Persisting positron emission tomography lesion activity and Mycobacterium tuberculosis mRNA after tuberculosis cure View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-10

AUTHORS

Stephanus T Malherbe, Shubhada Shenai, Katharina Ronacher, Andre G Loxton, Gregory Dolganov, Magdalena Kriel, Tran Van, Ray Y Chen, James Warwick, Laura E Via, Taeksun Song, Myungsun Lee, Gary Schoolnik, Gerard Tromp, David Alland, Clifton E Barry, Jill Winter, Gerhard Walzl, Catalysis TB–Biomarker Consortium, Lance Lucas, Gian van der Spuy, Kim Stanley, Lani Thiart, Bronwyn Smith, Nelita Du Plessis, Caroline G G Beltran, Elizna Maasdorp, Annare Ellmann, Hongjo Choi, Joonsung Joh, Lori E Dodd, Brian Allwood, Coenie Koegelenberg, Morné Vorster, Stephanie Griffith-Richards

ABSTRACT

The absence of a gold standard to determine when antibiotics induce a sterilizing cure has confounded the development of new approaches to treat pulmonary tuberculosis (PTB). We detected positron emission tomography and computerized tomography (PET-CT) imaging response patterns consistent with active disease, along with the presence of Mycobacterium tuberculosis (MTB) mRNA in sputum and bronchoalveolar lavage samples, in a substantial proportion of adult, HIV-negative patients with PTB after a standard 6-month treatment plus 1 year follow-up, including patients with a durable cure and others who later developed recurrent disease. The presence of MTB mRNA in the context of nonresolving and intensifying lesions on PET-CT images might indicate ongoing transcription, suggesting that even apparently curative treatment for PTB may not eradicate all of the MTB bacteria in most patients. This suggests an important complementary role for the immune response in maintaining a disease-free state. Sterilizing drugs or host-directed therapies, and better treatment response markers, are probably needed for the successful development of improved and shortened PTB-treatment strategies. More... »

