Presence of hematopoietic stem cells in the adult liver View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-02

AUTHORS

Hideki Taniguchi, Tomoko Toyoshima, Katashi Fukao, Hiromitsu Nakauchi

ABSTRACT

Recently, cases have been reported in which a mixed chimeric state of blood cells is established after liver transplantation. Because the established chimerism may have aided in the induction of donor–specific tolerance, the mechanism responsible for this chimerism is of clinical importance. To establish this, we examined cells in adult mouse liver and identified the presence of c–kit+ Sca–1+ Linlo/− cells. These cells were capable of forming in vivo as well as in vitro colonies. Furthermore, the cells could reconstitute bone marrow of lethally irradiated recipient mice for at least 12 months. These data obtained from the mouse study strongly suggest that hematopoietic stem cells residing in the donor liver are responsible for mixed chimerism and maintenance of tolerance after liver transplantation. More... »

PAGES

198-203

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nm0296-198

DOI

http://dx.doi.org/10.1038/nm0296-198

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1008766623

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8574965


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