Biphasic kinetics of peripheral blood T cells after triple combination therapy in HIV-1 infection: A composite of redistribution and proliferation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1998-02

AUTHORS

Nadine G. Pakker, Daan W. Notermans, Rob J. De Boer, Marijke T.L. Roos, Frank De Wolf, Andrew Hill, John M. Leonard, Sven A. Danner, Frank Miedema, Peter T.A. Schellekens

ABSTRACT

The origin of CD4+ T cells reappearing in the blood following antiretroviral therapy in human immunodeficiency virus type-1 (HIV-1) infection is still controversial. Here we show, using mathematical modeling, that redistribution of T cells to the blood can explain the striking correlation between the initial CD4+ and CD8+ memory T-cell repopulation and the observation that 3 weeks after the start of treatment memory CD4+ T-cell numbers reach a plateau. The increase in CD4+ T cells following therapy most likely is a composite of initial redistribution, accompanied by a continuous slow repopulation with newly produced naive T cells. More... »

PAGES

208-214

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nm0298-208

DOI

http://dx.doi.org/10.1038/nm0298-208

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046625046

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9461195


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