Targeting the T cell receptor β-chain constant region for immunotherapy of T cell malignancies View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Paul M Maciocia, Patrycja A Wawrzyniecka, Brian Philip, Ida Ricciardelli, Ayse U Akarca, Shimobi C Onuoha, Mateusz Legut, David K Cole, Andrew K Sewell, Giuseppe Gritti, Joan Somja, Miguel A Piris, Karl S Peggs, David C Linch, Teresa Marafioti, Martin A Pule

ABSTRACT

Mature T cell cancers are typically aggressive, treatment resistant and associated with poor prognosis. Clinical application of immunotherapeutic approaches has been limited by a lack of target antigens that discriminate malignant from healthy (normal) T cells. Unlike B cell depletion, pan-T cell aplasia is prohibitively toxic. We report a new targeting strategy based on the mutually exclusive expression of T cell receptor β-chain constant domains 1 and 2 (TRBC1 and TRBC2). We identify an antibody with unique TRBC1 specificity and use it to demonstrate that normal and virus-specific T cell populations contain both TRBC1+ and TRBC2+ compartments, whereas malignancies are restricted to only one. As proof of concept for anti-TRBC immunotherapy, we developed anti-TRBC1 chimeric antigen receptor (CAR) T cells, which recognized and killed normal and malignant TRBC1+, but not TRBC2+, T cells in vitro and in a disseminated mouse model of leukemia. Unlike nonselective approaches targeting the entire T cell population, TRBC-targeted immunotherapy could eradicate a T cell malignancy while preserving sufficient normal T cells to maintain cellular immunity. More... »

