SNP-mediated disruption of CTCF binding at the IFITM3 promoter is associated with risk of severe influenza in humans View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-08

AUTHORS

E Kaitlynn Allen, Adrienne G Randolph, Tushar Bhangale, Pranay Dogra, Maikke Ohlson, Christine M Oshansky, Anthony E Zamora, John P Shannon, David Finkelstein, Amy Dressen, John DeVincenzo, Miguela Caniza, Ben Youngblood, Carrie M Rosenberger, Paul G Thomas

ABSTRACT

Previous studies have reported associations of IFITM3 SNP rs12252 with severe influenza, but evidence of association and the mechanism by which risk is conferred remain controversial. We prioritized SNPs in IFITM3 on the basis of putative biological function and identified rs34481144 in the 5' UTR. We found evidence of a new association of rs34481144 with severe influenza in three influenza-infected cohorts characterized by different levels of influenza illness severity. We determined a role for rs34481144 as an expression quantitative trait locus (eQTL) for IFITM3, with the risk allele associated with lower mRNA expression. The risk allele was found to have decreased IRF3 binding and increased CTCF binding in promoter-binding assays, and risk allele carriage diminished transcriptional correlations among IFITM3-neighboring genes, indicative of CTCF boundary activity. Furthermore, the risk allele disrupts a CpG site that undergoes differential methylation in CD8+ T cell subsets. Carriers of the risk allele had reduced numbers of CD8+ T cells in their airways during natural influenza infection, consistent with IFITM3 promoting accumulation of CD8+ T cells in airways and indicating that a critical function for IFITM3 may be to promote immune cell persistence at mucosal sites.Our study identifies a new regulator of IFITM3 expression that associates with CD8+ T cell levels in the airways and a spectrum of clinical outcomes. More... »