PAGES

1094-1100

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nm.4177

DOI

http://dx.doi.org/10.1038/nm.4177

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1008800680

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27595324


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antitubercular Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bronchoalveolar Lavage Fluid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lung", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mycobacterium tuberculosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Positron Emission Tomography Computed Tomography", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "South Africa", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sputum", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tuberculosis, Pulmonary", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Young Adult", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Stellenbosch University", 
          "id": "https://www.grid.ac/institutes/grid.11956.3a", 
          "name": [
            "Department of Science and Technology\u2013National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, Stellenbosch University, Cape Town, South Africa.", 
            "South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Malherbe", 
        "givenName": "Stephanus T", 
        "id": "sg:person.0742310253.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0742310253.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Rutgers University\u2013Newark", 
          "id": "https://www.grid.ac/institutes/grid.469131.8", 
          "name": [
            "Center for Emerging Pathogens, Department of Medicine, Rutgers New Jersey Medical School, Newark, New Jersey, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shenai", 
        "givenName": "Shubhada", 
        "id": "sg:person.01357434325.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357434325.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Stellenbosch University", 
          "id": "https://www.grid.ac/institutes/grid.11956.3a", 
          "name": [
            "Department of Science and Technology\u2013National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, Stellenbosch University, Cape Town, South Africa.", 
            "South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ronacher", 
        "givenName": "Katharina", 
        "id": "sg:person.01301524471.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301524471.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Stellenbosch University", 
          "id": "https://www.grid.ac/institutes/grid.11956.3a", 
          "name": [
            "Department of Science and Technology\u2013National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, Stellenbosch University, Cape Town, South Africa.", 
            "South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Loxton", 
        "givenName": "Andre G", 
        "id": "sg:person.01003000534.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003000534.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Stanford University", 
          "id": "https://www.grid.ac/institutes/grid.168010.e", 
          "name": [
            "Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dolganov", 
        "givenName": "Gregory", 
        "id": "sg:person.014353141727.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014353141727.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Stellenbosch University", 
          "id": "https://www.grid.ac/institutes/grid.11956.3a", 
          "name": [
            "Department of Science and Technology\u2013National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, Stellenbosch University, Cape Town, South Africa.", 
            "South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kriel", 
        "givenName": "Magdalena", 
        "id": "sg:person.0651147712.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0651147712.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Stanford University", 
          "id": "https://www.grid.ac/institutes/grid.168010.e", 
          "name": [
            "Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Van", 
        "givenName": "Tran", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute of Allergy and Infectious Diseases", 
          "id": "https://www.grid.ac/institutes/grid.419681.3", 
          "name": [
            "Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Ray Y", 
        "id": "sg:person.01156752757.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156752757.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Stellenbosch University", 
          "id": "https://www.grid.ac/institutes/grid.11956.3a", 
          "name": [
            "Western Cape Academic Positron Emission Tomography\u2013Computed Tomography Centre, Tygerberg Academic Hospital, Cape Town, South Africa.", 
            "Division of Nuclear Medicine, Department of Medical Imaging and Clinical Oncology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Warwick", 
        "givenName": "James", 
        "id": "sg:person.01130765136.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130765136.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Cape Town", 
          "id": "https://www.grid.ac/institutes/grid.7836.a", 
          "name": [
            "Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.", 
            "Institute of Infectious Disease and Molecular Medicine, Department of Clinical Laboratory Sciences, University of Cape Town, Cape Town, South Africa."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Via", 
        "givenName": "Laura E", 
        "id": "sg:person.0615676337.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615676337.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "International Tuberculosis Research Center", 
          "id": "https://www.grid.ac/institutes/grid.495992.a", 
          "name": [
            "International Tuberculosis Research Center, Seoul, South Korea."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Song", 
        "givenName": "Taeksun", 
        "id": "sg:person.01300233413.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300233413.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "International Tuberculosis Research Center", 
          "id": "https://www.grid.ac/institutes/grid.495992.a", 
          "name": [
            "International Tuberculosis Research Center, Seoul, South Korea."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Myungsun", 
        "id": "sg:person.0702062527.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702062527.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Stanford University", 
          "id": "https://www.grid.ac/institutes/grid.168010.e", 
          "name": [
            "Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schoolnik", 
        "givenName": "Gary", 
        "id": "sg:person.0705577640.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705577640.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Stellenbosch University", 
          "id": "https://www.grid.ac/institutes/grid.11956.3a", 
          "name": [
            "Department of Science and Technology\u2013National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, Stellenbosch University, Cape Town, South Africa.", 
            "South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tromp", 
        "givenName": "Gerard", 
        "id": "sg:person.07675140577.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07675140577.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Rutgers University\u2013Newark", 
          "id": "https://www.grid.ac/institutes/grid.469131.8", 
          "name": [
            "Center for Emerging Pathogens, Department of Medicine, Rutgers New Jersey Medical School, Newark, New Jersey, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Alland", 
        "givenName": "David", 
        "id": "sg:person.01265250464.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265250464.54"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Barry", 
        "givenName": "Clifton E", 
        "id": "sg:person.013611750377.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013611750377.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Catalysis Foundation for Health", 
          "id": "https://www.grid.ac/institutes/grid.474940.a", 
          "name": [
            "Catalysis Foundation for Health, Emeryville, California, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Winter", 
        "givenName": "Jill", 
        "id": "sg:person.01322246224.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322246224.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Stellenbosch University", 
          "id": "https://www.grid.ac/institutes/grid.11956.3a", 
          "name": [
            "Department of Science and Technology\u2013National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, Stellenbosch University, Cape Town, South Africa.", 
            "South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Walzl", 
        "givenName": "Gerhard", 
        "id": "sg:person.01043531757.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043531757.64"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Consortium", 
        "givenName": "Catalysis TB\u2013Biomarker", 
        "id": "sg:person.012545716155.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012545716155.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Stellenbosch University", 
          "id": "https://www.grid.ac/institutes/grid.11956.3a", 
          "name": [
            "Department of Science and Technology\u2013National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, Stellenbosch University, Cape Town, South Africa.", 
            "South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lucas", 
        "givenName": "Lance", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Stellenbosch University", 
          "id": "https://www.grid.ac/institutes/grid.11956.3a", 
          "name": [
            "Department of Science and Technology\u2013National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, Stellenbosch University, Cape Town, South Africa.", 
            "South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa."
          ], 
          "type": "Organization"
        }, 
        "familyName": "van der Spuy", 
        "givenName": "Gian", 
        "id": "sg:person.0760503015.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760503015.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Stellenbosch University", 
          "id": "https://www.grid.ac/institutes/grid.11956.3a", 
          "name": [
            "Department of Science and Technology\u2013National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, Stellenbosch University, Cape Town, South Africa.", 
            "South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stanley", 
        "givenName": "Kim", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Stellenbosch University", 
          "id": "https://www.grid.ac/institutes/grid.11956.3a", 
          "name": [
            "Department of Science and Technology\u2013National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, Stellenbosch University, Cape Town, South Africa.", 
            "South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thiart", 
        "givenName": "Lani", 
        "id": "sg:person.0614715513.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0614715513.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Stellenbosch University", 
          "id": "https://www.grid.ac/institutes/grid.11956.3a", 
          "name": [
            "Department of Science and Technology\u2013National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, Stellenbosch University, Cape Town, South Africa.", 
            "South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Smith", 
        "givenName": "Bronwyn", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Stellenbosch University", 
          "id": "https://www.grid.ac/institutes/grid.11956.3a", 
          "name": [
            "Department of Science and Technology\u2013National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, Stellenbosch University, Cape Town, South Africa.", 
            "South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Du Plessis", 
        "givenName": "Nelita", 
        "id": "sg:person.01230410574.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230410574.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Stellenbosch University", 
          "id": "https://www.grid.ac/institutes/grid.11956.3a", 
          "name": [
            "Department of Science and Technology\u2013National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, Stellenbosch University, Cape Town, South Africa.", 
            "South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Beltran", 
        "givenName": "Caroline G G", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Stellenbosch University", 
          "id": "https://www.grid.ac/institutes/grid.11956.3a", 
          "name": [
            "Department of Science and Technology\u2013National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, Stellenbosch University, Cape Town, South Africa.", 
            "South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Maasdorp", 
        "givenName": "Elizna", 
        "id": "sg:person.01306226371.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306226371.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Stellenbosch University", 
          "id": "https://www.grid.ac/institutes/grid.11956.3a", 
          "name": [
            "Western Cape Academic Positron Emission Tomography\u2013Computed Tomography Centre, Tygerberg Academic Hospital, Cape Town, South Africa.", 
            "Division of Nuclear Medicine, Department of Medical Imaging and Clinical Oncology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ellmann", 
        "givenName": "Annare", 
        "id": "sg:person.01237502327.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237502327.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "International Tuberculosis Research Center", 
          "id": "https://www.grid.ac/institutes/grid.495992.a", 
          "name": [
            "International Tuberculosis Research Center, Seoul, South Korea."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Choi", 
        "givenName": "Hongjo", 
        "id": "sg:person.01305377127.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305377127.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.415619.e", 
          "name": [