PAGES

1416

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nm.4444

DOI

http://dx.doi.org/10.1038/nm.4444

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1092656967

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29131157


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents, Immunological", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HEK293 Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunotherapy, Adoptive", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Jurkat Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "K562 Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leukemia, T-Cell", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Targeted Therapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Antigen, T-Cell, alpha-beta", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "T-Lymphocytes", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University College London", 
          "id": "https://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "Cancer Institute, University College London, London, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Maciocia", 
        "givenName": "Paul M", 
        "id": "sg:person.01316113437.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316113437.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University College London", 
          "id": "https://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "Cancer Institute, University College London, London, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wawrzyniecka", 
        "givenName": "Patrycja A", 
        "id": "sg:person.011466772677.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011466772677.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University College London", 
          "id": "https://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "Cancer Institute, University College London, London, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Philip", 
        "givenName": "Brian", 
        "id": "sg:person.0647566650.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647566650.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University College London", 
          "id": "https://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "Institute of Child Health, University College London, London, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ricciardelli", 
        "givenName": "Ida", 
        "id": "sg:person.01363677251.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01363677251.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University College London", 
          "id": "https://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "Cancer Institute, University College London, London, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Akarca", 
        "givenName": "Ayse U", 
        "id": "sg:person.0757322615.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0757322615.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Autolus (United Kingdom)", 
          "id": "https://www.grid.ac/institutes/grid.497906.5", 
          "name": [
            "Autolus, Ltd., London, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Onuoha", 
        "givenName": "Shimobi C", 
        "id": "sg:person.01035363623.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035363623.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cardiff University", 
          "id": "https://www.grid.ac/institutes/grid.5600.3", 
          "name": [
            "Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Legut", 
        "givenName": "Mateusz", 
        "id": "sg:person.01260320201.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260320201.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cardiff University", 
          "id": "https://www.grid.ac/institutes/grid.5600.3", 
          "name": [
            "Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cole", 
        "givenName": "David K", 
        "id": "sg:person.0656056514.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0656056514.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cardiff University", 
          "id": "https://www.grid.ac/institutes/grid.5600.3", 
          "name": [
            "Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sewell", 
        "givenName": "Andrew K", 
        "id": "sg:person.07563166044.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07563166044.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ospedale Papa Giovanni XXIII", 
          "id": "https://www.grid.ac/institutes/grid.460094.f", 
          "name": [
            "Hematology and Bone Marrow Transplant Units, Papa Giovanni XXIII Hospital, Bergamo, Italy."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gritti", 
        "givenName": "Giuseppe", 
        "id": "sg:person.01211123241.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211123241.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Li\u00e8ge", 
          "id": "https://www.grid.ac/institutes/grid.4861.b", 
          "name": [
            "Department of Anatomy and Cellular Pathology, University of Li\u00e8ge, Li\u00e8ge, Belgium."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Somja", 
        "givenName": "Joan", 
        "id": "sg:person.01300253056.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300253056.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz", 
          "id": "https://www.grid.ac/institutes/grid.419651.e", 
          "name": [
            "Department of Pathology, Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer (CIBERONC), Madrid, Spain."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Piris", 
        "givenName": "Miguel A", 
        "id": "sg:person.0665360572.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665360572.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University College London", 
          "id": "https://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "Cancer Institute, University College London, London, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Peggs", 
        "givenName": "Karl S", 
        "id": "sg:person.0630024242.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630024242.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University College London", 
          "id": "https://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "Cancer Institute, University College London, London, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Linch", 
        "givenName": "David C", 
        "id": "sg:person.01016620552.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016620552.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University College London", 
          "id": "https://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "Cancer Institute, University College London, London, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Marafioti", 
        "givenName": "Teresa", 
        "id": "sg:person.01054273773.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054273773.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Autolus (United Kingdom)", 
          "id": "https://www.grid.ac/institutes/grid.497906.5", 
          "name": [
            "Cancer Institute, University College London, London, UK.", 
            "Autolus, Ltd., London, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pule", 
        "givenName": "Martin A", 