PAGES

975-983

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nm.4370

DOI

http://dx.doi.org/10.1038/nm.4370

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1090740628

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28714988


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Alleles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blotting, Western", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "CCCTC-Binding Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "CD8-Positive T-Lymphocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Methylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Predisposition to Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genotype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Influenza, Human", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interferon Regulatory Factor-3", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nasal Lavage Fluid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymorphism, Single Nucleotide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Promoter Regions, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Quantitative Trait Loci", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Repressor Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Severity of Illness Index", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Allen", 
        "givenName": "E Kaitlynn", 
        "id": "sg:person.01114340734.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114340734.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Anesthesiology, Perioperative and Pain Medicine, Boston Children's Hospital, and Departments of Anesthesia and Pediatrics, Harvard Medical School, Boston, Massachusetts, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Randolph", 
        "givenName": "Adrienne G", 
        "id": "sg:person.01042045326.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042045326.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Roche (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418158.1", 
          "name": [
            "Human Genetics, Genentech, Inc., South San Francisco, California, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bhangale", 
        "givenName": "Tushar", 
        "id": "sg:person.0614175775.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0614175775.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dogra", 
        "givenName": "Pranay", 
        "id": "sg:person.01057644754.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057644754.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Roche (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418158.1", 
          "name": [
            "Biomarker Discovery, Genentech, Inc., South San Francisco, California, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ohlson", 
        "givenName": "Maikke", 
        "id": "sg:person.01272011457.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272011457.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oshansky", 
        "givenName": "Christine M", 
        "id": "sg:person.01303050257.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303050257.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zamora", 
        "givenName": "Anthony E", 
        "id": "sg:person.01214702775.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214702775.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shannon", 
        "givenName": "John P", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Finkelstein", 
        "givenName": "David", 
        "id": "sg:person.015743405662.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015743405662.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Roche (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418158.1", 
          "name": [
            "Human Genetics, Genentech, Inc., South San Francisco, California, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dressen", 
        "givenName": "Amy", 
        "id": "sg:person.0765647426.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765647426.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Le Bonheur Children's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.413728.b", 
          "name": [
            "Departments of Pediatrics and of Microbiology, Immunology and Molecular Biology, University of Tennessee School of Medicine, Memphis, Tennessee, USA.", 
            "Children's Foundation Research Institute, Le Bonheur Children's Hospital, Memphis, Tennessee, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "DeVincenzo", 
        "givenName": "John", 
        "id": "sg:person.0774516004.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774516004.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Caniza", 
        "givenName": "Miguela", 
        "id": "sg:person.01007067153.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007067153.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Youngblood", 
        "givenName": "Ben", 
        "id": "sg:person.013567204167.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013567204167.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Roche (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418158.1", 
          "name": [
            "Biomarker Discovery, Genentech, Inc., South San Francisco, California, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rosenberger", 
        "givenName": "Carrie M", 
        "id": "sg:person.01256406244.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256406244.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thomas", 
        "givenName": "Paul G", 
        "id": "sg:person.01230224471.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230224471.22"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/1521-1878(200101)23:1<46::aid-bies1006>3.0.co;2-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000930161"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1321748111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004290889"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0067816", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008081099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.chom.2013.03.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008439547"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2015.11.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009263836"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0143539", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011569311"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.stem.2015.11.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014419744"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.stem.2015.11.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014419744"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.02246-15", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014445509"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10096-016-2732-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015099223", 
          "https://doi.org/10.1007/s10096-016-2732-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10096-016-2732-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015099223", 
          "https://doi.org/10.1007/s10096-016-2732-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.136101.111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016398990"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.ppat.1001258", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017308394"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature16490", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017311368", 
          "https://doi.org/10.1038/nature16490"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ccm.0b013e318267633c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017824365"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ccm.0b013e318267633c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017824365"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrg3663", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017831086", 
          "https://doi.org/10.1038/nrg3663"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms2433", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018384161", 
