Adoptive transfer of costimulated CD4+ T cells induces expansion of peripheral T cells and decreased CCR5 expression in HIV infection View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-01

AUTHORS

Bruce L. Levine, Wendy B. Bernstein, Naomi E. Aronson, Katia Schlienger, Julio Cotte, Steven Perfetto, Mary J. Humphries, Silvia Ratto-Kim, Deborah L. Birx, Carolyn Steffens, Alan Landay, Richard G. Carroll, Carl H. June

ABSTRACT

To study the safety and feasibility of T-cell reconstitution in HIV-infected individuals, we adoptively transferred activated autologous CD4+ T cells. Polyclonal peripheral blood CD4+ cells were costimulated ex vivo and subjects were given infusions of up to 3 x 1010 activated CD4+ cells. Dose-dependent increases in CD4+ cell counts and in the CD4:CD8 ratio were observed. Sustained increases in the fraction of cytokine-secreting T cells and decreases in the percentage of CD4+CCR5+ cells were noted in vivo, suggesting enhanced function and resistance to HIV infection. The frequency of CD4+Ki-67+ cells increased whereas CD4+ T cells containing T cell-receptor rearrangement excision circles (TRECs) decreased. These findings indicate that expansion of the peripheral T-cell pool mediated the increase in CD4 counts and suggest that approaches to reconstitute CD4 helper cell activity and decrease CCR5 expression may augment natural immunity to HIV infection. More... »

PAGES

47

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nm0102-47

DOI

http://dx.doi.org/10.1038/nm0102-47

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1018873794

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11786906


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