        "id": "sg:person.01036017402.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036017402.29"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1182/blood-2004-11-4564", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000714496"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri.2016.28", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001842776", 
          "https://doi.org/10.1038/nri.2016.28"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2010-09-310342", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006386262"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.82.15.5068", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006420218"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1103849", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009197831"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ymthe.2005.04.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009255536"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ymthe.2005.04.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009255536"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/scitranslmed.3008226", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009684137"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2404481", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010503983", 
          "https://doi.org/10.1038/sj.leu.2404481"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2404481", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010503983", 
          "https://doi.org/10.1038/sj.leu.2404481"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1407222", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012474298"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1074-7613(00)80022-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014825820"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2014.56.2025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015070639"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/protein/gzg087", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016193642"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.03.6327", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017121360"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/eji.1830220237", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017553706"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci86000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020347220"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2015-02-629527", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021627505"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.092924.109", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025925546"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2008.16.4558", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029891295"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/312541a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030130235", 
          "https://doi.org/10.1038/312541a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/leu.2015.311", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030909712", 
          "https://doi.org/10.1038/leu.2015.311"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm0402-410", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035523287", 
          "https://doi.org/10.1038/nm0402-410"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm0402-410", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035523287", 
          "https://doi.org/10.1038/nm0402-410"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.2873", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040376253", 
          "https://doi.org/10.1038/ng.2873"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2014-01-545020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047143412"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2014-01-553362", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048157577"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1309/qf6n-vaqw-n74h-4je2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050635356"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/02841860903150502", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051829076"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/hyb.1992.11.701", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059275206"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1158545", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062457773"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078357876", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078816576", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079556020", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082390841", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083012804", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083095803", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-12", 
    "datePublishedReg": "2017-12-01", 
    "description": "Mature T cell cancers are typically aggressive, treatment resistant and associated with poor prognosis. Clinical application of immunotherapeutic approaches has been limited by a lack of target antigens that discriminate malignant from healthy (normal) T cells. Unlike B cell depletion, pan-T cell aplasia is prohibitively toxic. We report a new targeting strategy based on the mutually exclusive expression of T cell receptor \u03b2-chain constant domains 1 and 2 (TRBC1 and TRBC2). We identify an antibody with unique TRBC1 specificity and use it to demonstrate that normal and virus-specific T cell populations contain both TRBC1+ and TRBC2+ compartments, whereas malignancies are restricted to only one. As proof of concept for anti-TRBC immunotherapy, we developed anti-TRBC1 chimeric antigen receptor (CAR) T cells, which recognized and killed normal and malignant TRBC1+, but not TRBC2+, T cells in vitro and in a disseminated mouse model of leukemia. Unlike nonselective approaches targeting the entire T cell population, TRBC-targeted immunotherapy could eradicate a T cell malignancy while preserving sufficient normal T cells to maintain cellular immunity.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nm.4444", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.5072413", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1113716", 
        "issn": [
          "1078-8956", 
          "1546-170X"
        ], 
        "name": "Nature Medicine", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "12", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "23"
      }
    ], 
    "name": "Targeting the T cell receptor \u03b2-chain constant region for immunotherapy of T cell malignancies", 
    "pagination": "1416", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "db79b7d695987deb39f1c64cdab891e2f8dd6c2486b0c1a82a5072be91c768a0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29131157"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9502015"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nm.4444"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1092656967"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nm.4444", 
      "https://app.dimensions.ai/details/publication/pub.1092656967"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:25", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000362_0000000362/records_87104_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/nm.4444"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nm.4444'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nm.4444'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nm.4444'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nm.4444'


