Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1997-01

AUTHORS

M Citron, D Westaway, W Xia, G Carlson, T Diehl, G Levesque, K Johnson-Wood, M Lee, P Seubert, A Davis, D Kholodenko, R Motter, R Sherrington, B Perry, H Yao, R Strome, I Lieberburg, J Rommens, S Kim, D Schenk, P Fraser, P St George Hyslop, D J Selkoe

ABSTRACT

The mechanism by which mutations in the presenilin (PS) genes cause the most aggressive form of early-onset Alzheimer's disease (AD) is unknown, but fibroblasts from mutation carriers secrete increased levels of the amyloidogenic A beta 42 peptide, the main component of AD plaques. We established transfected cell and transgenic mouse models that coexpress human PS and amyloid beta-protein precursor (APP) genes and analyzed quantitatively the effects of PS expression on APP processing. In both models, expression of wild-type PS genes did not alter APP levels, alpha- and beta-secretase activity and A beta production. In the transfected cells, PS1 and PS2 mutations caused a highly significant increase in A beta 42 secretion in all mutant clones. Likewise, mutant but not wildtype PS1 transgenic mice showed significant overproduction of A beta 42 in the brain, and this effect was detectable as early as 2-4 months of age. Different PS mutations had differential effects on A beta generation. The extent of A beta 42 increase did not correlate with presenilin expression levels. Our data demonstrate that the presenilin mutations cause a dominant gain of function and may induce AD by enhancing A beta 42 production, thus promoting cerebral beta-amyloidosis. More... »

PAGES

67-72

Journal

TITLE

Nature Medicine

ISSUE

1

VOLUME

3

Author Affiliations

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nm0197-67

    DOI

    http://dx.doi.org/10.1038/nm0197-67

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1038157044

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/8986743


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