Translocation and dissemination of commensal bacteria in post-stroke infection View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-11

AUTHORS

Dragana Stanley, Linda J Mason, Kate E Mackin, Yogitha N Srikhanta, Dena Lyras, Monica D Prakash, Kulmira Nurgali, Andres Venegas, Michael D Hill, Robert J Moore, Connie H Y Wong

ABSTRACT

Bacterial infection is highly prevalent in patients who have had a stroke. Despite the potential contribution of micro-aspiration in post-stroke pneumonia, we found that the majority of the microorganisms detected in the patients who developed infections after having a stroke were common commensal bacteria that normally reside in the intestinal tracts. In a mouse model of ischemic stroke, post-stroke infection was only observed in mice that were born and raised in specific-pathogen-free facilities; this was not seen in mice that were born and raised in germ-free facilities. Using high-throughput 16S rRNA gene amplicon sequencing and bioinformatics analyses, we provide evidence demonstrating that the source of the bacteria forming the microbial community in the lungs of post-stroke mice was indeed the host small intestine. Additionally, stroke-induced gut barrier permeability and dysfunction preceded the dissemination of orally inoculated bacteria to peripheral tissues. This study identifies a novel pathway in which stroke promotes the translocation and dissemination of selective strains of bacteria that originated from the host gut microbiota. More... »

PAGES

1277-1284

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nm.4194

    DOI

    http://dx.doi.org/10.1038/nm.4194

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1006067533

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27694934


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