 

This table displays all metadata directly associated to this object as RDF triples.

351 TRIPLES      21 PREDICATES      77 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nm.4444 schema:about N208cfb680c7942cf942e409bc6ee8479
2 N2af8b622a3f048d3b81c272e7e38deb5
3 N345d89157d3b41119c7bec1b03bbf86d
4 N8549c22b042940c9a1b2b581505420ab
5 N86ed9f814f0e493c8b4cac971eb1f5d9
6 N8c6ce074ce044d68813defa73ec11dfb
7 N9148565810854d85a56d0210eef57243
8 N93a6e06d43c34b01bbc2237593727887
9 Nb03177b7e0384351ba00327b84d17206
10 Nc3d01e1f492c4e20820adec76ad4c71d
11 Nc56fccb4085749969e9201899a8e86d0
12 Ne239e83402fa4f1caccc9fbe19da8ff3
13 Nf6d8196f32584ebba82b7a56cff235d1
14 Nf9c0015563ca40ed8ec04af009df2985
15 anzsrc-for:11
16 anzsrc-for:1107
17 schema:author Nce29e487e64448e7b30d84625197b38c
18 schema:citation sg:pub.10.1038/312541a0
19 sg:pub.10.1038/leu.2015.311
20 sg:pub.10.1038/ng.2873
21 sg:pub.10.1038/nm0402-410
22 sg:pub.10.1038/nri.2016.28
23 sg:pub.10.1038/sj.leu.2404481
24 https://app.dimensions.ai/details/publication/pub.1078357876
25 https://app.dimensions.ai/details/publication/pub.1078816576
26 https://app.dimensions.ai/details/publication/pub.1079556020
27 https://app.dimensions.ai/details/publication/pub.1082390841
28 https://app.dimensions.ai/details/publication/pub.1083012804
29 https://app.dimensions.ai/details/publication/pub.1083095803
30 https://doi.org/10.1002/eji.1830220237
31 https://doi.org/10.1016/j.ymthe.2005.04.016
32 https://doi.org/10.1016/s1074-7613(00)80022-9
33 https://doi.org/10.1056/nejmoa1103849
34 https://doi.org/10.1056/nejmoa1407222
35 https://doi.org/10.1073/pnas.82.15.5068
36 https://doi.org/10.1089/hyb.1992.11.701
37 https://doi.org/10.1093/protein/gzg087
38 https://doi.org/10.1101/gr.092924.109
39 https://doi.org/10.1126/science.1158545
40 https://doi.org/10.1126/scitranslmed.3008226
41 https://doi.org/10.1172/jci86000
42 https://doi.org/10.1182/blood-2004-11-4564
43 https://doi.org/10.1182/blood-2010-09-310342
44 https://doi.org/10.1182/blood-2014-01-545020
45 https://doi.org/10.1182/blood-2014-01-553362
46 https://doi.org/10.1182/blood-2015-02-629527
47 https://doi.org/10.1200/jco.2005.03.6327
48 https://doi.org/10.1200/jco.2008.16.4558
49 https://doi.org/10.1200/jco.2014.56.2025
50 https://doi.org/10.1309/qf6n-vaqw-n74h-4je2
51 https://doi.org/10.3109/02841860903150502
52 schema:datePublished 2017-12
53 schema:datePublishedReg 2017-12-01
54 schema:description Mature T cell cancers are typically aggressive, treatment resistant and associated with poor prognosis. Clinical application of immunotherapeutic approaches has been limited by a lack of target antigens that discriminate malignant from healthy (normal) T cells. Unlike B cell depletion, pan-T cell aplasia is prohibitively toxic. We report a new targeting strategy based on the mutually exclusive expression of T cell receptor β-chain constant domains 1 and 2 (TRBC1 and TRBC2). We identify an antibody with unique TRBC1 specificity and use it to demonstrate that normal and virus-specific T cell populations contain both TRBC1<sup>+</sup> and TRBC2<sup>+</sup> compartments, whereas malignancies are restricted to only one. As proof of concept for anti-TRBC immunotherapy, we developed anti-TRBC1 chimeric antigen receptor (CAR) T cells, which recognized and killed normal and malignant TRBC1<sup>+</sup>, but not TRBC2<sup>+</sup>, T cells in vitro and in a disseminated mouse model of leukemia. Unlike nonselective approaches targeting the entire T cell population, TRBC-targeted immunotherapy could eradicate a T cell malignancy while preserving sufficient normal T cells to maintain cellular immunity.
55 schema:genre research_article
56 schema:inLanguage en
57 schema:isAccessibleForFree true
58 schema:isPartOf N2912f1217e284cc9931567c149cd84e0
59 Ne56fb98c858e41328e56c6e938dc578c
60 sg:journal.1113716
61 schema:name Targeting the T cell receptor β-chain constant region for immunotherapy of T cell malignancies
62 schema:pagination 1416
63 schema:productId N51b1b7882a3c472ca5d9a7e287e6f658
64 N56d33a1aaeec41e789b904599a6d6d18
65 N6d212e251b364db5b979b379cb2238b5
66 Nb4c2ccb88b064e7fa0f2a0fdeddeadc6
67 Nc0213df69a4b440fb9dad132a5e91afb
68 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092656967
69 https://doi.org/10.1038/nm.4444
70 schema:sdDatePublished 2019-04-11T12:25
71 schema:sdLicense https://scigraph.springernature.com/explorer/license/
72 schema:sdPublisher Na1845a03e26c4066ab89b57d4009221f
73 schema:url https://www.nature.com/articles/nm.4444
74 sgo:license sg:explorer/license/
75 sgo:sdDataset articles
76 rdf:type schema:ScholarlyArticle
77 N0ac4ff7aa84c40829df49c93a2a4d98f rdf:first sg:person.01300253056.57
78 rdf:rest Nf0a5526cf2aa4244abd413013341a22e
79 N208cfb680c7942cf942e409bc6ee8479 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Leukemia, T-Cell
81 rdf:type schema:DefinedTerm
82 N2912f1217e284cc9931567c149cd84e0 schema:volumeNumber 23
83 rdf:type schema:PublicationVolume
