Rps14 haploinsufficiency causes a block in erythroid differentiation mediated by S100A8 and S100A9 View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-02-15

AUTHORS

Rebekka K Schneider, Monica Schenone, Monica Ventura Ferreira, Rafael Kramann, Cailin E Joyce, Christina Hartigan, Fabian Beier, Tim H Brümmendorf, Ulrich Germing, Uwe Platzbecker, Guntram Büsche, Ruth Knüchel, Michelle C Chen, Christopher S Waters, Edwin Chen, Lisa P Chu, Carl D Novina, R Coleman Lindsley, Steven A Carr, Benjamin L Ebert

ABSTRACT

In a mouse model of the 5q- subtype of myelodysplastic syndrome, haploinsufficiency of the ribosomal protein gene Rps14 leads to anemia through a mechanism involving innate immune signaling and the Tlr4 ligand S100A8, which induces a p53-dependent block to erythroid differentiation.

PAGES

288-297

References to SciGraph publications

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  • Journal

    TITLE

    Nature Medicine

    ISSUE

    3

    VOLUME

    22

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nm.4047

    DOI

    http://dx.doi.org/10.1038/nm.4047

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1007256400

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26878232


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