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Miedema", 
        "givenName": "Frank", 
        "id": "sg:person.012755664317.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012755664317.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands", 
          "id": "http://www.grid.ac/institutes/grid.5650.6", 
          "name": [
            "Department of Clinical Viro-Immunology, Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Plesmanlaan 125, 1066 CX, Amsterdam, The Netherlands", 
            "Laboratory for Experimental and Clinical Immunology, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands", 
            "Department of Internal Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schellekens", 
        "givenName": "Peter T.A.", 
        "id": "sg:person.0760130432.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760130432.03"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nm0597-533", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002856145", 
          "https://doi.org/10.1038/nm0597-533"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/375195a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056439026", 
          "https://doi.org/10.1038/375195a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/387188a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026180202", 
          "https://doi.org/10.1038/387188a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/373117a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025418642", 
          "https://doi.org/10.1038/373117a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/373123a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014949926", 
          "https://doi.org/10.1038/373123a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4899-0191-0_9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000227096", 
          "https://doi.org/10.1007/978-1-4899-0191-0_9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/362355a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041590783", 
          "https://doi.org/10.1038/362355a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/375193b0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018438812", 
          "https://doi.org/10.1038/375193b0"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1998-02", 
    "datePublishedReg": "1998-02-01", 
    "description": "The origin of CD4+ T cells reappearing in the blood following antiretroviral therapy in human immunodeficiency virus type-1 (HIV-1) infection is still controversial. Here we show, using mathematical modeling, that redistribution of T cells to the blood can explain the striking correlation between the initial CD4+ and CD8+ memory T-cell repopulation and the observation that 3 weeks after the start of treatment memory CD4+ T-cell numbers reach a plateau. The increase in CD4+ T cells following therapy most likely is a composite of initial redistribution, accompanied by a continuous slow repopulation with newly produced naive T cells.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/nm0298-208", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1113716", 
        "issn": [
          "1078-8956", 
          "1546-170X"
        ], 
        "name": "Nature Medicine", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "4"
      }
    ], 
    "keywords": [
      "T cells", 
      "human immunodeficiency virus type 1 (HIV-1) infection", 
      "virus type 1 infection", 
      "peripheral blood T cells", 
      "T cell repopulation", 
      "T cell numbers", 
      "triple combination therapy", 
      "HIV-1 infection", 
      "type 1 infection", 
      "blood T cells", 
      "naive T cells", 
      "antiretroviral therapy", 
      "initial CD4", 
      "memory CD4", 
      "combination therapy", 
      "CD4", 
      "therapy", 
      "infection", 
      "slow repopulation", 
      "blood", 
      "cells", 
      "repopulation", 
      "initial redistribution", 
      "CD8", 
      "striking correlation", 
      "weeks", 
      "proliferation", 
      "biphasic kinetics", 
      "start", 
      "correlation", 
      "increase", 
      "number", 
      "origin", 
      "redistribution", 
      "observations", 
      "plateau", 
      "kinetics", 
      "mathematical modeling", 
      "modeling", 
      "composites"
    ], 
    "name": "Biphasic kinetics of peripheral blood T cells after triple combination therapy in HIV-1 infection: A composite of redistribution and proliferation", 
    "pagination": "208-214", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1046625046"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nm0298-208"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "9461195"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nm0298-208", 
      "https://app.dimensions.ai/details/publication/pub.1046625046"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-08-04T16:52", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_284.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/nm0298-208"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nm0298-208'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nm0298-208'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nm0298-208'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nm0298-208'


 

This table displays all metadata directly associated to this object as RDF triples.