          "https://doi.org/10.1038/ncomms2433"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/rccm.201309-1616oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020261631"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni.2525", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020698873", 
          "https://doi.org/10.1038/ni.2525"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature15393", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021812064", 
          "https://doi.org/10.1038/nature15393"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.ppat.1002337", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023172947"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gks1165", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023208428"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.ppat.1004048", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024694857"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.ppat.1002909", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026359171"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1262110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029707840"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature10921", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031194819", 
          "https://doi.org/10.1038/nature10921"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1105136", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031973383"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth.2089", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035817137", 
          "https://doi.org/10.1038/nmeth.2089"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2015.04.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036170624"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2015.04.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036170624"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/emm.2015.33", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037029094", 
          "https://doi.org/10.1038/emm.2015.33"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/biostatistics/4.2.249", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037543114"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btp324", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038266369"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0000000000000632", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040299985"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0000000000000632", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040299985"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/genes6030734", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042341838"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/c2mb05500g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043701671"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.2310", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046029840", 
          "https://doi.org/10.1038/ng.2310"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1246980", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046908038"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btq340", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047276303"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2014.11.021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047951603"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/infdis/jit468", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050524603"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/rccm.201412-2245ed", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051374762"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.15252/embr.201642771", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051848102"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0124985", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052283082"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btu638", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053282140"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/bts635", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053365587"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/107999002753452665", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059207040"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/107999099314360", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059207399"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.aaa1578", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062665089"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.01254-16", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062712719"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078211883", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/infdis/jix242", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085553857"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-08", 
    "datePublishedReg": "2017-08-01", 
    "description": "Previous studies have reported associations of IFITM3 SNP rs12252 with severe influenza, but evidence of association and the mechanism by which risk is conferred remain controversial. We prioritized SNPs in IFITM3 on the basis of putative biological function and identified rs34481144 in the 5' UTR. We found evidence of a new association of rs34481144 with severe influenza in three influenza-infected cohorts characterized by different levels of influenza illness severity. We determined a role for rs34481144 as an expression quantitative trait locus (eQTL) for IFITM3, with the risk allele associated with lower mRNA expression. The risk allele was found to have decreased IRF3 binding and increased CTCF binding in promoter-binding assays, and risk allele carriage diminished transcriptional correlations among IFITM3-neighboring genes, indicative of CTCF boundary activity. Furthermore, the risk allele disrupts a CpG site that undergoes differential methylation in CD8+ T cell subsets. Carriers of the risk allele had reduced numbers of CD8+ T cells in their airways during natural influenza infection, consistent with IFITM3 promoting accumulation of CD8+ T cells in airways and indicating that a critical function for IFITM3 may be to promote immune cell persistence at mucosal sites.Our study identifies a new regulator of IFITM3 expression that associates with CD8+ T cell levels in the airways and a spectrum of clinical outcomes.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nm.4370", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2622412", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6617025", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3857074", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2666415", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2458751", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1113716", 
        "issn": [
          "1078-8956", 
          "1546-170X"
        ], 
        "name": "Nature Medicine", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "8", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "23"
      }
    ], 
    "name": "SNP-mediated disruption of CTCF binding at the IFITM3 promoter is associated with risk of severe influenza in humans", 
    "pagination": "975-983", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "f5cf2d38bc156858fdbba36e3f2169c0dd3bfc316fc05af0e5d3f87fedd3421e"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28714988"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9502015"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nm.4370"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1090740628"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nm.4370", 
      "https://app.dimensions.ai/details/publication/pub.1090740628"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:27", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000362_0000000362/records_87115_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/nm.4370"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nm.4370'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nm.4370'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nm.4370'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nm.4370'


