Preimplantation-stage stem cells induce long-term allogeneic graft acceptance without supplementary host conditioning View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-02

AUTHORS

Fred Fändrich, Xiongbin Lin, Gui X. Chai, Maren Schulze, Detlev Ganten, Michael Bader, Julia Holle, Dong-Sheng Huang, Reza Parwaresch, Nicholaus Zavazava, Bert Binas

ABSTRACT

Hematopoietic stem cells have been successfully employed for tolerance induction in a variety of rodent and large animal studies. However, clinical transplantation of fully allogeneic bone marrow or blood-borne stem cells is still associated with major obstacles, such as graft-versus-host disease or cytoreductive conditioning-related toxicity. Here we show that when rat embryonic stem cell-like cells of WKY origin are injected intraportally into fully MHC-mismatched DA rats, they engraft permanently (>150 days) without supplementary host conditioning. This deviation of a potentially alloreactive immune response sets the basis for long-term graft acceptance of second-set transplanted WKY cardiac allografts. Graft survival was strictly correlated with a state of mixed chimerism, which required functional thymic host competence. Our results provide a rationale for using preimplantation-stage stem cells as vehicles in gene therapy and for the induction of long-term graft acceptance. More... »

PAGES

171

Journal

TITLE

Nature Medicine

ISSUE

2

VOLUME

8

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nm0202-171

    DOI

    http://dx.doi.org/10.1038/nm0202-171

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1031135177

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/11821902


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