259 TRIPLES      21 PREDICATES      85 URIs      69 LITERALS      18 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nm0298-208 schema:about N2c7c149c149346eebb4be05233adc294
2 N2ec5f948b1764e8db0f26b827e964252
3 N3e2c714259924ce3a8c100a4b641b402
4 N4502dce97fd64eca9459f50d3dc984dd
5 N598d0a5356c74ccf8ec07f11b4182d73
6 N7500fe03223e4c03b83e924120b53233
7 N8ac2775144c44311b54841513777e226
8 Na76fd13a6f0042a38b53d062d9a5431a
9 Nb420da2819a84aecbfbb7a4ba82c6334
10 Ne49c2437eeb646b2bf001d0bec3a93b7
11 Ne5276dfe737b4766a45a6b8448134947
12 anzsrc-for:11
13 anzsrc-for:1107
14 schema:author N8fdd8bbefb0f47cca42468bff7846079
15 schema:citation sg:pub.10.1007/978-1-4899-0191-0_9
16 sg:pub.10.1038/362355a0
17 sg:pub.10.1038/373117a0
18 sg:pub.10.1038/373123a0
19 sg:pub.10.1038/375193b0
20 sg:pub.10.1038/375195a0
21 sg:pub.10.1038/387188a0
22 sg:pub.10.1038/nm0597-533
23 schema:datePublished 1998-02
24 schema:datePublishedReg 1998-02-01
25 schema:description The origin of CD4+ T cells reappearing in the blood following antiretroviral therapy in human immunodeficiency virus type-1 (HIV-1) infection is still controversial. Here we show, using mathematical modeling, that redistribution of T cells to the blood can explain the striking correlation between the initial CD4+ and CD8+ memory T-cell repopulation and the observation that 3 weeks after the start of treatment memory CD4+ T-cell numbers reach a plateau. The increase in CD4+ T cells following therapy most likely is a composite of initial redistribution, accompanied by a continuous slow repopulation with newly produced naive T cells.
26 schema:genre article
27 schema:isAccessibleForFree true
28 schema:isPartOf N4bd439ffdfc04da09b387ca8b29efef7
29 Na6b463a2b2684fa69d64340743bcef94
30 sg:journal.1113716
31 schema:keywords CD4
32 CD8
33 HIV-1 infection
34 T cell numbers
35 T cell repopulation
36 T cells
37 antiretroviral therapy
38 biphasic kinetics
39 blood
40 blood T cells
41 cells
42 combination therapy
43 composites
44 correlation
45 human immunodeficiency virus type 1 (HIV-1) infection
46 increase
47 infection
48 initial CD4
49 initial redistribution
50 kinetics
51 mathematical modeling
52 memory CD4
53 modeling
54 naive T cells
55 number
56 observations
57 origin
58 peripheral blood T cells
59 plateau
60 proliferation
61 redistribution
62 repopulation
63 slow repopulation
64 start
65 striking correlation
66 therapy
67 triple combination therapy
68 type 1 infection
69 virus type 1 infection
70 weeks
71 schema:name Biphasic kinetics of peripheral blood T cells after triple combination therapy in HIV-1 infection: A composite of redistribution and proliferation
72 schema:pagination 208-214
73 schema:productId N54f413f5eaae4a52a43b2a6137a91b74
74 N628ad3fd676e4420b2db6522c009cd95
75 Nab819e58dc614b0a9d8d2dcbad924b2a
76 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046625046
77 https://doi.org/10.1038/nm0298-208
78 schema:sdDatePublished 2022-08-04T16:52
79 schema:sdLicense https://scigraph.springernature.com/explorer/license/
80 schema:sdPublisher Nc283a9f67d24462d89d0d533fc332bb9
81 schema:url https://doi.org/10.1038/nm0298-208
82 sgo:license sg:explorer/license/
83 sgo:sdDataset articles
84 rdf:type schema:ScholarlyArticle
85 N0660b7d980164e93b80e56c89148e803 rdf:first sg:person.0760130432.03
86 rdf:rest rdf:nil
87 N2c7c149c149346eebb4be05233adc294 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Drug Therapy, Combination
89 rdf:type schema:DefinedTerm
90 N2ec5f948b1764e8db0f26b827e964252 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name CD4-Positive T-Lymphocytes
92 rdf:type schema:DefinedTerm
93 N32a00fbe4e7c4d6bb86692a18e96d82f rdf:first sg:person.01342544700.31
94 rdf:rest N7fc7e25dee5a4c089c110f6813320a1d
95 N33c794538e7444329b02f1b02cdac511 rdf:first sg:person.012745551202.91
96 rdf:rest Nf5fa5be0a21147758fd2f5adc76c126e
97 N3e2c714259924ce3a8c100a4b641b402 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name RNA, Viral
99 rdf:type schema:DefinedTerm