            "National Medical Center, Seoul, South Korea."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Joh", 
        "givenName": "Joonsung", 
        "id": "sg:person.0610064747.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610064747.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute of Allergy and Infectious Diseases", 
          "id": "https://www.grid.ac/institutes/grid.419681.3", 
          "name": [
            "Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dodd", 
        "givenName": "Lori E", 
        "id": "sg:person.01030041706.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030041706.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Stellenbosch University", 
          "id": "https://www.grid.ac/institutes/grid.11956.3a", 
          "name": [
            "Division of Pulmonology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Allwood", 
        "givenName": "Brian", 
        "id": "sg:person.01301723421.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301723421.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Stellenbosch University", 
          "id": "https://www.grid.ac/institutes/grid.11956.3a", 
          "name": [
            "Division of Pulmonology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Koegelenberg", 
        "givenName": "Coenie", 
        "id": "sg:person.012656674674.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012656674674.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Stellenbosch University", 
          "id": "https://www.grid.ac/institutes/grid.11956.3a", 
          "name": [
            "Division of Pulmonology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vorster", 
        "givenName": "Morn\u00e9", 
        "id": "sg:person.01262343505.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262343505.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Stellenbosch University", 
          "id": "https://www.grid.ac/institutes/grid.11956.3a", 
          "name": [
            "Division of Radiodiagnosis, Department of Medical Imaging and Clinical Oncology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Griffith-Richards", 
        "givenName": "Stephanie", 
        "id": "sg:person.01070527543.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070527543.46"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1164/ajrccm.162.6.2003125", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000814826"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3324/haematol.2009.016105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000955950"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/infdis/jiu632", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001721122"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00259-011-1838-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001884653", 
          "https://doi.org/10.1007/s00259-011-1838-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/aac.00277-13", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002304346"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2967/jnumed.110.078501", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002768569"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1315817", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003947236"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2010.07.490", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006325679"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/aac.00789-09", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008722593"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2458-10-259", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009821725", 
          "https://doi.org/10.1186/1471-2458-10-259"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.sult.2010.10.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011037592"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.3412", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011920694", 
          "https://doi.org/10.1038/nm.3412"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1590/s1806-37132006000100010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011928136"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/00365540701558698", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011928782"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00586-014-3483-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012411409", 
          "https://doi.org/10.1007/s00586-014-3483-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(01)06712-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013355879"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2458-11-140", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013640837", 
          "https://doi.org/10.1186/1471-2458-11-140"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00259-010-1490-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014574340", 
          "https://doi.org/10.1007/s00259-010-1490-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00259-010-1490-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014574340", 
          "https://doi.org/10.1007/s00259-010-1490-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.39463.640787.be", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016446620"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/rccm.200904-0536oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016509088"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.76.6.771", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017650213"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gks1019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018169728"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/aac.00531-12", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020342757"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bjid.2015.06.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020990704"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/rccm.200305-714oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021234110"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-3156.2008.02213.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022450960"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1314210", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023600147"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/rlu.0000000000001102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028061509"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/rlu.0000000000001102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028061509"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5588/ijtld.13.0565", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028456050"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/thorax.55.1.32", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031994830"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/thorax.55.1.32", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031994830"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0007749", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033477567"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00259-008-1009-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035954151", 
          "https://doi.org/10.1007/s00259-008-1009-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00259-008-1009-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035954151", 
          "https://doi.org/10.1007/s00259-008-1009-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.rmed.2011.07.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036633677"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/theoncologist.2009-s2-30", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037263340"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.07-0755", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037291327"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1472-765x.2008.02374.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037365450"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12864-015-2197-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037413011", 
          "https://doi.org/10.1186/s12864-015-2197-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature12337", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037601902", 
          "https://doi.org/10.1038/nature12337"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jb.182.22.6358-6365.2000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037907835"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2967/jnumed.111.088914", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040091269"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2967/jnumed.110.083709", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040688222"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/cid/ciu186", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041182368"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.1201593", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041497315"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/infdis/jiv149", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042306309"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5588/ijtld.11.0692", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042583588"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s2213-2600(13)70119-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043123225"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1407426", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044281588"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2967/jnumed.111.099531", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044694185"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejme1410977", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044962010"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/iai.01599-13", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045607304"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1590/s1806-37132012000200004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046233300"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/thx.2010.136242", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049360575"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/thx.2010.136242", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049360575"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.06-2949", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051971421"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/ajrccm.149.3.8118630", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052536790"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5588/ijtld.12.0049", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052801883"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/scitranslmed.3009501", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062688445"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jb.178.15.4484-4492.1996", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062725051"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5588/ijtld.12.0010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073012101"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077003949", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077465133", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077585842", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077729867", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078145721", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/08.2010/jcpsp.542544", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078197885"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082585406", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083123026", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-10", 
    "datePublishedReg": "2016-10-01", 
    "description": "The absence of a gold standard to determine when antibiotics induce a sterilizing cure has confounded the development of new approaches to treat pulmonary tuberculosis (PTB). We detected positron emission tomography and computerized tomography (PET-CT) imaging response patterns consistent with active disease, along with the presence of Mycobacterium tuberculosis (MTB) mRNA in sputum and bronchoalveolar lavage samples, in a substantial proportion of adult, HIV-negative patients with PTB after a standard 6-month treatment plus 1 year follow-up, including patients with a durable cure and others who later developed recurrent disease. The presence of MTB mRNA in the context of nonresolving and intensifying lesions on PET-CT images might indicate ongoing transcription, suggesting that even apparently curative treatment for PTB may not eradicate all of the MTB bacteria in most patients. This suggests an important complementary role for the immune response in maintaining a disease-free state. Sterilizing drugs or host-directed therapies, and better treatment response markers, are probably needed for the successful development of improved and shortened PTB-treatment strategies.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nm.4177", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.6500464", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2723275", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2709150", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1113716", 
        "issn": [
          "1078-8956", 
          "1546-170X"
        ], 
        "name": "Nature Medicine", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "10", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "22"
      }
    ], 
    "name": "Persisting positron emission tomography lesion activity and Mycobacterium tuberculosis mRNA after tuberculosis cure", 
    "pagination": "1094-1100", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "29ee380e0e2364cc884e957854b6a11fc9227179dd587cc604ea9e768fb0ce74"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27595324"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9502015"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nm.4177"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1008800680"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nm.4177", 
      "https://app.dimensions.ai/details/publication/pub.1008800680"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:27", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000362_0000000362/records_87117_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/nm.4177"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nm.4177'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nm.4177'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nm.4177'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nm.4177'