 

This table displays all metadata directly associated to this object as RDF triples.

416 TRIPLES      21 PREDICATES      96 URIs      39 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nm.4370 schema:about N053962a2d44a43fbbadb7c1a12fd7180
2 N184445f8a7bf466b8fec240933e9f7bb
3 N208e91ebb952497b9b5c18d314847913
4 N23f155e904ac4e7891ddb22123c50d32
5 N2cd8c2f0c2924cf7b7d2851db1268d6c
6 N55f96394a3344d0697ef2439c9a7a7bd
7 N7f8b4c0892474512ac0f82cf8fae7456
8 N909c15cfb7c04a938f085285435c1377
9 N98073afaa92b43e586c110aaa10aa6c5
10 N99f312ce9ba246f7bdcb37d13b8103b3
11 N9e3c35d3fe664d4fbb2a03d81c8ff423
12 Na7c7c475784b477da57c323ffdc4c835
13 Nb71e361167874b2f9a6f49e0501388a8
14 Nd70075ac7ddc4e9ea5c31ea3a0aee749
15 Ne2c363badbf0426490f4710ffcf5d7e0
16 Ne2c637a1a8b3447988a8769b192a59cc
17 Ne4dcc379f52e42c99bdc9721516451a8
18 Ne9bc979664ff4d8b88394886fc1a1433
19 anzsrc-for:11
20 anzsrc-for:1103
21 schema:author N1e31b435e4954210962ed50802b9cc90
22 schema:citation sg:pub.10.1007/s10096-016-2732-7
23 sg:pub.10.1038/emm.2015.33
24 sg:pub.10.1038/nature10921
25 sg:pub.10.1038/nature15393
26 sg:pub.10.1038/nature16490
27 sg:pub.10.1038/ncomms2433
28 sg:pub.10.1038/ng.2310
29 sg:pub.10.1038/ni.2525
30 sg:pub.10.1038/nmeth.2089
31 sg:pub.10.1038/nrg3663
32 https://app.dimensions.ai/details/publication/pub.1078211883
33 https://doi.org/10.1002/1521-1878(200101)23:1<46::aid-bies1006>3.0.co;2-3
34 https://doi.org/10.1016/j.cell.2014.11.021
35 https://doi.org/10.1016/j.cell.2015.04.004
36 https://doi.org/10.1016/j.cell.2015.11.024
37 https://doi.org/10.1016/j.chom.2013.03.006
38 https://doi.org/10.1016/j.stem.2015.11.007
39 https://doi.org/10.1039/c2mb05500g
40 https://doi.org/10.1073/pnas.1321748111
41 https://doi.org/10.1089/107999002753452665
42 https://doi.org/10.1089/107999099314360
43 https://doi.org/10.1093/bioinformatics/btp324
44 https://doi.org/10.1093/bioinformatics/btq340
45 https://doi.org/10.1093/bioinformatics/bts635
46 https://doi.org/10.1093/bioinformatics/btu638
47 https://doi.org/10.1093/biostatistics/4.2.249
48 https://doi.org/10.1093/infdis/jit468
49 https://doi.org/10.1093/infdis/jix242
50 https://doi.org/10.1093/nar/gks1165
51 https://doi.org/10.1097/ccm.0b013e318267633c
52 https://doi.org/10.1097/qad.0000000000000632
53 https://doi.org/10.1101/gr.136101.111
54 https://doi.org/10.1126/science.1105136
55 https://doi.org/10.1126/science.1246980
56 https://doi.org/10.1126/science.1262110
57 https://doi.org/10.1126/science.aaa1578
58 https://doi.org/10.1128/jvi.01254-16
59 https://doi.org/10.1128/jvi.02246-15
60 https://doi.org/10.1164/rccm.201309-1616oc
61 https://doi.org/10.1164/rccm.201412-2245ed
62 https://doi.org/10.1371/journal.pone.0067816
63 https://doi.org/10.1371/journal.pone.0124985
64 https://doi.org/10.1371/journal.pone.0143539
65 https://doi.org/10.1371/journal.ppat.1001258
66 https://doi.org/10.1371/journal.ppat.1002337
67 https://doi.org/10.1371/journal.ppat.1002909
68 https://doi.org/10.1371/journal.ppat.1004048
69 https://doi.org/10.15252/embr.201642771
70 https://doi.org/10.3390/genes6030734
71 schema:datePublished 2017-08
72 schema:datePublishedReg 2017-08-01
73 schema:description Previous studies have reported associations of IFITM3 SNP rs12252 with severe influenza, but evidence of association and the mechanism by which risk is conferred remain controversial. We prioritized SNPs in IFITM3 on the basis of putative biological function and identified rs34481144 in the 5' UTR. We found evidence of a new association of rs34481144 with severe influenza in three influenza-infected cohorts characterized by different levels of influenza illness severity. We determined a role for rs34481144 as an expression quantitative trait locus (eQTL) for IFITM3, with the risk allele associated with lower mRNA expression. The risk allele was found to have decreased IRF3 binding and increased CTCF binding in promoter-binding assays, and risk allele carriage diminished transcriptional correlations among IFITM3-neighboring genes, indicative of CTCF boundary activity. Furthermore, the risk allele disrupts a CpG site that undergoes differential methylation in CD8<sup>+</sup> T cell subsets. Carriers of the risk allele had reduced numbers of CD8<sup>+</sup> T cells in their airways during natural influenza infection, consistent with IFITM3 promoting accumulation of CD8<sup>+</sup> T cells in airways and indicating that a critical function for IFITM3 may be to promote immune cell persistence at mucosal sites.Our study identifies a new regulator of IFITM3 expression that associates with CD8<sup>+</sup> T cell levels in the airways and a spectrum of clinical outcomes.
74 schema:genre research_article
75 schema:inLanguage en
76 schema:isAccessibleForFree false
77 schema:isPartOf N721bf21ac7e74f3ea9a104a0e9dddac5