100 N4502dce97fd64eca9459f50d3dc984dd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Cell Division
102 rdf:type schema:DefinedTerm
103 N4bd439ffdfc04da09b387ca8b29efef7 schema:volumeNumber 4
104 rdf:type schema:PublicationVolume
105 N51bd764c861548d5bfc66e398a061c31 rdf:first sg:person.012755664317.02
106 rdf:rest N0660b7d980164e93b80e56c89148e803
107 N54f413f5eaae4a52a43b2a6137a91b74 schema:name doi
108 schema:value 10.1038/nm0298-208
109 rdf:type schema:PropertyValue
110 N598d0a5356c74ccf8ec07f11b4182d73 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name HIV Infections
112 rdf:type schema:DefinedTerm
113 N628ad3fd676e4420b2db6522c009cd95 schema:name dimensions_id
114 schema:value pub.1046625046
115 rdf:type schema:PropertyValue
116 N7500fe03223e4c03b83e924120b53233 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Anti-HIV Agents
118 rdf:type schema:DefinedTerm
119 N75be1740f6d84f688103486e48ef3ae3 schema:affiliation grid-institutes:grid.7177.6
120 schema:familyName Wolf
121 schema:givenName Frank De
122 rdf:type schema:Person
123 N7fc7e25dee5a4c089c110f6813320a1d rdf:first sg:person.01303761254.85
124 rdf:rest N51bd764c861548d5bfc66e398a061c31
125 N8ac2775144c44311b54841513777e226 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name CD8-Positive T-Lymphocytes
127 rdf:type schema:DefinedTerm
128 N8fdd8bbefb0f47cca42468bff7846079 rdf:first sg:person.0736206324.46
129 rdf:rest Nd2f158b38a394dad84fa33fb07581dee
130 N98ab04023546418bb062123e07f0db55 rdf:first sg:person.0774503452.97
131 rdf:rest N33c794538e7444329b02f1b02cdac511
132 Na6b463a2b2684fa69d64340743bcef94 schema:issueNumber 2
133 rdf:type schema:PublicationIssue
134 Na76fd13a6f0042a38b53d062d9a5431a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Models, Immunological
136 rdf:type schema:DefinedTerm
137 Nab819e58dc614b0a9d8d2dcbad924b2a schema:name pubmed_id
138 schema:value 9461195
139 rdf:type schema:PropertyValue
140 Nb420da2819a84aecbfbb7a4ba82c6334 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name HIV-1
142 rdf:type schema:DefinedTerm
143 Nc283a9f67d24462d89d0d533fc332bb9 schema:name Springer Nature - SN SciGraph project
144 rdf:type schema:Organization
145 Nc6600310fd6741f9bf27f8fee745da4e rdf:first sg:person.01002031561.92
146 rdf:rest N32a00fbe4e7c4d6bb86692a18e96d82f
147 Nd2f158b38a394dad84fa33fb07581dee rdf:first sg:person.0732260043.24
148 rdf:rest N98ab04023546418bb062123e07f0db55
149 Ne49c2437eeb646b2bf001d0bec3a93b7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Humans
151 rdf:type schema:DefinedTerm
152 Ne5276dfe737b4766a45a6b8448134947 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name T-Lymphocytes
154 rdf:type schema:DefinedTerm
155 Nf5fa5be0a21147758fd2f5adc76c126e rdf:first N75be1740f6d84f688103486e48ef3ae3
156 rdf:rest Nc6600310fd6741f9bf27f8fee745da4e
157 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
158 schema:name Medical and Health Sciences
159 rdf:type schema:DefinedTerm
160 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
161 schema:name Immunology
162 rdf:type schema:DefinedTerm
163 sg:journal.1113716 schema:issn 1078-8956
164 1546-170X
165 schema:name Nature Medicine
166 schema:publisher Springer Nature
167 rdf:type schema:Periodical
168 sg:person.01002031561.92 schema:affiliation grid-institutes:grid.417574.4
169 schema:familyName Hill
170 schema:givenName Andrew
171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002031561.92
172 rdf:type schema:Person
173 sg:person.012745551202.91 schema:affiliation grid-institutes:grid.7177.6
174 schema:familyName Roos
175 schema:givenName Marijke T.L.
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012745551202.91
177 rdf:type schema:Person
178 sg:person.012755664317.02 schema:affiliation grid-institutes:grid.7177.6
179 schema:familyName Miedema
180 schema:givenName Frank
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012755664317.02
182 rdf:type schema:Person
183 sg:person.01303761254.85 schema:affiliation grid-institutes:grid.5650.6
184 schema:familyName Danner
185 schema:givenName Sven A.
