Ontology type: schema:ScholarlyArticle Open Access: True
2018-02
AUTHORSEnrico Velardi, Jennifer J Tsai, Stefan Radtke, Kirsten Cooper, Kimon V Argyropoulos, Shieh Jae-Hung, Lauren F Young, Amina Lazrak, Odette M Smith, Sophie Lieberman, Fabiana Kreines, Yusuke Shono, Tobias Wertheimer, Robert R Jenq, Alan M Hanash, Prema Narayan, Zhenmin Lei, Malcolm A Moore, Hans-Peter Kiem, Marcel R M van den Brink, Jarrod A Dudakov
ABSTRACTThere is a substantial unmet clinical need for new strategies to protect the hematopoietic stem cell (HSC) pool and regenerate hematopoiesis after radiation injury from either cancer therapy or accidental exposure. Increasing evidence suggests that sex hormones, beyond their role in promoting sexual dimorphism, regulate HSC self-renewal, differentiation, and proliferation. We and others have previously reported that sex-steroid ablation promotes bone marrow (BM) lymphopoiesis and HSC recovery in aged and immunodepleted mice. Here we found that a luteinizing hormone (LH)-releasing hormone antagonist (LHRH-Ant), currently in wide clinical use for sex-steroid inhibition, promoted hematopoietic recovery and mouse survival when administered 24 h after an otherwise-lethal dose of total-body irradiation (L-TBI). Unexpectedly, this protective effect was independent of sex steroids and instead relied on suppression of LH levels. Human and mouse long-term self-renewing HSCs (LT-HSCs) expressed high levels of the LH/choriogonadotropin receptor (LHCGR) and expanded ex vivo when stimulated with LH. In contrast, the suppression of LH after L-TBI inhibited entry of HSCs into the cell cycle, thus promoting HSC quiescence and protecting the cells from exhaustion. These findings reveal a role of LH in regulating HSC function and offer a new therapeutic approach for hematopoietic regeneration after hematopoietic injury. More... »
PAGES239
http://scigraph.springernature.com/pub.10.1038/nm.4470
DOIhttp://dx.doi.org/10.1038/nm.4470
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1100241875
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/29309056
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Clinical Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "University of Perugia",
"id": "https://www.grid.ac/institutes/grid.9027.c",
"name": [
"Department of Immunology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.",
"Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy."
],
"type": "Organization"
},
"familyName": "Velardi",
"givenName": "Enrico",
"id": "sg:person.01106304612.54",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106304612.54"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Washington",
"id": "https://www.grid.ac/institutes/grid.34477.33",
"name": [
"Department of Immunology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.",
"Program in Immunology, Clinical Research Division and Immunotherapy Integrated Research Center, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.",
"Department of Immunology, University of Washington, Seattle, Washington, USA."
],
"type": "Organization"
},
"familyName": "Tsai",
"givenName": "Jennifer J",
"id": "sg:person.01003457273.22",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003457273.22"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Fred Hutchinson Cancer Research Center",
"id": "https://www.grid.ac/institutes/grid.270240.3",
"name": [
"Stem Cell and Gene Therapy Program, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.",
"Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany."
],
"type": "Organization"
},
"familyName": "Radtke",
"givenName": "Stefan",
"id": "sg:person.0600774137.20",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600774137.20"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Washington",
"id": "https://www.grid.ac/institutes/grid.34477.33",
"name": [
"Program in Immunology, Clinical Research Division and Immunotherapy Integrated Research Center, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.",
"Department of Immunology, University of Washington, Seattle, Washington, USA."
],
"type": "Organization"
},
"familyName": "Cooper",
"givenName": "Kirsten",
"id": "sg:person.012602650644.30",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012602650644.30"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Memorial Sloan Kettering Cancer Center",
"id": "https://www.grid.ac/institutes/grid.51462.34",
"name": [
"Department of Immunology, Memorial Sloan Kettering Cancer Center, New York, New York, USA."
],
"type": "Organization"
},
"familyName": "Argyropoulos",
"givenName": "Kimon V",
"id": "sg:person.01206777247.84",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206777247.84"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Memorial Sloan Kettering Cancer Center",
"id": "https://www.grid.ac/institutes/grid.51462.34",
"name": [
"Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA."
],
"type": "Organization"
},
"familyName": "Jae-Hung",
"givenName": "Shieh",
"id": "sg:person.016366133244.09",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016366133244.09"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Memorial Sloan Kettering Cancer Center",
"id": "https://www.grid.ac/institutes/grid.51462.34",
"name": [
"Department of Immunology, Memorial Sloan Kettering Cancer Center, New York, New York, USA."
],
"type": "Organization"
},
"familyName": "Young",
"givenName": "Lauren F",
"id": "sg:person.01276361243.54",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276361243.54"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Memorial Sloan Kettering Cancer Center",
"id": "https://www.grid.ac/institutes/grid.51462.34",
"name": [
"Department of Immunology, Memorial Sloan Kettering Cancer Center, New York, New York, USA."