 

This table displays all metadata directly associated to this object as RDF triples.

602 TRIPLES      21 PREDICATES      112 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nm.4177 schema:about N0cc4cc8d18854724808825de64c4c6d8
2 N2900a81d80d645708249568b443cf5bf
3 N51773d3823504556a7b31dc157bba8ad
4 N51c2f10ef0c24210a12269c52cf673e1
5 N7e7d6ec1743a48a2bf95ee93abc3fc44
6 N8f3d89f73dbb446eb73500fd7c181996
7 N95669b9c01d94d54959d830dd60e72d6
8 N9667251732bf4a6ca813903094f085a7
9 Na07216a4f5c845cd96a5726176bea1f2
10 Na64c886a6fdc4744a7ef39a1299de769
11 Na80c1cb264964642acebc6d4fa648842
12 Nae684cc6b15a4b989e4b3b31fbfb66cb
13 Nd3cda76efd1741f18afa0460cf3381b1
14 Ne4fc4f6e7d3e44468e15021f61d74899
15 Ne8e9970bf6764c96a23aca8e508dc247
16 Nec075d6a6aad4defa1a6a8edafed9036
17 Nfff80c22240f44d89990594b6fea44ae
18 anzsrc-for:11
19 anzsrc-for:1103
20 schema:author N20cc4167fa2b404b8ddb51708bf742b5
21 schema:citation sg:pub.10.1007/s00259-008-1009-5
22 sg:pub.10.1007/s00259-010-1490-5
23 sg:pub.10.1007/s00259-011-1838-5
24 sg:pub.10.1007/s00586-014-3483-8
25 sg:pub.10.1038/nature12337
26 sg:pub.10.1038/nm.3412
27 sg:pub.10.1186/1471-2458-10-259
28 sg:pub.10.1186/1471-2458-11-140
29 sg:pub.10.1186/s12864-015-2197-6
30 https://app.dimensions.ai/details/publication/pub.1077003949
31 https://app.dimensions.ai/details/publication/pub.1077465133
32 https://app.dimensions.ai/details/publication/pub.1077585842
33 https://app.dimensions.ai/details/publication/pub.1077729867
34 https://app.dimensions.ai/details/publication/pub.1078145721
35 https://app.dimensions.ai/details/publication/pub.1082585406
36 https://app.dimensions.ai/details/publication/pub.1083123026
37 https://doi.org/08.2010/jcpsp.542544
38 https://doi.org/10.1016/j.bjid.2015.06.005
39 https://doi.org/10.1016/j.ijrobp.2010.07.490
40 https://doi.org/10.1016/j.rmed.2011.07.014
41 https://doi.org/10.1016/s0140-6736(01)06712-5
42 https://doi.org/10.1016/s2213-2600(13)70119-x
43 https://doi.org/10.1053/j.sult.2010.10.001
44 https://doi.org/10.1056/nejme1410977
45 https://doi.org/10.1056/nejmoa1314210
46 https://doi.org/10.1056/nejmoa1315817
47 https://doi.org/10.1056/nejmoa1407426
48 https://doi.org/10.1080/00365540701558698
49 https://doi.org/10.1093/cid/ciu186
50 https://doi.org/10.1093/infdis/jiu632
51 https://doi.org/10.1093/infdis/jiv149
52 https://doi.org/10.1093/nar/gks1019
53 https://doi.org/10.1097/rlu.0000000000001102
54 https://doi.org/10.1111/j.1365-3156.2008.02213.x
55 https://doi.org/10.1111/j.1472-765x.2008.02374.x
56 https://doi.org/10.1126/scitranslmed.3009501
57 https://doi.org/10.1128/aac.00277-13
58 https://doi.org/10.1128/aac.00531-12
59 https://doi.org/10.1128/aac.00789-09
60 https://doi.org/10.1128/iai.01599-13
61 https://doi.org/10.1128/jb.178.15.4484-4492.1996
62 https://doi.org/10.1128/jb.182.22.6358-6365.2000
63 https://doi.org/10.1136/bmj.39463.640787.be
64 https://doi.org/10.1136/thorax.55.1.32
65 https://doi.org/10.1136/thx.2010.136242
66 https://doi.org/10.1164/ajrccm.149.3.8118630
67 https://doi.org/10.1164/ajrccm.162.6.2003125
68 https://doi.org/10.1164/rccm.200305-714oc
69 https://doi.org/10.1164/rccm.200904-0536oc
70 https://doi.org/10.1371/journal.pone.0007749
71 https://doi.org/10.1378/chest.06-2949
72 https://doi.org/10.1378/chest.07-0755
73 https://doi.org/10.1378/chest.76.6.771
74 https://doi.org/10.1590/s1806-37132006000100010
75 https://doi.org/10.1590/s1806-37132012000200004
76 https://doi.org/10.1634/theoncologist.2009-s2-30
77 https://doi.org/10.2967/jnumed.110.078501
78 https://doi.org/10.2967/jnumed.110.083709
79 https://doi.org/10.2967/jnumed.111.088914
80 https://doi.org/10.2967/jnumed.111.099531
81 https://doi.org/10.3324/haematol.2009.016105
82 https://doi.org/10.4049/jimmunol.1201593
83 https://doi.org/10.5588/ijtld.11.0692
84 https://doi.org/10.5588/ijtld.12.0010
85 https://doi.org/10.5588/ijtld.12.0049
86 https://doi.org/10.5588/ijtld.13.0565
87 schema:datePublished 2016-10
88 schema:datePublishedReg 2016-10-01
89 schema:description The absence of a gold standard to determine when antibiotics induce a sterilizing cure has confounded the development of new approaches to treat pulmonary tuberculosis (PTB). We detected positron emission tomography and computerized tomography (PET-CT) imaging response patterns consistent with active disease, along with the presence of Mycobacterium tuberculosis (MTB) mRNA in sputum and bronchoalveolar lavage samples, in a substantial proportion of adult, HIV-negative patients with PTB after a standard 6-month treatment plus 1 year follow-up, including patients with a durable cure and others who later developed recurrent disease. The presence of MTB mRNA in the context of nonresolving and intensifying lesions on PET-CT images might indicate ongoing transcription, suggesting that even apparently curative treatment for PTB may not eradicate all of the MTB bacteria in most patients. This suggests an important complementary role for the immune response in maintaining a disease-free state. Sterilizing drugs or host-directed therapies, and better treatment response markers, are probably needed for the successful development of improved and shortened PTB-treatment strategies.
90 schema:genre research_article
91 schema:inLanguage en
92 schema:isAccessibleForFree true
93 schema:isPartOf N969f799778704c469bd3e5def7f130d7
94 N9c35b1275f724727ac7384956d0cf5c1
95 sg:journal.1113716
96 schema:name Persisting positron emission tomography lesion activity and Mycobacterium tuberculosis mRNA after tuberculosis cure
97 schema:pagination 1094-1100
98 schema:productId N0502f5fedc244e788904f4476fce1c8a
99 N236d461246eb443486872f5186e7527e
100 N91c6033901e046b0aaf04d1f8cfb3e46
101 Naa9d19dd6b564de1b89466c7c5dbc1af
102 Nc8526a9c88054620a0e2653fda1d0bcd
103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008800680
104 https://doi.org/10.1038/nm.4177
105 schema:sdDatePublished 2019-04-11T12:27
106 schema:sdLicense https://scigraph.springernature.com/explorer/license/
107 schema:sdPublisher N03a344994b364a908f9bdbd9dfb7db51
108 schema:url http://www.nature.com/articles/nm.4177
109 sgo:license sg:explorer/license/
110 sgo:sdDataset articles
111 rdf:type schema:ScholarlyArticle
112 N039b2ab365f1410bb0acd5219dda04a1 rdf:first sg:person.01130765136.87
113 rdf:rest Ncc0af2b0813b49e7bb2b2ede1d1231c5
114 N03a344994b364a908f9bdbd9dfb7db51 schema:name Springer Nature - SN SciGraph project
115 rdf:type schema:Organization
116 N0502f5fedc244e788904f4476fce1c8a schema:name pubmed_id
117 schema:value 27595324
118 rdf:type schema:PropertyValue
119 N074c3c97530043ce87692447f5abd6e0 schema:affiliation https://www.grid.ac/institutes/grid.168010.e
120 schema:familyName Van
121 schema:givenName Tran
122 rdf:type schema:Person
123 N0a4b8d8022b843d0926ce49568a91bfc rdf:first sg:person.012656674674.10
124 rdf:rest Neb60f3f344c5407284ff8511efbef014
125 N0cc4cc8d18854724808825de64c4c6d8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Aged