84 N2af8b622a3f048d3b81c272e7e38deb5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Humans
86 rdf:type schema:DefinedTerm
87 N345d89157d3b41119c7bec1b03bbf86d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Animals
89 rdf:type schema:DefinedTerm
90 N3bd3d9b256ae4bd68a105714c57ad65c rdf:first sg:person.01016620552.79
91 rdf:rest Nff9c86ae43be4f40ab43f40ed4099c1a
92 N421690bc9eee43b6949e5b11a41b5047 rdf:first sg:person.01036017402.29
93 rdf:rest rdf:nil
94 N51b1b7882a3c472ca5d9a7e287e6f658 schema:name nlm_unique_id
95 schema:value 9502015
96 rdf:type schema:PropertyValue
97 N56d33a1aaeec41e789b904599a6d6d18 schema:name readcube_id
98 schema:value db79b7d695987deb39f1c64cdab891e2f8dd6c2486b0c1a82a5072be91c768a0
99 rdf:type schema:PropertyValue
100 N6248b84046734f28a946386ef9512cab rdf:first sg:person.0656056514.46
101 rdf:rest N8b6dee20f0614d1fb65c5eb5d1ea72d2
102 N6d212e251b364db5b979b379cb2238b5 schema:name dimensions_id
103 schema:value pub.1092656967
104 rdf:type schema:PropertyValue
105 N7a8fbbf932384920af021fc05e037de1 rdf:first sg:person.0647566650.48
106 rdf:rest Ncc7398df1dcd4af0b8a77dab75a41a1c
107 N8549c22b042940c9a1b2b581505420ab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Receptors, Antigen, T-Cell, alpha-beta
109 rdf:type schema:DefinedTerm
110 N86ed9f814f0e493c8b4cac971eb1f5d9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name T-Lymphocytes
112 rdf:type schema:DefinedTerm
113 N892bafd917314104aca31a77522f10dc rdf:first sg:person.0757322615.98
114 rdf:rest Nda96b3455bdc4703880a9ea535d83f4e
115 N8b6dee20f0614d1fb65c5eb5d1ea72d2 rdf:first sg:person.07563166044.34
116 rdf:rest Nc3e01a641ba2445297e928f356980c0b
117 N8c6ce074ce044d68813defa73ec11dfb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Jurkat Cells
119 rdf:type schema:DefinedTerm
120 N9148565810854d85a56d0210eef57243 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Molecular Targeted Therapy
122 rdf:type schema:DefinedTerm
123 N93a6e06d43c34b01bbc2237593727887 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Immunotherapy, Adoptive
125 rdf:type schema:DefinedTerm
126 N9cc8b02547364703bcd33db690dd3dda rdf:first sg:person.01260320201.72
127 rdf:rest N6248b84046734f28a946386ef9512cab
128 Na1845a03e26c4066ab89b57d4009221f schema:name Springer Nature - SN SciGraph project
129 rdf:type schema:Organization
130 Na30bde9829d44bfd896def0a6cbaca59 rdf:first sg:person.011466772677.44
131 rdf:rest N7a8fbbf932384920af021fc05e037de1
132 Nb03177b7e0384351ba00327b84d17206 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Male
134 rdf:type schema:DefinedTerm
135 Nb4c2ccb88b064e7fa0f2a0fdeddeadc6 schema:name doi
136 schema:value 10.1038/nm.4444
137 rdf:type schema:PropertyValue
138 Nc0213df69a4b440fb9dad132a5e91afb schema:name pubmed_id
139 schema:value 29131157
140 rdf:type schema:PropertyValue
141 Nc3d01e1f492c4e20820adec76ad4c71d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name K562 Cells
143 rdf:type schema:DefinedTerm
144 Nc3e01a641ba2445297e928f356980c0b rdf:first sg:person.01211123241.25
145 rdf:rest N0ac4ff7aa84c40829df49c93a2a4d98f
146 Nc56fccb4085749969e9201899a8e86d0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name HEK293 Cells
148 rdf:type schema:DefinedTerm
149 Ncad33ed1651946f5b621998fee791e47 rdf:first sg:person.0630024242.03
150 rdf:rest N3bd3d9b256ae4bd68a105714c57ad65c
151 Ncc7398df1dcd4af0b8a77dab75a41a1c rdf:first sg:person.01363677251.20
152 rdf:rest N892bafd917314104aca31a77522f10dc
153 Nce29e487e64448e7b30d84625197b38c rdf:first sg:person.01316113437.11
154 rdf:rest Na30bde9829d44bfd896def0a6cbaca59
155 Nda96b3455bdc4703880a9ea535d83f4e rdf:first sg:person.01035363623.88
156 rdf:rest N9cc8b02547364703bcd33db690dd3dda
157 Ne239e83402fa4f1caccc9fbe19da8ff3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Antineoplastic Agents, Immunological
159 rdf:type schema:DefinedTerm
160 Ne56fb98c858e41328e56c6e938dc578c schema:issueNumber 12
161 rdf:type schema:PublicationIssue
162 Nf0a5526cf2aa4244abd413013341a22e rdf:first sg:person.0665360572.29
163 rdf:rest Ncad33ed1651946f5b621998fee791e47
164 Nf6d8196f32584ebba82b7a56cff235d1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Mice
166 rdf:type schema:DefinedTerm
167 Nf9c0015563ca40ed8ec04af009df2985 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Cells, Cultured
169 rdf:type schema:DefinedTerm
170 Nff9c86ae43be4f40ab43f40ed4099c1a rdf:first sg:person.01054273773.93
171 rdf:rest N421690bc9eee43b6949e5b11a41b5047
172 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
173 schema:name Medical and Health Sciences
174 rdf:type schema:DefinedTerm
175 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
176 schema:name Immunology
177 rdf:type schema:DefinedTerm
178 sg:grant.5072413 http://pending.schema.org/fundedItem sg:pub.10.1038/nm.4444
179 rdf:type schema:MonetaryGrant
180 sg:journal.1113716 schema:issn 1078-8956
181 1546-170X
182 schema:name Nature Medicine
183 rdf:type schema:Periodical