78 Nba1b2f81db134f14b975a9e0c60bac08
79 sg:journal.1113716
80 schema:name SNP-mediated disruption of CTCF binding at the IFITM3 promoter is associated with risk of severe influenza in humans
81 schema:pagination 975-983
82 schema:productId N0e5d8f86c1f74214866ceb4d9c7295d7
83 N387b0badec4c4c75a46226509ec71809
84 N80ba305a79b54def91fe0540032d6b9a
85 Ndf4cac0fccf0450c8c8f53b9f99b6fb0
86 Ndfb4a4f0495844adb1a6e5124d9c3ae7
87 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090740628
88 https://doi.org/10.1038/nm.4370
89 schema:sdDatePublished 2019-04-11T12:27
90 schema:sdLicense https://scigraph.springernature.com/explorer/license/
91 schema:sdPublisher N820f73e3757c449cad45a5b5aa747e9d
92 schema:url http://www.nature.com/articles/nm.4370
93 sgo:license sg:explorer/license/
94 sgo:sdDataset articles
95 rdf:type schema:ScholarlyArticle
96 N0276388de37140e9b9ddd8b495400753 rdf:first sg:person.0765647426.79
97 rdf:rest N4e5770a5a86a4fe4a31857aaeb67d412
98 N053962a2d44a43fbbadb7c1a12fd7180 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Repressor Proteins
100 rdf:type schema:DefinedTerm
101 N0c5855d478e34144bdc96f3b0d49a87b rdf:first sg:person.01214702775.41
102 rdf:rest Ndea508bd187c40e698900636b9dc0b21
103 N0e5d8f86c1f74214866ceb4d9c7295d7 schema:name doi
104 schema:value 10.1038/nm.4370
105 rdf:type schema:PropertyValue
106 N184445f8a7bf466b8fec240933e9f7bb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name DNA Methylation
108 rdf:type schema:DefinedTerm
109 N1e31b435e4954210962ed50802b9cc90 rdf:first sg:person.01114340734.50
110 rdf:rest N2d248e86caf24f948c1b7f0dcf2cebd2
111 N208e91ebb952497b9b5c18d314847913 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Polymorphism, Single Nucleotide
113 rdf:type schema:DefinedTerm
114 N23f155e904ac4e7891ddb22123c50d32 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name CD8-Positive T-Lymphocytes
116 rdf:type schema:DefinedTerm
117 N266b01a83f0241d79a789224cc881ded rdf:first sg:person.01272011457.58
118 rdf:rest N9e8cc9d2c7964c44a6ee3801e3236d36
119 N2cd8c2f0c2924cf7b7d2851db1268d6c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Genotype
121 rdf:type schema:DefinedTerm
122 N2d248e86caf24f948c1b7f0dcf2cebd2 rdf:first sg:person.01042045326.26
123 rdf:rest Nae1d0d53cf05466a95f8065a64dd7893
124 N387b0badec4c4c75a46226509ec71809 schema:name nlm_unique_id
125 schema:value 9502015
126 rdf:type schema:PropertyValue
127 N39ae1134eb14409cb7808d6c797c5ff9 rdf:first sg:person.01057644754.68
128 rdf:rest N266b01a83f0241d79a789224cc881ded
129 N4e5770a5a86a4fe4a31857aaeb67d412 rdf:first sg:person.0774516004.64
130 rdf:rest N74350cf5721d432085edbaf24c74efcc
131 N55f96394a3344d0697ef2439c9a7a7bd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Alleles
133 rdf:type schema:DefinedTerm
134 N5f4bcc8182b54d23866e32ddb700eef0 schema:name Department of Anesthesiology, Perioperative and Pain Medicine, Boston Children's Hospital, and Departments of Anesthesia and Pediatrics, Harvard Medical School, Boston, Massachusetts, USA.
135 rdf:type schema:Organization
136 N6a17bfb5794f4dbc93fae6144cc24010 rdf:first sg:person.013567204167.59
137 rdf:rest Ncc5980ccf3ec470f8f88ac4757f7ae64
138 N721bf21ac7e74f3ea9a104a0e9dddac5 schema:issueNumber 8
139 rdf:type schema:PublicationIssue
140 N74350cf5721d432085edbaf24c74efcc rdf:first sg:person.01007067153.76
141 rdf:rest N6a17bfb5794f4dbc93fae6144cc24010
142 N7dc2635168744ed58229d86e0d36d252 rdf:first sg:person.01230224471.22
143 rdf:rest rdf:nil
144 N7f8b4c0892474512ac0f82cf8fae7456 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name CCCTC-Binding Factor
146 rdf:type schema:DefinedTerm
147 N80ba305a79b54def91fe0540032d6b9a schema:name dimensions_id
148 schema:value pub.1090740628
149 rdf:type schema:PropertyValue
150 N820f73e3757c449cad45a5b5aa747e9d schema:name Springer Nature - SN SciGraph project
151 rdf:type schema:Organization
152 N8c555d1333624baab579ae243e68e116 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
153 schema:familyName Shannon
154 schema:givenName John P
155 rdf:type schema:Person
156 N909c15cfb7c04a938f085285435c1377 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Genetic Predisposition to Disease
158 rdf:type schema:DefinedTerm
159 N98073afaa92b43e586c110aaa10aa6c5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Interferon Regulatory Factor-3
161 rdf:type schema:DefinedTerm
162 N99f312ce9ba246f7bdcb37d13b8103b3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Severity of Illness Index
164 rdf:type schema:DefinedTerm
165 N9e3c35d3fe664d4fbb2a03d81c8ff423 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Influenza, Human
167 rdf:type schema:DefinedTerm
168 N9e8cc9d2c7964c44a6ee3801e3236d36 rdf:first sg:person.01303050257.10
169 rdf:rest N0c5855d478e34144bdc96f3b0d49a87b