127 rdf:type schema:DefinedTerm
128 N1a4026849e23422abe2a0a010266d943 rdf:first Nf8e91523d1714455bab0c80ed4bf6ce8
129 rdf:rest N5e6f4116d35f403aadb456e3739be466
130 N20cc4167fa2b404b8ddb51708bf742b5 rdf:first sg:person.0742310253.71
131 rdf:rest Nef16edf91b6048769c6d062142e4f6ca
132 N213675177a5d4ba4b5ba34bef831df61 rdf:first sg:person.01070527543.46
133 rdf:rest rdf:nil
134 N236d461246eb443486872f5186e7527e schema:name nlm_unique_id
135 schema:value 9502015
136 rdf:type schema:PropertyValue
137 N2753fe4fa50046a886406792fdf1e1d3 rdf:first sg:person.01003000534.27
138 rdf:rest N858c1da2aa7143279a8447e9a5f8e17d
139 N2900a81d80d645708249568b443cf5bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name RNA, Messenger
141 rdf:type schema:DefinedTerm
142 N424ef3b1ad654996bf77efd348b91655 rdf:first Ncc348a5f67d74563931fa5cd40fffbc2
143 rdf:rest Nd169b47186e146caab4da46e2b7598d6
144 N51773d3823504556a7b31dc157bba8ad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Middle Aged
146 rdf:type schema:DefinedTerm
147 N51c2f10ef0c24210a12269c52cf673e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Young Adult
149 rdf:type schema:DefinedTerm
150 N57d5c77a0e8e4b7cace0d49b91000e93 rdf:first sg:person.0705577640.89
151 rdf:rest Nd0a8dd25f53147c8ab413a251bacb173
152 N5e6f4116d35f403aadb456e3739be466 rdf:first sg:person.0760503015.16
153 rdf:rest N424ef3b1ad654996bf77efd348b91655
154 N60976f87a2134a78828712a267d3d781 rdf:first sg:person.0610064747.93
155 rdf:rest Naeb001ac2a604956ae30eb0ba6540630
156 N663d3dc91f2040a18a0d1c4142062877 rdf:first sg:person.0651147712.59
157 rdf:rest N7c3185de2d874995a4b3211524ae9ca7
158 N67b3ba992a7e490fbf946baa7cd436fa rdf:first sg:person.01301723421.40
159 rdf:rest N0a4b8d8022b843d0926ce49568a91bfc
160 N7b762c5dd11846d2883a20c82470f2d8 rdf:first sg:person.01237502327.53
161 rdf:rest Nbf4f9af2261a43579bfe3efed542038b
162 N7c3185de2d874995a4b3211524ae9ca7 rdf:first N074c3c97530043ce87692447f5abd6e0
163 rdf:rest Ne6541f7f0d984c7fafbd50236e2b9730
164 N7e7d6ec1743a48a2bf95ee93abc3fc44 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Antitubercular Agents
166 rdf:type schema:DefinedTerm
167 N858c1da2aa7143279a8447e9a5f8e17d rdf:first sg:person.014353141727.86
168 rdf:rest N663d3dc91f2040a18a0d1c4142062877
169 N8d3d35fa0c4b49e0883683d4116f8dd8 rdf:first Nba21ffe9e3f34591a4704c0cc3d42c8d
170 rdf:rest Neca919e51aca4cdbb74c9ec23f497972
171 N8f3d89f73dbb446eb73500fd7c181996 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Bronchoalveolar Lavage Fluid
173 rdf:type schema:DefinedTerm
174 N91c6033901e046b0aaf04d1f8cfb3e46 schema:name doi
175 schema:value 10.1038/nm.4177
176 rdf:type schema:PropertyValue
177 N92c51dc09920434eaaa971feff7a88bf rdf:first sg:person.01300233413.33
178 rdf:rest Nf7dc81d0724744d1bbb44c3447099b0c
179 N95669b9c01d94d54959d830dd60e72d6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Humans
181 rdf:type schema:DefinedTerm
182 N9667251732bf4a6ca813903094f085a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Tuberculosis, Pulmonary
184 rdf:type schema:DefinedTerm
185 N969f799778704c469bd3e5def7f130d7 schema:volumeNumber 22
186 rdf:type schema:PublicationVolume
187 N9c35b1275f724727ac7384956d0cf5c1 schema:issueNumber 10
188 rdf:type schema:PublicationIssue
189 Na07216a4f5c845cd96a5726176bea1f2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Female
191 rdf:type schema:DefinedTerm
192 Na64c886a6fdc4744a7ef39a1299de769 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
193 schema:name Adolescent
194 rdf:type schema:DefinedTerm
195 Na80c1cb264964642acebc6d4fa648842 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
196 schema:name Male
197 rdf:type schema:DefinedTerm
198 Naa9d19dd6b564de1b89466c7c5dbc1af schema:name dimensions_id
199 schema:value pub.1008800680
200 rdf:type schema:PropertyValue
201 Nae684cc6b15a4b989e4b3b31fbfb66cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
202 schema:name Mycobacterium tuberculosis
203 rdf:type schema:DefinedTerm
204 Naeb001ac2a604956ae30eb0ba6540630 rdf:first sg:person.01030041706.98
205 rdf:rest N67b3ba992a7e490fbf946baa7cd436fa
206 Nba21ffe9e3f34591a4704c0cc3d42c8d schema:affiliation https://www.grid.ac/institutes/grid.11956.3a
207 schema:familyName Smith
208 schema:givenName Bronwyn
209 rdf:type schema:Person
210 Nbecc828106f84b33974ef2fa514be809 rdf:first sg:person.012545716155.90
211 rdf:rest N1a4026849e23422abe2a0a010266d943
212 Nbf4f9af2261a43579bfe3efed542038b rdf:first sg:person.01305377127.89
213 rdf:rest N60976f87a2134a78828712a267d3d781
214 Nc0ea059711114163bdc9ffe1d31f6bb6 rdf:first sg:person.01265250464.54
215 rdf:rest Ne51d93e6e7ad4f84a4c1fe4dd7823c69
216 Nc8526a9c88054620a0e2653fda1d0bcd schema:name readcube_id
217 schema:value 29ee380e0e2364cc884e957854b6a11fc9227179dd587cc604ea9e768fb0ce74
218 rdf:type schema:PropertyValue
219 Ncaa472bf487947b0a90305c5449cf321 rdf:first sg:person.01306226371.48
220 rdf:rest N7b762c5dd11846d2883a20c82470f2d8
221 Ncc0af2b0813b49e7bb2b2ede1d1231c5 rdf:first sg:person.0615676337.47
222 rdf:rest N92c51dc09920434eaaa971feff7a88bf
223 Ncc348a5f67d74563931fa5cd40fffbc2 schema:affiliation https://www.grid.ac/institutes/grid.11956.3a
224 schema:familyName Stanley
225 schema:givenName Kim
226 rdf:type schema:Person
227 Nd0a8dd25f53147c8ab413a251bacb173 rdf:first sg:person.07675140577.42
228 rdf:rest Nc0ea059711114163bdc9ffe1d31f6bb6
229 Nd169b47186e146caab4da46e2b7598d6 rdf:first sg:person.0614715513.99
230 rdf:rest N8d3d35fa0c4b49e0883683d4116f8dd8
231 Nd3cda76efd1741f18afa0460cf3381b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
232 schema:name South Africa
233 rdf:type schema:DefinedTerm
234 Ndd1d4c9d634b4a11aec03c68aca2ce78 rdf:first sg:person.01043531757.64
235 rdf:rest Nbecc828106f84b33974ef2fa514be809
236 Ne0f79ff0adc94e01963c2579d55a9f31 schema:affiliation https://www.grid.ac/institutes/grid.11956.3a
237 schema:familyName Beltran
238 schema:givenName Caroline G G
239 rdf:type schema:Person
240 Ne4fc4f6e7d3e44468e15021f61d74899 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
241 schema:name Adult
242 rdf:type schema:DefinedTerm
243 Ne51d93e6e7ad4f84a4c1fe4dd7823c69 rdf:first sg:person.013611750377.27
244 rdf:rest Nfa064adf433849cebc601bd8e352cb7e
245 Ne6541f7f0d984c7fafbd50236e2b9730 rdf:first sg:person.01156752757.90
246 rdf:rest N039b2ab365f1410bb0acd5219dda04a1
247 Ne8e9970bf6764c96a23aca8e508dc247 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
248 schema:name Positron Emission Tomography Computed Tomography
249 rdf:type schema:DefinedTerm
250 Ne940986f9028497db964c037c771b908 rdf:first Ne0f79ff0adc94e01963c2579d55a9f31
251 rdf:rest Ncaa472bf487947b0a90305c5449cf321
252 Neb60f3f344c5407284ff8511efbef014 rdf:first sg:person.01262343505.84
253 rdf:rest N213675177a5d4ba4b5ba34bef831df61
254 Nec075d6a6aad4defa1a6a8edafed9036 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
255 schema:name Lung
256 rdf:type schema:DefinedTerm
