Plk1 regulates contraction of postmitotic smooth muscle cells and is required for vascular homeostasis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-07-10

AUTHORS

Guillermo de Cárcer, Paulina Wachowicz, Sara Martínez-Martínez, Jorge Oller, Nerea Méndez-Barbero, Beatriz Escobar, Alejandra González-Loyola, Tohru Takaki, Aicha El Bakkali, Juan A Cámara, Luis J Jiménez-Borreguero, Xosé R Bustelo, Marta Cañamero, Francisca Mulero, María de los Ángeles Sevilla, María Jose Montero, Juan Miguel Redondo, Marcos Malumbres

ABSTRACT

The kinase Plk1 has been studied primarily as a mitotic regulator in dividing cells, but de Cárcer et al. find that Plk1 deficiency or inhibition in mice causes nonmitotic defects in the vasculature, including aortic aneurysm and rupture, as well as defective vascular smooth muscle contractility. These results recommend a note of caution in the clinical use of PLK1 inhibitors as anticancer agents. More... »

PAGES

964-974

References to SciGraph publications

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  • Journal

    TITLE

    Nature Medicine

    ISSUE

    8

    VOLUME

    23

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nm.4364

    DOI

    http://dx.doi.org/10.1038/nm.4364

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1090571972

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28692064


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