],
"type": "Organization"
},
"familyName": "Lazrak",
"givenName": "Amina",
"id": "sg:person.011257015457.98",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011257015457.98"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Memorial Sloan Kettering Cancer Center",
"id": "https://www.grid.ac/institutes/grid.51462.34",
"name": [
"Department of Immunology, Memorial Sloan Kettering Cancer Center, New York, New York, USA."
],
"type": "Organization"
},
"familyName": "Smith",
"givenName": "Odette M",
"id": "sg:person.0655774766.05",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655774766.05"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Memorial Sloan Kettering Cancer Center",
"id": "https://www.grid.ac/institutes/grid.51462.34",
"name": [
"Department of Immunology, Memorial Sloan Kettering Cancer Center, New York, New York, USA."
],
"type": "Organization"
},
"familyName": "Lieberman",
"givenName": "Sophie",
"id": "sg:person.010526555644.43",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010526555644.43"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Memorial Sloan Kettering Cancer Center",
"id": "https://www.grid.ac/institutes/grid.51462.34",
"name": [
"Department of Immunology, Memorial Sloan Kettering Cancer Center, New York, New York, USA."
],
"type": "Organization"
},
"familyName": "Kreines",
"givenName": "Fabiana",
"id": "sg:person.01340672670.07",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340672670.07"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Memorial Sloan Kettering Cancer Center",
"id": "https://www.grid.ac/institutes/grid.51462.34",
"name": [
"Department of Immunology, Memorial Sloan Kettering Cancer Center, New York, New York, USA."
],
"type": "Organization"
},
"familyName": "Shono",
"givenName": "Yusuke",
"id": "sg:person.01136604042.05",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136604042.05"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Memorial Sloan Kettering Cancer Center",
"id": "https://www.grid.ac/institutes/grid.51462.34",
"name": [
"Department of Immunology, Memorial Sloan Kettering Cancer Center, New York, New York, USA."
],
"type": "Organization"
},
"familyName": "Wertheimer",
"givenName": "Tobias",
"id": "sg:person.01230153262.51",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230153262.51"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "The University of Texas MD Anderson Cancer Center",
"id": "https://www.grid.ac/institutes/grid.240145.6",
"name": [
"Departments of Genomic Medicine and Stem Cell Transplantation Cellular Therapy, Division of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas, USA."
],
"type": "Organization"
},
"familyName": "Jenq",
"givenName": "Robert R",
"id": "sg:person.0714450277.09",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714450277.09"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Memorial Sloan Kettering Cancer Center",
"id": "https://www.grid.ac/institutes/grid.51462.34",
"name": [
"Department of Immunology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.",
"Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA."
],
"type": "Organization"
},
"familyName": "Hanash",
"givenName": "Alan M",
"id": "sg:person.0667203543.79",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667203543.79"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Southern Illinois University School of Medicine",
"id": "https://www.grid.ac/institutes/grid.280418.7",
"name": [
"Department of Physiology, Southern Illinois University School of Medicine, Carbondale, Illinois, USA."
],
"type": "Organization"
},
"familyName": "Narayan",
"givenName": "Prema",
"id": "sg:person.0733307343.52",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733307343.52"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Louisville",
"id": "https://www.grid.ac/institutes/grid.266623.5",
"name": [
"Department of OB/GYN & Women\u2032s Health, University of Louisville School of Medicine, Louisville, Kentucky, USA."
],
"type": "Organization"
},
"familyName": "Lei",
"givenName": "Zhenmin",
"id": "sg:person.0612130042.43",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612130042.43"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Memorial Sloan Kettering Cancer Center",
"id": "https://www.grid.ac/institutes/grid.51462.34",
"name": [
"Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA."
],
"type": "Organization"
},
"familyName": "Moore",
"givenName": "Malcolm A",
"id": "sg:person.07455026572.07",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07455026572.07"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Washington",
"id": "https://www.grid.ac/institutes/grid.34477.33",
"name": [
"Stem Cell and Gene Therapy Program, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.",
"Department of Medicine, University of Washington School of Medicine, Seattle, Washington, USA.",
"Department of Pathology, University of Washington School of Medicine, Seattle, Washington, USA."
],
"type": "Organization"
},
"familyName": "Kiem",
"givenName": "Hans-Peter",
"id": "sg:person.01350411276.47",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01350411276.47"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Cornell University",
"id": "https://www.grid.ac/institutes/grid.5386.8",
"name": [
"Department of Immunology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.",
"Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.",
"Department of Immunology and Microbial Pathogenesis, Weill Cornell Medical College, New York, New York, USA."
],
"type": "Organization"
},
"familyName": "van den Brink",
"givenName": "Marcel R M",
"id": "sg:person.016204530577.32",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016204530577.32"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Washington",
"id": "https://www.grid.ac/institutes/grid.34477.33",
"name": [
"Program in Immunology, Clinical Research Division and Immunotherapy Integrated Research Center, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.",
"Department of Immunology, University of Washington, Seattle, Washington, USA."