257 Neca919e51aca4cdbb74c9ec23f497972 rdf:first sg:person.01230410574.93
258 rdf:rest Ne940986f9028497db964c037c771b908
259 Nef16edf91b6048769c6d062142e4f6ca rdf:first sg:person.01357434325.20
260 rdf:rest Nfc469cf8b75f4efa8c39842740e179cb
261 Nf7dc81d0724744d1bbb44c3447099b0c rdf:first sg:person.0702062527.88
262 rdf:rest N57d5c77a0e8e4b7cace0d49b91000e93
263 Nf8e91523d1714455bab0c80ed4bf6ce8 schema:affiliation https://www.grid.ac/institutes/grid.11956.3a
264 schema:familyName Lucas
265 schema:givenName Lance
266 rdf:type schema:Person
267 Nfa064adf433849cebc601bd8e352cb7e rdf:first sg:person.01322246224.03
268 rdf:rest Ndd1d4c9d634b4a11aec03c68aca2ce78
269 Nfc469cf8b75f4efa8c39842740e179cb rdf:first sg:person.01301524471.92
270 rdf:rest N2753fe4fa50046a886406792fdf1e1d3
271 Nfff80c22240f44d89990594b6fea44ae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
272 schema:name Sputum
273 rdf:type schema:DefinedTerm
274 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
275 schema:name Medical and Health Sciences
276 rdf:type schema:DefinedTerm
277 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
278 schema:name Clinical Sciences
279 rdf:type schema:DefinedTerm
280 sg:grant.2709150 http://pending.schema.org/fundedItem sg:pub.10.1038/nm.4177
281 rdf:type schema:MonetaryGrant
282 sg:grant.2723275 http://pending.schema.org/fundedItem sg:pub.10.1038/nm.4177
283 rdf:type schema:MonetaryGrant
284 sg:grant.6500464 http://pending.schema.org/fundedItem sg:pub.10.1038/nm.4177
285 rdf:type schema:MonetaryGrant
286 sg:journal.1113716 schema:issn 1078-8956
287 1546-170X
288 schema:name Nature Medicine
289 rdf:type schema:Periodical
290 sg:person.01003000534.27 schema:affiliation https://www.grid.ac/institutes/grid.11956.3a
291 schema:familyName Loxton
292 schema:givenName Andre G
293 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003000534.27
294 rdf:type schema:Person
295 sg:person.01030041706.98 schema:affiliation https://www.grid.ac/institutes/grid.419681.3
296 schema:familyName Dodd
297 schema:givenName Lori E
298 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030041706.98
299 rdf:type schema:Person
300 sg:person.01043531757.64 schema:affiliation https://www.grid.ac/institutes/grid.11956.3a
301 schema:familyName Walzl
302 schema:givenName Gerhard
303 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043531757.64
304 rdf:type schema:Person
305 sg:person.01070527543.46 schema:affiliation https://www.grid.ac/institutes/grid.11956.3a
306 schema:familyName Griffith-Richards
307 schema:givenName Stephanie
308 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070527543.46
309 rdf:type schema:Person
310 sg:person.01130765136.87 schema:affiliation https://www.grid.ac/institutes/grid.11956.3a
311 schema:familyName Warwick
312 schema:givenName James
313 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130765136.87
314 rdf:type schema:Person
315 sg:person.01156752757.90 schema:affiliation https://www.grid.ac/institutes/grid.419681.3
316 schema:familyName Chen
317 schema:givenName Ray Y
318 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156752757.90
319 rdf:type schema:Person
320 sg:person.01230410574.93 schema:affiliation https://www.grid.ac/institutes/grid.11956.3a
321 schema:familyName Du Plessis
322 schema:givenName Nelita
323 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230410574.93
324 rdf:type schema:Person
325 sg:person.01237502327.53 schema:affiliation https://www.grid.ac/institutes/grid.11956.3a
326 schema:familyName Ellmann
327 schema:givenName Annare
328 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237502327.53
329 rdf:type schema:Person
330 sg:person.012545716155.90 schema:familyName Consortium
331 schema:givenName Catalysis TB–Biomarker
332 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012545716155.90
333 rdf:type schema:Person
334 sg:person.01262343505.84 schema:affiliation https://www.grid.ac/institutes/grid.11956.3a
335 schema:familyName Vorster
336 schema:givenName Morné
337 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262343505.84
338 rdf:type schema:Person
339 sg:person.01265250464.54 schema:affiliation https://www.grid.ac/institutes/grid.469131.8
340 schema:familyName Alland
341 schema:givenName David
342 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265250464.54
343 rdf:type schema:Person
344 sg:person.012656674674.10 schema:affiliation https://www.grid.ac/institutes/grid.11956.3a
345 schema:familyName Koegelenberg
346 schema:givenName Coenie
347 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012656674674.10
348 rdf:type schema:Person
349 sg:person.01300233413.33 schema:affiliation https://www.grid.ac/institutes/grid.495992.a
350 schema:familyName Song
351 schema:givenName Taeksun
352 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300233413.33
353 rdf:type schema:Person
354 sg:person.01301524471.92 schema:affiliation https://www.grid.ac/institutes/grid.11956.3a
355 schema:familyName Ronacher
356 schema:givenName Katharina
357 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301524471.92
358 rdf:type schema:Person
359 sg:person.01301723421.40 schema:affiliation https://www.grid.ac/institutes/grid.11956.3a
360 schema:familyName Allwood
361 schema:givenName Brian
362 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301723421.40
363 rdf:type schema:Person
364 sg:person.01305377127.89 schema:affiliation https://www.grid.ac/institutes/grid.495992.a
365 schema:familyName Choi
366 schema:givenName Hongjo
367 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305377127.89
368 rdf:type schema:Person
369 sg:person.01306226371.48 schema:affiliation https://www.grid.ac/institutes/grid.11956.3a
370 schema:familyName Maasdorp
371 schema:givenName Elizna
372 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306226371.48
373 rdf:type schema:Person
374 sg:person.01322246224.03 schema:affiliation https://www.grid.ac/institutes/grid.474940.a
375 schema:familyName Winter
376 schema:givenName Jill
377 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322246224.03
378 rdf:type schema:Person
379 sg:person.01357434325.20 schema:affiliation https://www.grid.ac/institutes/grid.469131.8
380 schema:familyName Shenai
381 schema:givenName Shubhada
382 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357434325.20
383 rdf:type schema:Person
384 sg:person.013611750377.27 schema:familyName Barry
385 schema:givenName Clifton E
386 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013611750377.27
387 rdf:type schema:Person
388 sg:person.014353141727.86 schema:affiliation https://www.grid.ac/institutes/grid.168010.e
389 schema:familyName Dolganov
390 schema:givenName Gregory
391 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014353141727.86
392 rdf:type schema:Person
393 sg:person.0610064747.93 schema:affiliation https://www.grid.ac/institutes/grid.415619.e
394 schema:familyName Joh
395 schema:givenName Joonsung