184 sg:person.01016620552.79 schema:affiliation https://www.grid.ac/institutes/grid.83440.3b
185 schema:familyName Linch
186 schema:givenName David C
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016620552.79
188 rdf:type schema:Person
189 sg:person.01035363623.88 schema:affiliation https://www.grid.ac/institutes/grid.497906.5
190 schema:familyName Onuoha
191 schema:givenName Shimobi C
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035363623.88
193 rdf:type schema:Person
194 sg:person.01036017402.29 schema:affiliation https://www.grid.ac/institutes/grid.497906.5
195 schema:familyName Pule
196 schema:givenName Martin A
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036017402.29
198 rdf:type schema:Person
199 sg:person.01054273773.93 schema:affiliation https://www.grid.ac/institutes/grid.83440.3b
200 schema:familyName Marafioti
201 schema:givenName Teresa
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054273773.93
203 rdf:type schema:Person
204 sg:person.011466772677.44 schema:affiliation https://www.grid.ac/institutes/grid.83440.3b
205 schema:familyName Wawrzyniecka
206 schema:givenName Patrycja A
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011466772677.44
208 rdf:type schema:Person
209 sg:person.01211123241.25 schema:affiliation https://www.grid.ac/institutes/grid.460094.f
210 schema:familyName Gritti
211 schema:givenName Giuseppe
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211123241.25
213 rdf:type schema:Person
214 sg:person.01260320201.72 schema:affiliation https://www.grid.ac/institutes/grid.5600.3
215 schema:familyName Legut
216 schema:givenName Mateusz
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260320201.72
218 rdf:type schema:Person
219 sg:person.01300253056.57 schema:affiliation https://www.grid.ac/institutes/grid.4861.b
220 schema:familyName Somja
221 schema:givenName Joan
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300253056.57
223 rdf:type schema:Person
224 sg:person.01316113437.11 schema:affiliation https://www.grid.ac/institutes/grid.83440.3b
225 schema:familyName Maciocia
226 schema:givenName Paul M
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316113437.11
228 rdf:type schema:Person
229 sg:person.01363677251.20 schema:affiliation https://www.grid.ac/institutes/grid.83440.3b
230 schema:familyName Ricciardelli
231 schema:givenName Ida
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01363677251.20
233 rdf:type schema:Person
234 sg:person.0630024242.03 schema:affiliation https://www.grid.ac/institutes/grid.83440.3b
235 schema:familyName Peggs
236 schema:givenName Karl S
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630024242.03
238 rdf:type schema:Person
239 sg:person.0647566650.48 schema:affiliation https://www.grid.ac/institutes/grid.83440.3b
240 schema:familyName Philip
241 schema:givenName Brian
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647566650.48
243 rdf:type schema:Person
244 sg:person.0656056514.46 schema:affiliation https://www.grid.ac/institutes/grid.5600.3
245 schema:familyName Cole
246 schema:givenName David K
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0656056514.46
248 rdf:type schema:Person
249 sg:person.0665360572.29 schema:affiliation https://www.grid.ac/institutes/grid.419651.e
250 schema:familyName Piris
251 schema:givenName Miguel A
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665360572.29
253 rdf:type schema:Person
254 sg:person.07563166044.34 schema:affiliation https://www.grid.ac/institutes/grid.5600.3
255 schema:familyName Sewell
256 schema:givenName Andrew K
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07563166044.34
258 rdf:type schema:Person
259 sg:person.0757322615.98 schema:affiliation https://www.grid.ac/institutes/grid.83440.3b
260 schema:familyName Akarca
261 schema:givenName Ayse U
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0757322615.98
263 rdf:type schema:Person
264 sg:pub.10.1038/312541a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030130235
265 https://doi.org/10.1038/312541a0
266 rdf:type schema:CreativeWork
267 sg:pub.10.1038/leu.2015.311 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030909712
268 https://doi.org/10.1038/leu.2015.311
269 rdf:type schema:CreativeWork
270 sg:pub.10.1038/ng.2873 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040376253
271 https://doi.org/10.1038/ng.2873
272 rdf:type schema:CreativeWork
273 sg:pub.10.1038/nm0402-410 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035523287
274 https://doi.org/10.1038/nm0402-410
275 rdf:type schema:CreativeWork
276 sg:pub.10.1038/nri.2016.28 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001842776
277 https://doi.org/10.1038/nri.2016.28
278 rdf:type schema:CreativeWork
279 sg:pub.10.1038/sj.leu.2404481 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010503983
280 https://doi.org/10.1038/sj.leu.2404481
281 rdf:type schema:CreativeWork
282 https://app.dimensions.ai/details/publication/pub.1078357876 schema:CreativeWork
