Ontology type: schema:ScholarlyArticle
2016-11
AUTHORSDragana Stanley, Linda J Mason, Kate E Mackin, Yogitha N Srikhanta, Dena Lyras, Monica D Prakash, Kulmira Nurgali, Andres Venegas, Michael D Hill, Robert J Moore, Connie H Y Wong
ABSTRACTBacterial infection is highly prevalent in patients who have had a stroke. Despite the potential contribution of micro-aspiration in post-stroke pneumonia, we found that the majority of the microorganisms detected in the patients who developed infections after having a stroke were common commensal bacteria that normally reside in the intestinal tracts. In a mouse model of ischemic stroke, post-stroke infection was only observed in mice that were born and raised in specific-pathogen-free facilities; this was not seen in mice that were born and raised in germ-free facilities. Using high-throughput 16S rRNA gene amplicon sequencing and bioinformatics analyses, we provide evidence demonstrating that the source of the bacteria forming the microbial community in the lungs of post-stroke mice was indeed the host small intestine. Additionally, stroke-induced gut barrier permeability and dysfunction preceded the dissemination of orally inoculated bacteria to peripheral tissues. This study identifies a novel pathway in which stroke promotes the translocation and dissemination of selective strains of bacteria that originated from the host gut microbiota. More... »
PAGES1277-1284
http://scigraph.springernature.com/pub.10.1038/nm.4194
DOIhttp://dx.doi.org/10.1038/nm.4194
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/27694934
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JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nm.4194'
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curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nm.4194'
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curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nm.4194'
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This table displays all metadata directly associated to this object as RDF triples.
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