],
"type": "Organization"
},
"familyName": "Dudakov",
"givenName": "Jarrod A",
"id": "sg:person.0773755073.57",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773755073.57"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1126/science.1201219",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000801719"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.89.20.9464",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000909131"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.exphem.2016.02.011",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001100902"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1084/jem.20081297",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001917778"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature07815",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002035943",
"https://doi.org/10.1038/nature07815"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1084/jem.20121610",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003376253"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1182/blood-2013-08-521716",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009744873"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4049/jimmunol.0900196",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011456596"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1182/blood-2013-07-515619",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012931959"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00004032-200305000-00001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015475928"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00004032-200305000-00001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015475928"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1172/jci7954",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016602870"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0301-472x(02)00802-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018791198"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.3758/brm.41.4.1149",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019543365",
"https://doi.org/10.3758/brm.41.4.1149"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1172/jci76838",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021097749"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1634/stemcells.2005-0598",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021642548"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.stem.2014.11.002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022326706"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nm.3070",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023511140",
"https://doi.org/10.1038/nm.3070"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/pbc.22004",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023677825"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/pbc.22004",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023677825"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ncb2699",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025593780",
"https://doi.org/10.1038/ncb2699"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.mce.2013.12.009",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025643869"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1101/gad.2024411",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027637451"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nri3433",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030400072",
"https://doi.org/10.1038/nri3433"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1182/blood-2009-06-229443",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030673534"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nm.2969",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032280409",
"https://doi.org/10.1038/nm.2969"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nbt.1517",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033056074",
"https://doi.org/10.1038/nbt.1517"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1172/jci41402",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036001235"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1172/jci41402",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036001235"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.exphem.2004.07.015",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037281884"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.287.5459.1804",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038093676"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1210/en.2012-2179",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040877611"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1634/stemcells.2006-0631",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041126701"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cell.2016.06.042",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041248245"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cell.2016.06.042",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041248245"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature12932",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045557644",
"https://doi.org/10.1038/nature12932"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.stemcr.2015.01.018",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050985461"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1084/jem.20131289",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051452174"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1182/blood-2005-04-1418",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053720932"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1089/scd.2014.0546",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1059311119"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.1106114",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062451294"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1210/en.2007-0160",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064248555"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1259/bjr/16386034",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064568117"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1667/rr1880.1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1068195668"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4049/jimmunol.0802446",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1077894634"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4049/jimmunol.0802445",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1078164194"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1079353859",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082467308",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1083092736",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/scitranslmed.aal3986",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1085071136"
],
"type": "CreativeWork"
}
],
"datePublished": "2018-02",
"datePublishedReg": "2018-02-01",
"description": "There is a substantial unmet clinical need for new strategies to protect the hematopoietic stem cell (HSC) pool and regenerate hematopoiesis after radiation injury from either cancer therapy or accidental exposure. Increasing evidence suggests that sex hormones, beyond their role in promoting sexual dimorphism, regulate HSC self-renewal, differentiation, and proliferation. We and others have previously reported that sex-steroid ablation promotes bone marrow (BM) lymphopoiesis and HSC recovery in aged and immunodepleted mice. Here we found that a luteinizing hormone (LH)-releasing hormone antagonist (LHRH-Ant), currently in wide clinical use for sex-steroid inhibition, promoted hematopoietic recovery and mouse survival when administered 24 h after an otherwise-lethal dose of total-body irradiation (L-TBI). Unexpectedly, this protective effect was independent of sex steroids and instead relied on suppression of LH levels. Human and mouse long-term self-renewing HSCs (LT-HSCs) expressed high levels of the LH/choriogonadotropin receptor (LHCGR) and expanded ex vivo when stimulated with LH. In contrast, the suppression of LH after L-TBI inhibited entry of HSCs into the cell cycle, thus promoting HSC quiescence and protecting the cells from exhaustion. These findings reveal a role of LH in regulating HSC function and offer a new therapeutic approach for hematopoietic regeneration after hematopoietic injury.",
"genre": "research_article",
"id": "sg:pub.10.1038/nm.4470",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isFundedItemOf": [
{
"id": "sg:grant.2538545",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2435422",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.4241576",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2458446",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2414460",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2459635",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2438826",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.3800519",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.7026967",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2459713",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2438793",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.5124551",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1113716",
"issn": [
"1078-8956",
"1546-170X"
],
"name": "Nature Medicine",
"type": "Periodical"
},
{
"issueNumber": "2",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "24"
}
],
"name": "Suppression of luteinizing hormone enhances HSC recovery after hematopoietic injury",
"pagination": "239",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"c24389bf18a04d91805bde233c94bd3c7d6a6a10dabf981cd340f6c939da569a"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"29309056"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"9502015"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/nm.4470"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1100241875"
]
}
],
"sameAs": [
"https://doi.org/10.1038/nm.4470",
"https://app.dimensions.ai/details/publication/pub.1100241875"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T12:14",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000361_0000000361/records_54008_00000001.jsonl",
"type": "ScholarlyArticle",
"url": "https://www.nature.com/articles/nm.4470"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nm.4470'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nm.4470'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nm.4470'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nm.4470'
This table displays all metadata directly associated to this object as RDF triples.
408 TRIPLES
21 PREDICATES
75 URIs
21 LITERALS
9 BLANK NODES