HIV persistence in tissue macrophages of humanized myeloid-only mice during antiretroviral therapy View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-05

AUTHORS

Jenna B Honeycutt, William O Thayer, Caroline E Baker, Ruy M Ribeiro, Steven M Lada, Youfang Cao, Rachel A Cleary, Michael G Hudgens, Douglas D Richman, J Victor Garcia

ABSTRACT

Despite years of fully suppressive antiretroviral therapy (ART), HIV persists in its hosts and is never eradicated. One major barrier to eradication is that the virus infects multiple cell types that may individually contribute to HIV persistence. Tissue macrophages are critical contributors to HIV pathogenesis; however, their specific role in HIV persistence during long-term suppressive ART has not been established. Using humanized myeloid-only mice (MoM), we demonstrate that HIV infection of tissue macrophages is rapidly suppressed by ART, as reflected by a rapid drop in plasma viral load and a dramatic decrease in the levels of cell-associated viral RNA and DNA. No viral rebound was observed in the plasma of 67% of the ART-treated animals at 7 weeks after ART interruption, and no replication-competent virus was rescued from the tissue macrophages obtained from these animals. In contrast, in a subset of animals (∼33%), a delayed viral rebound was observed that is consistent with the establishment of persistent infection in tissue macrophages. These observations represent the first direct evidence, to our knowledge, of HIV persistence in tissue macrophages in vivo. More... »

PAGES

638-643

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nm.4319

DOI

http://dx.doi.org/10.1038/nm.4319

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1084861064

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28414330


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