Immunomodulatory drugs disrupt the cereblon–CD147–MCT1 axis to exert antitumor activity and teratogenicity View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-06-13

AUTHORS

Ruth Eichner, Michael Heider, Vanesa Fernández-Sáiz, Frauke van Bebber, Anne-Kathrin Garz, Simone Lemeer, Martina Rudelius, Bianca-Sabrina Targosz, Laura Jacobs, Anna-Maria Knorn, Jolanta Slawska, Uwe Platzbecker, Ulrich Germing, Christian Langer, Stefan Knop, Herrmann Einsele, Christian Peschel, Christian Haass, Ulrich Keller, Bettina Schmid, Katharina S Götze, Bernhard Kuster, Florian Bassermann

ABSTRACT

Thalidomide and its derivatives lenalidomide and pomalidomide, which are used to treat multiple myeloma and del(5q) myelodysplastic syndrome, have antitumor and teratogenic effects through a mechanism involving destabilization of the CD147 and MCT1 proteins.

PAGES

735-743

References to SciGraph publications

  • 2013-09-10. Lenalidomide as a disease-modifying agent in patients with del(5q) myelodysplastic syndromes: linking mechanism of action to clinical outcomes in ANNALS OF HEMATOLOGY
  • 2015-05-25. The Cyclophilin A–CD147 complex promotes the proliferation and homing of multiple myeloma cells in NATURE MEDICINE
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  • 2016-02-24. Structural basis of lenalidomide-induced CK1α degradation by the CRL4CRBN ubiquitin ligase in NATURE
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  • 2004-04. The evolution of thalidomide and its IMiD derivatives as anticancer agents in NATURE REVIEWS CANCER
  • 2015-07-01. Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS in NATURE
  • 2012-03-30. Increased expression of extracellular matrix metalloproteinase inducer (CD147) in multiple myeloma: role in regulation of myeloma cell proliferation in LEUKEMIA
  • 2014-07-16. Structure of the DDB1–CRBN E3 ubiquitin ligase in complex with thalidomide in NATURE
  • 2012-12-23. SCFFbxo9 and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myeloma in NATURE CELL BIOLOGY
  • 2006-10. Molecular architecture and assembly of the DDB1–CUL4A ubiquitin ligase machinery in NATURE
  • 2013-08-23. Disrupting proton dynamics and energy metabolism for cancer therapy in NATURE REVIEWS CANCER
  • 2014-11-24. Disruption of the PRKCD–FBXO25–HAX-1 axis attenuates the apoptotic response and drives lymphomagenesis in NATURE MEDICINE
  • 2012-05-03. Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide in LEUKEMIA
  • Journal

    TITLE

    Nature Medicine

    ISSUE

    7

    VOLUME

    22

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nm.4128

    DOI

    http://dx.doi.org/10.1038/nm.4128

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1016584456

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27294876


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