Blocking microglial pannexin-1 channels alleviates morphine withdrawal in rodents View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-01-30

AUTHORS

Nicole E Burma, Robert P Bonin, Heather Leduc-Pessah, Corey Baimel, Zoe F Cairncross, Michael Mousseau, Jhenkruthi Vijaya Shankara, Patrick L Stemkowski, Dinara Baimoukhametova, Jaideep S Bains, Michael C Antle, Gerald W Zamponi, Catherine M Cahill, Stephanie L Borgland, Yves De Koninck, Tuan Trang

ABSTRACT

The release of ATP from spinal microglia via pannexin-1 channels is required for withdrawal symptoms after termination of chronic opioid treatment in rodents, and pharmacological blockade of pannexin-1 channels reduces the severity of withdrawal without affecting opiate analgesia.

PAGES

355-360

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nm.4281

DOI

http://dx.doi.org/10.1038/nm.4281

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1074247388

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28134928


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