396 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610064747.93
397 rdf:type schema:Person
398 sg:person.0614715513.99 schema:affiliation https://www.grid.ac/institutes/grid.11956.3a
399 schema:familyName Thiart
400 schema:givenName Lani
401 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0614715513.99
402 rdf:type schema:Person
403 sg:person.0615676337.47 schema:affiliation https://www.grid.ac/institutes/grid.7836.a
404 schema:familyName Via
405 schema:givenName Laura E
406 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615676337.47
407 rdf:type schema:Person
408 sg:person.0651147712.59 schema:affiliation https://www.grid.ac/institutes/grid.11956.3a
409 schema:familyName Kriel
410 schema:givenName Magdalena
411 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0651147712.59
412 rdf:type schema:Person
413 sg:person.0702062527.88 schema:affiliation https://www.grid.ac/institutes/grid.495992.a
414 schema:familyName Lee
415 schema:givenName Myungsun
416 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702062527.88
417 rdf:type schema:Person
418 sg:person.0705577640.89 schema:affiliation https://www.grid.ac/institutes/grid.168010.e
419 schema:familyName Schoolnik
420 schema:givenName Gary
421 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705577640.89
422 rdf:type schema:Person
423 sg:person.0742310253.71 schema:affiliation https://www.grid.ac/institutes/grid.11956.3a
424 schema:familyName Malherbe
425 schema:givenName Stephanus T
426 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0742310253.71
427 rdf:type schema:Person
428 sg:person.0760503015.16 schema:affiliation https://www.grid.ac/institutes/grid.11956.3a
429 schema:familyName van der Spuy
430 schema:givenName Gian
431 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760503015.16
432 rdf:type schema:Person
433 sg:person.07675140577.42 schema:affiliation https://www.grid.ac/institutes/grid.11956.3a
434 schema:familyName Tromp
435 schema:givenName Gerard
436 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07675140577.42
437 rdf:type schema:Person
438 sg:pub.10.1007/s00259-008-1009-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035954151
439 https://doi.org/10.1007/s00259-008-1009-5
440 rdf:type schema:CreativeWork
441 sg:pub.10.1007/s00259-010-1490-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014574340
442 https://doi.org/10.1007/s00259-010-1490-5
443 rdf:type schema:CreativeWork
444 sg:pub.10.1007/s00259-011-1838-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001884653
445 https://doi.org/10.1007/s00259-011-1838-5
446 rdf:type schema:CreativeWork
447 sg:pub.10.1007/s00586-014-3483-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012411409
448 https://doi.org/10.1007/s00586-014-3483-8
449 rdf:type schema:CreativeWork
450 sg:pub.10.1038/nature12337 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037601902
451 https://doi.org/10.1038/nature12337
452 rdf:type schema:CreativeWork
453 sg:pub.10.1038/nm.3412 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011920694
454 https://doi.org/10.1038/nm.3412
455 rdf:type schema:CreativeWork
456 sg:pub.10.1186/1471-2458-10-259 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009821725
457 https://doi.org/10.1186/1471-2458-10-259
458 rdf:type schema:CreativeWork
459 sg:pub.10.1186/1471-2458-11-140 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013640837
460 https://doi.org/10.1186/1471-2458-11-140
461 rdf:type schema:CreativeWork
462 sg:pub.10.1186/s12864-015-2197-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037413011
463 https://doi.org/10.1186/s12864-015-2197-6
464 rdf:type schema:CreativeWork
465 https://app.dimensions.ai/details/publication/pub.1077003949 schema:CreativeWork
466 https://app.dimensions.ai/details/publication/pub.1077465133 schema:CreativeWork
467 https://app.dimensions.ai/details/publication/pub.1077585842 schema:CreativeWork
468 https://app.dimensions.ai/details/publication/pub.1077729867 schema:CreativeWork
469 https://app.dimensions.ai/details/publication/pub.1078145721 schema:CreativeWork
470 https://app.dimensions.ai/details/publication/pub.1082585406 schema:CreativeWork
471 https://app.dimensions.ai/details/publication/pub.1083123026 schema:CreativeWork
472 https://doi.org/08.2010/jcpsp.542544 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078197885
473 rdf:type schema:CreativeWork
474 https://doi.org/10.1016/j.bjid.2015.06.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020990704
475 rdf:type schema:CreativeWork
476 https://doi.org/10.1016/j.ijrobp.2010.07.490 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006325679
477 rdf:type schema:CreativeWork
478 https://doi.org/10.1016/j.rmed.2011.07.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036633677
479 rdf:type schema:CreativeWork
480 https://doi.org/10.1016/s0140-6736(01)06712-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013355879
481 rdf:type schema:CreativeWork
482 https://doi.org/10.1016/s2213-2600(13)70119-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1043123225
483 rdf:type schema:CreativeWork
484 https://doi.org/10.1053/j.sult.2010.10.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011037592
485 rdf:type schema:CreativeWork
486 https://doi.org/10.1056/nejme1410977 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044962010
487 rdf:type schema:CreativeWork
488 https://doi.org/10.1056/nejmoa1314210 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023600147
489 rdf:type schema:CreativeWork
490 https://doi.org/10.1056/nejmoa1315817 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003947236
491 rdf:type schema:CreativeWork
492 https://doi.org/10.1056/nejmoa1407426 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044281588
493 rdf:type schema:CreativeWork
494 https://doi.org/10.1080/00365540701558698 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011928782
495 rdf:type schema:CreativeWork
496 https://doi.org/10.1093/cid/ciu186 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041182368
497 rdf:type schema:CreativeWork
498 https://doi.org/10.1093/infdis/jiu632 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001721122
499 rdf:type schema:CreativeWork
500 https://doi.org/10.1093/infdis/jiv149 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042306309
501 rdf:type schema:CreativeWork
502 https://doi.org/10.1093/nar/gks1019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018169728
503 rdf:type schema:CreativeWork
504 https://doi.org/10.1097/rlu.0000000000001102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028061509
505 rdf:type schema:CreativeWork
506 https://doi.org/10.1111/j.1365-3156.2008.02213.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1022450960
507 rdf:type schema:CreativeWork
508 https://doi.org/10.1111/j.1472-765x.2008.02374.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1037365450
509 rdf:type schema:CreativeWork
510 https://doi.org/10.1126/scitranslmed.3009501 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062688445