283 https://app.dimensions.ai/details/publication/pub.1078816576 schema:CreativeWork
284 https://app.dimensions.ai/details/publication/pub.1079556020 schema:CreativeWork
285 https://app.dimensions.ai/details/publication/pub.1082390841 schema:CreativeWork
286 https://app.dimensions.ai/details/publication/pub.1083012804 schema:CreativeWork
287 https://app.dimensions.ai/details/publication/pub.1083095803 schema:CreativeWork
288 https://doi.org/10.1002/eji.1830220237 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017553706
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1016/j.ymthe.2005.04.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009255536
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1016/s1074-7613(00)80022-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014825820
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1056/nejmoa1103849 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009197831
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1056/nejmoa1407222 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012474298
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1073/pnas.82.15.5068 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006420218
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1089/hyb.1992.11.701 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059275206
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1093/protein/gzg087 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016193642
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1101/gr.092924.109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025925546
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1126/science.1158545 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062457773
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1126/scitranslmed.3008226 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009684137
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1172/jci86000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020347220
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1182/blood-2004-11-4564 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000714496
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1182/blood-2010-09-310342 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006386262
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1182/blood-2014-01-545020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047143412
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1182/blood-2014-01-553362 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048157577
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1182/blood-2015-02-629527 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021627505
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1200/jco.2005.03.6327 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017121360
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1200/jco.2008.16.4558 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029891295
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1200/jco.2014.56.2025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015070639
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1309/qf6n-vaqw-n74h-4je2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050635356
329 rdf:type schema:CreativeWork
330 https://doi.org/10.3109/02841860903150502 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051829076
331 rdf:type schema:CreativeWork
332 https://www.grid.ac/institutes/grid.419651.e schema:alternateName Hospital Universitario Fundación Jiménez Díaz
333 schema:name Department of Pathology, Fundación Jiménez Díaz, Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.
334 rdf:type schema:Organization
335 https://www.grid.ac/institutes/grid.460094.f schema:alternateName Ospedale Papa Giovanni XXIII
336 schema:name Hematology and Bone Marrow Transplant Units, Papa Giovanni XXIII Hospital, Bergamo, Italy.
337 rdf:type schema:Organization
338 https://www.grid.ac/institutes/grid.4861.b schema:alternateName University of Liège
339 schema:name Department of Anatomy and Cellular Pathology, University of Liège, Liège, Belgium.
340 rdf:type schema:Organization
341 https://www.grid.ac/institutes/grid.497906.5 schema:alternateName Autolus (United Kingdom)
342 schema:name Autolus, Ltd., London, UK.
343 Cancer Institute, University College London, London, UK.
344 rdf:type schema:Organization
345 https://www.grid.ac/institutes/grid.5600.3 schema:alternateName Cardiff University
346 schema:name Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, UK.
347 rdf:type schema:Organization
348 https://www.grid.ac/institutes/grid.83440.3b schema:alternateName University College London
349 schema:name Cancer Institute, University College London, London, UK.
350 Institute of Child Health, University College London, London, UK.
351 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...