Combined inhibition of DDR1 and Notch signaling is a therapeutic strategy for KRAS-driven lung adenocarcinoma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-02-08

AUTHORS

Chiara Ambrogio, Gonzalo Gómez-López, Mattia Falcone, August Vidal, Ernest Nadal, Nicola Crosetto, Rafael B Blasco, Pablo J Fernández-Marcos, Montserrat Sánchez-Céspedes, Xiaomei Ren, Zhen Wang, Ke Ding, Manuel Hidalgo, Manuel Serrano, Alberto Villanueva, David Santamaría, Mariano Barbacid

ABSTRACT

Transcriptional profiling of Kras-driven early lesions—aimed at identifying founder events—reveals DDR1 as a therapeutic target relevant to adenocarcinoma.

PAGES

270-277

References to SciGraph publications

  • 2003-07. Consensus Clustering: A Resampling-Based Method for Class Discovery and Visualization of Gene Expression Microarray Data in MACHINE LEARNING
  • 2002-08-19. Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells in NATURE MEDICINE
  • 2014-04-30. Therapeutic modulation of Notch signalling — are we there yet? in NATURE REVIEWS DRUG DISCOVERY
  • 2012-03-18. A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response in NATURE
  • 2012-02-26. Discoidin domain receptor tyrosine kinases: new players in cancer progression in CANCER AND METASTASIS REVIEWS
  • 2014-06-26. Identifying Direct Notch Transcriptional Targets Using the GSI-Washout Assay in NOTCH SIGNALING
  • 2004-12-19. An oncogenic KRAS2 expression signature identified by cross-species gene-expression analysis in NATURE GENETICS
  • 2001-11-05. Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer in NATURE GENETICS
  • 2013-09-18. Tumour heterogeneity and cancer cell plasticity in NATURE
  • 2014-02-05. Alveolar progenitor and stem cells in lung development, renewal and cancer in NATURE
  • 2013-06-13. Discoidin domain receptor 1 is associated with poor prognosis of non-small cell lung cancer and promotes cell invasion via epithelial-to-mesenchymal transition in MEDICAL ONCOLOGY
  • 2001. Clinically Accurate Orthotopic Mouse Models of Cancer in METASTASIS RESEARCH PROTOCOLS
  • 2015-05-07. Translational value of mouse models in oncology drug development in NATURE MEDICINE
  • 2010-02-28. A chemical and phosphoproteomic characterization of dasatinib action in lung cancer in NATURE CHEMICAL BIOLOGY
  • Journal

    TITLE

    Nature Medicine

    ISSUE

    3

    VOLUME

    22

    From Grant

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nm.4041

    DOI

    http://dx.doi.org/10.1038/nm.4041

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1045260954

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26855149


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