170 Na7c7c475784b477da57c323ffdc4c835 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Nasal Lavage Fluid
172 rdf:type schema:DefinedTerm
173 Nae1d0d53cf05466a95f8065a64dd7893 rdf:first sg:person.0614175775.24
174 rdf:rest N39ae1134eb14409cb7808d6c797c5ff9
175 Nb71e361167874b2f9a6f49e0501388a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Humans
177 rdf:type schema:DefinedTerm
178 Nba1b2f81db134f14b975a9e0c60bac08 schema:volumeNumber 23
179 rdf:type schema:PublicationVolume
180 Nbd33d7fb8f814937930cab88dd115955 rdf:first sg:person.015743405662.61
181 rdf:rest N0276388de37140e9b9ddd8b495400753
182 Ncc5980ccf3ec470f8f88ac4757f7ae64 rdf:first sg:person.01256406244.23
183 rdf:rest N7dc2635168744ed58229d86e0d36d252
184 Nd70075ac7ddc4e9ea5c31ea3a0aee749 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Membrane Proteins
186 rdf:type schema:DefinedTerm
187 Ndea508bd187c40e698900636b9dc0b21 rdf:first N8c555d1333624baab579ae243e68e116
188 rdf:rest Nbd33d7fb8f814937930cab88dd115955
189 Ndf4cac0fccf0450c8c8f53b9f99b6fb0 schema:name pubmed_id
190 schema:value 28714988
191 rdf:type schema:PropertyValue
192 Ndfb4a4f0495844adb1a6e5124d9c3ae7 schema:name readcube_id
193 schema:value f5cf2d38bc156858fdbba36e3f2169c0dd3bfc316fc05af0e5d3f87fedd3421e
194 rdf:type schema:PropertyValue
195 Ne2c363badbf0426490f4710ffcf5d7e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
196 schema:name Blotting, Western
197 rdf:type schema:DefinedTerm
198 Ne2c637a1a8b3447988a8769b192a59cc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
199 schema:name RNA-Binding Proteins
200 rdf:type schema:DefinedTerm
201 Ne4dcc379f52e42c99bdc9721516451a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
202 schema:name Promoter Regions, Genetic
203 rdf:type schema:DefinedTerm
204 Ne9bc979664ff4d8b88394886fc1a1433 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
205 schema:name Quantitative Trait Loci
206 rdf:type schema:DefinedTerm
207 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
208 schema:name Medical and Health Sciences
209 rdf:type schema:DefinedTerm
210 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
211 schema:name Clinical Sciences
212 rdf:type schema:DefinedTerm
213 sg:grant.2458751 http://pending.schema.org/fundedItem sg:pub.10.1038/nm.4370
214 rdf:type schema:MonetaryGrant
215 sg:grant.2622412 http://pending.schema.org/fundedItem sg:pub.10.1038/nm.4370
216 rdf:type schema:MonetaryGrant
217 sg:grant.2666415 http://pending.schema.org/fundedItem sg:pub.10.1038/nm.4370
218 rdf:type schema:MonetaryGrant
219 sg:grant.3857074 http://pending.schema.org/fundedItem sg:pub.10.1038/nm.4370
220 rdf:type schema:MonetaryGrant
221 sg:grant.6617025 http://pending.schema.org/fundedItem sg:pub.10.1038/nm.4370
222 rdf:type schema:MonetaryGrant
223 sg:journal.1113716 schema:issn 1078-8956
224 1546-170X
225 schema:name Nature Medicine
226 rdf:type schema:Periodical
227 sg:person.01007067153.76 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
228 schema:familyName Caniza
229 schema:givenName Miguela
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007067153.76
231 rdf:type schema:Person
232 sg:person.01042045326.26 schema:affiliation N5f4bcc8182b54d23866e32ddb700eef0
233 schema:familyName Randolph
234 schema:givenName Adrienne G
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042045326.26
236 rdf:type schema:Person
237 sg:person.01057644754.68 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
238 schema:familyName Dogra
239 schema:givenName Pranay
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057644754.68
241 rdf:type schema:Person
242 sg:person.01114340734.50 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
243 schema:familyName Allen
244 schema:givenName E Kaitlynn
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114340734.50
246 rdf:type schema:Person
247 sg:person.01214702775.41 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
248 schema:familyName Zamora
249 schema:givenName Anthony E
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214702775.41
251 rdf:type schema:Person
252 sg:person.01230224471.22 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
253 schema:familyName Thomas
254 schema:givenName Paul G
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230224471.22
256 rdf:type schema:Person
257 sg:person.01256406244.23 schema:affiliation https://www.grid.ac/institutes/grid.418158.1
258 schema:familyName Rosenberger
259 schema:givenName Carrie M
260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256406244.23
261 rdf:type schema:Person
262 sg:person.01272011457.58 schema:affiliation https://www.grid.ac/institutes/grid.418158.1
263 schema:familyName Ohlson
264 schema:givenName Maikke
265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272011457.58
266 rdf:type schema:Person