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303761254.85
187 rdf:type schema:Person
188 sg:person.01342544700.31 schema:affiliation grid-institutes:grid.418236.a
189 schema:familyName Leonard
190 schema:givenName John M.
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342544700.31
192 rdf:type schema:Person
193 sg:person.0732260043.24 schema:affiliation grid-institutes:grid.7177.6
194 schema:familyName Notermans
195 schema:givenName Daan W.
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732260043.24
197 rdf:type schema:Person
198 sg:person.0736206324.46 schema:affiliation grid-institutes:grid.7177.6
199 schema:familyName Pakker
200 schema:givenName Nadine G.
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736206324.46
202 rdf:type schema:Person
203 sg:person.0760130432.03 schema:affiliation grid-institutes:grid.5650.6
204 schema:familyName Schellekens
205 schema:givenName Peter T.A.
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760130432.03
207 rdf:type schema:Person
208 sg:person.0774503452.97 schema:affiliation grid-institutes:grid.5477.1
209 schema:familyName De Boer
210 schema:givenName Rob J.
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774503452.97
212 rdf:type schema:Person
213 sg:pub.10.1007/978-1-4899-0191-0_9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000227096
214 https://doi.org/10.1007/978-1-4899-0191-0_9
215 rdf:type schema:CreativeWork
216 sg:pub.10.1038/362355a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041590783
217 https://doi.org/10.1038/362355a0
218 rdf:type schema:CreativeWork
219 sg:pub.10.1038/373117a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025418642
220 https://doi.org/10.1038/373117a0
221 rdf:type schema:CreativeWork
222 sg:pub.10.1038/373123a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014949926
223 https://doi.org/10.1038/373123a0
224 rdf:type schema:CreativeWork
225 sg:pub.10.1038/375193b0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018438812
226 https://doi.org/10.1038/375193b0
227 rdf:type schema:CreativeWork
228 sg:pub.10.1038/375195a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056439026
229 https://doi.org/10.1038/375195a0
230 rdf:type schema:CreativeWork
231 sg:pub.10.1038/387188a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026180202
232 https://doi.org/10.1038/387188a0
233 rdf:type schema:CreativeWork
234 sg:pub.10.1038/nm0597-533 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002856145
235 https://doi.org/10.1038/nm0597-533
236 rdf:type schema:CreativeWork
237 grid-institutes:grid.417574.4 schema:alternateName Abbott Laboratories, 60064, Abbott Park, Illinois, USA
238 schema:name Abbott Laboratories, 60064, Abbott Park, Illinois, USA
239 rdf:type schema:Organization
240 grid-institutes:grid.418236.a schema:alternateName Glaxo-Wellcome Research and Development, Greenford-Middlesex, UB6 0HE, United Kingdom
241 schema:name Glaxo-Wellcome Research and Development, Greenford-Middlesex, UB6 0HE, United Kingdom
242 rdf:type schema:Organization
243 grid-institutes:grid.5477.1 schema:alternateName Theoretical Biology, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands
244 schema:name Theoretical Biology, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands
245 rdf:type schema:Organization
246 grid-institutes:grid.5650.6 schema:alternateName Department of Internal Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands
247 schema:name Department of Clinical Viro-Immunology, Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Plesmanlaan 125, 1066 CX, Amsterdam, The Netherlands
248 Department of Internal Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands
249 Division of Infectious Diseases, Tropical Medicine and AIDS and National AIDS Therapy Evaluation Center, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands
250 Laboratory for Experimental and Clinical Immunology, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands
251 rdf:type schema:Organization
252 grid-institutes:grid.7177.6 schema:alternateName Department of Human Retrovirology, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands
253 Division of Infectious Diseases, Tropical Medicine and AIDS and National AIDS Therapy Evaluation Center, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands
254 Laboratory for Experimental and Clinical Immunology, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands
255 schema:name Department of Clinical Viro-Immunology, Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Plesmanlaan 125, 1066 CX, Amsterdam, The Netherlands
256 Department of Human Retrovirology, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands
257 Division of Infectious Diseases, Tropical Medicine and AIDS and National AIDS Therapy Evaluation Center, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands
258 Laboratory for Experimental and Clinical Immunology, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands
259 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...