A human-specific AS3MT isoform and BORCS7 are molecular risk factors in the 10q24.32 schizophrenia-associated locus View Full Text


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Article Info

DATE

2016-06

AUTHORS

Ming Li, Andrew E Jaffe, Richard E Straub, Ran Tao, Joo Heon Shin, Yanhong Wang, Qiang Chen, Chao Li, Yankai Jia, Kazutaka Ohi, Brady J Maher, Nicholas J Brandon, Alan Cross, Joshua G Chenoweth, Daniel J Hoeppner, Huijun Wei, Thomas M Hyde, Ronald McKay, Joel E Kleinman, Daniel R Weinberger

ABSTRACT

Genome-wide association studies (GWASs) have reported many single nucleotide polymorphisms (SNPs) associated with psychiatric disorders, but knowledge is lacking regarding molecular mechanisms. Here we show that risk alleles spanning multiple genes across the 10q24.32 schizophrenia-related locus are associated in the human brain selectively with an increase in the expression of both BLOC-1 related complex subunit 7 (BORCS7) and a previously uncharacterized, human-specific arsenite methyltransferase (AS3MT) isoform (AS3MT(d2d3)), which lacks arsenite methyltransferase activity and is more abundant in individuals with schizophrenia than in controls. Conditional-expression analysis suggests that BORCS7 and AS3MT(d2d3) signals are largely independent. GWAS risk SNPs across this region are linked with a variable number tandem repeat (VNTR) polymorphism in the first exon of AS3MT that is associated with the expression of AS3MT(d2d3) in samples from both Caucasians and African Americans. The VNTR genotype predicts promoter activity in luciferase assays, as well as DNA methylation within the AS3MT gene. Both AS3MT(d2d3) and BORCS7 are expressed in adult human neurons and astrocytes, and they are upregulated during human stem cell differentiation toward neuronal fates. Our results provide a molecular explanation for the prominent 10q24.32 locus association, including a novel and evolutionarily recent protein that is involved in early brain development and confers risk for psychiatric illness. More... »

PAGES

649

References to SciGraph publications

  • 2014-06. The Effects of Arsenic Exposure on Neurological and Cognitive Dysfunction in Human and Rodent Studies: A Review in CURRENT ENVIRONMENTAL HEALTH REPORTS
  • 2008-09. Identification of loci associated with schizophrenia by genome-wide association and follow-up in NATURE GENETICS
  • 2010-02. The dysbindin-containing complex (BLOC-1) in brain: developmental regulation, interaction with SNARE proteins and role in neurite outgrowth in MOLECULAR PSYCHIATRY
  • 2012-09. Association between genetic variation in a region on chromosome 11 and schizophrenia in large samples from Europe in MOLECULAR PSYCHIATRY
  • 2009-05. Effects of selenium on the structure and function of recombinant human S-adenosyl-l-methionine dependent arsenic (+3 oxidation state) methyltransferase in E. coli in JBIC JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
  • 2011-10. Genome-wide association study identifies five new schizophrenia loci in NATURE GENETICS
  • 2013-06. The Genotype-Tissue Expression (GTEx) project in NATURE GENETICS
  • 2014-02. Revisiting DARPP-32 in postmortem human brain: changes in schizophrenia and bipolar disorder and genetic associations with t-DARPP-32 expression in MOLECULAR PSYCHIATRY
  • 2014-07. Biological insights from 108 schizophrenia-associated genetic loci in NATURE
  • 2015-01. Developmental regulation of human cortex transcription and its clinical relevance at single base resolution in NATURE NEUROSCIENCE
  • 2015-05. A coding-independent function of an alternative Ube3a transcript during neuronal development in NATURE NEUROSCIENCE
  • 2013-10. Genome-wide association analysis identifies 13 new risk loci for schizophrenia in NATURE GENETICS
  • 2004-06. The hippocampus in schizophrenia: a review of the neuropathological evidence and its pathophysiological implications in PSYCHOPHARMACOLOGY
  • 2011-12. Common variants on 8p12 and 1q24.2 confer risk of schizophrenia in NATURE GENETICS
  • 2016-01. Mapping DNA methylation across development, genotype and schizophrenia in the human frontal cortex in NATURE NEUROSCIENCE
  • 2009-05. A primate-specific, brain isoform of KCNH2 affects cortical physiology, cognition, neuronal repolarization and risk of schizophrenia in NATURE MEDICINE
  • 2011-10. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4 in NATURE GENETICS
  • 2001-11. Replication validity of genetic association studies in NATURE GENETICS
  • 2009-07-01. Common variants on chromosome 6p22.1 are associated with schizophrenia in NATURE
  • 2009-07-01. Common variants conferring risk of schizophrenia in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nm.4096

    DOI

    http://dx.doi.org/10.1038/nm.4096

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1008270787

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27158905


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