267 sg:person.01303050257.10 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
268 schema:familyName Oshansky
269 schema:givenName Christine M
270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303050257.10
271 rdf:type schema:Person
272 sg:person.013567204167.59 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
273 schema:familyName Youngblood
274 schema:givenName Ben
275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013567204167.59
276 rdf:type schema:Person
277 sg:person.015743405662.61 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
278 schema:familyName Finkelstein
279 schema:givenName David
280 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015743405662.61
281 rdf:type schema:Person
282 sg:person.0614175775.24 schema:affiliation https://www.grid.ac/institutes/grid.418158.1
283 schema:familyName Bhangale
284 schema:givenName Tushar
285 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0614175775.24
286 rdf:type schema:Person
287 sg:person.0765647426.79 schema:affiliation https://www.grid.ac/institutes/grid.418158.1
288 schema:familyName Dressen
289 schema:givenName Amy
290 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765647426.79
291 rdf:type schema:Person
292 sg:person.0774516004.64 schema:affiliation https://www.grid.ac/institutes/grid.413728.b
293 schema:familyName DeVincenzo
294 schema:givenName John
295 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774516004.64
296 rdf:type schema:Person
297 sg:pub.10.1007/s10096-016-2732-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015099223
298 https://doi.org/10.1007/s10096-016-2732-7
299 rdf:type schema:CreativeWork
300 sg:pub.10.1038/emm.2015.33 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037029094
301 https://doi.org/10.1038/emm.2015.33
302 rdf:type schema:CreativeWork
303 sg:pub.10.1038/nature10921 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031194819
304 https://doi.org/10.1038/nature10921
305 rdf:type schema:CreativeWork
306 sg:pub.10.1038/nature15393 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021812064
307 https://doi.org/10.1038/nature15393
308 rdf:type schema:CreativeWork
309 sg:pub.10.1038/nature16490 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017311368
310 https://doi.org/10.1038/nature16490
311 rdf:type schema:CreativeWork
312 sg:pub.10.1038/ncomms2433 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018384161
313 https://doi.org/10.1038/ncomms2433
314 rdf:type schema:CreativeWork
315 sg:pub.10.1038/ng.2310 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046029840
316 https://doi.org/10.1038/ng.2310
317 rdf:type schema:CreativeWork
318 sg:pub.10.1038/ni.2525 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020698873
319 https://doi.org/10.1038/ni.2525
320 rdf:type schema:CreativeWork
321 sg:pub.10.1038/nmeth.2089 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035817137
322 https://doi.org/10.1038/nmeth.2089
323 rdf:type schema:CreativeWork
324 sg:pub.10.1038/nrg3663 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017831086
325 https://doi.org/10.1038/nrg3663
326 rdf:type schema:CreativeWork
327 https://app.dimensions.ai/details/publication/pub.1078211883 schema:CreativeWork
328 https://doi.org/10.1002/1521-1878(200101)23:1<46::aid-bies1006>3.0.co;2-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000930161
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1016/j.cell.2014.11.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047951603
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1016/j.cell.2015.04.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036170624
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1016/j.cell.2015.11.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009263836
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1016/j.chom.2013.03.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008439547
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1016/j.stem.2015.11.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014419744
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1039/c2mb05500g schema:sameAs https://app.dimensions.ai/details/publication/pub.1043701671
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1073/pnas.1321748111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004290889
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1089/107999002753452665 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059207040
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1089/107999099314360 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059207399
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1093/bioinformatics/btp324 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038266369
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1093/bioinformatics/btq340 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047276303