511 rdf:type schema:CreativeWork
512 https://doi.org/10.1128/aac.00277-13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002304346
513 rdf:type schema:CreativeWork
514 https://doi.org/10.1128/aac.00531-12 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020342757
515 rdf:type schema:CreativeWork
516 https://doi.org/10.1128/aac.00789-09 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008722593
517 rdf:type schema:CreativeWork
518 https://doi.org/10.1128/iai.01599-13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045607304
519 rdf:type schema:CreativeWork
520 https://doi.org/10.1128/jb.178.15.4484-4492.1996 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062725051
521 rdf:type schema:CreativeWork
522 https://doi.org/10.1128/jb.182.22.6358-6365.2000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037907835
523 rdf:type schema:CreativeWork
524 https://doi.org/10.1136/bmj.39463.640787.be schema:sameAs https://app.dimensions.ai/details/publication/pub.1016446620
525 rdf:type schema:CreativeWork
526 https://doi.org/10.1136/thorax.55.1.32 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031994830
527 rdf:type schema:CreativeWork
528 https://doi.org/10.1136/thx.2010.136242 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049360575
529 rdf:type schema:CreativeWork
530 https://doi.org/10.1164/ajrccm.149.3.8118630 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052536790
531 rdf:type schema:CreativeWork
532 https://doi.org/10.1164/ajrccm.162.6.2003125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000814826
533 rdf:type schema:CreativeWork
534 https://doi.org/10.1164/rccm.200305-714oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1021234110
535 rdf:type schema:CreativeWork
536 https://doi.org/10.1164/rccm.200904-0536oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1016509088
537 rdf:type schema:CreativeWork
538 https://doi.org/10.1371/journal.pone.0007749 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033477567
539 rdf:type schema:CreativeWork
540 https://doi.org/10.1378/chest.06-2949 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051971421
541 rdf:type schema:CreativeWork
542 https://doi.org/10.1378/chest.07-0755 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037291327
543 rdf:type schema:CreativeWork
544 https://doi.org/10.1378/chest.76.6.771 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017650213
545 rdf:type schema:CreativeWork
546 https://doi.org/10.1590/s1806-37132006000100010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011928136
547 rdf:type schema:CreativeWork
548 https://doi.org/10.1590/s1806-37132012000200004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046233300
549 rdf:type schema:CreativeWork
550 https://doi.org/10.1634/theoncologist.2009-s2-30 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037263340
551 rdf:type schema:CreativeWork
552 https://doi.org/10.2967/jnumed.110.078501 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002768569
553 rdf:type schema:CreativeWork
554 https://doi.org/10.2967/jnumed.110.083709 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040688222
555 rdf:type schema:CreativeWork
556 https://doi.org/10.2967/jnumed.111.088914 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040091269
557 rdf:type schema:CreativeWork
558 https://doi.org/10.2967/jnumed.111.099531 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044694185
559 rdf:type schema:CreativeWork
560 https://doi.org/10.3324/haematol.2009.016105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000955950
561 rdf:type schema:CreativeWork
562 https://doi.org/10.4049/jimmunol.1201593 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041497315
563 rdf:type schema:CreativeWork
564 https://doi.org/10.5588/ijtld.11.0692 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042583588
565 rdf:type schema:CreativeWork
566 https://doi.org/10.5588/ijtld.12.0010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073012101
567 rdf:type schema:CreativeWork
568 https://doi.org/10.5588/ijtld.12.0049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052801883
569 rdf:type schema:CreativeWork
570 https://doi.org/10.5588/ijtld.13.0565 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028456050
571 rdf:type schema:CreativeWork
572 https://www.grid.ac/institutes/grid.11956.3a schema:alternateName Stellenbosch University
573 schema:name Department of Science and Technology–National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, Stellenbosch University, Cape Town, South Africa.
574 Division of Nuclear Medicine, Department of Medical Imaging and Clinical Oncology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
575 Division of Pulmonology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
576 Division of Radiodiagnosis, Department of Medical Imaging and Clinical Oncology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
577 South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
578 Western Cape Academic Positron Emission Tomography–Computed Tomography Centre, Tygerberg Academic Hospital, Cape Town, South Africa.
579 rdf:type schema:Organization
580 https://www.grid.ac/institutes/grid.168010.e schema:alternateName Stanford University
581 schema:name Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, USA.
582 rdf:type schema:Organization
583 https://www.grid.ac/institutes/grid.415619.e schema:alternateName National Medical Center
584 schema:name National Medical Center, Seoul, South Korea.
585 rdf:type schema:Organization
586 https://www.grid.ac/institutes/grid.419681.3 schema:alternateName National Institute of Allergy and Infectious Diseases
587 schema:name Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
588 Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
589 rdf:type schema:Organization
590 https://www.grid.ac/institutes/grid.469131.8 schema:alternateName Rutgers University–Newark
591 schema:name Center for Emerging Pathogens, Department of Medicine, Rutgers New Jersey Medical School, Newark, New Jersey, USA.
592 rdf:type schema:Organization
593 https://www.grid.ac/institutes/grid.474940.a schema:alternateName Catalysis Foundation for Health
594 schema:name Catalysis Foundation for Health, Emeryville, California, USA.
595 rdf:type schema:Organization
596 https://www.grid.ac/institutes/grid.495992.a schema:alternateName International Tuberculosis Research Center
597 schema:name International Tuberculosis Research Center, Seoul, South Korea.
598 rdf:type schema:Organization
599 https://www.grid.ac/institutes/grid.7836.a schema:alternateName University of Cape Town
600 schema:name Institute of Infectious Disease and Molecular Medicine, Department of Clinical Laboratory Sciences, University of Cape Town, Cape Town, South Africa.
601 Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
602 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...