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1093/bioinformatics/bts635 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053365587
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1093/bioinformatics/btu638 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053282140
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1093/biostatistics/4.2.249 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037543114
357 rdf:type schema:CreativeWork
358 https://doi.org/10.1093/infdis/jit468 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050524603
359 rdf:type schema:CreativeWork
360 https://doi.org/10.1093/infdis/jix242 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085553857
361 rdf:type schema:CreativeWork
362 https://doi.org/10.1093/nar/gks1165 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023208428
363 rdf:type schema:CreativeWork
364 https://doi.org/10.1097/ccm.0b013e318267633c schema:sameAs https://app.dimensions.ai/details/publication/pub.1017824365
365 rdf:type schema:CreativeWork
366 https://doi.org/10.1097/qad.0000000000000632 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040299985
367 rdf:type schema:CreativeWork
368 https://doi.org/10.1101/gr.136101.111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016398990
369 rdf:type schema:CreativeWork
370 https://doi.org/10.1126/science.1105136 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031973383
371 rdf:type schema:CreativeWork
372 https://doi.org/10.1126/science.1246980 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046908038
373 rdf:type schema:CreativeWork
374 https://doi.org/10.1126/science.1262110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029707840
375 rdf:type schema:CreativeWork
376 https://doi.org/10.1126/science.aaa1578 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062665089
377 rdf:type schema:CreativeWork
378 https://doi.org/10.1128/jvi.01254-16 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062712719
379 rdf:type schema:CreativeWork
380 https://doi.org/10.1128/jvi.02246-15 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014445509
381 rdf:type schema:CreativeWork
382 https://doi.org/10.1164/rccm.201309-1616oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1020261631
383 rdf:type schema:CreativeWork
384 https://doi.org/10.1164/rccm.201412-2245ed schema:sameAs https://app.dimensions.ai/details/publication/pub.1051374762
385 rdf:type schema:CreativeWork
386 https://doi.org/10.1371/journal.pone.0067816 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008081099
387 rdf:type schema:CreativeWork
388 https://doi.org/10.1371/journal.pone.0124985 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052283082
389 rdf:type schema:CreativeWork
390 https://doi.org/10.1371/journal.pone.0143539 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011569311
391 rdf:type schema:CreativeWork
392 https://doi.org/10.1371/journal.ppat.1001258 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017308394
393 rdf:type schema:CreativeWork
394 https://doi.org/10.1371/journal.ppat.1002337 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023172947
395 rdf:type schema:CreativeWork
396 https://doi.org/10.1371/journal.ppat.1002909 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026359171
397 rdf:type schema:CreativeWork
398 https://doi.org/10.1371/journal.ppat.1004048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024694857
399 rdf:type schema:CreativeWork
400 https://doi.org/10.15252/embr.201642771 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051848102
401 rdf:type schema:CreativeWork
402 https://doi.org/10.3390/genes6030734 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042341838
403 rdf:type schema:CreativeWork
404 https://www.grid.ac/institutes/grid.240871.8 schema:alternateName St. Jude Children's Research Hospital
405 schema:name Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
406 Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
407 Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
408 rdf:type schema:Organization
409 https://www.grid.ac/institutes/grid.413728.b schema:alternateName Le Bonheur Children's Hospital
410 schema:name Children's Foundation Research Institute, Le Bonheur Children's Hospital, Memphis, Tennessee, USA.
411 Departments of Pediatrics and of Microbiology, Immunology and Molecular Biology, University of Tennessee School of Medicine, Memphis, Tennessee, USA.
412 rdf:type schema:Organization
413 https://www.grid.ac/institutes/grid.418158.1 schema:alternateName Roche (United States)
414 schema:name Biomarker Discovery, Genentech, Inc., South San Francisco, California, USA.
415 Human Genetics, Genentech, Inc., South San Francisco, California, USA.
416 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...